JP2008536825A5 - - Google Patents
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- Publication number
- JP2008536825A5 JP2008536825A5 JP2008504368A JP2008504368A JP2008536825A5 JP 2008536825 A5 JP2008536825 A5 JP 2008536825A5 JP 2008504368 A JP2008504368 A JP 2008504368A JP 2008504368 A JP2008504368 A JP 2008504368A JP 2008536825 A5 JP2008536825 A5 JP 2008536825A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- piperidin
- ethyl
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66719905P | 2005-03-31 | 2005-03-31 | |
| PCT/US2006/011663 WO2006105304A2 (en) | 2005-03-31 | 2006-03-30 | Phenyl and pyridyl lta4h modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536825A JP2008536825A (ja) | 2008-09-11 |
| JP2008536825A5 true JP2008536825A5 (enExample) | 2009-05-14 |
Family
ID=36950133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504368A Withdrawn JP2008536825A (ja) | 2005-03-31 | 2006-03-30 | フェニルおよびピリジルｌｔａ４ｈモジュレータ |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060223792A1 (enExample) |
| EP (1) | EP1868605A2 (enExample) |
| JP (1) | JP2008536825A (enExample) |
| KR (1) | KR20080003385A (enExample) |
| CN (1) | CN101189012A (enExample) |
| AU (1) | AU2006230379A1 (enExample) |
| BR (1) | BRPI0607742A2 (enExample) |
| CA (1) | CA2603122A1 (enExample) |
| CO (1) | CO6382173A2 (enExample) |
| CR (1) | CR9480A (enExample) |
| EA (1) | EA200702128A1 (enExample) |
| IL (1) | IL186432A0 (enExample) |
| MX (1) | MX2007012235A (enExample) |
| NI (1) | NI200700250A (enExample) |
| NO (1) | NO20075429L (enExample) |
| WO (1) | WO2006105304A2 (enExample) |
| ZA (1) | ZA200709346B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200730474A (en) | 2005-12-29 | 2007-08-16 | Schering Ag | Diamine derivatives as inhibitors of leukotriene A4 hydrolease |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| PT2336125E (pt) * | 2008-04-11 | 2013-03-18 | Janssen Pharmaceutica Nv | Tiazolopiridina-2-iloxi-fenil e tiazolopirazin-2-iloxifenil aminas como moduladores de leucotrieno a4 hidrolase |
| WO2010132599A1 (en) * | 2009-05-14 | 2010-11-18 | Janssen Pharmaceutica Nv | Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase |
| TR201802550T4 (tr) | 2011-03-14 | 2018-03-21 | Boehringer Ingelheim Int | Lökotrien üretiminin benzodioksan inhibitörleri. |
| JP5987220B2 (ja) | 2011-07-19 | 2016-09-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエンａ４ヒドロラーゼの阻害剤としてのアリールピラゾールエーテル |
| FR2984730A1 (fr) * | 2011-12-22 | 2013-06-28 | Diverchim | Nouvelles compositions cosmetiques anti-age et depigmentantes |
| AR091315A1 (es) | 2012-03-06 | 2015-01-28 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno |
| AR090259A1 (es) | 2012-03-06 | 2014-10-29 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno para terapia de combinacion |
| EP2885285B1 (en) | 2012-07-17 | 2016-10-19 | Boehringer Ingelheim International GmbH | Pyrazole drivatives which inhibit leukotriene production |
| RU2686101C2 (ru) | 2013-03-12 | 2019-04-24 | Селтакссис, Инк. | Способы ингибирования лейкотриен- а4-гидролазы |
| EP2970309A4 (en) | 2013-03-14 | 2016-11-09 | Celtaxsys Inc | INHIBITORS OF LEUCOTRIENE A4 HYDROLASE |
| JP6562898B2 (ja) | 2013-03-14 | 2019-08-21 | セルタクシス，インコーポレイテッド | ロイコトリエンａ４加水分解酵素の阻害剤 |
| AU2014240042C1 (en) | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| US9303018B2 (en) | 2013-07-15 | 2016-04-05 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| JP2016523982A (ja) | 2013-07-15 | 2016-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| BR102013020313B1 (pt) * | 2013-08-09 | 2021-07-06 | Fundação Oswaldo Cruz | derivados bifeniloxi-alquil-aminas e ariloxi-alquil-aminas, e, composição farmacêutica |
| EP3083593A1 (de) | 2013-12-19 | 2016-10-26 | Bayer Pharma Aktiengesellschaft | Substituierte piperidinyl-tetrahydrochinoline |
