JP2014509621A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014509621A5 JP2014509621A5 JP2014501567A JP2014501567A JP2014509621A5 JP 2014509621 A5 JP2014509621 A5 JP 2014509621A5 JP 2014501567 A JP2014501567 A JP 2014501567A JP 2014501567 A JP2014501567 A JP 2014501567A JP 2014509621 A5 JP2014509621 A5 JP 2014509621A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- pharmaceutical composition
- composition according
- reactive compound
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 10
- 230000002378 acidificating effect Effects 0.000 claims 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- UUIQMZJEGPQKFD-UHFFFAOYSA-N n-butyric acid methyl ester Natural products CCCC(=O)OC UUIQMZJEGPQKFD-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- 239000012535 impurity Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 3
- -1 phosphoric acid inorganic acid Chemical class 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 2
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 235000010233 benzoic acid Nutrition 0.000 claims 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 230000007774 longterm Effects 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- UWYVPFMHMJIBHE-OWOJBTEDSA-N (e)-2-hydroxybut-2-enedioic acid Chemical compound OC(=O)\C=C(\O)C(O)=O UWYVPFMHMJIBHE-OWOJBTEDSA-N 0.000 claims 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 1
- PKRSYEPBQPFNRB-UHFFFAOYSA-N 2-phenoxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1OC1=CC=CC=C1 PKRSYEPBQPFNRB-UHFFFAOYSA-N 0.000 claims 1
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000005189 Embolism Diseases 0.000 claims 1
- 206010022562 Intermittent claudication Diseases 0.000 claims 1
- 208000000770 Non-ST Elevated Myocardial Infarction Diseases 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 208000001435 Thromboembolism Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 206010053648 Vascular occlusion Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 235000013985 cinnamic acid Nutrition 0.000 claims 1
- 229930016911 cinnamic acid Natural products 0.000 claims 1
- 238000007887 coronary angioplasty Methods 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 235000011087 fumaric acid Nutrition 0.000 claims 1
- 229940093915 gynecological organic acid Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 229960000443 hydrochloric acid Drugs 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 1
- 229960004838 phosphoric acid Drugs 0.000 claims 1
- 229940107700 pyruvic acid Drugs 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 239000001509 sodium citrate Substances 0.000 claims 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000002537 thrombolytic effect Effects 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 208000021331 vascular occlusion disease Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305347.4 | 2011-03-29 | ||
| EP11305347 | 2011-03-29 | ||
| US201161499941P | 2011-06-22 | 2011-06-22 | |
| US61/499,941 | 2011-06-22 | ||
| PCT/EP2012/055361 WO2012130819A1 (en) | 2011-03-29 | 2012-03-27 | Otamixaban formulations with improved stability |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014509621A JP2014509621A (ja) | 2014-04-21 |
| JP2014509621A5 true JP2014509621A5 (https=) | 2015-03-19 |
| JP5993933B2 JP5993933B2 (ja) | 2016-09-14 |
Family
ID=44584895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501567A Expired - Fee Related JP5993933B2 (ja) | 2011-03-29 | 2012-03-27 | 安定性を改善したオタミキサバン製剤 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20120252852A1 (https=) |
