JP2014508759A - シアリル化抗体の生産の方法 - Google Patents

シアリル化抗体の生産の方法 Download PDF

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Publication number
JP2014508759A
JP2014508759A JP2013554892A JP2013554892A JP2014508759A JP 2014508759 A JP2014508759 A JP 2014508759A JP 2013554892 A JP2013554892 A JP 2013554892A JP 2013554892 A JP2013554892 A JP 2013554892A JP 2014508759 A JP2014508759 A JP 2014508759A
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antibody
seq
domain
sequence
antiabeta
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JP2014508759A5 (https=
Inventor
ブランシユ，フランシス
カムロン，ベアトリス
ジユネ，ブリユノ
スブリエ，フアブリエンヌ
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2013554892A 2011-02-24 2012-02-23 シアリル化抗体の生産の方法 Pending JP2014508759A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11305200.5 2011-02-24
EP11305200 2011-02-24
EP11306090 2011-09-01
EP11306090.9 2011-09-01
PCT/EP2012/053065 WO2012113863A1 (en) 2011-02-24 2012-02-23 Method of production of sialylated antibodies

Publications (2)

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JP2014508759A true JP2014508759A (ja) 2014-04-10
JP2014508759A5 JP2014508759A5 (https=) 2015-02-19

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JP2013554892A Pending JP2014508759A (ja) 2011-02-24 2012-02-23 シアリル化抗体の生産の方法

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US (1) US20140046032A1 (https=)
EP (1) EP2678357A1 (https=)
JP (1) JP2014508759A (https=)
AR (1) AR085302A1 (https=)
TW (1) TW201241182A (https=)
WO (1) WO2012113863A1 (https=)

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JP2020515524A (ja) * 2017-01-31 2020-05-28 サノフイＳａｎｏｆｉ ベータアミロイドペプチドのプロトフィブリル形態に特異的な抗体の神経細胞保護作用
JP2021522216A (ja) * 2018-04-20 2021-08-30 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 高度にシアル化された自己抗体およびその使用

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US9701753B2 (en) 2013-03-11 2017-07-11 Genzyme Corporation Hyperglycosylated binding polypeptides
HK1207960A1 (en) 2013-03-12 2016-02-19 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US10450361B2 (en) 2013-03-15 2019-10-22 Momenta Pharmaceuticals, Inc. Methods related to CTLA4-Fc fusion proteins
ES2802274T3 (es) * 2013-05-02 2021-01-18 Momenta Pharmaceuticals Inc Glicoproteínas sialiladas
WO2014186310A1 (en) 2013-05-13 2014-11-20 Momenta Pharmaceuticals, Inc. Methods for the treatment of neurodegeneration
CA2908407C (en) 2013-05-29 2022-06-14 F. Hoffmann-La Roche Ag Quantitative control of sialylation
EP3017057B1 (en) 2013-07-05 2019-10-02 F.Hoffmann-La Roche Ag Process for the mono- and bi-sialylation of glycoproteins employing n-terminally truncated beta-galactoside alpha-2,6-sialyltransferase mutants
EP2824176A1 (en) 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
WO2015057622A1 (en) * 2013-10-16 2015-04-23 Momenta Pharmaceuticals, Inc. Sialylated glycoproteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
WO2015143091A1 (en) 2014-03-19 2015-09-24 Genzyme Corporation Site-specific glycoengineering of targeting moieties
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3037527A1 (en) * 2014-12-22 2016-06-29 F. Hoffmann-La Roche AG Sialyltransferase without CMP-dependent sialidase activity
WO2016102436A1 (en) 2014-12-22 2016-06-30 F. Hoffmann-La Roche Ag Cmp-dependent sialidase activity
JP7516047B2 (ja) 2016-11-23 2024-07-16 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストン脱アセチル化酵素阻害剤とｃｄ３８阻害剤とを含む医薬組み合わせ物及びその使用方法
CN120192414A (zh) 2019-04-03 2025-06-24 建新公司 具有降低的断裂的抗αβTCR结合多肽
TWI869528B (zh) 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
EP4430174A1 (en) * 2021-11-09 2024-09-18 Amgen Inc. Production of therapeutic proteins
WO2025101901A1 (en) * 2023-11-10 2025-05-15 The Board Of Trustees Of The Leland Stanford Junior University Use of sialylated ivig or igg fc region-containing protein for preventing or treating respiratory virus diseases

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2020515524A (ja) * 2017-01-31 2020-05-28 サノフイＳａｎｏｆｉ ベータアミロイドペプチドのプロトフィブリル形態に特異的な抗体の神経細胞保護作用
JP2021522216A (ja) * 2018-04-20 2021-08-30 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 高度にシアル化された自己抗体およびその使用

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EP2678357A1 (en) 2014-01-01
WO2012113863A1 (en) 2012-08-30
US20140046032A1 (en) 2014-02-13
AR085302A1 (es) 2013-09-18
TW201241182A (en) 2012-10-16

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