JP2019500907A5 - - Google Patents

Info

Publication number

JP2019500907A5

JP2019500907A5 JP2018554648A JP2018554648A JP2019500907A5 JP 2019500907 A5 JP2019500907 A5 JP 2019500907A5 JP 2018554648 A JP2018554648 A JP 2018554648A JP 2018554648 A JP2018554648 A JP 2018554648A JP 2019500907 A5 JP2019500907 A5 JP 2019500907A5

Authority

JP

Japan

Prior art keywords

sequence

taa

mva

recombinant

pharmaceutical composition

Prior art date

2017-01-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 108060003393 Granulin Proteins 0.000 claims 9
• 230000037430 deletion Effects 0.000 claims 8
• 238000012217 deletion Methods 0.000 claims 8
• 230000028993 immune response Effects 0.000 claims 7
• 108090000623 proteins and genes Proteins 0.000 claims 7
• 239000012634 fragment Substances 0.000 claims 5
• 108090000288 Glycoproteins Proteins 0.000 claims 4
• 102000003886 Glycoproteins Human genes 0.000 claims 4
• 102100034256 Mucin-1 Human genes 0.000 claims 4
• 108010008707 Mucin-1 Proteins 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 108020004705 Codon Proteins 0.000 claims 2
• 241001115401 Marburgvirus Species 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 230000003834 intracellular effect Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 230000003472 neutralizing effect Effects 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 230000037432 silent mutation Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 1
• 230000024932 T cell mediated immunity Effects 0.000 claims 1
• 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229920001519 homopolymer Polymers 0.000 claims 1
• 230000028996 humoral immune response Effects 0.000 claims 1
• 230000006698 induction Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000007912 intraperitoneal administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 230000021633 leukocyte mediated immunity Effects 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000003248 secreting effect Effects 0.000 claims 1
• 230000001629 suppression Effects 0.000 claims 1
• 238000013518 transcription Methods 0.000 claims 1
• 230000035897 transcription Effects 0.000 claims 1
• 208000007089 vaccinia Diseases 0.000 claims 1