JP2014504508A5 - - Google Patents
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- Publication number
- JP2014504508A5 JP2014504508A5 JP2013552630A JP2013552630A JP2014504508A5 JP 2014504508 A5 JP2014504508 A5 JP 2014504508A5 JP 2013552630 A JP2013552630 A JP 2013552630A JP 2013552630 A JP2013552630 A JP 2013552630A JP 2014504508 A5 JP2014504508 A5 JP 2014504508A5
- Authority
- JP
- Japan
- Prior art keywords
- coa
- crotonyl
- reductase
- alcohol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 33
- 102000004316 Oxidoreductases Human genes 0.000 claims 32
- 108090000854 Oxidoreductases Proteins 0.000 claims 32
- 108010011384 acyl-CoA dehydrogenase (NADP+) Proteins 0.000 claims 24
- MLUCVPSAIODCQM-NSCUHMNNSA-N Crotonaldehyde Chemical compound C\C=C\C=O MLUCVPSAIODCQM-NSCUHMNNSA-N 0.000 claims 20
- WCASXYBKJHWFMY-NSCUHMNNSA-N Crotyl alcohol Chemical compound C\C=C\CO WCASXYBKJHWFMY-NSCUHMNNSA-N 0.000 claims 20
- 244000005700 microbiome Species 0.000 claims 19
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 230000037361 pathway Effects 0.000 claims 16
- 230000015572 biosynthetic process Effects 0.000 claims 15
- 238000005755 formation reaction Methods 0.000 claims 15
- 102000003960 Ligases Human genes 0.000 claims 12
- 108090000364 Ligases Proteins 0.000 claims 12
- 102000004357 Transferases Human genes 0.000 claims 12
- 108090000992 Transferases Proteins 0.000 claims 12
- 150000001299 aldehydes Chemical class 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 108010031139 3-aminobutyryl-CoA deaminase Proteins 0.000 claims 8
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims 8
- ZSLZBFCDCINBPY-ZSJPKINUSA-N Acetyl-CoA Chemical group O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 8
- 108010003902 Acetyl-CoA C-Acyltransferase Proteins 0.000 claims 8
- 108030005660 EC 4.2.1.55 Proteins 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 8
- 108090000790 Enzymes Proteins 0.000 claims 8
- 102100017778 GCDH Human genes 0.000 claims 8
- 108010015451 Glutaryl-CoA Dehydrogenase Proteins 0.000 claims 8
- 102100004876 HADHB Human genes 0.000 claims 8
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 claims 8
- LDHQCZJRKDOVOX-NSCUHMNNSA-M crotonate Chemical compound C\C=C\C([O-])=O LDHQCZJRKDOVOX-NSCUHMNNSA-M 0.000 claims 8
- ZSLZBFCDCINBPY-ZZSFXRQLSA-N Acetyl-CoA Natural products S(C(=O)C)CCNC(=O)CCNC(=O)[C@H](O)C(CO[P@@](=O)(O[P@](=O)(OC[C@@H]1[C@@H](OP(=O)(O)O)[C@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C ZSLZBFCDCINBPY-ZZSFXRQLSA-N 0.000 claims 7
- 108010068207 glutaconyl CoA decarboxylase Proteins 0.000 claims 6
- LDHQCZJRKDOVOX-NSCUHMNNSA-N Crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims 4
- KAKZBPTYRLMSJV-UHFFFAOYSA-N butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 claims 2
- 239000001963 growth media Substances 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 1
- KFWWCMJSYSSPSK-PAXLJYGASA-N crotonoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)/C=C/C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 KFWWCMJSYSSPSK-PAXLJYGASA-N 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 239000002609 media Substances 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161438947P | 2011-02-02 | 2011-02-02 | |
US61/438,947 | 2011-02-02 | ||
PCT/US2012/023632 WO2012106516A1 (en) | 2011-02-02 | 2012-02-02 | Microorganisms and methods for the biosynthesis of butadiene |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016124920A Division JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014504508A JP2014504508A (ja) | 2014-02-24 |
JP2014504508A5 true JP2014504508A5 (hr) | 2015-03-26 |
JP5960729B2 JP5960729B2 (ja) | 2016-08-02 |
Family
ID=46603080
