JP2014508781A5 - - Google Patents
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- JP2014508781A5 JP2014508781A5 JP2013557919A JP2013557919A JP2014508781A5 JP 2014508781 A5 JP2014508781 A5 JP 2014508781A5 JP 2013557919 A JP2013557919 A JP 2013557919A JP 2013557919 A JP2013557919 A JP 2013557919A JP 2014508781 A5 JP2014508781 A5 JP 2014508781A5
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- Prior art keywords
- alkyl
- alkoxy
- alkylamino
- hydrogen
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161452017P | 2011-03-11 | 2011-03-11 | |
| US61/452,017 | 2011-03-11 | ||
| PCT/US2012/028569 WO2012125488A1 (en) | 2011-03-11 | 2012-03-09 | C4-monomethyl triterpenoid derivatives and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508781A JP2014508781A (ja) | 2014-04-10 |
| JP2014508781A5 true JP2014508781A5 (cg-RX-API-DMAC7.html) | 2015-04-30 |
| JP6129084B2 JP6129084B2 (ja) | 2017-05-17 |
Family
ID=45856041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557919A Active JP6129084B2 (ja) | 2011-03-11 | 2012-03-09 | Ｃ４−モノメチルトリテルペノイド誘導体およびその使用方法 |
Country Status (31)
Families Citing this family (36)
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| US6326507B1 (en) | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| EP3492077A1 (en) | 2008-01-11 | 2019-06-05 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids and methods of use in the treatment of disease |
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| AU2009237578C1 (en) | 2008-04-18 | 2014-12-04 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring |
| KR101782020B1 (ko) | 2008-04-18 | 2017-09-26 | 리타 파마슈티컬스 잉크. | 산화방지성 염증 조절제 ｃ-17 일치된 올레아놀산 유도체 |
| ES2449396T3 (es) | 2008-07-22 | 2014-03-19 | Trustees Of Dartmouth College | Cianoenonas monocíclicas y métodos de uso de las mismas |
| EA025568B1 (ru) | 2010-12-17 | 2017-01-30 | Рита Фармасьютикалз, Инк. | Пиразолильные и пиримидинильные трициклические еноны в качестве антиоксидантных модуляторов воспаления |
| BR112013023174B1 (pt) | 2011-03-11 | 2021-09-21 | Reata Pharmaceuticals, Inc | Compostos derivados de triterpenoide de c4-monometila e composição farmacêutica compreendendo os referidos compostos |
| MX357060B (es) * | 2012-04-27 | 2018-06-25 | Reata Pharmaceuticals Inc | Derivados de 2,2-difluoropropionamida de bardoxolon metilo, formas polimorficas y metodo para su uso de los mismos. |
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| TW201514192A (zh) | 2013-03-19 | 2015-04-16 | Daiichi Sankyo Co Ltd | 萜類衍生物 |
| UY39092A (es) | 2013-04-24 | 2021-03-26 | Abbvie Inc | Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso |
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| CN104861028A (zh) * | 2014-02-24 | 2015-08-26 | 上海兰蒂斯生物医药科技有限公司 | 新型熊果酸衍生物、其制备方法及其应用 |
| US10208082B2 (en) | 2014-09-10 | 2019-02-19 | Daiichi Sankyo Company, Limited | Sustained-release pharmaceutical composition for treatment and prevention of eye disease |
| AU2016219109B2 (en) | 2015-02-12 | 2020-05-14 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant iflammation modulators |
| CA2998681C (en) | 2015-09-23 | 2024-02-06 | Reata Pharmaceuticals, Inc. | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses |
| CN105820207A (zh) * | 2016-03-24 | 2016-08-03 | 庄立 | 一种茴拉西坦的药物组合物及其抗氧化作用 |
| BR112019009256A2 (pt) | 2016-11-08 | 2019-07-16 | Reata Pharmaceuticals Inc | métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| IL322405A (en) | 2018-06-15 | 2025-09-01 | Reata Pharmaceuticals Inc | Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of IL-17 and ROR-gamma |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
