JP2014158493A5 - - Google Patents

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JP2014158493A5
JP2014158493A5 JP2014089510A JP2014089510A JP2014158493A5 JP 2014158493 A5 JP2014158493 A5 JP 2014158493A5 JP 2014089510 A JP2014089510 A JP 2014089510A JP 2014089510 A JP2014089510 A JP 2014089510A JP 2014158493 A5 JP2014158493 A5 JP 2014158493A5
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detection system
nanochannel
polymer
signal
gradient
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JP2014089510A 2006-07-19 2014-04-23 ナノノズル装置アレイ:その作製および高分子分析における利用 Active JP6030599B2 (ja)

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US83177206P 2006-07-19 2006-07-19
US60/831,772 2006-07-19
US90858407P 2007-03-28 2007-03-28
US90858207P 2007-03-28 2007-03-28
US60/908,582 2007-03-28
US60/908,584 2007-03-28

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JP2014158493A JP2014158493A (ja) 2014-09-04
JP2014158493A5 true JP2014158493A5 (enExample) 2014-12-18
JP6030599B2 JP6030599B2 (ja) 2016-11-24

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JP2014089510A Active JP6030599B2 (ja) 2006-07-19 2014-04-23 ナノノズル装置アレイ:その作製および高分子分析における利用

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US (5) US9061901B2 (enExample)
EP (2) EP3978121A1 (enExample)
JP (2) JP2010510476A (enExample)
CN (1) CN103203256B (enExample)
AU (1) AU2007338862B2 (enExample)
CA (1) CA2658122C (enExample)
SG (1) SG173398A1 (enExample)
WO (1) WO2008079169A2 (enExample)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3978121A1 (en) 2006-07-19 2022-04-06 BioNano Genomics, Inc. Nanonozzle device arrays: their preparation and use for macromolecular analysis
US8722327B2 (en) 2007-03-28 2014-05-13 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
US8278047B2 (en) 2007-10-01 2012-10-02 Nabsys, Inc. Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment
WO2009046445A1 (en) * 2007-10-04 2009-04-09 Halcyon Molecular Sequencing nucleic acid polymers with electron microscopy
US8628919B2 (en) 2008-06-30 2014-01-14 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
EP2321429B1 (en) 2008-09-03 2016-08-17 Quantumdx Group Limited Methods and kits for nucleic acid sequencing
US8882980B2 (en) 2008-09-03 2014-11-11 Nabsys, Inc. Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
JP5822726B2 (ja) 2008-09-03 2015-11-24 クワンタムディーエックス・グループ・リミテッド 電荷量タグを含む合成ヌクレオチドのデザイン、合成及び使用
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US10759824B2 (en) 2008-09-03 2020-09-01 Quantumdx Group Limited Design, synthesis and use of synthetic nucleotides comprising charge mass tags
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
WO2010042007A1 (en) * 2008-10-10 2010-04-15 Jonas Tegenfeldt Method for the mapping of the local at/gc ratio along dna
JP5846703B2 (ja) 2008-11-18 2016-01-20 バイオナノ ジェノミックス、インク. ポリヌクレオチドのマッピング及び配列決定
US8394584B2 (en) * 2008-12-19 2013-03-12 The Board Of Trustees Of The University Of Illinois Detecting and sorting methylated DNA using a synthetic nanopore
KR101383004B1 (ko) 2009-12-02 2014-04-08 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 유로 디바이스 및 그것을 포함하는 샘플 처리 장치
US8748091B2 (en) 2009-12-18 2014-06-10 The Board Of Trustees Of The University Of Illinois Characterizing stretched polynucleotides in a synthetic nanopassage
US20120052188A1 (en) 2010-02-08 2012-03-01 Genia Technologies, Inc. Systems and methods for assembling a lipid bilayer on a substantially planar solid surface
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
WO2011108540A1 (ja) 2010-03-03 2011-09-09 国立大学法人大阪大学 ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
US9422154B2 (en) 2010-11-02 2016-08-23 International Business Machines Corporation Feedback control of dimensions in nanopore and nanofluidic devices