| JP2017503778A (ja) * | 2013-12-19 | 2017-02-02 | バイエル ファーマ アクチエンゲゼルシャフト | アドレナリン受容体α２Ｃ拮抗薬としての置換されたビピペリジニル誘導体 |
| JOP20200052A1 (ar) | 2013-12-19 | 2017-06-16 | Bayer Pharma AG | بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c |
| JP2017503783A (ja) | 2013-12-19 | 2017-02-02 | バイエル ファーマ アクチエンゲゼルシャフト | アドレナリン受容体アルファ２ｃ拮抗薬としての置換されたビピペリジニル誘導体 |
| KR101499007B1 (ko) * | 2014-04-24 | 2015-03-05 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
| WO2016071792A1 (en) * | 2014-11-03 | 2016-05-12 | Laboratorio Chimico Internazionale S.P.A. | Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters |
| PT109740B (pt) * | 2016-11-14 | 2020-07-30 | Hovione Farmaciencia Sa | Processo para a preparação de brometo de umeclidínio |
| EP3619196B1 (de) | 2017-05-04 | 2022-03-30 | Bayer CropScience Aktiengesellschaft | 2-{[2-(phenyloxymethyl)pyridin-5-yl]oxy}-ethanamin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel z.b. für den pflanzenschutz |
| EP3801559B1 (en) | 2018-05-31 | 2025-01-01 | Celltaxis, LLC | Method of reducing pulmonary exacerbations in respiratory disease patients |
| CN112513026B (zh) * | 2018-07-31 | 2025-02-25 | 诺华股份有限公司 | Lta4h抑制剂的晶型 |
| SG11202107080VA (en) * | 2019-01-11 | 2021-07-29 | Naegis Pharmaceuticals Inc | Leukotriene synthesis inhibitors |
| CN110229091B (zh) * | 2019-06-21 | 2022-11-22 | 天津科技大学 | 具有白三烯a4水解酶抑制作用的1，5-二取代吲哚衍生物及应用 |
| CN113683491A (zh) * | 2021-09-01 | 2021-11-23 | 王传良 | 一种4-(2-溴乙基)苯酚的制备方法 |
| US11957671B2 (en) | 2021-11-01 | 2024-04-16 | Alkahest, Inc. | Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038412A (en) * | 1975-08-25 | 1977-07-26 | Richardson-Merrell Inc. | N-(phenylether-substituted benzyl)alkanediamines |
| JPH0696532B2 (ja) * | 1988-08-11 | 1994-11-30 | 山之内製薬株式会社 | 血小板活性化因子拮抗剤 |
| ATE173247T1 (de) * | 1991-10-04 | 1998-11-15 | Taisho Pharmaceutical Co Ltd | Alkoxyphenylalkylaminderivat |
| US6506876B1 (en) * | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US6110944A (en) * | 1997-03-12 | 2000-08-29 | G. D. Searle & Co. | LTA4, hydrolase inhibitors |
| US5925654A (en) * | 1997-03-12 | 1999-07-20 | G.D. Searle & Co. | LTA4 , hydrolase inhibitors |
| AU2002222550A1 (en) * | 2000-11-29 | 2002-06-11 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
| JP2007500703A (ja) * | 2003-07-28 | 2007-01-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ベンズイミダゾール、ベンズチアゾールおよびベンゾキサゾール誘導体およびｌｔａ４ｈモジュレーターとしてのそれらの使用 |
| CN1874991A (zh) * | 2003-08-29 | 2006-12-06 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
-
2006
- 2006-03-30 CN CNA2006800193012A patent/CN101189012A/zh active Pending
- 2006-03-30 EA EA200702128A patent/EA200702128A1/ru unknown
- 2006-03-30 CA CA002603122A patent/CA2603122A1/en not_active Abandoned
- 2006-03-30 JP JP2008504368A patent/JP2008536825A/ja not_active Withdrawn
- 2006-03-30 BR BRPI0607742-0A patent/BRPI0607742A2/pt not_active IP Right Cessation
- 2006-03-30 MX MX2007012235A patent/MX2007012235A/es unknown
- 2006-03-30 KR KR1020077025142A patent/KR20080003385A/ko not_active Withdrawn
- 2006-03-30 AU AU2006230379A patent/AU2006230379A1/en not_active Abandoned
- 2006-03-30 EP EP06740056A patent/EP1868605A2/en not_active Withdrawn
- 2006-03-30 US US11/393,532 patent/US20060223792A1/en not_active Abandoned
- 2006-03-30 WO PCT/US2006/011663 patent/WO2006105304A2/en not_active Ceased
-
2007
- 2007-09-28 NI NI200700250A patent/NI200700250A/es unknown
- 2007-10-07 IL IL186432A patent/IL186432A0/en unknown
- 2007-10-16 CO CO07108538A patent/CO6382173A2/es not_active Application Discontinuation
- 2007-10-25 NO NO20075429A patent/NO20075429L/no not_active Application Discontinuation
- 2007-10-29 CR CR9480A patent/CR9480A/es unknown
- 2007-10-30 ZA ZA200709346A patent/ZA200709346B/xx unknown