JP2019535311A - 合成キメラポックスウイルス - Google Patents

合成キメラポックスウイルス Download PDF

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Publication number
JP2019535311A
JP2019535311A JP2019545700A JP2019545700A JP2019535311A JP 2019535311 A JP2019535311 A JP 2019535311A JP 2019545700 A JP2019545700 A JP 2019545700A JP 2019545700 A JP2019545700 A JP 2019545700A JP 2019535311 A JP2019535311 A JP 2019535311A
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JP
Japan
Prior art keywords
virus
schpxv
dna
scopv
genome
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Pending
Application number
JP2019545700A
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English (en)
Japanese (ja)
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JP2019535311A5 (OSRAM
Inventor
デイビッド エバンス，
デイビッド エバンス，
ライアン ノイス，
ライアン ノイス，
セス レーダーマン，
セス レーダーマン，
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Individual
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Individual
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Publication of JP2019535311A publication Critical patent/JP2019535311A/ja
Publication of JP2019535311A5 publication Critical patent/JP2019535311A5/ja
Priority to JP2022140113A priority Critical patent/JP2022164900A/ja
Priority to JP2024093677A priority patent/JP2024107257A/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2019545700A 2016-11-02 2017-11-02 合成キメラポックスウイルス Pending JP2019535311A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022140113A JP2022164900A (ja) 2016-11-02 2022-09-02 合成キメラポックスウイルス
JP2024093677A JP2024107257A (ja) 2016-11-02 2024-06-10 合成キメラポックスウイルス

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662416577P 2016-11-02 2016-11-02
US62/416,577 2016-11-02
US201662434794P 2016-12-15 2016-12-15
US62/434,794 2016-12-15
PCT/US2017/059782 WO2018085582A1 (en) 2016-11-02 2017-11-02 Synthetic chimeric poxviruses

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022140113A Division JP2022164900A (ja) 2016-11-02 2022-09-02 合成キメラポックスウイルス

Publications (2)

Publication Number Publication Date
JP2019535311A true JP2019535311A (ja) 2019-12-12
JP2019535311A5 JP2019535311A5 (OSRAM) 2020-12-10

Family

ID=62075555

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019545700A Pending JP2019535311A (ja) 2016-11-02 2017-11-02 合成キメラポックスウイルス
JP2022140113A Withdrawn JP2022164900A (ja) 2016-11-02 2022-09-02 合成キメラポックスウイルス
JP2024093677A Pending JP2024107257A (ja) 2016-11-02 2024-06-10 合成キメラポックスウイルス

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022140113A Withdrawn JP2022164900A (ja) 2016-11-02 2022-09-02 合成キメラポックスウイルス
JP2024093677A Pending JP2024107257A (ja) 2016-11-02 2024-06-10 合成キメラポックスウイルス

Country Status (14)

Country Link
US (2) US11345896B2 (OSRAM)
EP (1) EP3535389A4 (OSRAM)
JP (3) JP2019535311A (OSRAM)
CN (1) CN110431228B (OSRAM)
AU (2) AU2017353868C1 (OSRAM)
BR (1) BR112019008781A2 (OSRAM)
CA (1) CA3042694A1 (OSRAM)
IL (2) IL266399B2 (OSRAM)
MX (1) MX2019005102A (OSRAM)
NZ (1) NZ752893A (OSRAM)
SG (1) SG11201903893PA (OSRAM)
TW (2) TW202528334A (OSRAM)
WO (1) WO2018085582A1 (OSRAM)
ZA (3) ZA201902868B (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021522784A (ja) * 2018-05-02 2021-09-02 トニックス ファーマ ホールディングス リミテッド 合成キメラワクシニアウイルス
JP2023515582A (ja) * 2020-02-26 2023-04-13 トニックス ファーマ リミテッド ＳＡＲＳ－ＣｏＶ－２ウイルスに対する、組換えポックスウイルスに基づくワクチン

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ752893A (en) 2016-11-02 2025-10-31 Tonix Pharma Ltd Synthetic chimeric poxviruses
WO2018148710A1 (en) * 2017-02-13 2018-08-16 Excision Biotherapeutics, Inc. Visualizing viral reservoirs and dissemination in vivo
US20240024393A1 (en) * 2019-01-25 2024-01-25 Virocure, Inc. Pharmaceutical composition for preventing or treating cancer, comprising squirrel fibroma virus and reovirus
US20230097513A1 (en) * 2020-02-03 2023-03-30 City Of Hope Poxvirus-based vectors produced by natural or synthetic dna and uses thereof
KR20240001116A (ko) 2021-02-02 2024-01-03 지오박스, 인크. 백신접종 동안 t-세포 프라이밍을 증진시키는 데 사용하기 위한 바이러스 구축물
WO2023168286A1 (en) 2022-03-01 2023-09-07 Tonix Pharmaceuticals Holding Corp. Recombinant poxvirus based vaccine against the omicron strain of sars-cov-2 virus and variants thereof
CN117264909B (zh) * 2023-10-25 2024-11-26 深圳湾实验室 反式互补缺陷猴痘病毒及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014034A1 (en) * 2002-06-06 2004-01-22 Evans David H Method of producing a recombinant virus

