JP2014507414A - 代謝疾患及び炎症疾患の治療に有用なアゼチジン誘導体 - Google Patents

代謝疾患及び炎症疾患の治療に有用なアゼチジン誘導体 Download PDF

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JP2014507414A
JP2014507414A JP2013549769A JP2013549769A JP2014507414A JP 2014507414 A JP2014507414 A JP 2014507414A JP 2013549769 A JP2013549769 A JP 2013549769A JP 2013549769 A JP2013549769 A JP 2013549769A JP 2014507414 A JP2014507414 A JP 2014507414A
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methyl
azetidine
chloro
alkyl
compound
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JP2014507414A5 (enExample
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ライモンド マウリセ サニエレ ラウレント
ラフアエル ピズゾネロ マトヒエウ
トリバルレアウ ニクオラス
エルネスト レネ バンデグヒンステ ニクク
イルマ ジョエル デ ボス ステベ
クフリストプヘ クアビエル ブリス レギナルド
ドミニクエ ポウルバイク‐ル‘エブラリ クフリステルレ
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Galapagos NV
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2013549769A 2011-01-19 2012-01-10 代謝疾患及び炎症疾患の治療に有用なアゼチジン誘導体 Pending JP2014507414A (ja)

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US201161434077P 2011-01-19 2011-01-19
US61/434,077 2011-01-19
PCT/EP2012/050297 WO2012098033A1 (en) 2011-01-19 2012-01-10 Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases

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US (2) US8759334B2 (enExample)
EP (1) EP2665704A1 (enExample)
JP (1) JP2014507414A (enExample)
KR (1) KR20140040104A (enExample)
CN (1) CN103328442A (enExample)
AR (1) AR084857A1 (enExample)
AU (1) AU2012208693B2 (enExample)
BR (1) BR112013018286A2 (enExample)
CA (1) CA2824460A1 (enExample)
CO (1) CO6741223A2 (enExample)
GB (1) GB2489382A (enExample)
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RU (1) RU2013138372A (enExample)
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Cited By (1)

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JPWO2017006968A1 (ja) * 2015-07-07 2018-04-19 日本たばこ産業株式会社 ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその中間体

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SG191291A1 (en) * 2011-01-19 2013-07-31 Galapagos Nv Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases
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