US8859201B2 (en) 2010-11-16 2014-10-14 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
US8962242B2 (en) * 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US11274341B2 (en) 2011-02-11 2022-03-15 NABsys, 2.0 LLC Assay methods using DNA binding proteins
KR101203292B1 (ko) 2011-05-13 2012-11-20 이상현 나노 미세 기공의 가공방법
JP2013042681A (ja) * 2011-08-23 2013-03-04 Kyocer Slc Technologies Corp 遺伝子解析用配線基板
WO2013039778A2 (en) 2011-09-12 2013-03-21 The University Of North Carolina At Chapel Hill Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods
EP2812708B1 (en) * 2012-02-10 2019-09-04 The University of North Carolina At Chapel Hill Method of analysing an analyte with fluidic nanofunnels
US9718668B2 (en) 2012-02-16 2017-08-01 Board Of Trustees Of The University Of Arkansas Method of fabricating a nanochannel system for DNA sequencing and nanoparticle characterization
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
US8969827B2 (en) * 2012-07-09 2015-03-03 Materials Analysis Technology (Us) Corp. Specimen preparation for transmission electron microscopy
JP6276182B2 (ja) 2012-08-17 2018-02-07 クオンタムバイオシステムズ株式会社 試料の分析方法
WO2014036265A2 (en) * 2012-08-30 2014-03-06 Atfi Transport of liquids and solute materials in nanochannels
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
US9791453B2 (en) 2012-12-26 2017-10-17 International Business Machines Corporation Methods for determining binding capability of target ligands with G protein-coupled receptors using translocation through nanochannels
US8835362B2 (en) 2012-12-26 2014-09-16 International Business Machines Corporation Modifying single proteins (GPCR), ligands, and nanopore surfaces to create binding-induced molecular changes of protein-ligand complexes detected in nanochannel translocation
US10294516B2 (en) 2013-01-18 2019-05-21 Nabsys 2.0 Llc Enhanced probe binding
CN105143462A (zh) 2013-02-05 2015-12-09 生物纳米基因有限公司 用于单分子分析的方法
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
US9687847B1 (en) * 2013-02-13 2017-06-27 University Of South Florida Microfluidic platforms for optical biosensing
CN105229168B (zh) * 2013-02-20 2020-07-17 生物纳米基因有限公司 纳米流体中分子的表征
US10844424B2 (en) 2013-02-20 2020-11-24 Bionano Genomics, Inc. Reduction of bias in genomic coverage measurements
KR20150132125A (ko) 2013-02-28 2015-11-25 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 거대분자의 통제된 포획, 고정, 및 전달을 위한 통합된 부품을 가진 나노유체 장치 및 관련 분석 방법
NZ711033A (en) 2013-03-13 2020-03-27 Univ North Carolina Chapel Hill Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis
US10139390B2 (en) * 2013-06-28 2018-11-27 Hitachi High-Technologies Corporation Analysis device
US20150037787A1 (en) * 2013-07-31 2015-02-05 International Business Machines Corporation Polynucleotide configuration for reliable electrical and optical sensing
RU142580U1 (ru) * 2013-08-02 2014-06-27 Байонано Дженомикс, Инк. Система наноанализа
JP6334118B2 (ja) * 2013-09-24 2018-05-30 クオンタムバイオシステムズ株式会社 単分子識別方法、装置、及びプログラム
CN106104274B (zh) 2013-09-18 2018-05-22 量子生物有限公司 生物分子测序装置、系统和方法
US9303310B2 (en) 2013-10-15 2016-04-05 International Business Machines Corporation Nanofluidic sensor comprising spatially separated functional sensing components
US9255321B2 (en) 2013-10-15 2016-02-09 Globalfoundries Inc. Directed surface functionalization on selected surface areas of topographical features with nanometer resolution
US10024851B2 (en) 2013-10-15 2018-07-17 International Business Machines Corporation Use of disulfide bonds to form a reversible and reusable coating for nanofluidic devices
JP2015077652A (ja) 2013-10-16 2015-04-23 クオンタムバイオシステムズ株式会社 ナノギャップ電極およびその製造方法