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013552630A Active JP5960729B2 (ja) | 2011-02-02 | 2012-02-02 | ブタジエンの生合成のための微生物および方法 |
JP2016124920A Pending JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
JP2018122381A Pending JP2018166514A (ja) | 2011-02-02 | 2018-06-27 | ブタジエンの生合成のための微生物および方法 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016124920A Pending JP2016192974A (ja) | 2011-02-02 | 2016-06-23 | ブタジエンの生合成のための微生物および方法 |
JP2018122381A Pending JP2018166514A (ja) | 2011-02-02 | 2018-06-27 | ブタジエンの生合成のための微生物および方法 |
Country Status (12)
Country | Link |
---|---|
US (4) | US9321701B2 (hr) |
EP (1) | EP2670852A4 (hr) |
JP (3) | JP5960729B2 (hr) |
KR (1) | KR20140145935A (hr) |
CN (2) | CN103459602B (hr) |
AU (1) | AU2012212118B2 (hr) |
BR (1) | BR112013019811A2 (hr) |
CA (1) | CA2826293A1 (hr) |
MX (1) | MX348334B (hr) |
MY (2) | MY162964A (hr) |
SG (1) | SG192614A1 (hr) |
WO (1) | WO2012106516A1 (hr) |
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AU2009327490A1 (en) | 2008-12-16 | 2011-07-28 | Genomatica, Inc. | Microorganisms and methods for conversion of syngas and other carbon sources to useful products |
JP2012529889A (ja) | 2009-06-10 | 2012-11-29 | ゲノマチカ, インク. | Mek及び2−ブタノールの炭素効率のよい生合成のための微生物及び方法 |
JP2013513384A (ja) | 2009-12-10 | 2013-04-22 | ジェノマティカ・インコーポレイテッド | 合成ガスまたは他のガス状の炭素源およびメタノールを1,3−ブタンジオールへ変換するための方法および生物 |
BR112012028049A2 (pt) | 2010-05-05 | 2015-11-24 | Genomatica Inc | organismo microbiano de ocorrência não natural e método para produzir butadieno, meio de cultura, butadieno biossintetizado, composição, produto químico orgânico, polímero e uso de butadieno biossintetizado |
US9321701B2 (en) * | 2011-02-02 | 2016-04-26 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
BR112013032516A2 (pt) | 2011-06-17 | 2017-03-01 | Invista Tech Sarl | método de biosintetizar butadieno e método para produzir butadieno |
US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
JP6440497B2 (ja) * | 2011-10-19 | 2018-12-19 | サイエンティスト・オブ・フォーチュン・ソシエテ・アノニム | ブタジエンの酵素的製造のための方法 |
WO2013071074A1 (en) * | 2011-11-11 | 2013-05-16 | Invista North America S.A. R.L. | Methods of producing butadiene |
EP2925871A1 (en) | 2012-11-28 | 2015-10-07 | Invista Technologies S.A R.L. | Methods for biosynthesis of isobutene |
BR112015013049B1 (pt) | 2012-12-07 | 2021-12-21 | Global Bioenergies | Produção fermentativa de um hidrocarboneto |
CN104884628A (zh) | 2012-12-07 | 2015-09-02 | 环球生物能源公司 | 改进的发酵方法 |
JP2014161252A (ja) * | 2013-02-22 | 2014-09-08 | Sekisui Chem Co Ltd | 組換え細胞 |
US20160040172A1 (en) | 2013-03-15 | 2016-02-11 | Genomatica, Inc. | Microorganisms and methods for producing butadiene and related compounds by formate assimilation |
US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
EP3030667A2 (en) | 2013-08-05 | 2016-06-15 | Invista Technologies S.a r.l. | Methods for biosynthesis of isoprene |
BR112016002626A2 (pt) | 2013-08-05 | 2017-09-12 | Invista Tech Sarl | método para sintetizar isobuteno e hospedeiro recombinante |
SI3077501T1 (sl) | 2013-12-03 | 2022-02-28 | Genomatica, Inc. | Mikroorganizmi in metode za izboljšanje donosa izdelkov z uporabo sinteze acetil-coa |
EP3744830B1 (en) | 2013-12-27 | 2023-11-22 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
US9938543B2 (en) | 2014-06-16 | 2018-04-10 | Invista North America S.A.R.L. | Methods, reagents and cells for biosynthesizing glutarate methyl ester |
US10669561B2 (en) | 2014-07-03 | 2020-06-02 | Genomatica, Inc. | Microorganisms for producing 4C-5C compounds with unsaturation and methods related thereto |
WO2016007196A1 (en) * | 2014-07-07 | 2016-01-14 | Cobalt Technologies, Inc. | Biomass conversion to butadiene |
US20170298363A1 (en) | 2014-09-18 | 2017-10-19 | Genomatica, Inc | Non-natural microbial organisms with improved energetic efficiency |
