JP2014505095A5 - - Google Patents
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- JP2014505095A5 JP2014505095A5 JP2013553013A JP2013553013A JP2014505095A5 JP 2014505095 A5 JP2014505095 A5 JP 2014505095A5 JP 2013553013 A JP2013553013 A JP 2013553013A JP 2013553013 A JP2013553013 A JP 2013553013A JP 2014505095 A5 JP2014505095 A5 JP 2014505095A5
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- 150000001875 compounds Chemical class 0.000 claims 25
- 238000000034 method Methods 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 21
- 238000011282 treatment Methods 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 239000003085 diluting agent Substances 0.000 claims 9
- 230000007850 degeneration Effects 0.000 claims 8
- 230000002265 prevention Effects 0.000 claims 7
- 208000024827 Alzheimer disease Diseases 0.000 claims 6
- 238000010511 deprotection reaction Methods 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 208000011580 syndromic disease Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 201000010374 Down Syndrome Diseases 0.000 claims 4
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 4
- 201000002832 Lewy body dementia Diseases 0.000 claims 4
- 229930195725 Mannitol Natural products 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 4
- 102100040243 Microtubule-associated protein tau Human genes 0.000 claims 4
- 208000027089 Parkinsonian disease Diseases 0.000 claims 4
- 206010034010 Parkinsonism Diseases 0.000 claims 4
- 241000710886 West Nile virus Species 0.000 claims 4
- 230000004931 aggregating effect Effects 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 4
- 239000008101 lactose Substances 0.000 claims 4
- 239000000594 mannitol Substances 0.000 claims 4
- 235000010355 mannitol Nutrition 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000007909 solid dosage form Substances 0.000 claims 4
- 210000003523 substantia nigra Anatomy 0.000 claims 4
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 3
- -1 N-protected 3,7-diamino-10H-phenothiazine Chemical class 0.000 claims 3
- 208000014060 Niemann-Pick disease Diseases 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 238000007906 compression Methods 0.000 claims 3
- 230000006835 compression Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 102000014461 Ataxins Human genes 0.000 claims 2
- 108010078286 Ataxins Proteins 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 2
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 claims 2
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims 2
- 206010013142 Disinhibition Diseases 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 208000005176 Hepatitis C Diseases 0.000 claims 2
- 208000027747 Kennedy disease Diseases 0.000 claims 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims 2
- 229920002774 Maltodextrin Polymers 0.000 claims 2
- 239000005913 Maltodextrin Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 claims 2
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 208000034799 Tauopathies Diseases 0.000 claims 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 230000037444 atrophy Effects 0.000 claims 2
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 210000004227 basal ganglia Anatomy 0.000 claims 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
- 235000010216 calcium carbonate Nutrition 0.000 claims 2
- 239000001506 calcium phosphate Substances 0.000 claims 2
- 159000000007 calcium salts Chemical class 0.000 claims 2
- 235000011132 calcium sulphate Nutrition 0.000 claims 2
- 210000003591 cerebellar nuclei Anatomy 0.000 claims 2
- 210000003710 cerebral cortex Anatomy 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 208000030381 cutaneous melanoma Diseases 0.000 claims 2
- 208000017004 dementia pugilistica Diseases 0.000 claims 2
- 239000008121 dextrose Substances 0.000 claims 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 2
