JP2014506466A5 - - Google Patents
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- JP2014506466A5 JP2014506466A5 JP2013553588A JP2013553588A JP2014506466A5 JP 2014506466 A5 JP2014506466 A5 JP 2014506466A5 JP 2013553588 A JP2013553588 A JP 2013553588A JP 2013553588 A JP2013553588 A JP 2013553588A JP 2014506466 A5 JP2014506466 A5 JP 2014506466A5
- Authority
- JP
- Japan
- Prior art keywords
- genetically modified
- polypeptide
- optionally
- dehydrogenase
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims 33
- AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 claims 15
- 230000000813 microbial effect Effects 0.000 claims 13
- 238000006243 chemical reaction Methods 0.000 claims 11
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 10
- 241000588724 Escherichia coli Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 230000003197 catalytic effect Effects 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 4
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 4
- 241000194035 Lactococcus lactis Species 0.000 claims 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 4
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 4
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 3
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 2
- 101710177708 Alpha-ketoglutarate semialdehyde dehydrogenase Proteins 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 2
- 244000063299 Bacillus subtilis Species 0.000 claims 2
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 241000588921 Enterobacteriaceae Species 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 108010055471 Phenylacetaldehyde dehydrogenase Proteins 0.000 claims 2
- 241000589776 Pseudomonas putida Species 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 2
- 241000194018 Streptococcaceae Species 0.000 claims 2
- 241000194017 Streptococcus Species 0.000 claims 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 2
- 101150014383 adhE gene Proteins 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- OGKCMUHKYFDVQB-UHFFFAOYSA-N 2-methylpropanal;2-methylpropanoic acid Chemical compound CC(C)C=O.CC(C)C(O)=O OGKCMUHKYFDVQB-UHFFFAOYSA-N 0.000 claims 1
- 102100027278 4-trimethylaminobutyraldehyde dehydrogenase Human genes 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 108010000700 Acetolactate synthase Proteins 0.000 claims 1
- 108010065763 Aminobutyraldehyde dehydrogenase Proteins 0.000 claims 1
- 101100098786 Bacillus subtilis (strain 168) tapA gene Proteins 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241001646647 Burkholderia ambifaria Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108700016168 Dihydroxy-acid dehydratases Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 101001131614 Escherichia coli (strain K12) NADP/NAD-dependent aldehyde dehydrogenase PuuC Proteins 0.000 claims 1
- 101100108235 Escherichia coli (strain K12) adhP gene Proteins 0.000 claims 1
- 101100321116 Escherichia coli (strain K12) yqhD gene Proteins 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 108010000200 Ketol-acid reductoisomerase Proteins 0.000 claims 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 101100462488 Phlebiopsis gigantea p2ox gene Proteins 0.000 claims 1
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims 1
- 101100490769 Rattus norvegicus Aldh1a1 gene Proteins 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 241000235344 Saccharomycetaceae Species 0.000 claims 1
- 101100297542 Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494) phpC gene Proteins 0.000 claims 1
- 108010084086 Succinate-Semialdehyde Dehydrogenase Proteins 0.000 claims 1
- 102000005566 Succinate-Semialdehyde Dehydrogenase Human genes 0.000 claims 1
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 claims 1
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 108010008221 formate C-acetyltransferase Proteins 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 101150111581 pflB gene Proteins 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 101150060030 poxB gene Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161441939P | 2011-02-11 | 2011-02-11 | |
| US61/441,939 | 2011-02-11 | ||