| EP (1) | EP2691075A1 (https=) |
| JP (1) | JP5993933B2 (https=) |
| KR (1) | KR101844623B1 (https=) |
| CN (1) | CN103561723B (https=) |
| AR (1) | AR085580A1 (https=) |
| AU (1) | AU2012234323A1 (https=) |
| BR (1) | BR112013024801A2 (https=) |
| CA (1) | CA2830962C (https=) |
| CO (1) | CO6801755A2 (https=) |
| EA (1) | EA025572B1 (https=) |
| IL (1) | IL228573A (https=) |
| MA (1) | MA35050B1 (https=) |
| MX (1) | MX342324B (https=) |
| PH (1) | PH12013501991A1 (https=) |
| SG (1) | SG193932A1 (https=) |
| UY (1) | UY33975A (https=) |
| WO (1) | WO2012130819A1 (https=) |
| ZA (1) | ZA201308061B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2691075A1 (en) | 2011-03-29 | 2014-02-05 | Sanofi | Otamixaban formulations with improved stability |
| KR102295748B1 (ko) | 2013-01-31 | 2021-09-01 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널의 조절제로서의 피리돈 아미드 |
| DE102013212933B3 (de) * | 2013-07-03 | 2014-11-27 | Schaeffler Technologies Gmbh & Co. Kg | Lageranordnung in einem Elektromotor |
| DK3668516T3 (da) | 2017-08-16 | 2021-12-13 | Merck Patent Gmbh | Stabile lyofilisater omfattende 5,10-methylen-(6r)-tetrahydrofolsyre og en dicarboxylsyre |
| CN109010273B (zh) * | 2018-10-08 | 2021-03-19 | 中国药科大学 | 一种阿哌沙班纳米混悬剂及其制备方法 |
| CN113384526A (zh) * | 2021-08-03 | 2021-09-14 | 合肥医工医药股份有限公司 | 一种稳定的阿哌沙班口服溶液制剂及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3030272A (en) * | 1960-05-26 | 1962-04-17 | Abbott Lab | Stable heaparin solution |
| ES2224200T3 (es) | 1992-11-27 | 2005-03-01 | Mayne Pharma (Usa) Inc. | Composicion inyectable estable de paclitaxel. |
| US6080767A (en) | 1996-01-02 | 2000-06-27 | Aventis Pharmaceuticals Products Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| DK0906094T3 (da) | 1996-01-02 | 2003-10-20 | Aventis Pharma Inc | Substituerede N-[(aminoiminomethyl- eller aminomethyl)phenyl]propylamider |
| GB0108903D0 (en) * | 2000-10-05 | 2001-05-30 | Aventis Pharm Prod Inc | Novel crystalline forms of a factor Xa inhibitor |
| US20050059719A1 (en) * | 2003-09-16 | 2005-03-17 | Badawy Sherif Ibrahim Farag | Solid dosage formulation containing a Factor Xa inhibitor and method |
| FR2863891B1 (fr) * | 2003-12-23 | 2006-03-24 | Pf Medicament | Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation |
| NZ597957A (en) * | 2009-07-29 | 2014-05-30 | Sanofi Sa | Otamixaban for treatment of elderly and renal impaired non-st elevation myocardial infarction patients |
| EP2691075A1 (en) | 2011-03-29 | 2014-02-05 | Sanofi | Otamixaban formulations with improved stability |
| ES2539236T3 (es) | 2011-03-29 | 2015-06-29 | Sanofi | Sal de ácido benzoico de Otamixaban |
-
2012
- 2012-03-27 EP EP12710516.1A patent/EP2691075A1/en not_active Withdrawn
- 2012-03-27 AR ARP120101016A patent/AR085580A1/es unknown
- 2012-03-27 US US13/431,571 patent/US20120252852A1/en not_active Abandoned
- 2012-03-27 MX MX2013011260A patent/MX342324B/es active IP Right Grant
- 2012-03-27 AU AU2012234323A patent/AU2012234323A1/en not_active Abandoned
- 2012-03-27 UY UY0001033975A patent/UY33975A/es not_active Application Discontinuation
- 2012-03-27 JP JP2014501567A patent/JP5993933B2/ja not_active Expired - Fee Related
- 2012-03-27 SG SG2013071352A patent/SG193932A1/en unknown
- 2012-03-27 CA CA2830962A patent/CA2830962C/en not_active Expired - Fee Related