CN104298866B (zh) * | 2014-09-30 | 2017-06-06 | 杭州电子科技大学 | 一种克劳斯硫磺回收过程中反应炉动态建模方法 |
WO2016066869A1 (es) | 2014-10-30 | 2016-05-06 | Abengoa Research, S.L. | Catalizador microporoso con encapsulación selectiva de óxidos metálicos útil para producir precursores de butadieno |
WO2016066873A1 (es) | 2014-10-30 | 2016-05-06 | Abengoa Research, S.L. | Óxidos mixtos que comprenden magnesio y boro, y su uso como catalizadores para producir precursores de butadieno |
WO2016135609A1 (en) * | 2015-02-23 | 2016-09-01 | Versalis S.P.A. | Process for the production of dienes |
CN107750276A (zh) | 2015-04-09 | 2018-03-02 | 基因组股份公司 | 用于改进巴豆醇生产的工程化微生物和方法 |
CN108026214B (zh) | 2015-05-30 | 2021-03-02 | 基因组股份公司 | 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用 |
EP3341471A4 (en) * | 2015-08-24 | 2020-07-22 | White Dog Labs, Inc. | MICROBIAL ORGANISMS FOR CONVERTING ACETYL-COA IN CROTYL ALCOHOL AND METHOD FOR PRODUCING CROTYL ALCOHOL |
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EA201891926A1 (ru) * | 2017-02-03 | 2019-04-30 | Киверди, Инк. | Микроорганизмы и искусственные экосистемы для производства белка, продуктов питания и полезных побочных продуктов из субстратов c1 |
US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
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MY156588A (en) | 2008-09-15 | 2016-03-15 | Danisco Us Inc | Systems using cell culture for production of isoprene |
KR102115497B1 (ko) | 2009-04-30 | 2020-05-26 | 게노마티카 인코포레이티드 | 1,3-부탄다이올 생산 유기체 |
US20120276606A1 (en) | 2009-10-30 | 2012-11-01 | Daicel Corporation | Recombinant microorganisms with 1,3-butanediol-producing function and uses thereof |
BR112012028049A2 (pt) * | 2010-05-05 | 2015-11-24 | Genomatica Inc | organismo microbiano de ocorrência não natural e método para produzir butadieno, meio de cultura, butadieno biossintetizado, composição, produto químico orgânico, polímero e uso de butadieno biossintetizado |
WO2012081723A1 (ja) * | 2010-12-17 | 2012-06-21 | 三菱化学株式会社 | 合成経路作成装置、合成経路作成方法及び合成経路作成プログラムならびに3-ヒドロキシプロピオン酸、クロトニルアルコールおよびブタジエンの製造方法 |
US9321701B2 (en) * | 2011-02-02 | 2016-04-26 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
US9169486B2 (en) * | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
-
2012
- 2012-02-02 US US13/365,132 patent/US9321701B2/en active Active
- 2012-02-02 MY MYPI2013701358A patent/MY162964A/en unknown
- 2012-02-02 MX MX2013008988A patent/MX348334B/es active IP Right Grant
- 2012-02-02 EP EP12742132.9A patent/EP2670852A4/en not_active Withdrawn
- 2012-02-02 CA CA2826293A patent/CA2826293A1/en not_active Abandoned
- 2012-02-02 CN CN201280016837.4A patent/CN103459602B/zh not_active Expired - Fee Related
- 2012-02-02 KR KR1020137023026A patent/KR20140145935A/ko not_active Application Discontinuation
- 2012-02-02 WO PCT/US2012/023632 patent/WO2012106516A1/en active Application Filing
- 2012-02-02 CN CN201610552260.9A patent/CN106191132A/zh active Pending
- 2012-02-02 AU AU2012212118A patent/AU2012212118B2/en not_active Ceased
- 2012-02-02 JP JP2013552630A patent/JP5960729B2/ja active Active
- 2012-02-02 BR BR112013019811A patent/BR112013019811A2/pt not_active Application Discontinuation
- 2012-02-02 SG SG2013059167A patent/SG192614A1/en unknown
-
2013
- 2013-08-01 MY MYPI2017702592A patent/MY179664A/en unknown
-
2016
- 2016-03-23 US US15/078,437 patent/US20170044572A1/en not_active Abandoned
- 2016-06-23 JP JP2016124920A patent/JP2016192974A/ja active Pending
-
2018
- 2018-03-09 US US15/917,411 patent/US20190048366A1/en not_active Abandoned
- 2018-06-27 JP JP2018122381A patent/JP2018166514A/ja active Pending
-
2020
- 2020-06-25 US US16/912,409 patent/US20210147881A1/en not_active Abandoned
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