- 229940038472 dicalcium phosphate Drugs 0.000 claims 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000007908 dry granulation Methods 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 229940035034 maltodextrin Drugs 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 208000005340 mucopolysaccharidosis III Diseases 0.000 claims 2
- 201000000585 muscular atrophy Diseases 0.000 claims 2
- 230000001898 pallidal effect Effects 0.000 claims 2
- 230000009256 peri post natal development Effects 0.000 claims 2
- 229920000155 polyglutamine Polymers 0.000 claims 2
- 108010040003 polyglutamine Proteins 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 210000000463 red nucleus Anatomy 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 201000003708 skin melanoma Diseases 0.000 claims 2
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 229940032147 starch Drugs 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 235000000346 sugar Nutrition 0.000 claims 2
- 150000008163 sugars Chemical class 0.000 claims 2
- 230000009529 traumatic brain injury Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 125000006585 (C6-C10) arylene group Chemical group 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 208000002678 Mucopolysaccharidoses Diseases 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 238000005054 agglomeration Methods 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000006242 amine protecting group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000007907 direct compression Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000007888 film coating Substances 0.000 claims 1
- 238000009501 film coating Methods 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000011872 intimate mixture Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 229940098895 maleic acid Drugs 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 206010028093 mucopolysaccharidosis Diseases 0.000 claims 1
- 208000036709 mucopolysaccharidosis type 3B Diseases 0.000 claims 1
- 229960004838 phosphoric acid Drugs 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000004845 protein aggregation Effects 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 229920003109 sodium starch glycolate Polymers 0.000 claims 1
- 229940079832 sodium starch glycolate Drugs 0.000 claims 1
- 239000008109 sodium starch glycolate Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 208000033556 type C1 Niemann-Pick disease Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 238000005550 wet granulation Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG2011010600 | 2011-02-11 | ||
| SG201101060-0 | 2011-02-11 | ||
| US201161485880P | 2011-05-13 | 2011-05-13 | |
| US61/485,880 | 2011-05-13 | ||
| PCT/GB2011/001221 WO2012107706A1 (en) | 2011-02-11 | 2011-08-15 | Phenothiazine diaminium salts and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016035263A Division JP6093890B2 (ja) | 2011-02-11 | 2016-02-26 | フェノチアジンジアミニウム塩およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014505095A JP2014505095A (ja) | 2014-02-27 |
| JP2014505095A5 true JP2014505095A5 (https=) | 2014-09-18 |
| JP5898701B2 JP5898701B2 (ja) | 2016-04-13 |
Family
ID=44532939
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553013A Active JP5898701B2 (ja) | 2011-02-11 | 2011-08-15 | フェノチアジンジアミニウム塩およびそれらの使用 |
| JP2016035263A Active JP6093890B2 (ja) | 2011-02-11 | 2016-02-26 | フェノチアジンジアミニウム塩およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016035263A Active JP6093890B2 (ja) | 2011-02-11 | 2016-02-26 | フェノチアジンジアミニウム塩およびそれらの使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (6) | US9283230B2 (https=) |
| EP (1) | EP2673266B1 (https=) |
| JP (2) | JP5898701B2 (https=) |
| KR (1) | KR101888713B1 (https=) |
| CN (2) | CN105853439A (https=) |
| AR (2) | AR082699A1 (https=) |
| AU (1) | AU2011358840B2 (https=) |
| BR (1) | BR112013020539A2 (https=) |
| CA (1) | CA2827027C (https=) |
| CY (1) | CY1118102T1 (https=) |
| DK (1) | DK2673266T3 (https=) |
| EA (1) | EA025033B1 (https=) |
