JP2014506466A - イソ酪酸を製造するための細胞及び方法 - Google Patents

イソ酪酸を製造するための細胞及び方法 Download PDF

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JP2014506466A
JP2014506466A JP2013553588A JP2013553588A JP2014506466A JP 2014506466 A JP2014506466 A JP 2014506466A JP 2013553588 A JP2013553588 A JP 2013553588A JP 2013553588 A JP2013553588 A JP 2013553588A JP 2014506466 A JP2014506466 A JP 2014506466A
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cell
polypeptide
genetically modified
isobutyrate
recombinant cell
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JP2014506466A5 (https=
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ケチェン チャン
ミンヨン ション
ピー．ウッドラフ アダム
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University of Minnesota Twin Cities
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University of Minnesota System
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013553588A 2011-02-11 2012-02-10 イソ酪酸を製造するための細胞及び方法 Pending JP2014506466A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161441939P 2011-02-11 2011-02-11
US61/441,939 2011-02-11
PCT/US2012/024640 WO2012109534A2 (en) 2011-02-11 2012-02-10 Cells and methods for producing isobutyric acid

Publications (2)

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JP2014506466A true JP2014506466A (ja) 2014-03-17
JP2014506466A5 JP2014506466A5 (https=) 2015-04-02

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US (1) US20140065697A1 (https=)
EP (1) EP2673355A2 (https=)
JP (1) JP2014506466A (https=)
KR (1) KR20140061303A (https=)
CN (1) CN103562375A (https=)
AU (1) AU2012214255A1 (https=)
SG (1) SG192706A1 (https=)
WO (1) WO2012109534A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015186749A1 (ja) * 2014-06-03 2015-12-10 味の素株式会社 Ｌ－アミノ酸の製造法
JP2020535801A (ja) * 2017-09-13 2020-12-10 ジーバイオティクス カンパニー プロバイオティック微生物の遺伝子発現系

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013055667A2 (en) * 2011-10-10 2013-04-18 Regents Of The University Of Minnesota Biocatalysis cells and methods
CN104685059A (zh) * 2012-05-29 2015-06-03 明尼苏达大学评议会 生物合成途径、重组细胞和方法
WO2013192237A1 (en) * 2012-06-18 2013-12-27 The Regents Of The University Of California Escherichia coli engineered for isobutyraldehyde production
WO2014028642A1 (en) 2012-08-17 2014-02-20 Easel Biotechnologies, Llc Two stage production of higher alcohols
CN105705650A (zh) * 2013-08-28 2016-06-22 英威达技术有限责任公司 用于生物合成异丁烯酸盐的方法
WO2015191611A1 (en) * 2014-06-09 2015-12-17 The Regents Of The University Of California Bacteria engineered for conversion of ethylene to n-butanol
AU2016265751A1 (en) 2015-05-19 2017-12-14 Lucite International Uk Limited Process for the biological production of methacrylic acid and derivatives thereof
CN105296410A (zh) * 2015-10-27 2016-02-03 中国科学院青岛生物能源与过程研究所 一种利用缬氨酸途径合成丙烷的大肠杆菌及其构建方法
US20200308610A1 (en) 2016-03-11 2020-10-01 Aemitis, Inc. Alpha-ketoisocaproic acid and & alpha-keto-3-methylvaleric acid decarboxylases and uses thereof
WO2017194696A1 (en) 2016-05-12 2017-11-16 Danmarks Tekniske Universitet Bacterial cells with improved tolerance to isobutyric acid
US11680280B2 (en) 2018-01-09 2023-06-20 Lygos, Inc. Recombinant host cells and methods for the production of isobutyric acid

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452999A (en) * 1979-12-20 1984-06-05 Rohm Gmbh Method for making isobutyric acid
WO2007024718A2 (en) * 2005-08-19 2007-03-01 The Regents Of The University Of California Genetically modified host cells and use of same for producing isoprenoid compounds
WO2008013405A1 (en) * 2006-07-28 2008-01-31 Korea Advanced Institute Of Science And Technology Novel engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same
WO2010017230A2 (en) * 2008-08-04 2010-02-11 The Regents Of The University Of Colorado Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol
WO2010051324A1 (en) * 2008-10-28 2010-05-06 Rice University Microaerobic cultures for converting glycerol to chemicals
WO2011142865A2 (en) * 2010-02-12 2011-11-17 Gevo, Inc. Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4754074A (en) 1986-12-22 1988-06-28 Amoco Corporation Preparation of dialkyl ketones from aliphatic carboxylic acids
KR20100031525A (ko) * 2007-06-01 2010-03-22 에보니크 룀 게엠베하 메타크릴산 또는 메타크릴산 에스테르의 제조 방법

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452999A (en) * 1979-12-20 1984-06-05 Rohm Gmbh Method for making isobutyric acid
WO2007024718A2 (en) * 2005-08-19 2007-03-01 The Regents Of The University Of California Genetically modified host cells and use of same for producing isoprenoid compounds
WO2008013405A1 (en) * 2006-07-28 2008-01-31 Korea Advanced Institute Of Science And Technology Novel engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same
WO2010017230A2 (en) * 2008-08-04 2010-02-11 The Regents Of The University Of Colorado Methods, systems and compositions related to microbial bio-production of butanol and/or isobutanol
WO2010051324A1 (en) * 2008-10-28 2010-05-06 Rice University Microaerobic cultures for converting glycerol to chemicals
WO2011142865A2 (en) * 2010-02-12 2011-11-17 Gevo, Inc. Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals, and amino acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN5014004133; Ｆｅｒｒａｎｄｅｚ　Ａｂｅｌ: ＦＥＢＳ　ＬＥＴＴＥＲＳ ４０６, 199707, ｐ．２３-２７ *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015186749A1 (ja) * 2014-06-03 2015-12-10 味の素株式会社 Ｌ－アミノ酸の製造法
US10563234B2 (en) 2014-06-03 2020-02-18 Ajinomoto Co., Inc. Method for producing L-amino acids
JP2020535801A (ja) * 2017-09-13 2020-12-10 ジーバイオティクス カンパニー プロバイオティック微生物の遺伝子発現系
US11696932B2 (en) 2017-09-13 2023-07-11 ZBiotics Company Gene expression system for probiotic microorganisms
JP7356967B2 (ja) 2017-09-13 2023-10-05 ジーバイオティクス カンパニー プロバイオティック微生物の遺伝子発現系
US11975033B2 (en) 2017-09-13 2024-05-07 ZBiotics Company Gene expression system for probiotic microorganisms
US12539317B2 (en) 2017-09-13 2026-02-03 ZBiotics Company Gene expression system for probiotic microorganisms

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WO2012109534A3 (en) 2012-10-04
EP2673355A2 (en) 2013-12-18
SG192706A1 (en) 2013-09-30
KR20140061303A (ko) 2014-05-21
AU2012214255A1 (en) 2013-09-12
WO2012109534A2 (en) 2012-08-16
US20140065697A1 (en) 2014-03-06
CN103562375A (zh) 2014-02-05

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