JP2014503534A5 - - Google Patents

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Publication number
JP2014503534A5
JP2014503534A5 JP2013544730A JP2013544730A JP2014503534A5 JP 2014503534 A5 JP2014503534 A5 JP 2014503534A5 JP 2013544730 A JP2013544730 A JP 2013544730A JP 2013544730 A JP2013544730 A JP 2013544730A JP 2014503534 A5 JP2014503534 A5 JP 2014503534A5
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JP
Japan
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alkyl
alkylene
halo
phenyl
och
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JP2013544730A
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English (en)
Japanese (ja)
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JP5944921B2 (ja
JP2014503534A (ja
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Priority claimed from PCT/US2011/064829 external-priority patent/WO2012082853A1/en
Publication of JP2014503534A publication Critical patent/JP2014503534A/ja
Publication of JP2014503534A5 publication Critical patent/JP2014503534A5/ja
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Publication of JP5944921B2 publication Critical patent/JP5944921B2/ja
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JP2013544730A 2010-12-15 2011-12-14 ネプリライシン阻害剤 Active JP5944921B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42318010P 2010-12-15 2010-12-15
US61/423,180 2010-12-15
PCT/US2011/064829 WO2012082853A1 (en) 2010-12-15 2011-12-14 Neprilysin inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015186389A Division JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Publications (3)

Publication Number Publication Date
JP2014503534A JP2014503534A (ja) 2014-02-13
JP2014503534A5 true JP2014503534A5 (OSRAM) 2014-11-20
JP5944921B2 JP5944921B2 (ja) 2016-07-05

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JP2013544730A Active JP5944921B2 (ja) 2010-12-15 2011-12-14 ネプリライシン阻害剤
JP2015186389A Withdrawn JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Family Applications After (1)

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JP2015186389A Withdrawn JP2016028089A (ja) 2010-12-15 2015-09-24 ネプリライシン阻害剤

Country Status (28)

Country Link
US (9) US8586536B2 (OSRAM)
EP (1) EP2651896B1 (OSRAM)
JP (2) JP5944921B2 (OSRAM)
KR (1) KR101892500B1 (OSRAM)
CN (2) CN105061314A (OSRAM)
AU (1) AU2011343899B2 (OSRAM)
BR (1) BR112013016595B1 (OSRAM)
CA (1) CA2817368C (OSRAM)
CO (1) CO6741228A2 (OSRAM)
DK (1) DK2651896T3 (OSRAM)
ES (1) ES2550324T3 (OSRAM)
HR (1) HRP20151115T1 (OSRAM)
HU (1) HUE028051T2 (OSRAM)
IL (1) IL226327A (OSRAM)
ME (1) ME02295B (OSRAM)
MX (1) MX2013006805A (OSRAM)
MY (1) MY170935A (OSRAM)
NZ (1) NZ610983A (OSRAM)
PH (1) PH12013501240A1 (OSRAM)
PL (1) PL2651896T3 (OSRAM)
PT (1) PT2651896E (OSRAM)
RS (1) RS54348B1 (OSRAM)
RU (1) RU2622288C2 (OSRAM)
SG (2) SG190432A1 (OSRAM)
SI (1) SI2651896T1 (OSRAM)
SM (1) SMT201500271B (OSRAM)
WO (1) WO2012082853A1 (OSRAM)
ZA (1) ZA201304205B (OSRAM)

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EP2714660B1 (en) 2011-05-31 2018-09-26 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
JP5959074B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
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JP6766055B2 (ja) 2015-02-11 2020-10-07 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤としての（２ｓ，４ｒ）−５−（５’−クロロ−２’−フルオロビフェニル−４−イル）−４−（エトキシオキサリルアミノ）−２−ヒドロキシメチル−２−メチルペンタン酸
HRP20210040T1 (hr) * 2015-02-19 2021-04-02 Theravance Biopharma R&D Ip, Llc (2r,4r)-5-(5′-klor-2’-fluorbifenil-4-il)-2-hidroksi-4-[(5-metiloksazol-2-karbonil)amino]pentanska kiselina
CA3015505C (en) 2016-03-08 2024-03-05 Theravance Biopharma R&D Ip, Llc Crystalline (2s,4r)-5-(5'-chloro-2'-fluoro-[1,1'-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
EP3887363A1 (en) 2018-11-27 2021-10-06 Novartis AG Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
CN113166204B (zh) 2018-11-27 2025-01-28 诺华股份有限公司 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状肽
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
CN112592294B (zh) * 2020-12-22 2022-05-13 江苏阿尔法药业股份有限公司 一种沙库巴曲药物中间体的合成方法
TW202333563A (zh) 2021-11-12 2023-09-01 瑞士商諾華公司 用於治療疾病或障礙之二胺基環戊基吡啶衍生物
CN119306633B (zh) * 2024-09-24 2025-04-25 深圳市第二人民医院(深圳市转化医学研究院) 一种β3-氨基酸衍生物的合成方法

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WO2012154249A1 (en) * 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
CN103380119B (zh) 2011-02-17 2016-02-17 施万生物制药研发Ip有限责任公司 作为脑啡肽酶抑制剂的经取代的氨基丁酸衍生物
EP2714660B1 (en) 2011-05-31 2018-09-26 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
JP5959074B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
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TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
MX356260B (es) 2012-06-08 2018-05-21 Theravance Biopharma R&D Ip Llc Inhibidores de la neprilisina.
CA2873328A1 (en) 2012-06-08 2013-12-12 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
CN104520277B (zh) 2012-08-08 2018-01-19 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂

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