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
GB2534737B (en) * 2013-11-08 2020-08-05 Hitachi High Tech Corp DNA transport control device and method for producing same, as well as DNA sequencing device
CN106414767A (zh) * 2014-01-24 2017-02-15 量子生物有限公司 生物分子的测序装置、系统及方法
CN106164295B (zh) 2014-02-25 2020-08-11 生物纳米基因公司 减小基因组覆盖测量中的偏差
US10438811B1 (en) 2014-04-15 2019-10-08 Quantum Biosystems Inc. Methods for forming nano-gap electrodes for use in nanosensors
WO2015170782A1 (en) 2014-05-08 2015-11-12 Osaka University Devices, systems and methods for linearization of polymers
US9921181B2 (en) 2014-06-26 2018-03-20 International Business Machines Corporation Detection of translocation events using graphene-based nanopore assemblies
US9557294B2 (en) 2014-12-19 2017-01-31 Genia Technologies, Inc. Nanopore-based sequencing with varying voltage stimulus
US9863904B2 (en) 2014-12-19 2018-01-09 Genia Technologies, Inc. Nanopore-based sequencing with varying voltage stimulus
KR102292998B1 (ko) * 2015-01-16 2021-08-26 더 리전트 오브 더 유니버시티 오브 캘리포니아 핵산 증폭용 led 구동 플라즈몬 가열 장치
JP6433804B2 (ja) * 2015-02-09 2018-12-05 株式会社東芝 マイクロ分析パッケージ及びパッケージ基板
WO2016182811A1 (en) 2015-05-11 2016-11-17 The University Of North Carolina At Chapel Hill Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis
CN107614675B (zh) * 2015-07-16 2021-08-17 香港科技大学 用于单分子dna分析的纳米通道的动态形成
US10126262B2 (en) * 2015-09-24 2018-11-13 Genia Technologies, Inc. Differential output of analog memories storing nanopore measurement samples
JP2019503174A (ja) 2016-01-04 2019-02-07 クァンタムディーエックス グループ リミテッドQuantumdx Group Limited 電荷量タグを含む合成ヌクレオチドのデザイン、合成、および使用
WO2023114548A1 (en) * 2021-12-17 2023-06-22 Avery Digital Data, Inc. Electronic assembly of long dna molecules
CN115595360A (zh) 2016-04-27 2023-01-13 因美纳剑桥有限公司(Gb) 用于生物分子的测量和测序的系统和方法
US10974244B2 (en) * 2017-01-19 2021-04-13 The Board Of Trustees Of The University Of Alabama Branched nanochannel devices for detection and sorting of nucleic acids
JP6950954B2 (ja) * 2017-12-22 2021-10-13 国立大学法人金沢大学 液体充填方法、sicm用プローブの製造方法、sicm用プローブ及びsicm
US10649098B2 (en) 2018-01-29 2020-05-12 Samsung Electronics Co., Ltd. Light converting nanoparticle, method of making the light converting nanoparticle, and composition and optical film comprising the same
JP2018151397A (ja) * 2018-05-01 2018-09-27 クオンタムバイオシステムズ株式会社 単分子識別方法、装置、及びプログラム
DE102019200929A1 (de) * 2019-01-25 2020-07-30 Robert Bosch Gmbh Verfahren und Vorrichtung zum optischen Erfassen einer Länge eines Makromoleküls
CN111250182B (zh) * 2020-02-11 2021-03-19 北京理工大学 一种高通量微流控电泳筛分芯片及其制备方法、应用方法
US12012329B2 (en) 2020-02-13 2024-06-18 Board Of Trustees Of The University Of Arkansas Carbyne-based sensing device for high spatial resolution in DNA sequencing and biomolecule characterization and method of fabricating the same
US11837302B1 (en) 2020-08-07 2023-12-05 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
US11545213B1 (en) 2020-08-07 2023-01-03 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
EP3984640A1 (en) * 2020-10-16 2022-04-20 Universität Hamburg An autonomous nanofluidic analysis device and a method for the analysis of dna molecules
JP7780783B2 (ja) * 2021-03-04 2025-12-05 国立大学法人大阪大学 デバイス、トンネル電流測定装置、核酸配列読取装置、トンネル電流測定方法、および、核酸配列読取方法
EP4562400A2 (en) * 2022-07-28 2025-06-04 Armonica Technologies, Inc. Polymer sequencing apparatus
EP4639178A1 (en) 2022-12-25 2025-10-29 Bionano Genomics, Inc. Optical genome mapping system
WO2024145268A2 (en) 2022-12-25 2024-07-04 Bionano Genomics, Inc. Optical genome mapping cartridges
EP4639177A1 (en) 2022-12-25 2025-10-29 Bionano Genomics, Inc. Instrumentation of optical genome mapping systems

