JP2014500861A5 - - Google Patents

Download PDF

Info

Publication number
JP2014500861A5
JP2014500861A5 JP2013536688A JP2013536688A JP2014500861A5 JP 2014500861 A5 JP2014500861 A5 JP 2014500861A5 JP 2013536688 A JP2013536688 A JP 2013536688A JP 2013536688 A JP2013536688 A JP 2013536688A JP 2014500861 A5 JP2014500861 A5 JP 2014500861A5
Authority
JP
Japan
Prior art keywords
compound
following structural
structural formula
group
following
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013536688A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014500861A (ja
JP5731004B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/057398 external-priority patent/WO2012058125A1/en
Publication of JP2014500861A publication Critical patent/JP2014500861A/ja
Publication of JP2014500861A5 publication Critical patent/JP2014500861A5/ja
Application granted granted Critical
Publication of JP5731004B2 publication Critical patent/JP5731004B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013536688A 2010-10-26 2011-10-21 C型肝炎ウイルスの阻害剤 Expired - Fee Related JP5731004B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US40697210P 2010-10-26 2010-10-26
US61/406,972 2010-10-26
US201161438429P 2011-02-01 2011-02-01
US61/438,429 2011-02-01
US201161524220P 2011-08-16 2011-08-16
US61/524,220 2011-08-16
PCT/US2011/057398 WO2012058125A1 (en) 2010-10-26 2011-10-21 Inhibitors of hepatitis c virus

Publications (3)

Publication Number Publication Date
JP2014500861A JP2014500861A (ja) 2014-01-16
JP2014500861A5 true JP2014500861A5 (US07794700-20100914-C00125.png) 2014-12-11
JP5731004B2 JP5731004B2 (ja) 2015-06-10

Family

ID=45994336

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013536688A Expired - Fee Related JP5731004B2 (ja) 2010-10-26 2011-10-21 C型肝炎ウイルスの阻害剤

Country Status (21)

