JP2014510042A5 - - Google Patents
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- Publication number
- JP2014510042A5 JP2014510042A5 JP2013551414A JP2013551414A JP2014510042A5 JP 2014510042 A5 JP2014510042 A5 JP 2014510042A5 JP 2013551414 A JP2013551414 A JP 2013551414A JP 2013551414 A JP2013551414 A JP 2013551414A JP 2014510042 A5 JP2014510042 A5 JP 2014510042A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- bimatoprost
- minoxidil
- alopecia
- hair loss
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 121
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 claims description 62
- 229960002470 bimatoprost Drugs 0.000 claims description 62
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 claims description 61
- 229960003632 minoxidil Drugs 0.000 claims description 61
- 201000004384 Alopecia Diseases 0.000 claims description 53
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 41
- 230000003676 hair loss Effects 0.000 claims description 28
- 208000024963 hair loss Diseases 0.000 claims description 28
- 239000002904 solvent Substances 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 231100000360 alopecia Toxicity 0.000 claims description 19
- 239000007788 liquid Substances 0.000 claims description 18
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical group CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 15
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 12
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 12
- 230000003779 hair growth Effects 0.000 claims description 11
- 239000004094 surface-active agent Substances 0.000 claims description 11
- 230000000699 topical effect Effects 0.000 claims description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 9
- 239000006260 foam Substances 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 9
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 9
- 239000003021 water soluble solvent Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 230000003472 neutralizing effect Effects 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 7
- 210000004761 scalp Anatomy 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 6
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 claims description 6
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 6
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 6
- 238000002512 chemotherapy Methods 0.000 claims description 6
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 6
- 229940113120 dipropylene glycol Drugs 0.000 claims description 6
- 229940051250 hexylene glycol Drugs 0.000 claims description 6
- 229960004063 propylene glycol Drugs 0.000 claims description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
- 208000004631 alopecia areata Diseases 0.000 claims description 5
- 229920001577 copolymer Polymers 0.000 claims description 5
- 239000003381 stabilizer Substances 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 3
- 206010020850 Hyperthyroidism Diseases 0.000 claims description 3
- 206010022971 Iron Deficiencies Diseases 0.000 claims description 3
- 206010039710 Scleroderma Diseases 0.000 claims description 3
- 206010043866 Tinea capitis Diseases 0.000 claims description 3
- 230000005856 abnormality Effects 0.000 claims description 3
- 206010068168 androgenetic alopecia Diseases 0.000 claims description 3
- 201000002996 androgenic alopecia Diseases 0.000 claims description 3
- 208000034557 congenital alopecia Diseases 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 210000004709 eyebrow Anatomy 0.000 claims description 3
- 210000004919 hair shaft Anatomy 0.000 claims description 3
- 230000003054 hormonal effect Effects 0.000 claims description 3
- 208000003532 hypothyroidism Diseases 0.000 claims description 3
- 230000002989 hypothyroidism Effects 0.000 claims description 3
- 239000012678 infectious agent Substances 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 206010025135 lupus erythematosus Diseases 0.000 claims description 3
- 150000007522 mineralic acids Chemical class 0.000 claims description 3
- 150000007524 organic acids Chemical class 0.000 claims description 3
- 230000000284 resting effect Effects 0.000 claims description 3
- 230000037390 scarring Effects 0.000 claims description 3
- 208000006379 syphilis Diseases 0.000 claims description 3
- 230000000472 traumatic effect Effects 0.000 claims description 3
- 239000003981 vehicle Substances 0.000 claims description 3
- 206010001767 Alopecia universalis Diseases 0.000 claims description 2
