JP2014501510A5 - - Google Patents
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- JP2014501510A5 JP2014501510A5 JP2013540387A JP2013540387A JP2014501510A5 JP 2014501510 A5 JP2014501510 A5 JP 2014501510A5 JP 2013540387 A JP2013540387 A JP 2013540387A JP 2013540387 A JP2013540387 A JP 2013540387A JP 2014501510 A5 JP2014501510 A5 JP 2014501510A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid residue
- binding protein
- terminal capping
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10192711 | 2010-11-26 | ||
| EP10192711.9 | 2010-11-26 | ||
| PCT/EP2011/071084 WO2012069655A2 (en) | 2010-11-26 | 2011-11-25 | Improved n-terminal capping modules for designed ankyrin repeat proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501510A JP2014501510A (ja) | 2014-01-23 |
| JP2014501510A5 true JP2014501510A5 (OSRAM) | 2014-11-27 |
| JP6173216B2 JP6173216B2 (ja) | 2017-08-02 |
Family
ID=43858162
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540387A Active JP6173216B2 (ja) | 2010-11-26 | 2011-11-25 | 設計アンキリンリピートタンパク質のための改善されたキャッピングモジュール |
| JP2013540386A Active JP6105479B2 (ja) | 2010-11-26 | 2011-11-25 | 血清アルブミンに結合する設計リピートタンパク質 |
| JP2016211658A Pending JP2017048216A (ja) | 2010-11-26 | 2016-10-28 | 血清アルブミンに結合する設計リピートタンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013540386A Active JP6105479B2 (ja) | 2010-11-26 | 2011-11-25 | 血清アルブミンに結合する設計リピートタンパク質 |
| JP2016211658A Pending JP2017048216A (ja) | 2010-11-26 | 2016-10-28 | 血清アルブミンに結合する設計リピートタンパク質 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9221892B2 (OSRAM) |
| EP (3) | EP2643349B1 (OSRAM) |
| JP (3) | JP6173216B2 (OSRAM) |
| KR (3) | KR101782790B1 (OSRAM) |
| CN (3) | CN103403024B (OSRAM) |
| AU (2) | AU2011333665B2 (OSRAM) |
| BR (3) | BR112013012786B1 (OSRAM) |
| CA (2) | CA2818990C (OSRAM) |
| DK (1) | DK2643349T3 (OSRAM) |
| ES (2) | ES2758352T3 (OSRAM) |
| PL (1) | PL2643349T3 (OSRAM) |
| RU (2) | RU2625882C2 (OSRAM) |
| WO (2) | WO2012069654A1 (OSRAM) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| KR101782790B1 (ko) | 2010-11-26 | 2017-09-28 | 몰리큘라 파트너스 아게 | 혈청 알부민에 결합하는 설계된 반복 단백질 |
| US10568934B2 (en) | 2012-05-07 | 2020-02-25 | Allergan, Inc. | Method of treating AMD in patients refractory to anti-VEGF therapy |
| KR20150023957A (ko) * | 2012-06-28 | 2015-03-05 | 몰리큘라 파트너스 아게 | 혈소판-유래 성장인자에 결합하는 설계된 안키린 반복 단백질 |
| AU2013331763B2 (en) * | 2012-10-15 | 2018-02-15 | Universitat Zurich | Bispecific HER2 ligands for cancer therapy |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| EP3444278A1 (en) | 2013-02-26 | 2019-02-20 | Roche Glycart AG | Bispecific t cell activating antigen binding molecules |
| CN105209483B (zh) | 2013-05-31 | 2021-07-27 | 分子组合公司 | 与肝细胞生长因子结合的设计锚蛋白重复蛋白 |
| KR20150097304A (ko) | 2014-02-18 | 2015-08-26 | 삼성전자주식회사 | 항 EGFR DARPin을 포함하는 EGFR/HER2 이중 특이 항체 |
| EP3167395B1 (en) | 2014-07-07 | 2020-09-02 | Yeda Research and Development Co., Ltd. | Method of computational protein design |
| SG11201707606RA (en) * | 2015-04-02 | 2017-10-30 | Molecular Partners Ag | Designed ankyrin repeat domains with binding specificity for serum albumin |
| NZ751689A (en) | 2016-09-22 | 2021-07-30 | Molecular Partners Ag | Recombinant binding proteins and their use |
| EP3535397B1 (en) * | 2016-11-01 | 2022-01-05 | Arrowhead Pharmaceuticals, Inc. | Alpha-v beta-6 integrin ligands and uses thereof |
| WO2018165046A1 (en) | 2017-03-07 | 2018-09-13 | Igc Bio, Inc. | A computational pipeline for antibody modeling and design |
| EP3623382A1 (en) | 2018-09-14 | 2020-03-18 | Universität Zürich | Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct |
