JP2019535311A5 - - Google Patents
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- JP2019535311A5 JP2019535311A5 JP2019545700A JP2019545700A JP2019535311A5 JP 2019535311 A5 JP2019535311 A5 JP 2019535311A5 JP 2019545700 A JP2019545700 A JP 2019545700A JP 2019545700 A JP2019545700 A JP 2019545700A JP 2019535311 A5 JP2019535311 A5 JP 2019535311A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- item
- scpv
- viral genome
- items
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 claims description 67
- 238000000034 method Methods 0.000 claims description 58
- 108020004414 DNA Proteins 0.000 claims description 49
- 238000012986 modification Methods 0.000 claims description 42
- 230000004048 modification Effects 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 37
- 241000700647 Variola virus Species 0.000 claims description 34
- 230000003612 virological effect Effects 0.000 claims description 30
- 239000012634 fragment Substances 0.000 claims description 29
- 241000700618 Vaccinia virus Species 0.000 claims description 28
- 239000002773 nucleotide Substances 0.000 claims description 27
- 125000003729 nucleotide group Chemical group 0.000 claims description 27
- 230000002194 synthesizing effect Effects 0.000 claims description 9
- 230000001939 inductive effect Effects 0.000 claims description 8
- 241000700627 Monkeypox virus Species 0.000 claims description 7
- 230000028993 immune response Effects 0.000 claims description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 5
- 238000012258 culturing Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 238000007747 plating Methods 0.000 claims description 5
- 241000700629 Orthopoxvirus Species 0.000 claims description 4
- 239000002299 complementary DNA Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000007420 reactivation Effects 0.000 claims description 4
- 238000005215 recombination Methods 0.000 claims description 4
- 230000006798 recombination Effects 0.000 claims description 4
- 230000000174 oncolytic effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 241000928771 Horsepox virus Species 0.000 description 17
- 241000700564 Rabbit fibroma virus Species 0.000 description 12
- 206010016629 fibroma Diseases 0.000 description 7
- 230000003053 immunization Effects 0.000 description 7
- 241001476589 Squirrel fibroma virus Species 0.000 description 6
- 230000009385 viral infection Effects 0.000 description 6
- 241000700626 Cowpox virus Species 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 206010056370 Congestive cardiomyopathy Diseases 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 201000010046 Dilated cardiomyopathy Diseases 0.000 description 3
- 241000700662 Fowlpox virus Species 0.000 description 3
- 208000009525 Myocarditis Diseases 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 206010014599 encephalitis Diseases 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000002777 nucleoside Substances 0.000 description 3
- 150000003833 nucleoside derivatives Chemical class 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 239000002157 polynucleotide Substances 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 229940124965 ACAM2000 Drugs 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241001137864 Camelpox virus Species 0.000 description 2
- 206010058314 Dysplasia Diseases 0.000 description 2
- 206010069582 Progressive vaccinia Diseases 0.000 description 2
- 241001455645 Rabbitpox virus Species 0.000 description 2
- 206010046865 Vaccinia virus infection Diseases 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 208000007089 vaccinia Diseases 0.000 description 2
