JP2014509326A5 - - Google Patents
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- Publication number
- JP2014509326A5 JP2014509326A5 JP2013555888A JP2013555888A JP2014509326A5 JP 2014509326 A5 JP2014509326 A5 JP 2014509326A5 JP 2013555888 A JP2013555888 A JP 2013555888A JP 2013555888 A JP2013555888 A JP 2013555888A JP 2014509326 A5 JP2014509326 A5 JP 2014509326A5
- Authority
- JP
- Japan
- Prior art keywords
- protein according
- amino acids
- seq
- procoagulant protein
- procoagulant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11156682.4 | 2011-03-02 | ||
| EP11156682 | 2011-03-02 | ||
| US201161449254P | 2011-03-04 | 2011-03-04 | |
| US61/449,254 | 2011-03-04 | ||
| PCT/EP2012/053619 WO2012117091A1 (en) | 2011-03-02 | 2012-03-02 | Coagulation factor-targeting to tlt-1 on activated platelets |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235148A Division JP2018043997A (ja) | 2011-03-02 | 2017-12-07 | 活性化血小板上のｔｌｔ−１に対する凝固因子の標的化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014509326A JP2014509326A (ja) | 2014-04-17 |
| JP2014509326A5 true JP2014509326A5 (https=) | 2015-04-16 |
| JP6309273B2 JP6309273B2 (ja) | 2018-04-11 |
Family
ID=44558650
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555888A Active JP6309273B2 (ja) | 2011-03-02 | 2012-03-02 | 活性化血小板上のｔｌｔ−１に対する凝固因子の標的化 |
| JP2017235148A Pending JP2018043997A (ja) | 2011-03-02 | 2017-12-07 | 活性化血小板上のｔｌｔ−１に対する凝固因子の標的化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235148A Pending JP2018043997A (ja) | 2011-03-02 | 2017-12-07 | 活性化血小板上のｔｌｔ−１に対する凝固因子の標的化 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20130337537A1 (https=) |
| EP (1) | EP2680875B1 (https=) |
| JP (2) | JP6309273B2 (https=) |
| KR (1) | KR20140012082A (https=) |
| CN (1) | CN103429256B (https=) |
| AU (1) | AU2012222366A1 (https=) |
| BR (1) | BR112013021661A2 (https=) |
| CA (1) | CA2828769A1 (https=) |
| IL (1) | IL227501A0 (https=) |
| MX (1) | MX2013009862A (https=) |
| RU (1) | RU2013142015A (https=) |
| WO (1) | WO2012117091A1 (https=) |
| ZA (1) | ZA201306111B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| SG10201505217WA (en) | 2010-07-09 | 2015-08-28 | Biogen Hemophilia Inc | Chimeric clotting factors |
| US9994632B2 (en) * | 2014-05-26 | 2018-06-12 | Samsung Electronics Co., Ltd. | Humanized or affinity-matured anti Ang-2 antibody and uses thereof |
| US11685785B2 (en) * | 2015-06-12 | 2023-06-27 | Ascendo Biotechnology, Inc. | Methods and antibodies for modulation of immunoresponse |
| WO2018053597A1 (en) * | 2016-09-23 | 2018-03-29 | Csl Limited | Coagulation factor binding proteins and uses thereof |
| AR110079A1 (es) | 2016-11-16 | 2019-02-20 | Bayer Healthcare Llc | Factor viii direccionado a los glóbulos rojos y método para su uso |
| EP3454063B1 (de) * | 2017-09-06 | 2022-05-18 | AVA Lifescience GmbH | Durchflusszytometrie-messverfahren |
| US10597462B1 (en) * | 2017-11-08 | 2020-03-24 | University Of Puerto Rico | Anti-TLT-1 antibody and uses thereof |
| BR112021019959A2 (pt) * | 2019-04-17 | 2022-02-08 | Novo Nordisk As | Anticorpo biespecífico, e, formulação farmacêutica |
| WO2020226907A1 (en) * | 2019-05-07 | 2020-11-12 | Beijing Neoletix Biological Technology Co., Ltd. | Fusion protein of single domain antibody and procoagulant |
| WO2025168826A1 (en) | 2024-02-08 | 2025-08-14 | Hemab Aps | Methods of treating coagulopathy |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
| EP0470128B2 (en) | 1989-04-19 | 2003-08-13 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5278299A (en) | 1991-03-18 | 1994-01-11 | Scripps Clinic And Research Foundation | Method and composition for synthesizing sialylated glycosyl compounds |
| WO1993010260A1 (en) | 1991-11-21 | 1993-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Controlling degradation of glycoprotein oligosaccharides by extracellular glycosisases |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| JP4451514B2 (ja) | 1999-08-24 | 2010-04-14 | 財団法人化学及血清療法研究所 | 血液凝固第ｖｉｉ因子改変体 |
| DE60143292D1 (de) | 2000-05-03 | 2010-12-02 | Novo Nordisk Healthcare Ag | Varianten des menschlichen Koagulationsfaktors VII |
| AU8755001A (en) | 2000-09-13 | 2002-03-26 | Novo Nordisk As | Human coagulation factor vii variants |
| AU2002218029A1 (en) | 2000-11-09 | 2002-05-21 | The Scripps Research Institute | Modified factor viia |
