JP2014506913A5 - - Google Patents
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- Publication number
- JP2014506913A5 JP2014506913A5 JP2013555935A JP2013555935A JP2014506913A5 JP 2014506913 A5 JP2014506913 A5 JP 2014506913A5 JP 2013555935 A JP2013555935 A JP 2013555935A JP 2013555935 A JP2013555935 A JP 2013555935A JP 2014506913 A5 JP2014506913 A5 JP 2014506913A5
- Authority
- JP
- Japan
- Prior art keywords
- deoxyuridine
- fluoro
- phosphate
- naphthyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1103582.1 | 2011-03-01 | ||
| GBGB1103582.1A GB201103582D0 (enExample) | 2011-03-01 | 2011-03-01 | |
| GB1105660.3 | 2011-04-01 | ||
| GBGB1105660.3A GB201105660D0 (en) | 2011-04-01 | 2011-04-01 | Chemical compounds |
| PCT/GB2012/050457 WO2012117246A1 (en) | 2011-03-01 | 2012-02-29 | Phosphoramidate derivatives of 5 - fluoro - 2 ' - deoxyuridine for use in the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506913A JP2014506913A (ja) | 2014-03-20 |
| JP2014506913A5 true JP2014506913A5 (enExample) | 2015-04-16 |
| JP5978232B2 JP5978232B2 (ja) | 2016-08-24 |
Family
ID=45841523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555935A Active JP5978232B2 (ja) | 2011-03-01 | 2012-02-29 | がん治療での使用のための５−フルオロ−２’−デオキシウリジンのホスホラミダート誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (7) | US8933053B2 (enExample) |
| EP (4) | EP3031812B1 (enExample) |
| JP (1) | JP5978232B2 (enExample) |
| KR (1) | KR101885940B1 (enExample) |
| CN (2) | CN103403013B (enExample) |
| AU (1) | AU2012223012C1 (enExample) |
| BR (1) | BR112013021986B1 (enExample) |
| CA (1) | CA2828326C (enExample) |
| CL (1) | CL2013002517A1 (enExample) |
| CY (2) | CY1117445T1 (enExample) |
| DK (3) | DK3447061T3 (enExample) |
| ES (4) | ES2569185T3 (enExample) |
| HR (2) | HRP20211967T1 (enExample) |
| HU (2) | HUE060127T2 (enExample) |
| IL (1) | IL228169A (enExample) |
| LT (1) | LT3447061T (enExample) |
| MX (1) | MX339822B (enExample) |
| NZ (1) | NZ615270A (enExample) |
| PH (2) | PH12013501723A1 (enExample) |
| PL (3) | PL3031812T3 (enExample) |
| PT (2) | PT3447061T (enExample) |
| RS (2) | RS54776B1 (enExample) |
| RU (1) | RU2614406C2 (enExample) |
| SG (1) | SG192841A1 (enExample) |
| SI (2) | SI2681227T1 (enExample) |
| SM (2) | SMT202100715T1 (enExample) |
| WO (1) | WO2012117246A1 (enExample) |
| ZA (2) | ZA201306468B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201016855D0 (en) | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| SI2681227T1 (sl) | 2011-03-01 | 2016-04-29 | Nucana Biomed Limited | Fosforamidatni derivati 5-fluoro-2'-deoksiuridina za uporabo pri zdravljenju raka |
| CN104903339A (zh) | 2012-11-16 | 2015-09-09 | 卡迪夫大学学院顾问有限公司 | 用于制备核苷前体药物的方法 |
| WO2015013352A2 (en) * | 2013-07-25 | 2015-01-29 | Patel Hasmukh B | Nucleoside phosphoramidates and phosphoramidites |
| CN104447923B (zh) * | 2013-09-23 | 2018-03-30 | 中国药科大学 | 2’‑脱氧‑2’‑氟‑2’‑甲基核苷衍生物及其制备方法与在制药中的用途 |
| RU2553996C1 (ru) * | 2013-11-27 | 2015-06-20 | Андрей Александрович Иващенко | Замещенные (2r,3r,5r)-3-гидрокси-(5-пиримидин-1-ил)тетрагидрофуран-2-илметил арил фосфорамидаты |
| WO2015154064A2 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| AU2015265607A1 (en) * | 2014-05-28 | 2016-11-17 | Idenix Pharmaceuticals Llc | Nucleoside derivatives for the treatment of cancer |
| CN105153257B (zh) * | 2014-06-12 | 2019-03-05 | 正大天晴药业集团股份有限公司 | 索非布韦的制备方法 |
| PL3160978T3 (pl) | 2014-06-25 | 2020-11-30 | NuCana plc | Proleki gemcytabiny |