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US2787577A (en) 1953-12-01 1957-04-02 Lilly Co Eli Stable smallpox vaccine
US4754065A (en) 1984-12-18 1988-06-28 Cetus Corporation Precursor to nucleic acid probe
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US6723325B1 (en) 2001-04-23 2004-04-20 Acambis, Inc. Smallpox vaccine
WO2005028634A2 (en) 2003-09-18 2005-03-31 Emory University Improved mva vaccines
WO2006022215A1 (ja) 2004-08-23 2006-03-02 The Japan Health Sciences Foundation SARS-コロナウイルスタンパク質をコードするDNAを保有する組換えワクチニアウイルスDIs株、およびその利用
CN101020055B (zh) 2006-02-16 2012-08-08 中国疾病预防控制中心性病艾滋病预防控制中心 基于复制型痘苗病毒载体的sars疫苗
US8052968B2 (en) 2006-10-16 2011-11-08 Genelux Corporation Modified vaccinia virus strains for use in diagnostic and therapeutic methods
US8795667B2 (en) * 2007-12-19 2014-08-05 Macrogenics, Inc. Compositions for the prevention and treatment of smallpox
FI20115914L (fi) 2011-09-16 2013-03-17 Oncos Therapeutics Ltd Muunnettu onkolyyttinen virus
WO2014160475A1 (en) 2013-03-13 2014-10-02 Aboody Karen S Tropic cell based virotherapy for the treatment of cancer
EP2984167B1 (en) 2013-04-10 2019-12-04 Tot Shanghai Rd Center Co. Ltd. Mutant vaccinia virus strains, uses thereof and method of producing the same
EP3045181B1 (en) 2015-01-19 2018-11-14 Ludwig-Maximilians-Universität München A novel vaccine against the middle east respiratory syndrome coronavirus (MERS-CoV)
JP6788663B2 (ja) 2015-08-11 2020-11-25 カリディ・バイオセラピューティクス・インコーポレイテッドＣａｌｉｄｉ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 癌処置のための天然痘ワクチン
CN110022867A (zh) 2016-09-21 2019-07-16 斯蒂芬·H·索恩 高迁移率族蛋白box i突变体
NZ752893A (en) 2016-11-02 2025-10-31 Tonix Pharma Ltd Synthetic chimeric poxviruses
ES2702618B2 (es) 2017-09-04 2019-10-31 Inst De Salud Carlos Iii Producto de combinación que comprende una célula madre mesenquimatosa modificada y una sustancia antigénica.
CN112261951A (zh) 2018-05-02 2021-01-22 通尼克斯制药控股有限公司 包含合成嵌合痘苗病毒的干细胞及其使用方法
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014034A1 (en) * 2002-06-06 2004-01-22 Evans David H Method of producing a recombinant virus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021522784A (ja) * 2018-05-02 2021-09-02 トニックス ファーマ ホールディングス リミテッド 合成キメラワクシニアウイルス
JP2023515582A (ja) * 2020-02-26 2023-04-13 トニックス ファーマ リミテッド ＳＡＲＳ－ＣｏＶ－２ウイルスに対する、組換えポックスウイルスに基づくワクチン

Also Published As

Publication number Publication date
IL266399A (en) 2019-06-30
ZA201902868B (en) 2022-12-21
AU2017353868A1 (en) 2019-05-16
CN110431228A (zh) 2019-11-08
MX2019005102A (es) 2019-10-30
JP2022164900A (ja) 2022-10-27
IL266399B1 (en) 2025-05-01
WO2018085582A1 (en) 2018-05-11
US11345896B2 (en) 2022-05-31
TW202528334A (zh) 2025-07-16
ZA202204981B (en) 2024-09-25
US20180251736A1 (en) 2018-09-06
AU2024200997A1 (en) 2024-03-07
TW201819400A (zh) 2018-06-01
CA3042694A1 (en) 2018-05-11
TWI887191B (zh) 2025-06-21
AU2017353868C1 (en) 2024-06-06
IL319942A (en) 2025-05-01
JP2024107257A (ja) 2024-08-08
EP3535389A4 (en) 2020-06-03
AU2017353868B2 (en) 2024-02-29
SG11201903893PA (en) 2019-05-30
NZ752893A (en) 2025-10-31
BR112019008781A2 (pt) 2019-07-16
ZA202403393B (en) 2025-08-27
EP3535389A1 (en) 2019-09-11
IL266399B2 (en) 2025-09-01
US20230002741A1 (en) 2023-01-05
CN110431228B (zh) 2024-04-02
US12365879B2 (en) 2025-07-22

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