| PCT/US2012/024640 WO2012109534A2 (en) | 2011-02-11 | 2012-02-10 | Cells and methods for producing isobutyric acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014506466A JP2014506466A (ja) | 2014-03-17 |
| JP2014506466A5 true JP2014506466A5 (https=) | 2015-04-02 |
Family
ID=45722726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553588A Pending JP2014506466A (ja) | 2011-02-11 | 2012-02-10 | イソ酪酸を製造するための細胞及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140065697A1 (https=) |
| EP (1) | EP2673355A2 (https=) |
| JP (1) | JP2014506466A (https=) |
| KR (1) | KR20140061303A (https=) |
| CN (1) | CN103562375A (https=) |
| AU (1) | AU2012214255A1 (https=) |
| SG (1) | SG192706A1 (https=) |
| WO (1) | WO2012109534A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013055667A2 (en) * | 2011-10-10 | 2013-04-18 | Regents Of The University Of Minnesota | Biocatalysis cells and methods |
| CN104685059A (zh) * | 2012-05-29 | 2015-06-03 | 明尼苏达大学评议会 | 生物合成途径、重组细胞和方法 |
| WO2013192237A1 (en) * | 2012-06-18 | 2013-12-27 | The Regents Of The University Of California | Escherichia coli engineered for isobutyraldehyde production |
| WO2014028642A1 (en) | 2012-08-17 | 2014-02-20 | Easel Biotechnologies, Llc | Two stage production of higher alcohols |
| CN105705650A (zh) * | 2013-08-28 | 2016-06-22 | 英威达技术有限责任公司 | 用于生物合成异丁烯酸盐的方法 |
| JP2017131111A (ja) | 2014-06-03 | 2017-08-03 | 味の素株式会社 | Ｌ−アミノ酸の製造法 |
| WO2015191611A1 (en) * | 2014-06-09 | 2015-12-17 | The Regents Of The University Of California | Bacteria engineered for conversion of ethylene to n-butanol |
| AU2016265751A1 (en) | 2015-05-19 | 2017-12-14 | Lucite International Uk Limited | Process for the biological production of methacrylic acid and derivatives thereof |
| CN105296410A (zh) * | 2015-10-27 | 2016-02-03 | 中国科学院青岛生物能源与过程研究所 | 一种利用缬氨酸途径合成丙烷的大肠杆菌及其构建方法 |
| US20200308610A1 (en) | 2016-03-11 | 2020-10-01 | Aemitis, Inc. | Alpha-ketoisocaproic acid and & alpha-keto-3-methylvaleric acid decarboxylases and uses thereof |
| WO2017194696A1 (en) | 2016-05-12 | 2017-11-16 | Danmarks Tekniske Universitet | Bacterial cells with improved tolerance to isobutyric acid |
| US10849938B2 (en) | 2017-09-13 | 2020-12-01 | ZBiotics Company | Gene expression system for probiotic microorganisms |
| US11680280B2 (en) | 2018-01-09 | 2023-06-20 | Lygos, Inc. | Recombinant host cells and methods for the production of isobutyric acid |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0031886B1 (de) * | 1979-12-20 | 1984-04-11 | Röhm Gmbh | Verfahren zur Herstellung von Isobuttersäure oder ihrer niederen Alkylester |
| US4754074A (en) | 1986-12-22 | 1988-06-28 | Amoco Corporation | Preparation of dialkyl ketones from aliphatic carboxylic acids |
| US20090053797A1 (en) * | 2005-08-19 | 2009-02-26 | Yoichiro Shiba | Genetically modified host cells and use of same for producing isoprenoid compounds |
| KR100780324B1 (ko) * | 2006-07-28 | 2007-11-29 | 한국과학기술원 | 신규 순수 숙신산 생성 변이 미생물 및 이를 이용한 숙신산제조방법 |
| KR20100031525A (ko) * | 2007-06-01 | 2010-03-22 | 에보니크 룀 게엠베하 | 메타크릴산 또는 메타크릴산 에스테르의 제조 방법 |
| US20110281314A1 (en) * | 2008-08-04 | 2011-11-17 | Lynch Michael D | Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol |
| EP2350299A4 (en) * | 2008-10-28 | 2012-04-25 | Univ Rice William M | MICROAEROBE CULTURES FOR THE CONVERSION OF GLYCERINE IN CHEMICALS |
| BR112012020261B8 (pt) * | 2010-02-12 | 2020-04-14 | California Inst Of Techn | saccharomyces cerevisiae recombinante e método de produção de isobutanol |
-
2012
- 2012-02-10 EP EP12705215.7A patent/EP2673355A2/en not_active Withdrawn
- 2012-02-10 CN CN201280017985.8A patent/CN103562375A/zh active Pending
- 2012-02-10 SG SG2013060769A patent/SG192706A1/en unknown
- 2012-02-10 US US13/984,502 patent/US20140065697A1/en not_active Abandoned
- 2012-02-10 WO PCT/US2012/024640 patent/WO2012109534A2/en not_active Ceased
- 2012-02-10 AU AU2012214255A patent/AU2012214255A1/en not_active Abandoned
- 2012-02-10 JP JP2013553588A patent/JP2014506466A/ja active Pending
- 2012-02-10 KR KR1020137023666A patent/KR20140061303A/ko not_active Withdrawn
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