| MXPA03008590A (es) | 2001-03-22 | 2003-12-08 | Novo Nordisk Healthcare Ag | Derivados del factor vii de coagulacion. |
| BR0212818A (pt) | 2001-09-27 | 2004-10-05 | Novo Nordisk Healthcare Ag | Polipeptìdeo de fator vii, construção de polionucletìdeo, célula hospedeira, animal transgênico, planta transgênica, método para produzir o polipeptìdeo de fator vii composição farmacêutica, uso de um polipeptìdeo de fator vii, e, método para o tratamento de distúrbios do sangramento em um sujeito ou para o aprimoramento do sistema hemostático normal |
| EP2042196B1 (en) | 2001-10-10 | 2016-07-13 | ratiopharm GmbH | Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF) |
| JP2005512524A (ja) | 2001-11-02 | 2005-05-12 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | ヒト凝固第ｖｉｉ因子ポリペプチド |
| ES2293088T3 (es) | 2002-09-25 | 2008-03-16 | Novo Nordisk Health Care Ag | Polipeptidos del factor vii de la coagulacion humana. |
| US20040180054A1 (en) | 2003-03-13 | 2004-09-16 | Hanmi Pharm. Co., Ltd. | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
| US20040180409A1 (en) * | 2003-03-16 | 2004-09-16 | Mcvicar Daniel | TLT-1, a novel platelet-associated receptor and uses therefor |
| EP2055189A1 (en) | 2003-04-09 | 2009-05-06 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| PT1624891E (pt) * | 2003-05-06 | 2010-01-05 | Syntonix Pharmaceuticals Inc | Proteínas quiméricas de factor de coagulação-fc destinadas ao tratamento da hemofilia |
| JP2006527590A (ja) | 2003-06-18 | 2006-12-07 | ディレボ・ビオテク・アーゲー | 新規生物学的実体およびその使用 |
| WO2005024006A2 (en) | 2003-09-09 | 2005-03-17 | Novo Nordisk Health Care Ag | Coagulation factor vii polypeptides |
| US7393833B2 (en) | 2005-03-09 | 2008-07-01 | The Board Of Regents Of The University Of Oklahoma | Chimeric proteins with phosphatidylserine binding domains |
| RU2007145085A (ru) | 2005-06-15 | 2009-07-20 | Ново Нордиск Хелс Кеа Аг (Ch) | Опосредованное трансглютаминазой коньюгирование гормона роста |
| JP5690047B2 (ja) | 2005-09-14 | 2015-03-25 | ノボ ノルディスク ヘルス ケア アーゲー | ヒト凝固第ｖｉｉ因子ポリペプチド |
| JP5216219B2 (ja) * | 2006-01-06 | 2013-06-19 | 真司 武岡 | 薬物運搬体 |
| CN101389356B (zh) | 2006-01-06 | 2012-09-05 | 武冈真司 | 药物输送物质 |
| US7553936B2 (en) * | 2006-12-04 | 2009-06-30 | The United States of America as represented by Secretary Department of Health and Human Services | Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions |
| CN105131127B (zh) | 2007-05-30 | 2018-09-07 | 浦项工科大学校产学协力团 | 免疫球蛋白融合蛋白 |
| KR101582841B1 (ko) | 2008-02-27 | 2016-01-11 | 노보 노르디스크 에이/에스 | 콘쥬게이트된 인자 ｖｉｉｉ 분자 |
| CN102112144A (zh) * | 2008-05-16 | 2011-06-29 | 拜耳医药保健有限公司 | 靶向性凝固因子及其使用方法 |
| EP2149603A1 (en) | 2008-07-28 | 2010-02-03 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Factor IX variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders |
| KR20110039348A (ko) | 2008-08-06 | 2011-04-15 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질 |
| JP5770161B2 (ja) * | 2009-04-06 | 2015-08-26 | ノヴォ ノルディスク アー／エス | 血小板への第ｖｉｉｉ因子タンパク質の標的送達 |
| EP2470561A1 (en) * | 2009-08-27 | 2012-07-04 | Novo Nordisk A/S | Targeting tissue factor to activated platelets |
-
2012
- 2012-03-02 BR BR112013021661A patent/BR112013021661A2/pt not_active Application Discontinuation
- 2012-03-02 EP EP12707095.1A patent/EP2680875B1/en active Active
- 2012-03-02 CA CA2828769A patent/CA2828769A1/en not_active Withdrawn
- 2012-03-02 CN CN201280011375.7A patent/CN103429256B/zh active Active
- 2012-03-02 JP JP2013555888A patent/JP6309273B2/ja active Active
- 2012-03-02 KR KR1020137023069A patent/KR20140012082A/ko not_active Withdrawn
- 2012-03-02 US US13/982,360 patent/US20130337537A1/en not_active Abandoned
- 2012-03-02 RU RU2013142015/10A patent/RU2013142015A/ru unknown
- 2012-03-02 MX MX2013009862A patent/MX2013009862A/es unknown
- 2012-03-02 WO PCT/EP2012/053619 patent/WO2012117091A1/en not_active Ceased
- 2012-03-02 AU AU2012222366A patent/AU2012222366A1/en not_active Withdrawn
-
2013
- 2013-07-16 IL IL227501A patent/IL227501A0/en unknown
- 2013-08-14 ZA ZA2013/06111A patent/ZA201306111B/en unknown
-
2016
- 2016-04-08 US US15/094,082 patent/US20160263230A1/en not_active Abandoned
-
2017
- 2017-12-07 JP JP2017235148A patent/JP2018043997A/ja active Pending
-
2018
- 2018-09-07 US US16/125,026 patent/US11135275B2/en active Active
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