| PL225283B1 (pl) * | 2014-07-24 | 2017-03-31 | Univ Im Adama Mickiewicza W Poznaniu | Pochodne 2,3’-anhydro-2’-deoksy-5-fluorourydyny o działaniu cytotoksycznym, sposób wytwarzania i zastosowanie |
| EP3683225A1 (en) | 2014-11-28 | 2020-07-22 | Nucana PLC | New 2' and/or 5' amino-acid ester phosphoramidate 3'-deoxy adenosine derivatives as anti-cancer compounds |
| MY190867A (en) | 2015-03-06 | 2022-05-13 | Atea Pharmaceuticals Inc | ? -d-2'-deoxy-2'-?-fluoro-2'- ? -c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment |
| CN108368147A (zh) * | 2015-05-27 | 2018-08-03 | 南方研究院 | 用于治疗癌症的核苷酸 |
| CN108431016A (zh) * | 2015-11-16 | 2018-08-21 | 艾可瑞恩治疗公司 | 核酸前体药物 |
| GB201522764D0 (en) * | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
| GB201609600D0 (en) * | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
| US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| PL3512863T3 (pl) | 2016-09-07 | 2022-04-04 | Atea Pharmaceuticals, Inc. | 2'-Podstawione-N6-podstawione nukleotydy purynowe do leczenia zakażeń wirusem RNA |
| CA3041362A1 (en) | 2016-11-13 | 2018-05-17 | Imagine Pharma, Llc | Compositions and methods for treating diabetes, hypertension and hypercholesterolemia |
| CN109863160B (zh) | 2016-12-23 | 2022-06-07 | 四川科伦博泰生物医药股份有限公司 | 核苷磷酸类化合物及其制备方法和用途 |
| RU2644156C1 (ru) * | 2017-02-28 | 2018-02-08 | Александр Васильевич Иващенко | Пролекарство ингибитора NS5B HCV полимеразы, способ его получения и применения |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| WO2019028646A1 (en) * | 2017-08-08 | 2019-02-14 | Sun Yat-Sen University | METHODS AND COMPOSITIONS FOR THE TREATMENT OF TUMORS WITH MULTIPLE DRUG RESISTANCE |
| GB201713916D0 (en) * | 2017-08-30 | 2017-10-11 | Nucana Biomed Ltd | Treatment regimens |
| GB201715011D0 (en) * | 2017-09-18 | 2017-11-01 | Nucana Biomed Ltd | Floxuridine synthesis |
| GB201720279D0 (en) | 2017-12-05 | 2018-01-17 | Nucana Biomed Ltd | Anticancer compounds |
| US11597745B2 (en) | 2018-03-09 | 2023-03-07 | Japan Science And Technology Agency | β-modified phosphoric acid compound precursor, β-modified phosphoric acid compound, reaction inhibitor and medicine containing the same, and method for inhibiting reaction |
| CN110387226A (zh) * | 2018-04-20 | 2019-10-29 | 天津大学 | 一种用于检测肿瘤的荧光探针及用途 |
| WO2020111279A1 (ja) * | 2018-11-30 | 2020-06-04 | 国立大学法人 東京大学 | カルボキシペプチダーゼ活性検出用蛍光プローブ |
| GB201904544D0 (en) | 2019-04-01 | 2019-05-15 | NuCana plc | Anticancer compounds |
| CN110840907B (zh) * | 2019-08-16 | 2022-11-25 | 南京医科大学 | 一类自由基敏感的尿嘧啶类ProTide前药及其药物用途 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| US20240043467A1 (en) * | 2020-08-31 | 2024-02-08 | Emory University | 5'-substituted nucleoside monophosphates, prodrugs thereof, and uses related thereto |
| WO2024121527A1 (en) | 2022-12-07 | 2024-06-13 | NuCana plc | Synthesis of nucleoside derivative nuc-3373 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2802005A (en) | 1957-08-06 | S-eluorourace | ||
| US1002239A (en) | 1902-04-11 | 1911-09-05 | Stromberg Carlson Telephone | Telephone system. |
| US2945038A (en) | 1956-09-26 | 1960-07-12 | Hoffmann La Roche | 5-fluorocytosine and preparation thereof |
| US3201387A (en) | 1963-09-18 | 1965-08-17 | Heidelberger Charles | 5-trifluoromethyluracil, derivatives thereof, and processes for preparing the same |
| US3792039A (en) | 1971-12-27 | 1974-02-12 | Miles Lab | Poly 2'-fluoro-2'-deoxyuridylic acid |
