JP2008536825A5 - - Google Patents
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- Publication number
- JP2008536825A5 JP2008536825A5 JP2008504368A JP2008504368A JP2008536825A5 JP 2008536825 A5 JP2008536825 A5 JP 2008536825A5 JP 2008504368 A JP2008504368 A JP 2008504368A JP 2008504368 A JP2008504368 A JP 2008504368A JP 2008536825 A5 JP2008536825 A5 JP 2008536825A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- piperidin
- ethyl
- ethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66719905P | 2005-03-31 | 2005-03-31 | |
| PCT/US2006/011663 WO2006105304A2 (en) | 2005-03-31 | 2006-03-30 | Phenyl and pyridyl lta4h modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536825A JP2008536825A (ja) | 2008-09-11 |
| JP2008536825A5 true JP2008536825A5 (enExample) | 2009-05-14 |
Family
ID=36950133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008504368A Withdrawn JP2008536825A (ja) | 2005-03-31 | 2006-03-30 | フェニルおよびピリジルｌｔａ４ｈモジュレータ |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20060223792A1 (enExample) |
| EP (1) | EP1868605A2 (enExample) |
| JP (1) | JP2008536825A (enExample) |
| KR (1) | KR20080003385A (enExample) |
| CN (1) | CN101189012A (enExample) |
| AU (1) | AU2006230379A1 (enExample) |
| BR (1) | BRPI0607742A2 (enExample) |
| CA (1) | CA2603122A1 (enExample) |
| CO (1) | CO6382173A2 (enExample) |
| CR (1) | CR9480A (enExample) |
| EA (1) | EA200702128A1 (enExample) |
| IL (1) | IL186432A0 (enExample) |
| MX (1) | MX2007012235A (enExample) |
| NI (1) | NI200700250A (enExample) |
| NO (1) | NO20075429L (enExample) |
| WO (1) | WO2006105304A2 (enExample) |
| ZA (1) | ZA200709346B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3205644A1 (en) | 2005-12-29 | 2017-08-16 | Celtaxsys Inc. | Diamine derivatives as inhibitors of leukotriene a4 hydrolase |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| PT2268646E (pt) * | 2008-04-11 | 2013-12-10 | Janssen Pharmaceutica Nv | Aminas de tiazolopiridina-2-iloxi-fenil e de tiazolopirazina-2-iloxi-fenilo como moduladores da hidrolase de leucotrieno a4 |
| MX2011012190A (es) * | 2009-05-14 | 2011-12-08 | Janssen Pharmaceutica Nv | Compuestos con dos porciones de heteroarilo biciclico fusionado como moduladores de la leucotrieno a4 hidrolasa. |
| AP3339A (en) | 2011-03-14 | 2015-07-31 | Boehringer Ingelheim Int | Benzodioxane inhibitors of leukotriene production |
| US9139567B2 (en) | 2011-07-19 | 2015-09-22 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene A4 hydrolase |
| FR2984730A1 (fr) * | 2011-12-22 | 2013-06-28 | Diverchim | Nouvelles compositions cosmetiques anti-age et depigmentantes |
| JP6080226B2 (ja) | 2012-03-06 | 2017-02-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン |
| AR091315A1 (es) | 2012-03-06 | 2015-01-28 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno |
| WO2014014874A1 (en) | 2012-07-17 | 2014-01-23 | Boehringer Ingelheim International Gmbh | Pyrazole derivatives which inhibit leukotriene production |
| AU2014249168B2 (en) | 2013-03-12 | 2018-07-12 | Celltaxis, Llc | Methods of inhibiting leukotriene A4 hydrolase |
| MX2015011678A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| EP2968265A4 (en) * | 2013-03-14 | 2016-12-28 | Celtaxsys Inc | INHIBITORS OF THE LEUKOTRIEN A4 HYDROLASE |
| AU2014240042C1 (en) | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| JP2016523982A (ja) | 2013-07-15 | 2016-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害剤 |
| WO2015009609A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| BR102013020313B1 (pt) * | 2013-08-09 | 2021-07-06 | Fundação Oswaldo Cruz | derivados bifeniloxi-alquil-aminas e ariloxi-alquil-aminas, e, composição farmacêutica |
| JP2017503783A (ja) * | 2013-12-19 | 2017-02-02 | バイエル ファーマ アクチエンゲゼルシャフト | アドレナリン受容体アルファ２ｃ拮抗薬としての置換されたビピペリジニル誘導体 |
| JP2017501164A (ja) | 2013-12-19 | 2017-01-12 | バイエル ファーマ アクチエンゲゼルシャフト | 置換されたピペリジニルテトラヒドロキノリン類 |