Country Link
US (4) US20130302282A1 (US07794700-20100914-C00125.png)
EP (1) EP2632261B1 (US07794700-20100914-C00125.png)
JP (1) JP5731004B2 (US07794700-20100914-C00125.png)
KR (1) KR101594166B1 (US07794700-20100914-C00125.png)
CN (1) CN103269586B (US07794700-20100914-C00125.png)
AR (1) AR083565A1 (US07794700-20100914-C00125.png)
AU (1) AU2011320696B2 (US07794700-20100914-C00125.png)
BR (1) BR112013009789A2 (US07794700-20100914-C00125.png)
CA (1) CA2815537A1 (US07794700-20100914-C00125.png)
CL (1) CL2013001141A1 (US07794700-20100914-C00125.png)
CO (1) CO6700883A2 (US07794700-20100914-C00125.png)
EA (1) EA025151B1 (US07794700-20100914-C00125.png)
HK (1) HK1185763A1 (US07794700-20100914-C00125.png)
IL (1) IL225853A0 (US07794700-20100914-C00125.png)
MX (1) MX2013004655A (US07794700-20100914-C00125.png)
NZ (1) NZ609564A (US07794700-20100914-C00125.png)
PE (1) PE20140109A1 (US07794700-20100914-C00125.png)
SG (1) SG189985A1 (US07794700-20100914-C00125.png)
TW (1) TWI486348B (US07794700-20100914-C00125.png)
WO (1) WO2012058125A1 (US07794700-20100914-C00125.png)
ZA (1) ZA201303752B (US07794700-20100914-C00125.png)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102656160A (zh) 2009-07-16 2012-09-05 顶点制药公司 用于治疗或预防黄病毒感染的苯并咪唑类似物
US8653025B2 (en) * 2010-01-27 2014-02-18 AB Pharma Ltd. Polyheterocyclic compounds highly potent as HCV inhibitors
WO2011119853A1 (en) 2010-03-24 2011-09-29 Vertex Pharmaceuticals Incorporated Analogues for the treatment or prevention of flavivirus infections
NZ609564A (en) 2010-10-26 2015-06-26 Presidio Pharmaceuticals Inc Inhibitors of hepatitis c virus
TWI532485B (zh) * 2011-10-21 2016-05-11 艾伯維有限公司 治療c型肝炎病毒(hcv)的方法
WO2013163466A1 (en) * 2012-04-25 2013-10-31 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis c virus
CN104884459A (zh) 2013-01-10 2015-09-02 百时美施贵宝公司 用于治疗丙型肝炎的大环苯并呋喃和氮杂苯并呋喃化合物
EP3119769A1 (en) * 2014-03-21 2017-01-25 Bristol-Myers Squibb Pharma Company Cyanoamino (aza)benzofuran compounds for the treatment of hepatitis c
ES2688554T3 (es) 2014-03-21 2018-11-05 Bristol-Myers Squibb Company Compuestos de azabenzofurano que contienen ciano para el tratamiento de la hepatitis C
WO2015143257A1 (en) 2014-03-21 2015-09-24 Bristol-Myers Squibb Company 6h-furo[2,3-e]indole compounds for the treatment of hepatitis c
US9840511B2 (en) 2014-05-21 2017-12-12 Bristol-Meyers Squibb Company 2-(aryl or heteroaryl-)phenyl (AZA)benzofuran compounds for the treatment of hepatitis C
EP3154963A1 (en) 2014-06-11 2017-04-19 Bristol-Myers Squibb Company Substituted 2-phenyl (aza)benzofuran compounds for the treatment of hepatitis c
EP3180346A1 (en) 2014-08-05 2017-06-21 Bristol-Myers Squibb Company Furopyridine compounds for the treatment of hepatitis c
US10202403B2 (en) 2014-10-02 2019-02-12 Bristol-Myers Squibb Company Macrocyclic benzofuran compounds for the treatment of hepatitis C
WO2016133961A1 (en) 2015-02-19 2016-08-25 Bristol-Myers Squibb Company Benzofurans substituted with bicyclic secondary benzamide as hcv inhibitors
US10087167B2 (en) 2015-02-19 2018-10-02 Bristol-Myers Squibb Company Benzofurans substituted with secondary benzamide as HCV inhibitors
WO2016133970A1 (en) 2015-02-19 2016-08-25 Bristol-Myers Squibb Company Benzofurans substituted with primary benzamide as hcv inhibitors
US10570108B2 (en) 2015-02-19 2020-02-25 Bristol-Myers Squibb Company Substituted benzofuran compounds for the treatment of hepatitis C
WO2016133948A1 (en) 2015-02-19 2016-08-25 Bristol-Myers Squibb Company Benzofuran compounds for the treatment of hepatitis c
US11831699B2 (en) * 2016-09-08 2023-11-28 Harmonic, Inc. Using web-based protocols to assist graphic presentations when providing digital video

