JP2014207903A5 - - Google Patents
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- JP2014207903A5 JP2014207903A5 JP2014083444A JP2014083444A JP2014207903A5 JP 2014207903 A5 JP2014207903 A5 JP 2014207903A5 JP 2014083444 A JP2014083444 A JP 2014083444A JP 2014083444 A JP2014083444 A JP 2014083444A JP 2014207903 A5 JP2014207903 A5 JP 2014207903A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- vector
- pharmaceutical composition
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000013598 vector Substances 0.000 claims 29
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 12
- 230000000139 costimulatory effect Effects 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 108010084313 CD58 Antigens Proteins 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000000666 Fowlpox Diseases 0.000 claims 4
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 4
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 4
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 4
- 206010057644 Testis cancer Diseases 0.000 claims 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 4
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 201000002314 small intestine cancer Diseases 0.000 claims 4
- 201000011549 stomach cancer Diseases 0.000 claims 4
- 201000003120 testicular cancer Diseases 0.000 claims 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims 4
- 206010046766 uterine cancer Diseases 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- 230000005907 cancer growth Effects 0.000 claims 2
- 230000004186 co-expression Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 102100025218 B-cell differentiation antigen CD72 Human genes 0.000 claims 1
- 241000251556 Chordata Species 0.000 claims 1
- 201000009047 Chordoma Diseases 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 101000934359 Homo sapiens B-cell differentiation antigen CD72 Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000013462 Interleukin-12 Human genes 0.000 claims 1
- 108010065805 Interleukin-12 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90423607P | 2007-02-28 | 2007-02-28 | |
| US60/904,236 | 2007-02-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551830A Division JP5596980B2 (ja) | 2007-02-28 | 2008-02-27 | ブラキュリポリペプチドおよび使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014207903A JP2014207903A (ja) | 2014-11-06 |
| JP2014207903A5 true JP2014207903A5 (OSRAM) | 2015-05-14 |
| JP5767733B2 JP5767733B2 (ja) | 2015-08-19 |
Family
ID=39650527
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551830A Active JP5596980B2 (ja) | 2007-02-28 | 2008-02-27 | ブラキュリポリペプチドおよび使用方法 |
| JP2014083444A Active JP5767733B2 (ja) | 2007-02-28 | 2014-04-15 | ブラキュリポリペプチドおよび使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009551830A Active JP5596980B2 (ja) | 2007-02-28 | 2008-02-27 | ブラキュリポリペプチドおよび使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8188214B2 (OSRAM) |
| EP (3) | EP2444410A3 (OSRAM) |
| JP (2) | JP5596980B2 (OSRAM) |
| AU (1) | AU2008221383B2 (OSRAM) |
| CA (1) | CA2678404C (OSRAM) |
| DK (1) | DK2918598T3 (OSRAM) |
| WO (1) | WO2008106551A2 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103476928B (zh) | 2010-12-09 | 2017-03-29 | 巴斯德研究所 | 用于获得高产量重组蛋白表达的基于mgmt的方法 |
| PL2685995T3 (pl) | 2011-03-17 | 2017-10-31 | Globeimmune Inc | Kompozycje immunoterapeutyczne drożdże-Brachyury |
| WO2014043535A1 (en) * | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
| EP2895191B1 (en) * | 2012-09-14 | 2019-06-05 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Brachyury protein, adenoviral vectors encoding brachyury protein, and their use |
| EP2976100B1 (en) | 2013-03-19 | 2020-07-01 | Globeimmune, Inc. | Yeast-based immunotherapy for chordoma |
| US9725494B2 (en) * | 2013-05-17 | 2017-08-08 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Soluble CD27 (sCD27) and the use thereof |
| WO2017021776A1 (en) * | 2015-07-31 | 2017-02-09 | Bavarian Nordic A/S | Promoters for enhancing expression in poxviruses |
| TWI748957B (zh) | 2015-08-03 | 2021-12-11 | 美商環球免疫公司 | 經修飾之酵母-短尾畸型（Ｂｒａｃｈｙｕｒｙ）免疫治療組合物 |
| AU2016302237B2 (en) | 2015-08-03 | 2022-08-04 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use |
| EP3400009A2 (en) | 2016-01-05 | 2018-11-14 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Combination of histone deacetylase inhibitor and immunotherapy |
| WO2017136342A1 (en) | 2016-02-02 | 2017-08-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells |
| JP6983819B2 (ja) * | 2016-06-03 | 2021-12-17 | エトゥビクス コーポレーション | 前立腺がん関連抗原を使用する腫瘍ワクチン接種用の組成物及び方法 |
| EP3464560A4 (en) * | 2016-06-03 | 2020-01-15 | Etubics Corporation | TUMOR IMMUNOTHERAPY COMPOSITIONS AND METHODS INVOLVING HER2 / NEU |
| AU2018266103B2 (en) | 2017-05-09 | 2024-06-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination PDL1 and TGF-beta blockade in patients with HPV+ malignancies |
| US11170872B2 (en) | 2019-11-05 | 2021-11-09 | Apeel Technology, Inc. | Prediction of latent infection in plant products |
| WO2022187963A1 (en) * | 2021-03-10 | 2022-09-15 | Provincial Health Services Authority | Immunotherapy agents targeting brachyury and methods of using same |
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-
2008
- 2008-02-27 CA CA2678404A patent/CA2678404C/en active Active
- 2008-02-27 EP EP11195533A patent/EP2444410A3/en not_active Withdrawn
- 2008-02-27 EP EP15162282.6A patent/EP2918598B1/en active Active
- 2008-02-27 WO PCT/US2008/055185 patent/WO2008106551A2/en not_active Ceased
- 2008-02-27 EP EP08743578.0A patent/EP2125868B1/en active Active
- 2008-02-27 US US12/528,796 patent/US8188214B2/en active Active
- 2008-02-27 JP JP2009551830A patent/JP5596980B2/ja active Active
- 2008-02-27 DK DK15162282.6T patent/DK2918598T3/en active
- 2008-02-27 AU AU2008221383A patent/AU2008221383B2/en active Active
-
2012
- 2012-04-30 US US13/460,587 patent/US8613933B2/en active Active
-
2013
- 2013-12-23 US US14/138,629 patent/US20140135488A1/en not_active Abandoned
-
2014
- 2014-04-15 JP JP2014083444A patent/JP5767733B2/ja active Active
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