TW201241182A - Method of production of sialylated antibodies - Google Patents

Method of production of sialylated antibodies Download PDF

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Publication number
TW201241182A
TW201241182A TW101106076A TW101106076A TW201241182A TW 201241182 A TW201241182 A TW 201241182A TW 101106076 A TW101106076 A TW 101106076A TW 101106076 A TW101106076 A TW 101106076A TW 201241182 A TW201241182 A TW 201241182A
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TW
Taiwan
Prior art keywords
ser
val
thr
pro
lys
Prior art date
Application number
TW101106076A
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English (en)
Chinese (zh)
Inventor
Francis Blanche
Beatrice Cameron
Bruno Genet
Fabienne Soubrier
Original Assignee
Sanofi Sa
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Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of TW201241182A publication Critical patent/TW201241182A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW101106076A 2011-02-24 2012-02-23 Method of production of sialylated antibodies TW201241182A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11305200 2011-02-24
EP11306090 2011-09-01

Publications (1)

Publication Number Publication Date
TW201241182A true TW201241182A (en) 2012-10-16

Family

ID=45774189

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101106076A TW201241182A (en) 2011-02-24 2012-02-23 Method of production of sialylated antibodies

Country Status (6)

Country Link
US (1) US20140046032A1 (https=)
EP (1) EP2678357A1 (https=)
JP (1) JP2014508759A (https=)
AR (1) AR085302A1 (https=)
TW (1) TW201241182A (https=)
WO (1) WO2012113863A1 (https=)

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EP3017057B1 (en) 2013-07-05 2019-10-02 F.Hoffmann-La Roche Ag Process for the mono- and bi-sialylation of glycoproteins employing n-terminally truncated beta-galactoside alpha-2,6-sialyltransferase mutants
EP2824176A1 (en) 2013-07-11 2015-01-14 Siamed'xpress Methods for producing sialylated therapeutic proteins
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
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US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
WO2015143091A1 (en) 2014-03-19 2015-09-24 Genzyme Corporation Site-specific glycoengineering of targeting moieties
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
EP3037527A1 (en) * 2014-12-22 2016-06-29 F. Hoffmann-La Roche AG Sialyltransferase without CMP-dependent sialidase activity
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JP7516047B2 (ja) 2016-11-23 2024-07-16 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストン脱アセチル化酵素阻害剤とｃｄ３８阻害剤とを含む医薬組み合わせ物及びその使用方法
EP3354278A1 (en) * 2017-01-31 2018-08-01 Sanofi Neuronal cell protective effect of antibodies specific for the protofibrillar form of the beta-amyloid peptide
FR3080376B1 (fr) * 2018-04-20 2022-12-09 Lab Francais Du Fractionnement Autoanticorps hautement sialyles et leurs utilisations
CN120192414A (zh) 2019-04-03 2025-06-24 建新公司 具有降低的断裂的抗αβTCR结合多肽
TWI869528B (zh) 2020-01-13 2025-01-11 美商威特拉公司 C5ar1抗體分子及其用途
EP4430174A1 (en) * 2021-11-09 2024-09-18 Amgen Inc. Production of therapeutic proteins
WO2025101901A1 (en) * 2023-11-10 2025-05-15 The Board Of Trustees Of The Leland Stanford Junior University Use of sialylated ivig or igg fc region-containing protein for preventing or treating respiratory virus diseases

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Also Published As

Publication number Publication date
EP2678357A1 (en) 2014-01-01
WO2012113863A1 (en) 2012-08-30
US20140046032A1 (en) 2014-02-13
JP2014508759A (ja) 2014-04-10
AR085302A1 (es) 2013-09-18

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