JP2014503600A5 - - Google Patents
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- Publication number
- JP2014503600A5 JP2014503600A5 JP2013551905A JP2013551905A JP2014503600A5 JP 2014503600 A5 JP2014503600 A5 JP 2014503600A5 JP 2013551905 A JP2013551905 A JP 2013551905A JP 2013551905 A JP2013551905 A JP 2013551905A JP 2014503600 A5 JP2014503600 A5 JP 2014503600A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- azabicyclo
- octane
- pyridinecarboxamide
- thiazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 5-propan-2-yl-2-thiazolyl Chemical group 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- MENMPXBUKLPJKR-UHFFFAOYSA-N 5-propan-2-yl-1,3-thiazol-2-amine Chemical compound CC(C)C1=CN=C(N)S1 MENMPXBUKLPJKR-UHFFFAOYSA-N 0.000 description 1
- LGQSJWWZZZJMNP-UHFFFAOYSA-N 6-oxo-1-(5-propan-2-yl-1,3-thiazol-2-yl)pyridine-3-carboxylic acid Chemical compound S1C(C(C)C)=CN=C1N1C(=O)C=CC(C(O)=O)=C1 LGQSJWWZZZJMNP-UHFFFAOYSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2011-0008962 | 2011-01-28 | ||
| KR20110008962 | 2011-01-28 | ||
| PCT/KR2012/000652 WO2012102583A1 (en) | 2011-01-28 | 2012-01-30 | Pharmaceutical composition comprising pyridone derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503600A JP2014503600A (ja) | 2014-02-13 |
| JP2014503600A5 true JP2014503600A5 (enExample) | 2015-01-22 |
| JP5859571B2 JP5859571B2 (ja) | 2016-02-10 |
Family
ID=46581020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551905A Active JP5859571B2 (ja) | 2011-01-28 | 2012-01-30 | ピリドン誘導体を含む医薬組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US8952165B2 (enExample) |
| EP (1) | EP2668185B1 (enExample) |
| JP (1) | JP5859571B2 (enExample) |
| KR (2) | KR101928505B1 (enExample) |
| CN (1) | CN103339131B (enExample) |
| AU (1) | AU2012209596B2 (enExample) |
| BR (1) | BR112013018781B1 (enExample) |
| CA (1) | CA2824679C (enExample) |
| CL (1) | CL2013002097A1 (enExample) |
| ES (1) | ES2613728T3 (enExample) |
| MX (1) | MX351180B (enExample) |
| PL (1) | PL2668185T3 (enExample) |
| RU (1) | RU2585287C2 (enExample) |
| WO (1) | WO2012102583A1 (enExample) |
| ZA (1) | ZA201305227B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101928505B1 (ko) * | 2011-01-28 | 2018-12-12 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
| KR101925971B1 (ko) * | 2011-01-28 | 2018-12-06 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| KR102373700B1 (ko) | 2014-04-02 | 2022-03-11 | 인터뮨, 인크. | 항섬유성 피리디논 |
| CN109293507B (zh) * | 2018-10-12 | 2020-12-18 | 河北科技大学 | 4-甲氧基甲烯基-2-烯戊二酸二甲酯的合成方法及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4404138A (en) | 1982-06-22 | 1983-09-13 | Warner-Lambert Company | 3-[2-(Azabicyclo) ethyl]-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones |
| SE0000540D0 (sv) * | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| US6492385B2 (en) * | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| KR100869722B1 (ko) * | 2000-12-22 | 2008-11-21 | 알미랄 에이쥐 | 퀴누클리딘 카르바메이트 유도체 및 ｍ3 길항제로서 그의사용 |
| US6569865B2 (en) * | 2001-06-01 | 2003-05-27 | Astrazeneca Ab | Spiro 1-azabicyclo[2.2.2]octane-3,2′(3′h)-furo[2,3-b]pyridine |
| AR036040A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| US6562816B2 (en) * | 2001-08-24 | 2003-05-13 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease |
| DE10156719A1 (de) * | 2001-11-19 | 2003-05-28 | Bayer Ag | Heteroarylcarbonsäureamide |
| FR2834511B1 (fr) | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
| WO2003072578A1 (en) * | 2002-02-20 | 2003-09-04 | Pharmacia & Upjohn Company | Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity |
| US7977485B2 (en) * | 2002-06-10 | 2011-07-12 | Bayer Schering Pharma Aktiengesellshaft | 2-heteroaryl carboxamides |
| JP2005537297A (ja) * | 2002-08-01 | 2005-12-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | アルファ−７ｎａｃｈｒ活性を有する１ｈ−ピラゾールおよび１ｈ−ピロール−アザビシクロ化合物 |
| CA2499128C (en) * | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| AU2004303740A1 (en) * | 2003-12-22 | 2005-07-07 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| CN103724343A (zh) * | 2004-03-25 | 2014-04-16 | 记忆药物公司 | 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途 |
| WO2006069097A2 (en) * | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| US8106066B2 (en) * | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| JP5775819B2 (ja) * | 2008-10-09 | 2015-09-09 | ハワード ヒューズ メディカル インスティチュート | 新規なキメラリガンド開口型イオンチャネルおよびその使用方法 |
| KR101928505B1 (ko) * | 2011-01-28 | 2018-12-12 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
| KR101925971B1 (ko) * | 2011-01-28 | 2018-12-06 | 에스케이바이오팜 주식회사 | 피리돈 유도체 및 이를 포함하는 약학적 조성물 |
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2012
- 2012-01-27 KR KR1020120008537A patent/KR101928505B1/ko active Active
- 2012-01-30 EP EP12739548.1A patent/EP2668185B1/en active Active
- 2012-01-30 CN CN201280006755.1A patent/CN103339131B/zh active Active
- 2012-01-30 AU AU2012209596A patent/AU2012209596B2/en active Active
- 2012-01-30 BR BR112013018781-6A patent/BR112013018781B1/pt active IP Right Grant
- 2012-01-30 RU RU2013138218/04A patent/RU2585287C2/ru active
- 2012-01-30 WO PCT/KR2012/000652 patent/WO2012102583A1/en not_active Ceased
- 2012-01-30 CA CA2824679A patent/CA2824679C/en active Active
- 2012-01-30 ES ES12739548.1T patent/ES2613728T3/es active Active
- 2012-01-30 MX MX2013008269A patent/MX351180B/es active IP Right Grant
- 2012-01-30 JP JP2013551905A patent/JP5859571B2/ja active Active
- 2012-01-30 US US13/980,821 patent/US8952165B2/en active Active
- 2012-01-30 PL PL12739548T patent/PL2668185T3/pl unknown
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2013
- 2013-07-11 ZA ZA2013/05227A patent/ZA201305227B/en unknown
- 2013-07-22 CL CL2013002097A patent/CL2013002097A1/es unknown
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2014
- 2014-12-23 US US14/581,482 patent/US9271976B2/en active Active
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2016
- 2016-01-18 US US14/997,754 patent/US9987259B2/en active Active
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2018
- 2018-05-23 US US15/987,550 patent/US10456385B2/en active Active
- 2018-12-06 KR KR1020180156158A patent/KR102034305B1/ko active Active
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2019
- 2019-09-12 US US16/568,400 patent/US20200000782A1/en not_active Abandoned
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2020
- 2020-12-01 US US17/108,052 patent/US20210085658A1/en not_active Abandoned
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2023
- 2023-08-21 US US18/236,001 patent/US20230390259A1/en not_active Abandoned