JP2014510520A5 - - Google Patents
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- JP2014510520A5 JP2014510520A5 JP2013554547A JP2013554547A JP2014510520A5 JP 2014510520 A5 JP2014510520 A5 JP 2014510520A5 JP 2013554547 A JP2013554547 A JP 2013554547A JP 2013554547 A JP2013554547 A JP 2013554547A JP 2014510520 A5 JP2014510520 A5 JP 2014510520A5
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- JP
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- Prior art keywords
- csf
- mouse
- human
- cell
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 53
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 52
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims description 47
- 241000699670 Mus sp. Species 0.000 claims description 28
- 238000010172 mouse model Methods 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 17
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 16
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 16
- 238000000338 in vitro Methods 0.000 claims description 12
- 210000002540 macrophage Anatomy 0.000 claims description 12
- 210000001616 monocyte Anatomy 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 11
- 150000007523 nucleic acids Chemical group 0.000 claims description 11
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 10
- 230000000638 stimulation Effects 0.000 claims description 10
- 230000004044 response Effects 0.000 claims description 9
- 230000035772 mutation Effects 0.000 claims description 8
- 230000028327 secretion Effects 0.000 claims description 8
- 210000000952 spleen Anatomy 0.000 claims description 8
- 101100193633 Danio rerio rag2 gene Proteins 0.000 claims description 7
- 101100193635 Mus musculus Rag2 gene Proteins 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 6
- 230000037430 deletion Effects 0.000 claims description 6
- 238000012217 deletion Methods 0.000 claims description 6
- 244000052637 human pathogen Species 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 210000004185 liver Anatomy 0.000 claims description 6
- 101100338243 Caenorhabditis elegans hil-6 gene Proteins 0.000 claims description 4
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 230000036765 blood level Effects 0.000 claims description 4
- 210000004556 brain Anatomy 0.000 claims description 4
- 230000000139 costimulatory effect Effects 0.000 claims description 4
- 210000005260 human cell Anatomy 0.000 claims description 4
- 210000003734 kidney Anatomy 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 4
- 210000001550 testis Anatomy 0.000 claims description 4
- 108700028369 Alleles Proteins 0.000 claims description 3
- 108700024394 Exon Proteins 0.000 claims description 3
- 210000001185 bone marrow Anatomy 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims description 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims description 2
- 101100099884 Homo sapiens CD40 gene Proteins 0.000 claims description 2
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 2
- 101000946850 Homo sapiens T-lymphocyte activation antigen CD86 Proteins 0.000 claims description 2
- 241000186359 Mycobacterium Species 0.000 claims description 2
- 206010057249 Phagocytosis Diseases 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 230000035605 chemotaxis Effects 0.000 claims description 2
- 102000054189 human CD80 Human genes 0.000 claims description 2
- 102000049849 human CD86 Human genes 0.000 claims description 2
- 102000052611 human IL6 Human genes 0.000 claims description 2
- 244000052769 pathogen Species 0.000 claims description 2
- 230000001717 pathogenic effect Effects 0.000 claims description 2
- 210000005259 peripheral blood Anatomy 0.000 claims description 2
- 239000011886 peripheral blood Substances 0.000 claims description 2
- 230000008782 phagocytosis Effects 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 230000003827 upregulation Effects 0.000 claims description 2