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000899864 Cherry mottle leaf virus Species 0.000 description 1
- 241000321597 Skunkpox virus Species 0.000 description 1
- 241000587120 Vaccinia virus Ankara Species 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000013086 organic photovoltaic Methods 0.000 description 1
- 210000002151 serous membrane Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022140113A JP2022164900A (ja) | 2016-11-02 | 2022-09-02 | 合成キメラポックスウイルス |
| JP2024093677A JP2024107257A (ja) | 2016-11-02 | 2024-06-10 | 合成キメラポックスウイルス |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416577P | 2016-11-02 | 2016-11-02 | |
| US62/416,577 | 2016-11-02 | ||
| US201662434794P | 2016-12-15 | 2016-12-15 | |
| US62/434,794 | 2016-12-15 | ||
| PCT/US2017/059782 WO2018085582A1 (en) | 2016-11-02 | 2017-11-02 | Synthetic chimeric poxviruses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022140113A Division JP2022164900A (ja) | 2016-11-02 | 2022-09-02 | 合成キメラポックスウイルス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019535311A JP2019535311A (ja) | 2019-12-12 |
| JP2019535311A5 true JP2019535311A5 (OSRAM) | 2020-12-10 |
Family
ID=62075555
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545700A Pending JP2019535311A (ja) | 2016-11-02 | 2017-11-02 | 合成キメラポックスウイルス |
| JP2022140113A Withdrawn JP2022164900A (ja) | 2016-11-02 | 2022-09-02 | 合成キメラポックスウイルス |
| JP2024093677A Pending JP2024107257A (ja) | 2016-11-02 | 2024-06-10 | 合成キメラポックスウイルス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022140113A Withdrawn JP2022164900A (ja) | 2016-11-02 | 2022-09-02 | 合成キメラポックスウイルス |
| JP2024093677A Pending JP2024107257A (ja) | 2016-11-02 | 2024-06-10 | 合成キメラポックスウイルス |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11345896B2 (OSRAM) |
| EP (1) | EP3535389A4 (OSRAM) |
| JP (3) | JP2019535311A (OSRAM) |
| CN (1) | CN110431228B (OSRAM) |
| AU (2) | AU2017353868C1 (OSRAM) |
| BR (1) | BR112019008781A2 (OSRAM) |
| CA (1) | CA3042694A1 (OSRAM) |
| IL (2) | IL266399B2 (OSRAM) |
| MX (1) | MX2019005102A (OSRAM) |
| NZ (1) | NZ752893A (OSRAM) |
| SG (1) | SG11201903893PA (OSRAM) |
| TW (2) | TW202528334A (OSRAM) |
| WO (1) | WO2018085582A1 (OSRAM) |
| ZA (3) | ZA201902868B (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ752893A (en) | 2016-11-02 | 2025-10-31 | Tonix Pharma Ltd | Synthetic chimeric poxviruses |
| WO2018148710A1 (en) * | 2017-02-13 | 2018-08-16 | Excision Biotherapeutics, Inc. | Visualizing viral reservoirs and dissemination in vivo |
| SG11202010272PA (en) * | 2018-05-02 | 2020-11-27 | David Evans | Synthetic chimeric vaccinia virus |
| US20240024393A1 (en) * | 2019-01-25 | 2024-01-25 | Virocure, Inc. | Pharmaceutical composition for preventing or treating cancer, comprising squirrel fibroma virus and reovirus |
| US20230097513A1 (en) * | 2020-02-03 | 2023-03-30 | City Of Hope | Poxvirus-based vectors produced by natural or synthetic dna and uses thereof |
| CN116348135A (zh) * | 2020-02-26 | 2023-06-27 | 通尼克斯制药有限公司 | 基于重组痘病毒的抗SARS-CoV-2病毒疫苗 |
| KR20240001116A (ko) | 2021-02-02 | 2024-01-03 | 지오박스, 인크. | 백신접종 동안 t-세포 프라이밍을 증진시키는 데 사용하기 위한 바이러스 구축물 |
| WO2023168286A1 (en) | 2022-03-01 | 2023-09-07 | Tonix Pharmaceuticals Holding Corp. | Recombinant poxvirus based vaccine against the omicron strain of sars-cov-2 virus and variants thereof |
| CN117264909B (zh) * | 2023-10-25 | 2024-11-26 | 深圳湾实验室 | 反式互补缺陷猴痘病毒及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2787577A (en) | 1953-12-01 | 1957-04-02 | Lilly Co Eli | Stable smallpox vaccine |
| US4754065A (en) | 1984-12-18 | 1988-06-28 | Cetus Corporation | Precursor to nucleic acid probe |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US6723325B1 (en) | 2001-04-23 | 2004-04-20 | Acambis, Inc. | Smallpox vaccine |