| DD279248A1 (de) | 1989-01-01 | 1990-05-30 | Akad Wissenschaften Ddr | Verfahren zur herstellung von 2',3'-didesoxythymidin-5'-diamidophosphaten |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| RU2197964C2 (ru) * | 1995-04-12 | 2003-02-10 | Дзе Проктер Энд Гэмбл Компани | Фармацевтическая композиция, композиция стандартной лекарственной формы и способ лечения злокачественных новообразований, опухолей и вирусных инфекций |
| IL137164A0 (en) | 1998-01-23 | 2001-07-24 | Newbiotics Inc | Enzyme catalyzed therapeutic agents |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| CN1390227A (zh) | 1999-07-22 | 2003-01-08 | 新生物生物公司 | 酶催化的治疗活化 |
| DE10109657A1 (de) | 2001-02-28 | 2002-09-05 | Menarini Ricerche Spa | Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin |
| WO2003000713A1 (en) | 2001-06-21 | 2003-01-03 | Glaxo Group Limited | Nucleoside compounds in hcv |
| GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| EP1827460A4 (en) | 2004-12-09 | 2012-03-14 | Univ Minnesota | NUCLEOSIDE WITH ANTIVIRAL AND ANTI-CANCER EFFECT |
| GB0505781D0 (en) | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
| CA2618335C (en) | 2005-08-15 | 2015-03-31 | F.Hoffmann-La Roche Ag | Antiviral phosphoramidates of 4'-substituted pronucleotides |
| WO2007056596A2 (en) | 2005-11-09 | 2007-05-18 | Wayne State University | Phosphoramidate derivatives of fau |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| CN101922935B (zh) | 2010-07-16 | 2012-07-18 | 北京大学 | 一种最小互易结构干涉型全光纤陀螺仪 |
| NZ606141A (en) | 2010-07-19 | 2015-03-27 | Gilead Sciences Inc | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| WO2012040126A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| CA2810928A1 (en) | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
| GB201016855D0 (en) | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| WO2012048013A2 (en) | 2010-10-06 | 2012-04-12 | Inhibitex, Inc. | Phosphorodiamidate derivatives of guanosine nucleoside compounds for treatment of viral injections |
| SI2681227T1 (sl) * | 2011-03-01 | 2016-04-29 | Nucana Biomed Limited | Fosforamidatni derivati 5-fluoro-2'-deoksiuridina za uporabo pri zdravljenju raka |
| EP2681219B1 (en) | 2011-03-01 | 2015-10-28 | Janssen Pharmaceutica, N.V. | 6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine derivatives useful as inhibitors of beta-secretase (bace) |
| EA033046B1 (ru) | 2014-06-25 | 2019-08-30 | НУКАНА ПиЭлСи | Состав, содержащий пролекарство гемцитабина |
| EP3683225A1 (en) | 2014-11-28 | 2020-07-22 | Nucana PLC | New 2' and/or 5' amino-acid ester phosphoramidate 3'-deoxy adenosine derivatives as anti-cancer compounds |
| KR20180021697A (ko) | 2015-05-14 | 2018-03-05 | 뉴카나 피엘씨 | 암 치료 |
| GB201522764D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
| GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
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2012
- 2012-02-29 SI SI201230488T patent/SI2681227T1/sl unknown
- 2012-02-29 WO PCT/GB2012/050457 patent/WO2012117246A1/en not_active Ceased
- 2012-02-29 PT PT181787151T patent/PT3447061T/pt unknown
- 2012-02-29 CN CN201280010761.4A patent/CN103403013B/zh active Active
- 2012-02-29 DK DK18178715.1T patent/DK3447061T3/da active
- 2012-02-29 MX MX2013009815A patent/MX339822B/es active IP Right Grant
- 2012-02-29 EP EP16150494.9A patent/EP3031812B1/en active Active
- 2012-02-29 RU RU2013143862A patent/RU2614406C2/ru active