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7741A (en) 1850-10-29 Cak-cottpling
US347A (en) 1837-08-08 dixon
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
ATE346085T1 (de) 1996-12-06 2006-12-15 Vertex Pharma Inhibitoren des interleukin-1-beta konvertierenden enzyms
EA004141B1 (ru) 1999-03-19 2004-02-26 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы фермента impdh
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
EP1256628A3 (en) 2001-05-10 2003-03-19 Agouron Pharmaceuticals, Inc. Hepatitis c virus (hcv) ns5b rna polymerase and mutants thereof
OA12622A (en) 2001-06-11 2006-06-12 Shire Biochem Inc Thiophene derivatives as antiviral agents for flavivirus infection.
CA2449999C (en) 2001-06-11 2012-07-31 Shire Biochem Inc. Compounds and methods for the treatment or prevention of flavivirus infections
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
WO2003007945A1 (en) 2001-07-20 2003-01-30 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
ES2289161T3 (es) 2001-11-02 2008-02-01 Glaxo Group Limited Derivados de 4-(heteroaril de 6 miembros)-acil pirrolidina como inhibidores de hcv.
MXPA05004608A (es) * 2002-11-01 2005-09-20 Viropharma Inc Compuestos de benzofurano, composiciones y metodos para tratamiento de profilaxis de infecciones virales de hepatitis c y enfermedades asociadas.
DK1625154T3 (da) * 2003-05-09 2014-02-24 Boehringer Ingelheim Int Hepatitis c virus ns5b-polymeraseinhibitor-bindende lomme
DE602005019979D1 (en) 2004-01-30 2010-04-29 Medivir Ab Hcv ns-3 serine protease inhibitoren
WO2005112640A2 (en) 2004-05-13 2005-12-01 Viropharma Incorporated Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases
EP1771169A1 (en) 2004-07-14 2007-04-11 PTC Therapeutics, Inc. Methods for treating hepatitis c
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
CA2618682C (en) * 2005-08-12 2011-06-21 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US20070265335A1 (en) 2005-11-10 2007-11-15 Wyeth Polymorphs of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsufonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and methods of making the same
KR20090012345A (ko) 2006-05-30 2009-02-03 애로우 쎄라퓨틱스 리미티드 바이페닐 유도체, 및 c형 간염 치료에 있어서의 이들의 용도
GB0614940D0 (en) 2006-07-27 2006-09-06 Arternis Intelligent Power Ltd Vehicle traction and stability control system employing control of fluid quanta
US8329159B2 (en) 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7659270B2 (en) 2006-08-11 2010-02-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7759495B2 (en) 2006-08-11 2010-07-20 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8303944B2 (en) 2006-08-11 2012-11-06 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US20080275032A1 (en) 2006-12-29 2008-11-06 Yuefen Zhou Pyridazinone compounds
EP2134683A2 (en) 2007-02-12 2009-12-23 Intermune, Inc. Novel inhibitors hepatitis c virus replication
GB0707000D0 (en) * 2007-04-12 2007-05-30 Istituto Di Ricerche D Biolog Antiviral agents
WO2008148010A1 (en) 2007-05-23 2008-12-04 Vgx Pharmaceuticals, Inc. Composition comprising high concentration of biologically active molecules and processes for preparing the same
US7728027B2 (en) 2007-08-08 2010-06-01 Bristol-Myers Squibb Company Process for synthesizing compounds useful for treating hepatitis C
WO2009023179A2 (en) 2007-08-10 2009-02-19 Genelabs Technologies, Inc. Nitrogen containing bicyclic chemical entities for treating viral infections
WO2009032124A1 (en) 2007-08-29 2009-03-12 Schering Corporation Substituted indole derivatives and methods of use thereof
KR100903410B1 (ko) 2007-10-16 2009-06-18 (주)다산알앤디 자동속도조절 러닝머신 및 그 제어모듈
CN102317285A (zh) 2007-11-16 2012-01-11 先灵公司 3-氨基磺酰基取代的吲哚衍生物及其使用方法
US8147818B2 (en) 2008-02-13 2012-04-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7704992B2 (en) 2008-02-13 2010-04-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
AU2009214194B2 (en) * 2008-02-14 2012-05-17 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
WO2009137493A1 (en) 2008-05-05 2009-11-12 Wyeth 2-substituted benzofuran compounds to treat infection with hepatitis c virus
WO2009137500A1 (en) * 2008-05-05 2009-11-12 Wyeth 6-substituted benzofuran compounds to treat infection with hepatitis c virus
CN101635673B (zh) 2008-07-25 2012-01-25 华为技术有限公司 预订路径的方法、系统及路径计算客户、路径计算单元
US7906655B2 (en) 2008-08-07 2011-03-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8048887B2 (en) 2008-09-11 2011-11-01 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7994171B2 (en) 2008-09-11 2011-08-09 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8198449B2 (en) 2008-09-11 2012-06-12 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8293909B2 (en) 2008-09-11 2012-10-23 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
JP2010092550A (ja) 2008-10-09 2010-04-22 Hitachi Global Storage Technologies Netherlands Bv 磁気記録ヘッド、その製造方法及び磁気記録再生装置
WO2010062821A1 (en) 2008-11-28 2010-06-03 Glaxosmithkline Llc Anti-viral compounds, compositions, and methods of use
MX2011005896A (es) 2008-12-03 2011-09-29 Presidio Pharmaceuticals Inc Inhibidores de hcv ns5a.
RU2505539C2 (ru) 2008-12-23 2014-01-27 Эбботт Лэборетриз Антивирусные соединения
TWI438200B (zh) 2009-02-17 2014-05-21 必治妥美雅史谷比公司 C型肝炎病毒抑制劑
WO2010096462A1 (en) 2009-02-17 2010-08-26 Enanta Pharmaceuticals, Inc Linked diimidazole derivatives
UY32462A (es) 2009-02-23 2010-09-30 Arrow Therapeutics Ltd Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644
WO2010099166A1 (en) 2009-02-27 2010-09-02 Siga Technologies, Inc. Thienopyridine derivatives for the treatment and prevention of dengue virus infections
EP2432554A1 (en) 2009-05-20 2012-03-28 F. Hoffmann-La Roche AG Heterocyclic antiviral compounds
CA2785488A1 (en) * 2009-12-22 2011-07-21 Merck Sharp & Dohme Corp. Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
WO2011103063A1 (en) 2010-02-19 2011-08-25 Glaxo Group Limited Therapeutic compounds
WO2011106986A1 (en) 2010-03-02 2011-09-09 Merck Sharp & Dohme Corp. Inhibitors of hepatitis c virus ns5b polymerase
WO2011106929A1 (en) 2010-03-02 2011-09-09 Merck Sharp & Dohme Corp. Inhibitors of hepatitis c virus ns5b polymerase
AR080433A1 (es) 2010-03-02 2012-04-11 Merck Sharp & Dohme Derivados de benzofurancarboxamidas utiles para tratar o prevenir infecciones por vhc y composiciones farmaceuticas que los contienen.
AR080676A1 (es) * 2010-03-09 2012-05-02 Schering Corp Compuestos de sililo triciclicos fusionados y metodos de uso de los mismos para el tratamiento de enfermedades virales
JP5572725B2 (ja) 2010-03-10 2014-08-13 ブリストル−マイヤーズ スクイブ カンパニー C型肝炎の処置のための化合物
US8354410B2 (en) 2010-03-11 2013-01-15 Bristol-Meyers Squibb Company Compounds for the treatment of hepatitis C
EP2545042A1 (en) 2010-03-11 2013-01-16 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis c
AR082453A1 (es) * 2010-04-21 2012-12-12 Novartis Ag Compuestos de furopiridina, composiciones farmaceuticas que los contienen y usos de los mismos
NZ609564A (en) 2010-10-26 2015-06-26 Presidio Pharmaceuticals Inc Inhibitors of hepatitis c virus
WO2013163466A1 (en) * 2012-04-25 2013-10-31 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis c virus