- 238000003209 gene knockout Methods 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 2
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 description 4
- 230000003915 cell function Effects 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102100026234 Cytokine receptor common subunit gamma Human genes 0.000 description 1
- 101001055227 Homo sapiens Cytokine receptor common subunit gamma Proteins 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161442946P | 2011-02-15 | 2011-02-15 | |
| US61/442,946 | 2011-02-15 | ||
| PCT/US2012/025040 WO2012112544A2 (en) | 2011-02-15 | 2012-02-14 | Humanized m-csf mice |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015214219A Division JP6188765B2 (ja) | 2011-02-15 | 2015-10-30 | ヒト化ｍ−ｃｓｆマウス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510520A JP2014510520A (ja) | 2014-05-01 |
| JP2014510520A5 true JP2014510520A5 (https=) | 2015-04-02 |
| JP5834097B2 JP5834097B2 (ja) | 2015-12-16 |
Family
ID=46673120
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554547A Active JP5834097B2 (ja) | 2011-02-15 | 2012-02-14 | ヒト化ｍ−ｃｓｆマウス |
| JP2015214219A Active JP6188765B2 (ja) | 2011-02-15 | 2015-10-30 | ヒト化ｍ−ｃｓｆマウス |
| JP2017148922A Active JP6505786B2 (ja) | 2011-02-15 | 2017-08-01 | ヒト化ｍ−ｃｓｆマウス |
| JP2019059688A Active JP6732987B2 (ja) | 2011-02-15 | 2019-03-27 | ヒト化ｍ−ｃｓｆマウス |
| JP2020117479A Active JP7181911B2 (ja) | 2011-02-15 | 2020-07-08 | ヒト化ｍ－ｃｓｆマウス |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015214219A Active JP6188765B2 (ja) | 2011-02-15 | 2015-10-30 | ヒト化ｍ−ｃｓｆマウス |
| JP2017148922A Active JP6505786B2 (ja) | 2011-02-15 | 2017-08-01 | ヒト化ｍ−ｃｓｆマウス |
| JP2019059688A Active JP6732987B2 (ja) | 2011-02-15 | 2019-03-27 | ヒト化ｍ−ｃｓｆマウス |
| JP2020117479A Active JP7181911B2 (ja) | 2011-02-15 | 2020-07-08 | ヒト化ｍ－ｃｓｆマウス |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US8847004B2 (https=) |
| EP (3) | EP3375284B1 (https=) |
| JP (5) | JP5834097B2 (https=) |
| KR (6) | KR102585058B1 (https=) |
| CN (3) | CN111808879B (https=) |
| AU (1) | AU2012217836B2 (https=) |
| CA (1) | CA2826714C (https=) |
| DK (3) | DK2675271T3 (https=) |
| ES (3) | ES2948210T3 (https=) |
| FI (2) | FI3375284T3 (https=) |
| IL (7) | IL227704A0 (https=) |
| MX (3) | MX338971B (https=) |
| MY (1) | MY162984A (https=) |
| PT (3) | PT2675271T (https=) |
| RU (2) | RU2577978C2 (https=) |
| SG (3) | SG10202008003VA (https=) |
| WO (1) | WO2012112544A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2449112A1 (en) * | 2009-07-01 | 2012-05-09 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for severe combined immunodeficiency (scid) |
| EP4502152A3 (en) | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| SG10202008003VA (en) | 2011-02-15 | 2020-10-29 | Regeneron Pharma | Humanized m-csf mice |
| CN108866101A (zh) | 2011-10-28 | 2018-11-23 | 瑞泽恩制药公司 | 人源化il-6和il-6受体 |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| FI2892330T3 (fi) | 2012-09-07 | 2023-03-25 | Univ Yale | Geneettisesti muokattuja hiiriä ja menetelmiä niiden käyttämiseksi |
| MX377561B (es) * | 2012-11-05 | 2025-03-10 | Regeneron Pharma | Animales no humanos genéticamente modificados y métodos de uso de los mismos. |
| MX384291B (es) | 2013-02-20 | 2025-03-14 | Regeneron Pharma | Modificación genética de ratas. |
| CN103409468B (zh) * | 2013-03-20 | 2015-08-12 | 中国科学院广州生物医药与健康研究院 | 一种免疫缺陷小鼠模型的建立方法 |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| WO2014204763A1 (en) | 2013-06-17 | 2014-12-24 | 3M Innovative Properties Company | Process for preparing guanidino-functional monomers |
| TR201901782T4 (tr) | 2013-09-23 | 2019-03-21 | Regeneron Pharma | İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar. |
| ES2613379T3 (es) | 2013-10-15 | 2017-05-24 | Regeneron Pharmaceuticals, Inc. | Animales con IL-15 humanizada |
