JP2014511877A5 - - Google Patents
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- Publication number
- JP2014511877A5 JP2014511877A5 JP2014505275A JP2014505275A JP2014511877A5 JP 2014511877 A5 JP2014511877 A5 JP 2014511877A5 JP 2014505275 A JP2014505275 A JP 2014505275A JP 2014505275 A JP2014505275 A JP 2014505275A JP 2014511877 A5 JP2014511877 A5 JP 2014511877A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- compound
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 137
- 150000001875 compounds Chemical class 0.000 claims 63
- 125000003118 aryl group Chemical group 0.000 claims 41
- 125000001072 heteroaryl group Chemical group 0.000 claims 36
- 125000000623 heterocyclic group Chemical group 0.000 claims 25
- -1 amino-O— Chemical class 0.000 claims 24
- 125000003545 alkoxy group Chemical group 0.000 claims 23
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 23
- 239000012453 solvate Substances 0.000 claims 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims 22
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical class 0.000 claims 17
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 15
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 150000001408 amides Chemical class 0.000 claims 14
- 150000001412 amines Chemical class 0.000 claims 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 14
- RWSOTUBLDIXVET-UHFFFAOYSA-M hydrosulfide Chemical group [SH-] RWSOTUBLDIXVET-UHFFFAOYSA-M 0.000 claims 14
- 229920001223 polyethylene glycol Polymers 0.000 claims 13
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 150000002148 esters Chemical class 0.000 claims 12
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 125000002883 imidazolyl group Chemical group 0.000 claims 6
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 4
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000004185 ester group Chemical group 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000003827 glycol group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000006468 Adrenal Cortex Neoplasms Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010023825 Laryngeal cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000005910 alkyl carbonate group Chemical group 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 210000004153 islets of langerhan Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 0 CC*C([C@](CS)N)=O Chemical compound CC*C([C@](CS)N)=O 0.000 description 8
- FQSPSDQIJRVOAA-LURJTMIESA-N CCCCNC([C@H](CS)N)=O Chemical compound CCCCNC([C@H](CS)N)=O FQSPSDQIJRVOAA-LURJTMIESA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474621P | 2011-04-12 | 2011-04-12 | |
| US61/474,621 | 2011-04-12 | ||
| US201261588470P | 2012-01-19 | 2012-01-19 | |
| US61/588,470 | 2012-01-19 | ||
| PCT/US2012/033259 WO2012142245A2 (en) | 2011-04-12 | 2012-04-12 | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014511877A JP2014511877A (ja) | 2014-05-19 |
| JP2014511877A5 true JP2014511877A5 (enExample) | 2015-05-28 |
Family
ID=46147674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505275A Pending JP2014511877A (ja) | 2011-04-12 | 2012-04-12 | ポロ様キナーゼ１ポロ−ボックスドメインのペプチド模倣リガンド及び使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10266565B2 (enExample) |
| EP (1) | EP2686342A2 (enExample) |
| JP (1) | JP2014511877A (enExample) |
| AU (1) | AU2012242784B2 (enExample) |
| CA (1) | CA2832073A1 (enExample) |
| WO (1) | WO2012142245A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014153101A2 (en) | 2013-03-14 | 2014-09-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use |
| KR101672975B1 (ko) * | 2014-07-03 | 2016-11-04 | 한국과학기술연구원 | 알로스테릭 ｐｌｋ1-ｐｂｄ 저해활성을 가지는 고리형 포스포펩티드 화합물 |
| KR101650778B1 (ko) * | 2014-10-17 | 2016-08-25 | 충북대학교 산학협력단 | 폴로유사인산화효소-1의 폴로박스 도메인에 특이적으로 결합하는 펩타이드 유사체 및 이를 유효성분으로 포함하는 피임용 조성물 |
| KR101670770B1 (ko) * | 2014-10-17 | 2016-11-01 | 충북대학교 산학협력단 | 폴로유사인산화효소-1의 폴로박스 도메인에 특이적으로 결합하는 펩타이드 유사체 및 이를 포함하는 항암용 조성물 |
| WO2017082924A1 (en) | 2015-11-13 | 2017-05-18 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use |
| WO2018085208A1 (en) | 2016-11-02 | 2018-05-11 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction |
| US20210322575A1 (en) | 2018-09-28 | 2021-10-21 | Nutcracker Therapeutics, Inc. | Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery |
| CN115873033B (zh) * | 2022-12-28 | 2025-03-18 | 永农生物科学有限公司 | 一种草铵膦的制备方法 |
| WO2025206344A1 (ja) * | 2024-03-28 | 2025-10-02 | 日産化学株式会社 | グラフェンリンカー化合物及び電界効果トランジスタバイオセンサー |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100523215C (zh) | 2000-12-01 | 2009-08-05 | 马普科技促进协会 | 介导rna干涉的小rna分子 |
| WO2010132869A2 (en) * | 2009-05-15 | 2010-11-18 | Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use |
-
2012
- 2012-04-12 CA CA2832073A patent/CA2832073A1/en not_active Abandoned
- 2012-04-12 US US14/111,540 patent/US10266565B2/en active Active
- 2012-04-12 AU AU2012242784A patent/AU2012242784B2/en not_active Ceased
- 2012-04-12 JP JP2014505275A patent/JP2014511877A/ja active Pending
- 2012-04-12 WO PCT/US2012/033259 patent/WO2012142245A2/en not_active Ceased
- 2012-04-12 EP EP12722945.8A patent/EP2686342A2/en not_active Withdrawn