- 2012-02-29 DK DK12709146.0T patent/DK2681227T3/da active
- 2012-02-29 RS RS20160211A patent/RS54776B1/sr unknown
- 2012-02-29 SI SI201231972T patent/SI3447061T1/sl unknown
- 2012-02-29 HR HRP20211967TT patent/HRP20211967T1/hr unknown
- 2012-02-29 RS RS20211549A patent/RS62721B1/sr unknown
- 2012-02-29 AU AU2012223012A patent/AU2012223012C1/en active Active
- 2012-02-29 LT LTEP18178715.1T patent/LT3447061T/lt unknown
- 2012-02-29 KR KR1020137025749A patent/KR101885940B1/ko active Active
- 2012-02-29 EP EP21209926.1A patent/EP4023299B1/en active Active
- 2012-02-29 HU HUE18178715A patent/HUE060127T2/hu unknown
- 2012-02-29 EP EP12709146.0A patent/EP2681227B1/en active Active
- 2012-02-29 US US14/000,682 patent/US8933053B2/en active Active
- 2012-02-29 JP JP2013555935A patent/JP5978232B2/ja active Active
- 2012-02-29 PL PL16150494T patent/PL3031812T3/pl unknown
- 2012-02-29 ES ES12709146.0T patent/ES2569185T3/es active Active
- 2012-02-29 ES ES18178715T patent/ES2903097T3/es active Active
- 2012-02-29 SG SG2013062823A patent/SG192841A1/en unknown
- 2012-02-29 ES ES21209926T patent/ES3039965T3/es active Active
- 2012-02-29 BR BR112013021986-6A patent/BR112013021986B1/pt active IP Right Grant
- 2012-02-29 HU HUE12709146A patent/HUE029022T2/en unknown
- 2012-02-29 PL PL12709146T patent/PL2681227T3/pl unknown
- 2012-02-29 CN CN201510329656.2A patent/CN104974206B/zh active Active
- 2012-02-29 PH PH1/2013/501723A patent/PH12013501723A1/en unknown
- 2012-02-29 ES ES16150494.9T patent/ES2686219T3/es active Active
- 2012-02-29 NZ NZ615270A patent/NZ615270A/en unknown
- 2012-02-29 DK DK16150494.9T patent/DK3031812T3/en active
- 2012-02-29 PL PL18178715T patent/PL3447061T3/pl unknown
- 2012-02-29 SM SM20210715T patent/SMT202100715T1/it unknown
- 2012-02-29 CA CA2828326A patent/CA2828326C/en active Active
- 2012-02-29 EP EP18178715.1A patent/EP3447061B1/en active Active
- 2012-02-29 HR HRP20160346TT patent/HRP20160346T1/hr unknown
- 2012-02-29 PT PT16150494T patent/PT3031812T/pt unknown
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2013
- 2013-08-28 IL IL228169A patent/IL228169A/en active IP Right Grant
- 2013-08-30 CL CL2013002517A patent/CL2013002517A1/es unknown
- 2013-09-09 ZA ZA2013/06468A patent/ZA201306468B/en unknown
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2014
- 2014-12-04 US US14/560,097 patent/US9221866B2/en active Active
- 2014-12-09 ZA ZA2014/09013A patent/ZA201409013B/en unknown
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2015
- 2015-03-05 PH PH12015500485A patent/PH12015500485A1/en unknown
- 2015-11-17 US US14/943,555 patent/US9655915B2/en active Active
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2016
- 2016-04-27 CY CY20161100360T patent/CY1117445T1/el unknown
- 2016-05-06 SM SM201600132T patent/SMT201600132B/it unknown
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2017
- 2017-04-18 US US15/489,884 patent/US10022390B2/en active Active
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2018
- 2018-06-28 US US16/021,103 patent/US10993957B2/en active Active
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2021
- 2021-04-06 US US17/223,241 patent/US11559542B2/en active Active
- 2021-12-17 CY CY20211101114T patent/CY1124871T1/el unknown
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2023
- 2023-01-11 US US18/095,937 patent/US11925658B2/en active Active
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