| US11655293B2 (en) | 2018-02-22 | 2023-05-23 | Universitat Zurich | Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT |
| EP3768833A1 (en) | 2018-03-22 | 2021-01-27 | Charité - Universitätsmedizin Berlin | Crispr associated protein reactive t cell immunity |
| US12448458B2 (en) | 2018-06-15 | 2025-10-21 | Universität Bern | Ligands to light or its receptor LTßR for use in haematologic malignancies |
| BR112021005670A2 (pt) | 2018-10-08 | 2021-06-22 | Universität Zürich | polipeptídeos tetraméricos de ligação a her2 |
| EP3883919A1 (en) | 2018-11-21 | 2021-09-29 | Universität Zürich | Photochemically induced conjugation of radiometals to small molecules, peptides and nanoparticles in a simultaneous one-pot reaction |
| EP3677911A3 (en) | 2019-01-03 | 2020-07-29 | Universität Basel | Use of non-agonist ligands for suppression of metastasis |
| US20220088144A1 (en) | 2019-01-11 | 2022-03-24 | Universitätsspital Basel | Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia after bariatric surgery |
| EP3930687A4 (en) | 2019-02-25 | 2023-06-07 | The University of Chicago | METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS |
| WO2020207771A1 (en) | 2019-04-10 | 2020-10-15 | Universität Zürich | A method for determining the likelihood of a patient being responsive to cancer immunotherapy |
| BR112021024231A2 (pt) | 2019-06-04 | 2022-04-26 | Molecular Partners Ag | Proteínas de ligação fap recombinantes e uso da mesma |
| WO2020245171A1 (en) | 2019-06-04 | 2020-12-10 | Molecular Partners Ag | Designed ankyrin repeat domain with improved stability |
| US20200385488A1 (en) | 2019-06-04 | 2020-12-10 | Molecular Partners Ag | Multispecific proteins |
| US20220332845A1 (en) | 2019-09-05 | 2022-10-20 | Genome Biologics Ug | Inhibition of mthfd1l for use in hypertrophic heart disease and heart failure |
| IL293698A (en) | 2019-12-11 | 2022-08-01 | Molecular Partners Ag | Recombinant peptide-mhc complex binding proteins, their production and use |
| EP4073093A2 (en) | 2019-12-11 | 2022-10-19 | Molecular Partners AG | Recombinant peptide-mhc complex binding proteins and their generation and use |
| WO2021122813A1 (en) | 2019-12-16 | 2021-06-24 | Universität Basel | Angiogenesis promoting agents for prevention of metastatic cancer |
| WO2021176008A1 (en) | 2020-03-04 | 2021-09-10 | Cornell University | Agents targeting baf155 or brg1 for use in treatment of advanced prostate cancer |
| EP4132578A1 (en) | 2020-04-06 | 2023-02-15 | Universität Zürich | Artc1 ligands for cancer treatment |
| AU2021267411A1 (en) | 2020-05-06 | 2022-12-08 | Molecular Partners Ag | Novel ankyrin repeat binding proteins and their uses |
| US20240279309A1 (en) * | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
| JP2023528204A (ja) | 2020-05-14 | 2023-07-04 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 多選択性タンパク質 |
| KR20230012559A (ko) | 2020-05-19 | 2023-01-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 치료를 위한 결합 분자 |
| WO2021239844A1 (en) | 2020-05-27 | 2021-12-02 | Universitätsspital Basel | Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia in prediabetes |
| WO2021239999A1 (en) | 2020-05-28 | 2021-12-02 | Universität Zürich | Il-12 pd-l1 ligand fusion protein |
| CA3189257A1 (en) | 2020-08-18 | 2022-02-24 | Universitat Zurich | A cd25-biased anti-il-2 antibody |
| EP3957649A1 (en) | 2020-08-18 | 2022-02-23 | Athebio AG | Improved n-terminal capping modules of ankyrin repeat domains |
| US11981710B2 (en) * | 2020-08-18 | 2024-05-14 | Athebio Ag | N-terminal capping modules of ankyrin repeat domains |
| CN114106194B (zh) * | 2020-08-31 | 2024-01-16 | 中国科学院天津工业生物技术研究所 | 一种用于治疗糖尿病和/或肥胖症的融合蛋白 |
| WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
| WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
| EP4263608A1 (en) | 2020-12-16 | 2023-10-25 | Molecular Partners AG | Recombinant cd3 binding proteins and their use |
| US20240108746A1 (en) | 2020-12-16 | 2024-04-04 | Molecular Partners Ag | Novel slow-release prodrugs |
| WO2022171831A1 (en) | 2021-02-11 | 2022-08-18 | Universität Zürich | Use of markers found on lymph node metastatic samples for the prognosis of breast cancer |
| EP4043481A1 (en) * | 2021-02-15 | 2022-08-17 | Affilogic | Compounds and methods for extending half life of biomolecules |
| EP4305063A1 (en) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Protease cleavable prodrugs |
| WO2022190018A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based cd123 engagers |
| JP2024509904A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規なＤＡＲＰｉｎに基づく多重特異性Ｔ細胞エンゲージャ |
| JP2024508969A (ja) | 2021-03-09 | 2024-02-28 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規のＤＡＲＰｉｎに基づくＣＤ３３エンゲージャ |
| EP4323388B1 (en) | 2021-04-16 | 2025-01-29 | Athebio AG | N-terminal capping modules of ankyrin repeat domains |
| AU2022322029A1 (en) | 2021-08-05 | 2024-02-15 | Immunos Therapeutics Ag | Combination medicaments comprising hla fusion proteins |
| JP2024529079A (ja) | 2021-08-05 | 2024-08-01 | イムノス セラピューティクス アーゲー | 発現量が増加した改変型ｈｌａ－ｂ５７ |
| WO2023021006A1 (en) | 2021-08-16 | 2023-02-23 | Universität Zürich | Il-1 targeting agents for treatment of pitiyriasis rubra pilaris |
| WO2023021050A1 (en) | 2021-08-17 | 2023-02-23 | Athebio Ag | Variants of ankyrin repeat domains |
| EP4137508A1 (en) | 2021-08-17 | 2023-02-22 | Athebio AG | Variants of ankyrin repeat domains |
| WO2023036849A1 (en) | 2021-09-07 | 2023-03-16 | ETH Zürich | Identifying and predicting future coronavirus variants |
| EP4163380A1 (en) | 2021-10-08 | 2023-04-12 | ETH Zurich | Device and method for manipulation of extracellular vesicles |
| WO2023110983A1 (en) | 2021-12-14 | 2023-06-22 | Molecular Partners Ag | Designed repeat domains with dual binding specificity and their use |
| WO2023110942A1 (en) | 2021-12-14 | 2023-06-22 | Charité-Universitätsmedizin Berlin | Prevention of impaired fracture healing |
| EP4260907A1 (en) | 2022-04-11 | 2023-10-18 | Universität Zürich | Agents for treatment of endometriosis and other benign gynecological neoplasms |
| WO2024002914A1 (en) | 2022-06-27 | 2024-01-04 | Charité-Universitätsmedizin Berlin | Prediction of, and composition to improve, tendon healing |
| CA3262553A1 (en) | 2022-08-01 | 2024-02-08 | Molecular Partners Ag | REHEARSAL AREAS DESIGNED WITH MODIFIED CHARGES AND THEIR USE |
| WO2024037743A1 (en) | 2022-08-16 | 2024-02-22 | Athebio Ag | Variants of ankyrin repeat domains |
| EP4573106A2 (en) | 2022-08-16 | 2025-06-25 | Athebio AG | Variants of ankyrin repeat domains |
| WO2024038307A1 (en) | 2022-08-19 | 2024-02-22 | Novartis Ag | Dosing regimens for sars-cov-2 binding molecules |
| WO2024064200A2 (en) * | 2022-09-20 | 2024-03-28 | The Texas A&M University System | Darpin-containing compositions and methods thereof |
| WO2024133013A1 (en) | 2022-12-19 | 2024-06-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. | Means and methods to target endogenous condensates |
| WO2024165671A1 (en) | 2023-02-08 | 2024-08-15 | Immunos Therapeutics Ag | FUSION PROTEINS OF ß2 MICROGLOBULIN, HLA HEAVY CHAIN POLYPEPTIDES, AND INHIBITOR OF CD47-SIRPA |
| CN120712282A (zh) | 2023-02-17 | 2025-09-26 | 阿布林克斯有限公司 | 结合新生儿fc受体的多肽 |
| WO2024179981A1 (en) | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
