|
US2699808A
(en)
|
1944-10-06 |
1955-01-18 |
Mark W Lowe |
Apparatus for peeling tomatoes
|
|
US2699508A
(en)
|
1951-12-21 |
1955-01-11 |
Selectronics Inc |
Method of mounting and construction of mounting for low frequency piezoelectric crystals
|
|
US4426330A
(en)
|
1981-07-20 |
1984-01-17 |
Lipid Specialties, Inc. |
Synthetic phospholipid compounds
|
|
US4534899A
(en)
|
1981-07-20 |
1985-08-13 |
Lipid Specialties, Inc. |
Synthetic phospholipid compounds
|
|
US5354844A
(en)
|
1989-03-16 |
1994-10-11 |
Boehringer Ingelheim International Gmbh |
Protein-polycation conjugates
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
US5227170A
(en)
|
1989-06-22 |
1993-07-13 |
Vestar, Inc. |
Encapsulation process
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5356633A
(en)
|
1989-10-20 |
1994-10-18 |
Liposome Technology, Inc. |
Method of treatment of inflamed tissues
|
|
US5527528A
(en)
|
1989-10-20 |
1996-06-18 |
Sequus Pharmaceuticals, Inc. |
Solid-tumor treatment method
|
|
US5469854A
(en)
|
1989-12-22 |
1995-11-28 |
Imarx Pharmaceutical Corp. |
Methods of preparing gas-filled liposomes
|
|
US5580575A
(en)
|
1989-12-22 |
1996-12-03 |
Imarx Pharmaceutical Corp. |
Therapeutic drug delivery systems
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US6582908B2
(en)
|
1990-12-06 |
2003-06-24 |
Affymetrix, Inc. |
Oligonucleotides
|
|
JP3220180B2
(ja)
|
1991-05-23 |
2001-10-22 |
三菱化学株式会社 |
薬剤含有タンパク質結合リポソーム
|
|
US5521291A
(en)
|
1991-09-30 |
1996-05-28 |
Boehringer Ingelheim International, Gmbh |
Conjugates for introducing nucleic acid into higher eucaryotic cells
|
|
NZ244306A
(en)
|
1991-09-30 |
1995-07-26 |
Boehringer Ingelheim Int |
Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation
|
|
US5583020A
(en)
|
1992-11-24 |
1996-12-10 |
Ribozyme Pharmaceuticals, Inc. |
Permeability enhancers for negatively charged polynucleotides
|
|
JPH08504559A
(ja)
|
1992-12-14 |
1996-05-14 |
ハネウエル・インコーポレーテッド |
個別に制御される冗長巻線を有するモータシステム
|
|
JP3351476B2
(ja)
|
1993-01-22 |
2002-11-25 |
三菱化学株式会社 |
リン脂質誘導体及びそれを含有するリポソーム
|
|
US5395619A
(en)
|
1993-03-03 |
1995-03-07 |
Liposome Technology, Inc. |
Lipid-polymer conjugates and liposomes
|
|
US5462854A
(en)
|
1993-04-19 |
1995-10-31 |
Beckman Instruments, Inc. |
Inverse linkage oligonucleotides for chemical and enzymatic processes
|
|
US5534259A
(en)
|
1993-07-08 |
1996-07-09 |
Liposome Technology, Inc. |
Polymer compound and coated particle composition
|
|
US5543158A
(en)
|
1993-07-23 |
1996-08-06 |
Massachusetts Institute Of Technology |
Biodegradable injectable nanoparticles
|
|
US5417978A
(en)
|
1993-07-29 |
1995-05-23 |
Board Of Regents, The University Of Texas System |
Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use
|
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
|
US5595756A
(en)
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
US5543152A
(en)
|
1994-06-20 |
1996-08-06 |
Inex Pharmaceuticals Corporation |
Sphingosomes for enhanced drug delivery
|
|
US5591721A
(en)
|
1994-10-25 |
1997-01-07 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
US5512295A
(en)
|
1994-11-10 |
1996-04-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Synthetic liposomes for enhanced uptake and delivery
|
|
US5726027A
(en)
|
1996-03-08 |
1998-03-10 |
The Regents Of The University Of California |
Method for treatment of insulin resistance
|
|
US5656408A
(en)
|
1996-04-29 |
1997-08-12 |
Xerox Corporation |
Coated carrier particles
|
|
US7875733B2
(en)
|
2003-09-18 |
2011-01-25 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
|
|
CA2269637A1
(en)
|
1996-11-04 |
1998-05-14 |
Merck Frosst Canada & Co. |
Ligands for phosphatase binding assay
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
JP4236812B2
(ja)
|
1997-09-12 |
2009-03-11 |
エクシコン エ／エス |
オリゴヌクレオチド類似体
|
|
KR100280206B1
(ko)
|
1997-12-06 |
2001-03-02 |
윤종용 |
고유전체 캐패시터 및 그의 제조 방법
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
US20030228597A1
(en)
|
1998-04-13 |
2003-12-11 |
Cowsert Lex M. |
Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
|
|
CN102180924A
(zh)
|
1999-05-04 |
2011-09-14 |
桑塔里斯制药公司 |
L-核糖-lna类似物
|
|
US6525191B1
(en)
|
1999-05-11 |
2003-02-25 |
Kanda S. Ramasamy |
Conformationally constrained L-nucleosides
|
|
US6043091A
(en)
|
1999-07-19 |
2000-03-28 |
Isis Pharmaceuticals Inc. |
Antisense modulation of liver glycogen phosphorylase expression
|
|
US6200807B1
(en)
|
1999-07-21 |
2001-03-13 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of SHP-2 expression