| ES (1) | ES2594703T3 (https=) |
| HR (1) | HRP20161291T1 (https=) |
| HU (1) | HUE031633T2 (https=) |
| IL (2) | IL227736A (https=) |
| LT (1) | LT2673266T (https=) |
| MY (1) | MY165906A (https=) |
| PL (1) | PL2673266T3 (https=) |
| PT (1) | PT2673266T (https=) |
| RS (1) | RS55237B1 (https=) |
| SG (1) | SG192666A1 (https=) |
| SI (1) | SI2673266T1 (https=) |
| SM (1) | SMT201600389B (https=) |
| WO (1) | WO2012107706A1 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2013191B3 (en) | 2006-03-29 | 2019-02-27 | Wista Laboratories Ltd. | 3,7-diamino-10h-phenothiazine salts and their use |
| DK3121169T3 (da) | 2006-07-11 | 2022-02-28 | Wista Lab Ltd | Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser |
| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| CN102958525B (zh) | 2010-04-30 | 2017-05-24 | 普罗瑟塔抗病毒股份有限公司 | 抗病毒化合物 |
| US8828986B2 (en) | 2011-04-20 | 2014-09-09 | Prosetta Antiviral Inc. | Antiviral compounds |
| EA025033B1 (ru) | 2011-02-11 | 2016-11-30 | Уиста Лэборэтэриз Лтд. | Диаминиевые соли фенотиазина и их применение |
| US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
| CA2889446C (en) | 2012-10-25 | 2021-05-11 | The General Hospital Corporation | Combination therapies for the treatment of alzheimer's disease and related disorders |
| US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
| BR112016002979A8 (pt) * | 2013-08-15 | 2020-02-04 | Eupharma Pty Ltd | processo para a purificação de um composto de diaminofenotiazínio, processo para a purificação de azul de metileno e uso de um complexo de diaminofenotiazínio estabilizado protonado |
| AU2014340182B2 (en) | 2013-10-22 | 2019-05-23 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
| EP3140384B1 (en) * | 2014-05-06 | 2024-02-14 | Milliken & Company | Laundry care compositions |
| HUE061213T2 (hu) * | 2015-04-16 | 2023-05-28 | Novartis Ag | Ribociklib tabletta |
| GB201512678D0 (en) * | 2015-07-20 | 2015-08-26 | Wista Lab Ltd | Methods of chemical synthesis |
| CN105541756B (zh) * | 2015-12-17 | 2018-02-09 | 陕西方舟制药有限公司 | 一种制备1‑(3，7‑双二甲氨基‑吩噻嗪‑10‑基)乙酮的方法 |
| CN106046027B (zh) * | 2016-06-30 | 2019-03-05 | 广东工业大学 | 一种含吡咯并吩噻嗪-1,3-二酮衍生物及其制备方法与应用 |
| KR102592614B1 (ko) | 2016-07-25 | 2023-10-24 | 위스타 레보레이토리스 리미티드 | 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage) |
| CA3033079A1 (en) | 2016-08-31 | 2018-03-08 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
| GB201614834D0 (en) * | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| GB201621817D0 (en) | 2016-12-21 | 2017-02-01 | Wista Lab Ltd | Methods of chemical synthesis |
| JP7202376B2 (ja) | 2017-07-20 | 2023-01-11 | エーゼットセラピーズ， インコーポレイテッド | クロモリンナトリウムおよびイブプロフェンの粉末製剤 |
| JP6958860B2 (ja) | 2017-11-07 | 2021-11-02 | 学校法人自治医科大学 | ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途 |
| KR20210071943A (ko) | 2018-07-02 | 2021-06-16 | 더 제너럴 하스피탈 코포레이션 | 크로몰린 소듐 및 α-락토스의 분말화된 제형 |
| MA52591A (fr) | 2018-07-12 | 2021-06-02 | Hexamer Therapeutics Inc | Échafaudage peptidique autoassemblé |
| DK3826639T3 (da) * | 2018-07-26 | 2024-09-23 | Wista Lab Ltd | Optimeret dosering af diaminophenothiaziner i populationer |
| WO2020048593A1 (en) | 2018-09-05 | 2020-03-12 | Wista Laboratories Ltd. | Network methods for neurodegenerative diseases |
| WO2020123449A1 (en) | 2018-12-10 | 2020-06-18 | The General Hospital Corporation | Cromolyn esters and uses thereof |
| GB201909493D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Therapeutic interactions |
| GB201909454D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Enhancers |
| GB201909506D0 (en) | 2019-07-02 | 2019-08-14 | Wista Lab Ltd | Synaptopathies |
| EP4132507A4 (en) | 2020-04-06 | 2024-05-15 | The General Hospital Corporation | Methods of treatment of coronavirus-induced inflammation conditions |
| JP2023524146A (ja) * | 2020-05-05 | 2023-06-08 | ウィスタ ラボラトリーズ リミテッド | 低酸素血症の治療に使用されるメチルチオニニウム化合物 |
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