| CA2431349A1 (en) * | 2002-06-06 | 2003-12-06 | Xiao-Dan Yao | Method of producing a recombinant virus |
| WO2005028634A2 (en) | 2003-09-18 | 2005-03-31 | Emory University | Improved mva vaccines |
| WO2006022215A1 (ja) | 2004-08-23 | 2006-03-02 | The Japan Health Sciences Foundation | SARS-コロナウイルスタンパク質をコードするDNAを保有する組換えワクチニアウイルスDIs株、およびその利用 |
| CN101020055B (zh) | 2006-02-16 | 2012-08-08 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 基于复制型痘苗病毒载体的sars疫苗 |
| US8052968B2 (en) | 2006-10-16 | 2011-11-08 | Genelux Corporation | Modified vaccinia virus strains for use in diagnostic and therapeutic methods |
| US8795667B2 (en) * | 2007-12-19 | 2014-08-05 | Macrogenics, Inc. | Compositions for the prevention and treatment of smallpox |
| FI20115914L (fi) | 2011-09-16 | 2013-03-17 | Oncos Therapeutics Ltd | Muunnettu onkolyyttinen virus |
| WO2014160475A1 (en) | 2013-03-13 | 2014-10-02 | Aboody Karen S | Tropic cell based virotherapy for the treatment of cancer |
| EP2984167B1 (en) | 2013-04-10 | 2019-12-04 | Tot Shanghai Rd Center Co. Ltd. | Mutant vaccinia virus strains, uses thereof and method of producing the same |
| EP3045181B1 (en) | 2015-01-19 | 2018-11-14 | Ludwig-Maximilians-Universität München | A novel vaccine against the middle east respiratory syndrome coronavirus (MERS-CoV) |
| JP6788663B2 (ja) | 2015-08-11 | 2020-11-25 | カリディ・バイオセラピューティクス・インコーポレイテッドＣａｌｉｄｉ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 癌処置のための天然痘ワクチン |
| CN110022867A (zh) | 2016-09-21 | 2019-07-16 | 斯蒂芬·H·索恩 | 高迁移率族蛋白box i突变体 |
| NZ752893A (en) | 2016-11-02 | 2025-10-31 | Tonix Pharma Ltd | Synthetic chimeric poxviruses |
| ES2702618B2 (es) | 2017-09-04 | 2019-10-31 | Inst De Salud Carlos Iii | Producto de combinación que comprende una célula madre mesenquimatosa modificada y una sustancia antigénica. |
| CN112261951A (zh) | 2018-05-02 | 2021-01-22 | 通尼克斯制药控股有限公司 | 包含合成嵌合痘苗病毒的干细胞及其使用方法 |
| SG11202010272PA (en) | 2018-05-02 | 2020-11-27 | David Evans | Synthetic chimeric vaccinia virus |
-
2017
- 2017-11-02 NZ NZ752893A patent/NZ752893A/en unknown
- 2017-11-02 BR BR112019008781-8A patent/BR112019008781A2/pt active Search and Examination
- 2017-11-02 AU AU2017353868A patent/AU2017353868C1/en active Active
- 2017-11-02 EP EP17868045.0A patent/EP3535389A4/en active Pending
- 2017-11-02 US US15/802,189 patent/US11345896B2/en active Active
- 2017-11-02 IL IL266399A patent/IL266399B2/en unknown
- 2017-11-02 TW TW113144133A patent/TW202528334A/zh unknown
- 2017-11-02 CN CN201780078546.0A patent/CN110431228B/zh active Active
- 2017-11-02 JP JP2019545700A patent/JP2019535311A/ja active Pending
- 2017-11-02 WO PCT/US2017/059782 patent/WO2018085582A1/en not_active Ceased
- 2017-11-02 CA CA3042694A patent/CA3042694A1/en active Pending
- 2017-11-02 MX MX2019005102A patent/MX2019005102A/es unknown
- 2017-11-02 IL IL319942A patent/IL319942A/en unknown
- 2017-11-02 TW TW106137976A patent/TWI887191B/zh active
- 2017-11-02 SG SG11201903893PA patent/SG11201903893PA/en unknown
-
2019
- 2019-05-07 ZA ZA2019/02868A patent/ZA201902868B/en unknown
-
2022
- 2022-05-06 ZA ZA2022/04981A patent/ZA202204981B/en unknown
- 2022-05-27 US US17/827,320 patent/US12365879B2/en active Active
- 2022-09-02 JP JP2022140113A patent/JP2022164900A/ja not_active Withdrawn
-
2024
- 2024-02-15 AU AU2024200997A patent/AU2024200997A1/en not_active Abandoned
- 2024-05-02 ZA ZA2024/03393A patent/ZA202403393B/en unknown
- 2024-06-10 JP JP2024093677A patent/JP2024107257A/ja active Pending
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