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147198A (en) 1988-09-15 2000-11-14 New York University Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
US6150089A (en) 1988-09-15 2000-11-21 New York University Method and characterizing polymer molecules or the like
US5720928A (en) 1988-09-15 1998-02-24 New York University Image processing and analysis of individual nucleic acid molecules
JPH02176457A (ja) 1988-09-15 1990-07-09 Carnegie Inst Of Washington パルス志向電気泳動
EP0391674B1 (en) 1989-04-05 1996-03-20 New York University A method for characterising particles
US5079169A (en) 1990-05-22 1992-01-07 The Regents Of The Stanford Leland Junior University Method for optically manipulating polymer filaments
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
JP3123249B2 (ja) 1991-09-10 2001-01-09 株式会社日立製作所 Dna分子の長さ計測方法および計測装置
US5314829A (en) 1992-12-18 1994-05-24 California Institute Of Technology Method for imaging informational biological molecules on a semiconductor substrate
US5427663A (en) * 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US5637458A (en) 1994-07-20 1997-06-10 Sios, Inc. Apparatus and method for the detection and assay of organic molecules
GB9417211D0 (en) 1994-08-25 1994-10-12 Solicitor For The Affairs Of H Nucleotide sequencing method
US8142708B2 (en) 1995-04-03 2012-03-27 Wisconsin Alumni Research Foundation Micro fluidic system for single molecule imaging
US7775368B2 (en) * 1995-04-03 2010-08-17 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
EP0851939A4 (en) 1995-08-30 2001-02-28 New York Medical College METHOD FOR MARKING DNA ENDS WITH HALOGENATED NUCLEOTIDES AND DETECTING THEM WITH ANTIBODIES
US5867266A (en) 1996-04-17 1999-02-02 Cornell Research Foundation, Inc. Multiple optical channels for chemical analysis
FR2755149B1 (fr) * 1996-10-30 1999-01-15 Pasteur Institut Procede de diagnostic de maladies genetiques par peignage moleculaire et coffret de diagnostic
US6403311B1 (en) 1997-02-12 2002-06-11 Us Genomics Methods of analyzing polymers using ordered label strategies
ATE273381T1 (de) 1997-02-12 2004-08-15 Eugene Y Chan Verfahren zur analyse von polymeren
US6117634A (en) 1997-03-05 2000-09-12 The Reagents Of The University Of Michigan Nucleic acid sequencing and mapping
US6197557B1 (en) 1997-03-05 2001-03-06 The Regents Of The University Of Michigan Compositions and methods for analysis of nucleic acids
US20020123063A1 (en) 1997-03-14 2002-09-05 Gjerde Douglas T. Band array display of polynucleotide separations
US6174671B1 (en) 1997-07-02 2001-01-16 Wisconsin Alumni Res Found Genomics via optical mapping ordered restriction maps
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6263286B1 (en) 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
US6790671B1 (en) 1998-08-13 2004-09-14 Princeton University Optically characterizing polymers
US6221592B1 (en) 1998-10-20 2001-04-24 Wisconsin Alumi Research Foundation Computer-based methods and systems for sequencing of individual nucleic acid molecules
US6607888B2 (en) 1998-10-20 2003-08-19 Wisconsin Alumni Research Foundation Method for analyzing nucleic acid reactions
US6438279B1 (en) 1999-01-07 2002-08-20 Cornell Research Foundation, Inc. Unitary microcapiliary and waveguide structure and method of fabrication
EP1157144A4 (en) 1999-01-13 2010-04-28 Cornell Res Foundation Inc MANUFACTURE OF FLUIDER MONOLITHIC STRUCTURES
US20010055764A1 (en) 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
US6635163B1 (en) 1999-06-01 2003-10-21 Cornell Research Foundation, Inc. Entropic trapping and sieving of molecules
US7344627B2 (en) 1999-06-08 2008-03-18 Broadley-James Corporation Reference electrode having a flowing liquid junction and filter members