- 2012-03-27 BR BR112013024801A patent/BR112013024801A2/pt not_active Application Discontinuation
- 2012-03-27 CN CN201280026572.6A patent/CN103561723B/zh not_active Expired - Fee Related
- 2012-03-27 EA EA201391406A patent/EA025572B1/ru not_active IP Right Cessation
- 2012-03-27 US US14/008,343 patent/US20140018398A1/en not_active Abandoned
- 2012-03-27 PH PH1/2013/501991A patent/PH12013501991A1/en unknown
- 2012-03-27 MA MA36345A patent/MA35050B1/fr unknown
- 2012-03-27 WO PCT/EP2012/055361 patent/WO2012130819A1/en not_active Ceased
- 2012-03-27 KR KR1020137028419A patent/KR101844623B1/ko not_active Expired - Fee Related
-
2013
- 2013-09-29 IL IL228573A patent/IL228573A/en active IP Right Grant
- 2013-10-23 CO CO13251310A patent/CO6801755A2/es unknown
- 2013-10-29 ZA ZA2013/08061A patent/ZA201308061B/en unknown
-
2016
- 2016-09-14 US US15/265,191 patent/US9993464B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014509621A5 (https=) | ||
| PE20061321A1 (es) | Sales fisiologicamente compatibles de ester etilico del acido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1h-bencimidazol-5-carbonil)-piridin-2-il-amino]-propionico | |
| HRP20140503T1 (hr) | Derivati tieno-piridina kao inhibitori mek | |
| HRP20150704T1 (hr) | Derivati piperidinona kao mdm2-inhibitori za lijeäśenje raka | |
| ES2631953T3 (es) | Composición para aplicación tópica, sus usos, dispositivo de aplicación y kit de partes | |
| HRP20110447T1 (hr) | Indazoli supstituirani amidom kao inhibitori poli(adp-riboza)polimeraze (parp) | |
| AR085580A1 (es) | Formulaciones de otamixaban con estabilidad mejorada | |
| NO20091548L (no) | Imidazolon- og imidazolidinonderivater som 11B-HSD1 inhibitorer for diabetes | |
| NO20070458L (no) | Aryl-pyridinderivater som 11-Beta-HSD1 inhibitorer | |
| JP2014515013A5 (https=) | ||
| WO2011093826A3 (en) | Effervescent formulations comprising cefaclor and clavulanic acid as active agents | |
| PE20070717A1 (es) | Sal de maleato y polimorfo de [2-({4-[(dimetilamino)iminometil]fenil}carbonilamino)-5-metoxifenil]-n-(5-cloro-(2-piridil))carboxamida | |
| PE20141318A1 (es) | Liberacion modificada de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida solubilizada utilizando acidos organicos | |
| JP2016527220A5 (https=) | ||
| NZ591914A (en) | Naphthylacetic acids | |
| CL2013002227A1 (es) | Sales de acido de (2s,3r)-n-(2-((3-piridinil)metil)-1-azabiciclo[2.2.2]oct-3-il)benzofuran-2-carboxamida, util en el tratamiento de enfermedades del snc. (divisional de la sol. 2271-08). | |
| PE20120989A1 (es) | Sales de disacarina, acido difumarico, acido d-1-hidroxi-2-naftoico y monobenzoico del 2-(4-((2-amino-4-metil-6-(pentilamino) pirimidin-5-il) metil) fenil) acetato de 4-(dimetilamino) butilo | |
| NZ587578A (en) | Stabilized single-liquid pharmaceutical composition containing docetaxel | |
| EA201792072A2 (ru) | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения | |
| TNSN07435A1 (en) | Novel piperidine carboxylic acid amide derivatives | |
| MX2014015855A (es) | Pro-farmacos derivados de (e)-n-metil-n-((3-metilbenzofuran-2-il)m etil)-3-(7-oxo-5,6,7,8-tetrahidro-1,8-naftiridin-3-il) acrilamida. | |
| JP6051305B2 (ja) | プロトポルフィリンｉｘ生成促進用医薬組成物 | |
| SG179031A1 (en) | Hsl inhibitors useful in the treatment of diabetes | |
| NZ590315A (en) | Fxa inhibitors with cyclic amidoxime or cyclic amidrazone as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof | |
| HRP20150613T1 (hr) | Sol benzojeve kiseline otamiksabana |