| JP2022501445A (ja) * | 2018-09-28 | 2022-01-06 | スーチョワン ハイスコ ファーマスーティカル カンパニー リミテッドSichuan Haisco Pharmaceutical Co., Ltd. | テルペノイド誘導体及びその用途 |
| CN114641483B (zh) * | 2019-07-19 | 2024-12-06 | 里亚塔医药公司 | C17极性的-取代的杂芳族合成三萜类化合物及其使用方法 |
| WO2022126129A1 (en) | 2020-12-11 | 2022-06-16 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids for use in therapy |
| AU2022208727A1 (en) | 2021-01-18 | 2023-08-03 | Reata Pharmaceuticals, Inc. | Synthetic ursolic acid derivatives and methods of use thereof |
| EP4479369A1 (en) | 2022-02-16 | 2024-12-25 | Firmenich SA | Process for preparing octahydro-2(1h)-naphthalenone derivatives |
| GB202211190D0 (en) * | 2022-08-01 | 2022-09-14 | Royal College Surgeons Ireland | Fluorination process |
| CN117964678A (zh) * | 2024-01-29 | 2024-05-03 | 烟台大学 | C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途 |
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| US6369101B1 (en) | 1999-02-26 | 2002-04-09 | Regents Of The University Of Minnesota | Therapeutic method to treat herpes virus infection |
| ATE370928T1 (de) | 1999-05-14 | 2007-09-15 | Nereus Pharmaceuticals Inc | Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren |
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| EP1465615B1 (en) | 2002-01-15 | 2012-08-01 | Trustees of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
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-
2012
- 2012-03-09 BR BR112013023174-2A patent/BR112013023174B1/pt active IP Right Grant
- 2012-03-09 SM SM20190433T patent/SMT201900433T1/it unknown
- 2012-03-09 PL PL12709768T patent/PL2683731T3/pl unknown
- 2012-03-09 PT PT12709768T patent/PT2683731T/pt unknown
- 2012-03-09 RS RSP20190859 patent/RS59200B1/sr unknown
- 2012-03-09 CN CN201280022645.4A patent/CN103619866B/zh active Active
- 2012-03-09 DK DK12709768.1T patent/DK2683731T3/da active
- 2012-03-09 WO PCT/US2012/028569 patent/WO2012125488A1/en not_active Ceased
- 2012-03-09 CA CA2829618A patent/CA2829618C/en active Active
- 2012-03-09 AU AU2012229244A patent/AU2012229244B2/en active Active
- 2012-03-09 EA EA201391313A patent/EA026847B1/ru unknown
- 2012-03-09 TR TR2019/09788T patent/TR201909788T4/tr unknown
- 2012-03-09 ES ES12709768T patent/ES2729405T3/es active Active
- 2012-03-09 MX MX2013010429A patent/MX348862B/es active IP Right Grant
- 2012-03-09 SG SG2013068291A patent/SG193404A1/en unknown
- 2012-03-09 KR KR1020137026782A patent/KR101956399B1/ko active Active
- 2012-03-09 HU HUE12709768A patent/HUE044081T2/hu unknown
- 2012-03-09 LT LTEP12709768.1T patent/LT2683731T/lt unknown
- 2012-03-09 JP JP2013557919A patent/JP6129084B2/ja active Active
- 2012-03-09 EP EP12709768.1A patent/EP2683731B1/en active Active
- 2012-03-09 SI SI201231611T patent/SI2683731T1/sl unknown
- 2012-03-09 ME MEP-2019-168A patent/ME03469B/me unknown
- 2012-03-09 UY UY0001033946A patent/UY33946A/es not_active Application Discontinuation
- 2012-03-09 HR HRP20191164TT patent/HRP20191164T1/hr unknown
- 2012-03-12 AR ARP120100803A patent/AR085666A1/es unknown
- 2012-03-12 US US13/417,519 patent/US9290536B2/en active Active
- 2012-03-12 TW TW101108395A patent/TWI535731B/zh active
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2013
- 2013-09-08 IL IL228297A patent/IL228297B/en active IP Right Grant
- 2013-09-11 CL CL2013002612A patent/CL2013002612A1/es unknown
- 2013-10-09 CO CO13240105A patent/CO6801741A2/es not_active Application Discontinuation
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2019
- 2019-07-01 CY CY20191100690T patent/CY1121744T1/el unknown