US6783643B2 (en) 1999-06-22 2004-08-31 President And Fellows Of Harvard College Control of solid state dimensional features
JP2003502166A (ja) 1999-06-22 2003-01-21 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ 固体状態の次元的特徴の制御
US6464842B1 (en) 1999-06-22 2002-10-15 President And Fellows Of Harvard College Control of solid state dimensional features
EP1200474A1 (en) 1999-07-15 2002-05-02 Solvay Pharmaceuticals B.V. Human g-protein coupled receptor
US6762059B2 (en) 1999-08-13 2004-07-13 U.S. Genomics, Inc. Methods and apparatuses for characterization of single polymers
JP2003507026A (ja) * 1999-08-13 2003-02-25 ユー.エス.ジェノミクス,インコーポレーテッド ポリマーを引き伸ばす方法および装置
US6927065B2 (en) 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US7831392B2 (en) 2000-09-28 2010-11-09 Wisconsin Alumni Research Foundation System and process for validating, aligning and reordering one or more genetic sequence maps using at least one ordered restriction map
US7678541B2 (en) 2000-11-21 2010-03-16 Hologic, Inc. Methods and compositions for the detection of a nucleic acid using a non-invasive cleavage reaction
JP4797196B2 (ja) 2001-02-14 2011-10-19 株式会社 フューエンス マイクロチップ
US20020123083A1 (en) * 2001-03-01 2002-09-05 Affymetrix, Inc. Nucleic acid endocing growth factor protein
US7316769B2 (en) 2001-03-19 2008-01-08 Cornell Research Foundation, Inc. Length-dependent recoil separation of long molecules
US20020187508A1 (en) 2001-06-08 2002-12-12 Wong Gordon G. Methods and products for analyzing nucleic acids using nick translation
WO2002101353A2 (en) 2001-06-08 2002-12-19 U.S. Genomics, Inc. Methods and products for analyzing nucleic acids based on methylation status
US20030104428A1 (en) 2001-06-21 2003-06-05 President And Fellows Of Harvard College Method for characterization of nucleic acid molecules
SG169225A1 (en) 2001-07-25 2011-03-30 Univ Princeton Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
JP2005504275A (ja) 2001-09-18 2005-02-10 ユー.エス. ジェノミクス, インコーポレイテッド 高分解能線形解析用のポリマーの差示的タグ付け
WO2003106693A2 (en) 2002-01-01 2003-12-24 Princeton University Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof
US20030215358A1 (en) 2002-01-15 2003-11-20 Schulman Lloyd S. Liquid permeable composition in dry reagent devices
AU2003215391B2 (en) 2002-02-21 2007-05-24 Abbott Diagnostics Scarborough, Inc. Recombinase Polymerase Amplification
US20030162181A1 (en) 2002-02-28 2003-08-28 Eastman Kodak Company DNA sequencing and gene identification
US20030219805A1 (en) 2002-03-13 2003-11-27 Zvi Kelman Detection of alternative and aberrant mRNA splicing
US20040110208A1 (en) 2002-03-26 2004-06-10 Selena Chan Methods and device for DNA sequencing using surface enhanced Raman scattering (SERS)
WO2004016729A2 (en) 2002-08-19 2004-02-26 Bioprocessors Corporation SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS
WO2004048514A2 (en) * 2002-05-09 2004-06-10 U.S. Genomics, Inc. Methods for analyzing a nucleic acid
WO2003095358A2 (en) 2002-05-13 2003-11-20 The Regents Of The University Of Michigan Method of forming manofluidic channels
US7282330B2 (en) 2002-05-28 2007-10-16 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
EP1546380A4 (en) 2002-05-28 2007-02-14 Us Genomics Inc METHODS AND APPARATUSES FOR ANALYZING SIMPLE POLYMERS
US6952651B2 (en) 2002-06-17 2005-10-04 Intel Corporation Methods and apparatus for nucleic acid sequencing by signal stretching and data integration
EP1552013A1 (en) 2002-07-26 2005-07-13 Applera Corporation Microfluidic device including purification column with excess diluent, and method
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
US7312033B2 (en) 2002-11-14 2007-12-25 Third Wave Technologies, Inc. CFTR allele detection assays
US20050250117A1 (en) 2003-10-07 2005-11-10 Xing Su Isolation of single polymeric molecules