| WO2024251742A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd2 binding proteins and their use |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| WO2024251695A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd47 binding proteins and their use |
| WO2025008519A1 (en) | 2023-07-05 | 2025-01-09 | Universität Bern | Il-1ra blockers for treatment and prevention of sepsis |
| WO2025021293A1 (en) | 2023-07-25 | 2025-01-30 | Universität Zürich | Disruption of rbr1 expression in plant cells |
| WO2025146490A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Recombinant cd117 binding proteins and their use |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
| WO2025146487A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Multispecific binding proteins |
| WO2025163083A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recobminant dll3 binding proteins and their use |
| WO2025163144A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recombinant mesothelin binding proteins and their use |
| WO2025202503A1 (en) | 2024-03-28 | 2025-10-02 | Universität Zürich | Extracellular vesicles carrying cancer specific splice variants |
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| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
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| US20110262964A1 (en) * | 2008-03-19 | 2011-10-27 | Hugues Bedouelle | Reagentless fluorescent biosensors comprising a designed ankyrin repeat protein module, rational design methods to create reagentless fluorescent biosensors and methods of their use |
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| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| WO2012060748A1 (en) * | 2010-11-03 | 2012-05-10 | Telefonaktiebolaget Lm Eriksson (Publ) | A radio base station and a method therein |
| KR101782790B1 (ko) * | 2010-11-26 | 2017-09-28 | 몰리큘라 파트너스 아게 | 혈청 알부민에 결합하는 설계된 반복 단백질 |
| KR20140039203A (ko) | 2011-04-29 | 2014-04-01 | 얀센 바이오테크 인코포레이티드 | Il4/il13 결합 반복 단백질 및 용도 |
| KR20150023957A (ko) | 2012-06-28 | 2015-03-05 | 몰리큘라 파트너스 아게 | 혈소판-유래 성장인자에 결합하는 설계된 안키린 반복 단백질 |
| EP2738180A1 (en) * | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| SG11201707606RA (en) * | 2015-04-02 | 2017-10-30 | Molecular Partners Ag | Designed ankyrin repeat domains with binding specificity for serum albumin |
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2011
- 2011-11-25 KR KR1020137014067A patent/KR101782790B1/ko active Active
- 2011-11-25 RU RU2013128896A patent/RU2625882C2/ru active
- 2011-11-25 US US13/989,181 patent/US9221892B2/en active Active
- 2011-11-25 CA CA2818990A patent/CA2818990C/en active Active
- 2011-11-25 EP EP11788815.6A patent/EP2643349B1/en active Active
- 2011-11-25 EP EP11788152.4A patent/EP2643348B1/en active Active
- 2011-11-25 DK DK11788815T patent/DK2643349T3/da active
- 2011-11-25 PL PL11788815T patent/PL2643349T3/pl unknown
- 2011-11-25 EP EP19160342.2A patent/EP3514169B1/en active Active
- 2011-11-25 WO PCT/EP2011/071083 patent/WO2012069654A1/en not_active Ceased
- 2011-11-25 BR BR112013012786-4A patent/BR112013012786B1/pt active IP Right Grant
- 2011-11-25 ES ES11788815T patent/ES2758352T3/es active Active
- 2011-11-25 ES ES19160342T patent/ES2981441T3/es active Active
- 2011-11-25 CN CN201180066084.3A patent/CN103403024B/zh active Active
- 2011-11-25 AU AU2011333665A patent/AU2011333665B2/en active Active
- 2011-11-25 WO PCT/EP2011/071084 patent/WO2012069655A2/en not_active Ceased
- 2011-11-25 BR BR122020011428-2A patent/BR122020011428B1/pt active IP Right Grant
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