JP2011177189A5 - - Google Patents
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- Publication number
- JP2011177189A5 JP2011177189A5 JP2011094093A JP2011094093A JP2011177189A5 JP 2011177189 A5 JP2011177189 A5 JP 2011177189A5 JP 2011094093 A JP2011094093 A JP 2011094093A JP 2011094093 A JP2011094093 A JP 2011094093A JP 2011177189 A5 JP2011177189 A5 JP 2011177189A5
- Authority
- JP
- Japan
- Prior art keywords
- aminopeptidase
- dna molecule
- encoding
- sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004400 Aminopeptidases Human genes 0.000 claims 2
- 108090000915 Aminopeptidases Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000002759 chromosomal effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32235001P | 2001-09-13 | 2001-09-13 | |
| US60/322,350 | 2001-09-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527095A Division JP4831932B2 (ja) | 2001-09-13 | 2002-09-12 | アミノペプチダーゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011177189A JP2011177189A (ja) | 2011-09-15 |
| JP2011177189A5 true JP2011177189A5 (OSRAM) | 2012-07-05 |
| JP5372061B2 JP5372061B2 (ja) | 2013-12-18 |
Family
ID=23254494
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527095A Expired - Lifetime JP4831932B2 (ja) | 2001-09-13 | 2002-09-12 | アミノペプチダーゼ |
| JP2011094093A Expired - Lifetime JP5372061B2 (ja) | 2001-09-13 | 2011-04-20 | アミノペプチダーゼ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527095A Expired - Lifetime JP4831932B2 (ja) | 2001-09-13 | 2002-09-12 | アミノペプチダーゼ |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6921659B2 (OSRAM) |
| EP (1) | EP1432793B1 (OSRAM) |
| JP (2) | JP4831932B2 (OSRAM) |
| KR (2) | KR100956907B1 (OSRAM) |
| CN (1) | CN100552023C (OSRAM) |
| AT (1) | ATE440134T1 (OSRAM) |
| AU (1) | AU2002326884B2 (OSRAM) |
| BR (1) | BR0212886A (OSRAM) |
| CA (1) | CA2460309C (OSRAM) |
| CY (1) | CY1109903T1 (OSRAM) |
| DE (1) | DE60233417D1 (OSRAM) |
| DK (1) | DK1432793T3 (OSRAM) |
| ES (1) | ES2329880T3 (OSRAM) |
| HU (3) | HU225346B1 (OSRAM) |
| IL (2) | IL160658A0 (OSRAM) |
| MX (1) | MXPA04002326A (OSRAM) |
| NZ (2) | NZ531516A (OSRAM) |
| PL (1) | PL206286B1 (OSRAM) |
| PT (1) | PT1432793E (OSRAM) |
| WO (1) | WO2003023030A2 (OSRAM) |
| ZA (1) | ZA200401752B (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2329880T3 (es) | 2001-09-13 | 2009-12-02 | Genentech, Inc. | Aminopeptidasa b2324. |
| CA2946323A1 (en) * | 2004-03-11 | 2005-09-22 | Genentech, Inc. | Process for producing polypeptides |
| US9637746B2 (en) | 2008-12-15 | 2017-05-02 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
| EP2379728A4 (en) * | 2008-12-22 | 2016-04-13 | Greenlight Biosciences Inc | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF A COMPOUND |
| WO2011140516A2 (en) | 2010-05-07 | 2011-11-10 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through enzyme relocation |
| WO2012030980A1 (en) | 2010-08-31 | 2012-03-08 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through protease manipulation |
| SG2014014377A (en) | 2011-09-09 | 2014-05-29 | Greenlight Biosciences Inc | Cell-free preparation of carbapenems |
| AU2014306074B2 (en) | 2013-08-05 | 2018-08-30 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| CA2980172A1 (en) | 2015-03-30 | 2016-10-06 | Greenlight Biosciences, Inc. | Cell-free production of ribonucleic acid |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| RU2018138975A (ru) | 2016-04-06 | 2020-05-12 | Гринлайт Байосайенсис, Инк. | Бесклеточная продукция рибонуклеиновой кислоты |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| CN106967658B (zh) * | 2017-02-23 | 2020-09-15 | 郑州大学 | 一种提高Fab抗体表达量的方法 |
| SG11202003192UA (en) | 2017-10-11 | 2020-05-28 | Greenlight Biosciences Inc | Methods and compositions for nucleoside triphosphate and ribonucleic acid production |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE122004000009I2 (de) * | 1984-08-16 | 2006-09-07 | Savient Pharmaceuticals Inc | Methode zur Herstellung von menschlichen Wachstumshormonen |