GB0324456D0 (en) 2003-10-20 2003-11-19 Isis Innovation Parallel DNA sequencing methods
US20050208538A1 (en) 2003-12-29 2005-09-22 Nurith Kurn Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
US8271251B2 (en) 2004-02-09 2012-09-18 Wisconsin Alumni Research Foundation Automated imaging system for single molecules
US20060014181A1 (en) 2004-06-07 2006-01-19 California Institute Of Technology Detection of DNA mismatches and oxidative lesions
WO2006017274A2 (en) 2004-07-13 2006-02-16 U.S. Genomics, Inc. Systems and methods for sample modification using fluidic chambers
US7511285B2 (en) * 2004-07-16 2009-03-31 The Charles Stark Draper Laboratory, Inc. Methods and apparatus for biomolecule identification
US7351538B2 (en) 2004-08-23 2008-04-01 U.S. Genomics Systems and methods for detecting and analyzing polymers
US20060073489A1 (en) * 2004-10-05 2006-04-06 Gangqiang Li Nanopore separation devices and methods of using same
WO2006098772A2 (en) 2004-10-13 2006-09-21 U.S. Genomics, Inc. Systems and methods for measurement optimization
US20060199202A1 (en) 2005-02-09 2006-09-07 Third Wave Technologies, Inc. Detection of allelic expression imbalance
US20060228734A1 (en) 2005-03-18 2006-10-12 Applera Corporation Fluid processing device with captured reagent beads
US20060275806A1 (en) 2005-05-11 2006-12-07 Schwartz David C Whole genome methylation profiles via single molecule analysis
US20060275911A1 (en) 2005-06-03 2006-12-07 Shih-Yuan Wang Method and apparatus for moleclular analysis using nanostructure-enhanced Raman spectroscopy
US20070128083A1 (en) 2005-07-18 2007-06-07 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
US7960105B2 (en) * 2005-11-29 2011-06-14 National Institutes Of Health Method of DNA analysis using micro/nanochannel
EP3978121A1 (en) 2006-07-19 2022-04-06 BioNano Genomics, Inc. Nanonozzle device arrays: their preparation and use for macromolecular analysis
US8722327B2 (en) 2007-03-28 2014-05-13 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
EP2179285A4 (en) 2007-08-15 2010-08-18 Opgen Inc METHOD, SYSTEM AND SOFTWARE ARRANGEMENT FOR COMPARATIVE ANALYSIS AND PHYLOGENIA WITH OPTICAL TOTAL GENERIC CARD
EP2207901B1 (en) 2007-10-17 2018-07-25 Wisconsin Alumni Research Foundation Methods of whole genome analysis
US7771944B2 (en) 2007-12-14 2010-08-10 The Board Of Trustees Of The University Of Illinois Methods for determining genetic haplotypes and DNA mapping
US20090208950A1 (en) 2008-02-19 2009-08-20 Opgen, Inc. Methods of identifying an organism from a heterogeneous sample
US20090317804A1 (en) 2008-02-19 2009-12-24 Opgen Inc. Methods of determining antibiotic resistance
EP2107040B1 (en) 2008-03-31 2011-10-26 Sony Deutschland Gmbh A method of fabricating a membrane having a tapered pore
EP2288725A4 (en) 2008-05-14 2012-03-21 Opgen Inc METHOD FOR DETERMINING MOLECULE PROPERTIES
WO2011050147A1 (en) 2009-10-21 2011-04-28 Bionanomatrix, Inc . Methods and related devices for single molecule whole genome analysis
US8628919B2 (en) 2008-06-30 2014-01-14 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
US8835110B2 (en) 2008-11-04 2014-09-16 The Johns Hopkins University DNA integrity assay (DIA) for cancer diagnostics, using confocal fluorescence spectroscopy
JP5846703B2 (ja) 2008-11-18 2016-01-20 バイオナノ ジェノミックス、インク. ポリヌクレオチドのマッピング及び配列決定
SG10201508373UA (en) 2010-10-20 2015-11-27 Bionano Genomics Inc Systems and methods for assessing biomolecule characteristics
US9568425B2 (en) 2011-02-01 2017-02-14 Dna Medicine Institute, Inc. Multicoded analytical nanostrips
CN105143462A (zh) 2013-02-05 2015-12-09 生物纳米基因有限公司 用于单分子分析的方法

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