- 208000032775 alopecia universalis congenita Diseases 0.000 claims description 2
- 230000003658 preventing hair loss Effects 0.000 claims description 2
- 210000000744 eyelid Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 32
- 210000003491 skin Anatomy 0.000 description 8
- 210000004209 hair Anatomy 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 229940058020 2-amino-2-methyl-1-propanol Drugs 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 3
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 description 2
- SLINHMUFWFWBMU-UHFFFAOYSA-N Triisopropanolamine Chemical compound CC(O)CN(CC(C)O)CC(C)O SLINHMUFWFWBMU-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 2
- 229940043276 diisopropanolamine Drugs 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- OTJFQRMIRKXXRS-UHFFFAOYSA-N (hydroxymethylamino)methanol Chemical compound OCNCO OTJFQRMIRKXXRS-UHFFFAOYSA-N 0.000 description 1
- KQIXMZWXFFHRAQ-UHFFFAOYSA-N 1-(2-hydroxybutylamino)butan-2-ol Chemical compound CCC(O)CNCC(O)CC KQIXMZWXFFHRAQ-UHFFFAOYSA-N 0.000 description 1
- BFIAIMMAHAIVFT-UHFFFAOYSA-N 1-[bis(2-hydroxybutyl)amino]butan-2-ol Chemical compound CCC(O)CN(CC(O)CC)CC(O)CC BFIAIMMAHAIVFT-UHFFFAOYSA-N 0.000 description 1
- IOAOAKDONABGPZ-UHFFFAOYSA-N 2-amino-2-ethylpropane-1,3-diol Chemical compound CCC(N)(CO)CO IOAOAKDONABGPZ-UHFFFAOYSA-N 0.000 description 1
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- JCBPETKZIGVZRE-UHFFFAOYSA-N 2-aminobutan-1-ol Chemical compound CCC(N)CO JCBPETKZIGVZRE-UHFFFAOYSA-N 0.000 description 1
- BTANRVKWQNVYAZ-UHFFFAOYSA-N 2-butanol Substances CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical group [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OPKOKAMJFNKNAS-UHFFFAOYSA-N N-methylethanolamine Chemical compound CNCCO OPKOKAMJFNKNAS-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- -1 Trimethamine Chemical compound 0.000 description 1
- 241000665112 Zonitoides nitidus Species 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- BUOSLGZEBFSUDD-BGPZCGNYSA-N bis[(1s,3s,4r,5r)-4-methoxycarbonyl-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2,4-diphenylcyclobutane-1,3-dicarboxylate Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1C(C=2C=CC=CC=2)C(C(=O)O[C@@H]2[C@@H]([C@H]3CC[C@H](N3C)C2)C(=O)OC)C1C1=CC=CC=C1 BUOSLGZEBFSUDD-BGPZCGNYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940117583 cocamine Drugs 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 229940043279 diisopropylamine Drugs 0.000 description 1
- BWMOYXPGDBYVGM-UHFFFAOYSA-N ethane-1,2-diamine;propan-2-amine Chemical compound CC(C)N.NCCN BWMOYXPGDBYVGM-UHFFFAOYSA-N 0.000 description 1
- 210000000720 eyelash Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- OHMBHFSEKCCCBW-UHFFFAOYSA-N hexane-2,5-diol Chemical group CC(O)CCC(C)O OHMBHFSEKCCCBW-UHFFFAOYSA-N 0.000 description 1
- GKQPCPXONLDCMU-CCEZHUSRSA-N lacidipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1C1=CC=CC=C1\C=C\C(=O)OC(C)(C)C GKQPCPXONLDCMU-CCEZHUSRSA-N 0.000 description 1
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical group CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 1
- 229940048848 lauryl glucoside Drugs 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437785P | 2011-01-31 | 2011-01-31 | |
| US61/437,785 | 2011-01-31 | ||
| PCT/US2012/023148 WO2012106249A2 (en) | 2011-01-31 | 2012-01-30 | Method of enhancing hair growth |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510042A JP2014510042A (ja) | 2014-04-24 |
| JP2014510042A5 true JP2014510042A5 (cg-RX-API-DMAC7.html) | 2015-03-26 |
| JP6017455B2 JP6017455B2 (ja) | 2016-11-02 |
Family
ID=45688992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551414A Expired - Fee Related JP6017455B2 (ja) | 2011-01-31 | 2012-01-30 | 毛髪成長を増強する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8932567B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2670488A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6017455B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140020895A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103747775A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2012212481A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013019519A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2826232C (cg-RX-API-DMAC7.html) |
| RU (1) | RU2013139682A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012106249A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5457371B2 (ja) | 2008-02-05 | 2014-04-02 | ザ、トラスティーズ オブ プリンストン ユニバーシティ | 印刷電子機器 |