| RU2671101C1 (ru) | 2013-11-19 | 2018-10-29 | Регенерон Фармасьютикалс, Инк. | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда |
| CA2929846C (en) * | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| EP3636073B1 (en) | 2014-05-05 | 2023-11-15 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
| NO2785538T3 (https=) | 2014-05-07 | 2018-08-04 | ||
| MX2016014995A (es) | 2014-05-19 | 2017-03-31 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| MX373055B (es) * | 2014-05-30 | 2020-05-20 | Regeneron Pharma | Animales con dipeptidil peptidasa iv (dpp4) humanizada. |
| HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| CN113412818B (zh) | 2014-12-09 | 2022-11-04 | 瑞泽恩制药公司 | 具有人源化分化簇274基因的非人动物 |
| ES2950399T3 (es) * | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| CN105994125B (zh) * | 2015-04-15 | 2019-05-17 | 中国科学院广州生物医药与健康研究院 | 一种评价免疫缺陷小鼠模型的免疫缺陷程度的方法 |
| EP3306313B1 (en) * | 2015-05-29 | 2020-07-15 | Central Institute For Experimental Animals | Method for evaluating hematological toxicity of drug under evaluation |
| HK1255123A1 (zh) | 2015-06-23 | 2019-08-02 | The Jackson Laboratory | 具有患者衍生异种移植物的非hla匹配的人源化nsg小鼠模型 |
| CN105145486A (zh) * | 2015-07-22 | 2015-12-16 | 中国医学科学院医学实验动物研究所 | Rag2基因敲除大鼠在建立个性化肿瘤治疗模型中的应用 |
| WO2017087780A1 (en) | 2015-11-20 | 2017-05-26 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
| SG11201806176PA (en) | 2016-02-04 | 2018-08-30 | Regeneron Pharma | Non-human animals having an engineered angptl8 gene |
| KR101887051B1 (ko) * | 2016-02-12 | 2018-08-10 | 한국과학기술원 | 오브젝트 탐닉행동을 활용한 동물행동 조절 방법 |
| DK3422845T3 (da) | 2016-02-29 | 2021-08-30 | Regeneron Pharma | Gnavere med et humaniseret tmprss-gen |
| CN110740641A (zh) * | 2016-11-30 | 2020-01-31 | 杰克逊实验室 | 具有改善的人先天免疫细胞发育的人源化小鼠模型 |
| ES2937797T3 (es) | 2017-04-17 | 2023-03-31 | Jackson Lab | Método de determinación de la toxicidad de un fármaco inmunomodulador para el uso en seres humanos |
| US20190098879A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use |
| HRP20240999T1 (hr) | 2018-07-16 | 2024-10-25 | Regeneron Pharmaceuticals, Inc. | Glodavački modeli bolesti ditra i njihova upotreba |
| WO2020041174A1 (en) * | 2018-08-20 | 2020-02-27 | The Jackson Laboratory | Method of determining toxicity of an immunomodulatory drug |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN111073907B (zh) * | 2018-12-25 | 2025-07-29 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子csf1基因改造非人动物的构建方法及应用 |
| KR102661779B1 (ko) | 2019-04-04 | 2024-04-30 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 응고 인자 12 좌위를 포함하는 비-인간 동물 |
| US11891618B2 (en) | 2019-06-04 | 2024-02-06 | Regeneron Pharmaceuticals, Inc. | Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use |
| MX2021015122A (es) | 2019-06-07 | 2022-04-06 | Regeneron Pharma | Animales no humanos que comprenden un locus de albumina humanizado. |
| WO2021011853A2 (en) * | 2019-07-17 | 2021-01-21 | Yale University | Genetically modified non-human animals and methods of use thereof |
| US11170872B2 (en) | 2019-11-05 | 2021-11-09 | Apeel Technology, Inc. | Prediction of latent infection in plant products |
| WO2021154791A1 (en) * | 2020-01-28 | 2021-08-05 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized pnpla3 locus and methods of use |
| KR20230074758A (ko) | 2020-09-24 | 2023-05-31 | 더 잭슨 래보라토리 | 면역 세포 요법을 평가하기 위한 인간화 마우스 모델 |
| CN113100175B (zh) * | 2021-03-08 | 2022-07-12 | 北京大学人民医院 | 一种巨细胞病毒感染的人源化小鼠模型及其构建方法 |
| WO2022222958A1 (en) * | 2021-04-20 | 2022-10-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric genes |
| IL318159A (en) | 2022-07-19 | 2025-03-01 | Regeneron Pharma | Genetically modified animal model and its use to model the human immune system |
| US20250255282A1 (en) | 2024-02-08 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
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