|
|
EP1212416A2
(en)
|
1999-08-31 |
2002-06-12 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid based modulators of gene expression
|
|
US6177273B1
(en)
|
1999-10-26 |
2001-01-23 |
Isis Pharmaceuticals Inc. |
Antisense modulation of integrin-linked kinase expression
|
|
US6261840B1
(en)
*
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US7179796B2
(en)
|
2000-01-18 |
2007-02-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
|
US6602857B1
(en)
|
2000-01-18 |
2003-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US6287860B1
(en)
|
2000-01-20 |
2001-09-11 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of MEKK2 expression
|
|
WO2002059137A1
(en)
|
2000-11-03 |
2002-08-01 |
Isis Pharmaceuticals, Inc. |
Nuclease-based method for detecting and quantitating oligonucleotides
|
|
EP1873259B1
(en)
|
2000-12-01 |
2012-01-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
RNA interference mediated by 21 and 22nt RNAs
|
|
US20030108883A1
(en)
|
2001-02-13 |
2003-06-12 |
Rondinone Cristina M. |
Methods for identifying compounds that inhibit or reduce PTP1B expression
|
|
US20050070497A1
(en)
|
2001-05-18 |
2005-03-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibtion of tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
|
|
US20040019001A1
(en)
|
2002-02-20 |
2004-01-29 |
Mcswiggen James A. |
RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
|
|
WO2002100396A1
(en)
|
2001-06-07 |
2002-12-19 |
Wyeth |
COMBINATION OF A PTPase INHIBITOR AND A THIAZOLIDINEDIONE AGENT
|
|
CA2682251A1
(en)
|
2001-07-17 |
2003-01-30 |
N-Gene Research Laboratories Inc. |
A synergistic pharmaceutical combination for the prevention or treatment of diabetes
|
|
US20040009946A1
(en)
|
2002-05-23 |
2004-01-15 |
Ceptyr, Inc. |
Modulation of PTP1B expression and signal transduction by RNA interference
|
|
EP1562971B1
(en)
|
2002-11-05 |
2014-02-12 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
US8604183B2
(en)
|
2002-11-05 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
EP2314691A3
(en)
|
2002-11-14 |
2012-01-18 |
Dharmacon, Inc. |
Fuctional and hyperfunctional siRNA
|
|
TWI347948B
(en)
|
2002-11-19 |
2011-09-01 |
Sankyo Co |
Novel 2',5'-oligoadenylic acid compositions
|
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
|
TW200516081A
(en)
|
2003-08-28 |
2005-05-16 |
Sankyo Co |
PTP1B anti-sense compounds
|
|
US7427672B2
(en)
|
2003-08-28 |
2008-09-23 |
Takeshi Imanishi |
Artificial nucleic acids of n-o bond crosslinkage type
|
|
US7687616B1
(en)
|
2004-05-14 |
2010-03-30 |
Rosetta Genomics Ltd |
Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof
|
|
US20060089325A1
(en)
|
2004-10-13 |
2006-04-27 |
Sanjay Bhanot |
Antisense modulation of PTP1B expression
|
|
CN102908630B
(zh)
|
2006-01-27 |
2014-11-19 |
Isis制药公司 |
6-修饰的双环核酸类似物
|
|
EP2015758B1
(en)
|
2006-05-05 |
2014-04-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression apob
|
|
EP2066684B1
(en)
|
2006-05-11 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
5'-modified bicyclic nucleic acid analogs
|
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
EP2125852B1
(en)
|
2007-02-15 |
2016-04-06 |
Ionis Pharmaceuticals, Inc. |
5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
|
|
US20100105134A1
(en)
|
2007-03-02 |
2010-04-29 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting gene expression and uses thereof
|
|
WO2008109369A2
(en)
*
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting tnf gene expression and uses thereof
|
|
ES2388590T3
(es)
|
2007-05-30 |
2012-10-16 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos con puente aminometileno N-sustituido.
|
|
WO2008154401A2
(en)
|
2007-06-08 |
2008-12-18 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
WO2009006478A2
(en)
|
2007-07-05 |
2009-01-08 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
WO2009046141A2
(en)
|
2007-10-01 |
2009-04-09 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
|
AT507215B1
(de)
|
2009-01-14 |
2010-03-15 |
Boehler Edelstahl Gmbh & Co Kg |
Verschleissbeständiger werkstoff
|
|
SG173182A1
(en)
|
2009-02-03 |
2011-09-29 |
Hoffmann La Roche |
Compositions and methods for inhibiting expression of ptp1b genes
|
|
US9984408B1
(en)
|
2012-05-30 |
2018-05-29 |
Amazon Technologies, Inc. |
Method, medium, and system for live video cooperative shopping
|
|
US9778708B1
(en)
|
2016-07-18 |
2017-10-03 |
Lenovo Enterprise Solutions (Singapore) Pte. Ltd. |
Dual sided latching retainer for computer modules
|