| WO1986007380A1 (fr) * | 1985-06-04 | 1986-12-18 | Takeda Chemical Industries, Ltd. | Procede de preparation de polypeptides |
| US4865974A (en) * | 1985-09-20 | 1989-09-12 | Cetus Corporation | Bacterial methionine N-terminal peptidase |
| US4946783A (en) * | 1987-01-30 | 1990-08-07 | President And Fellows Of Harvard College | Periplasmic protease mutants of Escherichia coli |
| WO1988005821A1 (en) | 1987-01-30 | 1988-08-11 | President And Fellows Of Harvard College | Periplasmic protease mutants of escherichia coli |
| JPH01181796A (ja) * | 1988-01-14 | 1989-07-19 | Ajinomoto Co Inc | 組換えｄｎａ法を用いたポリペプチドの製造法 |
| JP2844870B2 (ja) * | 1989-07-21 | 1999-01-13 | 味の素株式会社 | 組み替えｄｎａ法によるポリペプチドの製造法 |
| US5508192A (en) * | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5304472A (en) * | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
| US5573923A (en) * | 1993-12-22 | 1996-11-12 | Eli Lilly And Company | Method for removing N-terminal dipeptides from precursor polypeptides with immobilized dipeptidylaminopeptidase from dictyostelium discoideum |
| US6127144A (en) * | 1993-12-23 | 2000-10-03 | Cangene Corporation | Method for expression of proteins in bacterial host cells |
| US5789199A (en) * | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5639635A (en) * | 1994-11-03 | 1997-06-17 | Genentech, Inc. | Process for bacterial production of polypeptides |
| KR100369839B1 (ko) * | 1997-02-28 | 2003-06-12 | 주식회사 엘지생명과학 | 바실러스리케니포미스균주에서유래한아미노펩티다제,그의제조방법및이를이용한천연형단백질의제조방법 |
| CA2352046A1 (en) * | 1998-12-07 | 2000-06-15 | Novozymes A/S | Glucoamylases with n-terminal extensions |
| CA2370113A1 (en) | 1999-04-30 | 2000-11-09 | Monsanto Company | Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase |
| KR100400638B1 (ko) | 2000-12-06 | 2003-10-08 | 주식회사 엘지생명과학 | 재조합 인간 성장호르몬 유사체의 분리방법 |
| ES2329880T3 (es) | 2001-09-13 | 2009-12-02 | Genentech, Inc. | Aminopeptidasa b2324. |
-
2002
- 2002-09-12 ES ES02761635T patent/ES2329880T3/es not_active Expired - Lifetime
- 2002-09-12 HU HU0600310A patent/HU225346B1/hu unknown
- 2002-09-12 US US10/243,789 patent/US6921659B2/en not_active Expired - Lifetime
- 2002-09-12 AT AT02761635T patent/ATE440134T1/de active
- 2002-09-12 HU HU0600309A patent/HU225430B1/hu unknown
- 2002-09-12 CA CA2460309A patent/CA2460309C/en not_active Expired - Lifetime
- 2002-09-12 DK DK02761635T patent/DK1432793T3/da active
- 2002-09-12 DE DE60233417T patent/DE60233417D1/de not_active Expired - Lifetime
- 2002-09-12 JP JP2003527095A patent/JP4831932B2/ja not_active Expired - Lifetime
- 2002-09-12 HU HU0401869A patent/HU225243B1/hu unknown
- 2002-09-12 IL IL16065802A patent/IL160658A0/xx unknown
- 2002-09-12 AU AU2002326884A patent/AU2002326884B2/en not_active Expired
- 2002-09-12 WO PCT/US2002/029015 patent/WO2003023030A2/en not_active Ceased
- 2002-09-12 EP EP02761635A patent/EP1432793B1/en not_active Expired - Lifetime
- 2002-09-12 PL PL368463A patent/PL206286B1/pl unknown
- 2002-09-12 KR KR1020087030860A patent/KR100956907B1/ko not_active Expired - Lifetime
- 2002-09-12 NZ NZ531516A patent/NZ531516A/xx not_active IP Right Cessation
- 2002-09-12 NZ NZ544964A patent/NZ544964A/en not_active IP Right Cessation
- 2002-09-12 KR KR1020047003708A patent/KR100954641B1/ko not_active Expired - Lifetime
- 2002-09-12 PT PT02761635T patent/PT1432793E/pt unknown
- 2002-09-12 BR BR0212886-1A patent/BR0212886A/pt not_active Application Discontinuation
- 2002-09-12 CN CNB028179846A patent/CN100552023C/zh not_active Expired - Lifetime
- 2002-09-12 MX MXPA04002326A patent/MXPA04002326A/es active IP Right Grant
-
2004
- 2004-03-01 IL IL160658A patent/IL160658A/en unknown
- 2004-03-03 ZA ZA2004/01752A patent/ZA200401752B/en unknown
-
2005
- 2005-05-16 US US11/131,035 patent/US7229787B2/en not_active Expired - Lifetime
-
2007
- 2007-04-27 US US11/741,510 patent/US7632658B2/en not_active Expired - Lifetime
-
2009
- 2009-10-26 CY CY20091101111T patent/CY1109903T1/el unknown
-
2011
- 2011-04-20 JP JP2011094093A patent/JP5372061B2/ja not_active Expired - Lifetime
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