Similar Documents

Publication Publication Date Title
JP2014500861A5 (US07794700-20100914-C00125.png)
JP2013032389A5 (US07794700-20100914-C00125.png)
JP2011518833A5 (US07794700-20100914-C00125.png)
JP2010077141A5 (US07794700-20100914-C00125.png)
JP2013518107A5 (US07794700-20100914-C00125.png)
JP2012144574A5 (US07794700-20100914-C00125.png)
JP2010095546A5 (US07794700-20100914-C00125.png)
JP2006526031A5 (US07794700-20100914-C00125.png)
JP2012502037A5 (US07794700-20100914-C00125.png)
JP2016503793A5 (US07794700-20100914-C00125.png)
JP2017531038A5 (US07794700-20100914-C00125.png)
JP2015024998A5 (US07794700-20100914-C00125.png)
JP2012092103A5 (US07794700-20100914-C00125.png)
JP2013534248A5 (US07794700-20100914-C00125.png)
JP2014515013A5 (US07794700-20100914-C00125.png)
JP2013510120A5 (US07794700-20100914-C00125.png)
JP2020097577A5 (US07794700-20100914-C00125.png)
JP2013532130A5 (US07794700-20100914-C00125.png)
JP2012504133A5 (US07794700-20100914-C00125.png)
JP2013512277A5 (US07794700-20100914-C00125.png)
JP2007302689A5 (US07794700-20100914-C00125.png)
JP2014507477A5 (US07794700-20100914-C00125.png)
JP2013542261A5 (US07794700-20100914-C00125.png)
JP2012513416A5 (US07794700-20100914-C00125.png)
JP2013514980A5 (US07794700-20100914-C00125.png)