| US8859616B2 (en) * | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
| BR112013019519A2 (pt) | 2011-01-31 | 2016-08-09 | Allergan Inc | método de realce de crescimento capilar |
| CN105658221B (zh) * | 2013-09-26 | 2022-05-10 | 高德美国际公司 | 用于治疗萎缩性皮肤瘢痕形成的前列腺素F2α及其类似物 |
| WO2016159916A1 (en) * | 2015-03-31 | 2016-10-06 | Ogi̇g Sağlik Ürünleri̇ Ve Hi̇zmetleri̇ Sanayi̇ Ti̇caret Li̇mi̇ted Şi̇rketi̇ | A foamy pharmaceutical formulation used in dermatological diseases |
| MX2018001843A (es) * | 2015-08-13 | 2018-05-16 | River Town Therapeutics Inc | Composiciones y metodos para tratar alopecia. |
| JP7064820B2 (ja) * | 2016-03-31 | 2022-05-11 | ピアス株式会社 | 育毛剤、並びにε‐ポリリジンおよび／またはシャクヤク抽出物の使用 |
| KR102017796B1 (ko) * | 2016-07-28 | 2019-09-03 | 주식회사 큐어바이오 | 신규한 aimp1 단백질의 단편과 이를 유효성분으로 포함하는 발모 촉진용 조성물 |
| US10512670B2 (en) | 2016-08-08 | 2019-12-24 | Scm Lifescience Co., Ltd. | Pharmaceutical composition for preventing or treating hair loss comprising chemokine (C-X-C motif) ligand 1 (CXCL1) protein or CXCL1 protein and minoxidil as active ingredient |
| KR101849200B1 (ko) * | 2017-01-19 | 2018-04-16 | 주식회사 효성 | 충격강도가 개선된 폴리케톤 조성물 |
| KR101878795B1 (ko) * | 2017-03-22 | 2018-08-16 | 주식회사 효성 | 내열성이 개선된 폴리케톤 조성물 |
| KR102000217B1 (ko) * | 2017-08-08 | 2019-07-15 | 에스씨엠생명과학 주식회사 | Cxcl1 단백질 및 미녹시딜을 유효성분으로 포함하는 탈모 예방 또는 치료용 약학적 조성물 |
| WO2020028526A1 (en) * | 2018-08-02 | 2020-02-06 | Histogen, Inc. | Conditioned medium and extracellular matrix compositions and uses thereof |
| FI3886799T3 (fi) * | 2019-08-07 | 2023-12-13 | Aneira Pharma Inc | Koostumuksia hiustenlähdön hoitoon |
| CN110755286A (zh) * | 2019-11-18 | 2020-02-07 | 童婧 | 一种有助于生发的发际线填充组合物 |
| CN111110721A (zh) * | 2020-01-19 | 2020-05-08 | 朱炜 | 一种毛发防脱再生的复合制剂及其使用方法 |
| WO2021232054A1 (en) * | 2020-05-12 | 2021-11-18 | Chemistryrx | Compositions for treating hair loss |
| BR102021003531A2 (pt) | 2021-02-24 | 2022-08-30 | Eurofarma Laboratorios S.A. | Composição farmacêutica tópica espumável |
| KR102482658B1 (ko) * | 2021-12-07 | 2022-12-29 | 주식회사 바이오빌리프 | 비마토프로스트를 포함하는 국소 투여용 약학 조성물 |
| WO2025069091A1 (en) * | 2023-09-29 | 2025-04-03 | Pdfe Pharma Innovations - Fzco | Novel topical pharmaceutical composition for prevention and treatment of hair loss |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4139619A (en) | 1976-05-24 | 1979-02-13 | The Upjohn Company | 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth |
| US4968812A (en) | 1989-06-23 | 1990-11-06 | Shell Oil Company | Spirolactonelactams |
| US5352708A (en) | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| ATE306888T1 (de) * | 2000-04-07 | 2005-11-15 | Taisho Pharmaceutical Co Ltd | Haarwachstumstimulierende mittel mit verlängerter wirkung |
| US7351404B2 (en) * | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US7632868B2 (en) * | 2007-10-31 | 2009-12-15 | Meta Cosmetics, Llc | Prostaglandin analog compositions to treat epithelial-related conditions |
| US20080275118A1 (en) * | 2008-06-12 | 2008-11-06 | Shaw Mari M | Health and cosmetic composition and regime for stimulating hair growth and thickening on the head, including the scalp, eyelashes, and eyebrows, and which discourages hair loss |
| US8470833B2 (en) | 2009-12-15 | 2013-06-25 | Mcneil-Ppc, Inc. | Hair growth and/or regrowth compositions |
| BR112013019519A2 (pt) | 2011-01-31 | 2016-08-09 | Allergan Inc | método de realce de crescimento capilar |
-
2012
- 2012-01-30 BR BR112013019519A patent/BR112013019519A2/pt not_active IP Right Cessation
- 2012-01-30 CN CN201280016300.8A patent/CN103747775A/zh active Pending
- 2012-01-30 WO PCT/US2012/023148 patent/WO2012106249A2/en not_active Ceased
- 2012-01-30 JP JP2013551414A patent/JP6017455B2/ja not_active Expired - Fee Related
- 2012-01-30 KR KR1020137022980A patent/KR20140020895A/ko not_active Withdrawn
- 2012-01-30 US US13/361,615 patent/US8932567B2/en active Active
- 2012-01-30 AU AU2012212481A patent/AU2012212481A1/en not_active Abandoned
- 2012-01-30 CA CA2826232A patent/CA2826232C/en active Active
- 2012-01-30 EP EP12704965.8A patent/EP2670488A2/en not_active Ceased
- 2012-01-30 RU RU2013139682/15A patent/RU2013139682A/ru not_active Application Discontinuation
-
2014
- 2014-12-05 US US14/561,561 patent/US9700503B2/en active Active
-
2017
- 2017-04-21 AU AU2017202667A patent/AU2017202667B2/en not_active Ceased
- 2017-06-08 US US15/617,739 patent/US20180110711A1/en not_active Abandoned
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