| SG11201604978QA (en) | 2013-12-19 | 2016-07-28 | Bayer Pharma AG | Substituted piperidinyl-tetrahydroquinolines and their use as alpha-2c adrenoreceptor antagonists |
| CA2934134A1 (en) * | 2013-12-19 | 2015-06-25 | Bayer Pharma Aktiengesellschaft | Substituted bipiperidinyl derivatives as adrenoreceptor alpha 2c antagonists |
| KR101499007B1 (ko) * | 2014-04-24 | 2015-03-05 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
| EP3215489B1 (en) * | 2014-11-03 | 2019-07-24 | OLON S.p.A. | Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters |
| PT109740B (pt) * | 2016-11-14 | 2020-07-30 | Hovione Farmaciencia Sa | Processo para a preparação de brometo de umeclidínio |
| CN119285538A (zh) | 2017-05-04 | 2025-01-10 | 发现号收购集团 | 作为例如用于保护植物的害虫防治剂的2-{[2-(苯氧基甲基)吡啶-5-基]氧基}乙胺衍生物及相关化合物 |
| EP3801559B1 (en) | 2018-05-31 | 2025-01-01 | Celltaxis, LLC | Method of reducing pulmonary exacerbations in respiratory disease patients |
| TWI834581B (zh) * | 2018-07-31 | 2024-03-01 | 瑞士商諾華公司 | Lta4h抑制劑的晶型 |
| CA3126021A1 (en) | 2019-01-11 | 2020-07-16 | Naegis Pharmaceuticals Inc. | Leukotriene synthesis inhibitors |
| CN110229091B (zh) * | 2019-06-21 | 2022-11-22 | 天津科技大学 | 具有白三烯a4水解酶抑制作用的1，5-二取代吲哚衍生物及应用 |
| CN113683491A (zh) * | 2021-09-01 | 2021-11-23 | 王传良 | 一种4-(2-溴乙基)苯酚的制备方法 |
| CA3221177A1 (en) | 2021-11-01 | 2023-05-04 | Meghan Kerrisk Campbell | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
| CN116804675A (zh) * | 2023-04-19 | 2023-09-26 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 特应性皮炎的生物标志物及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038412A (en) * | 1975-08-25 | 1977-07-26 | Richardson-Merrell Inc. | N-(phenylether-substituted benzyl)alkanediamines |
| JPH0696532B2 (ja) * | 1988-08-11 | 1994-11-30 | 山之内製薬株式会社 | 血小板活性化因子拮抗剤 |
| JP2768008B2 (ja) * | 1991-10-04 | 1998-06-25 | 大正製薬株式会社 | アルコキシフェニルアルキルアミン誘導体 |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US6506876B1 (en) * | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| US5925654A (en) * | 1997-03-12 | 1999-07-20 | G.D. Searle & Co. | LTA4 , hydrolase inhibitors |
| US6110944A (en) * | 1997-03-12 | 2000-08-29 | G. D. Searle & Co. | LTA4, hydrolase inhibitors |
| AU2002222550A1 (en) * | 2000-11-29 | 2002-06-11 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
| WO2005012296A1 (en) * | 2003-07-28 | 2005-02-10 | Janssen Pharmaceutica N.V. | Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators |
| AU2004268455B2 (en) * | 2003-08-29 | 2009-12-17 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
| US7825109B2 (en) * | 2003-08-29 | 2010-11-02 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding S1P receptor and pharmaceutical use thereof |
-
2006
- 2006-03-30 WO PCT/US2006/011663 patent/WO2006105304A2/en not_active Ceased
- 2006-03-30 CN CNA2006800193012A patent/CN101189012A/zh active Pending
- 2006-03-30 CA CA002603122A patent/CA2603122A1/en not_active Abandoned
- 2006-03-30 BR BRPI0607742-0A patent/BRPI0607742A2/pt not_active IP Right Cessation
- 2006-03-30 JP JP2008504368A patent/JP2008536825A/ja not_active Withdrawn
- 2006-03-30 KR KR1020077025142A patent/KR20080003385A/ko not_active Withdrawn
- 2006-03-30 MX MX2007012235A patent/MX2007012235A/es unknown
- 2006-03-30 AU AU2006230379A patent/AU2006230379A1/en not_active Abandoned
- 2006-03-30 EP EP06740056A patent/EP1868605A2/en not_active Withdrawn
- 2006-03-30 EA EA200702128A patent/EA200702128A1/ru unknown
- 2006-03-30 US US11/393,532 patent/US20060223792A1/en not_active Abandoned
-
2007
- 2007-09-28 NI NI200700250A patent/NI200700250A/es unknown
- 2007-10-07 IL IL186432A patent/IL186432A0/en unknown
- 2007-10-16 CO CO07108538A patent/CO6382173A2/es not_active Application Discontinuation
- 2007-10-25 NO NO20075429A patent/NO20075429L/no not_active Application Discontinuation
- 2007-10-29 CR CR9480A patent/CR9480A/es unknown
- 2007-10-30 ZA ZA200709346A patent/ZA200709346B/xx unknown
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