JP2013545489A5 - - Google Patents
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- Publication number
- JP2013545489A5 JP2013545489A5 JP2013543905A JP2013543905A JP2013545489A5 JP 2013545489 A5 JP2013545489 A5 JP 2013545489A5 JP 2013543905 A JP2013543905 A JP 2013543905A JP 2013543905 A JP2013543905 A JP 2013543905A JP 2013545489 A5 JP2013545489 A5 JP 2013545489A5
- Authority
- JP
- Japan
- Prior art keywords
- culture medium
- cell culture
- item
- lipid
- trace mineral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006143 cell culture medium Substances 0.000 claims description 27
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 12
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims description 10
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 10
- 239000000758 substrate Substances 0.000 claims description 9
- 150000002632 lipids Chemical class 0.000 claims description 8
- 239000011573 trace mineral Substances 0.000 claims description 8
- 235000013619 trace mineral Nutrition 0.000 claims description 8
- 102000004877 Insulin Human genes 0.000 claims description 6
- 108090001061 Insulin Proteins 0.000 claims description 6
- 229940125396 insulin Drugs 0.000 claims description 6
- 239000003102 growth factor Substances 0.000 claims description 5
- 102000009027 Albumins Human genes 0.000 claims description 4
- 108010088751 Albumins Proteins 0.000 claims description 4
- 102000004338 Transferrin Human genes 0.000 claims description 4
- 108090000901 Transferrin Proteins 0.000 claims description 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims description 4
- 239000012581 transferrin Substances 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 3
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 3
- 102000000905 Cadherin Human genes 0.000 claims description 2
- 108050007957 Cadherin Proteins 0.000 claims description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 2
- 229930182816 L-glutamine Natural products 0.000 claims description 2
- HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 claims description 2
- 229940050528 albumin Drugs 0.000 claims description 2
- 239000003797 essential amino acid Substances 0.000 claims description 2
- 235000020776 essential amino acid Nutrition 0.000 claims description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 2
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 claims description 2
- 229940073577 lithium chloride Drugs 0.000 claims description 2
- 210000000130 stem cell Anatomy 0.000 claims description 2
- 108010038862 laminin 10 Proteins 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424273P | 2010-12-17 | 2010-12-17 | |
| US61/424,273 | 2010-12-17 | ||
| US201161488353P | 2011-05-20 | 2011-05-20 | |
| US61/488,353 | 2011-05-20 | ||
| US201161533063P | 2011-09-09 | 2011-09-09 | |
| US61/533,063 | 2011-09-09 | ||
| US201161537940P | 2011-09-22 | 2011-09-22 | |
| US61/537,940 | 2011-09-22 | ||
| US201161565380P | 2011-11-30 | 2011-11-30 | |
| US61/565,380 | 2011-11-30 | ||
| US201161565849P | 2011-12-01 | 2011-12-01 | |
| US61/565,849 | 2011-12-01 | ||
| PCT/IB2011/003265 WO2012080844A1 (en) | 2010-12-17 | 2011-12-16 | Cell culture medium |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013545489A JP2013545489A (ja) | 2013-12-26 |
| JP2013545489A5 true JP2013545489A5 (cg-RX-API-DMAC7.html) | 2015-02-05 |
| JP6002675B2 JP6002675B2 (ja) | 2016-10-05 |
Family
ID=45755415
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543905A Active JP6002675B2 (ja) | 2010-12-17 | 2011-12-16 | 細胞培養培地 |
| JP2013543904A Active JP5990531B2 (ja) | 2010-12-17 | 2011-12-16 | 組換えラミニン−５２１ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543904A Active JP5990531B2 (ja) | 2010-12-17 | 2011-12-16 | 組換えラミニン−５２１ |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10138292B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2651973B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6002675B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR101921350B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103384680B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011342904B2 (cg-RX-API-DMAC7.html) |
| BR (2) | BR112013017632A2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2826252C (cg-RX-API-DMAC7.html) |
| IL (2) | IL226971B (cg-RX-API-DMAC7.html) |
| MX (2) | MX345861B (cg-RX-API-DMAC7.html) |
| SG (3) | SG191216A1 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2012080844A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2203176B1 (en) | 2007-09-28 | 2014-11-26 | Anthrogenesis Corporation | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| IL281453B (en) | 2009-11-17 | 2022-07-01 | Astellas Inst For Regenerative Medicine | Methods for preparing human rpe cells and pharmaceutical preparations of human rpe cells |
| MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
| KR101921350B1 (ko) * | 2010-12-17 | 2018-11-22 | 바이오라미나 에이비 | 인간 다능성 줄기세포를 유지하기 위한 시스템 |
| CN104364263B (zh) * | 2011-09-22 | 2018-06-29 | 卡尔·特吕格瓦松 | 含有层粘连蛋白和钙粘蛋白的细胞培养基底 |
| US9828630B2 (en) | 2011-11-30 | 2017-11-28 | Biolamina Ab | Methods of enhancing genetic diagnosis |
| WO2013156855A1 (en) | 2012-04-20 | 2013-10-24 | Biolamina Ab | Maintenance of differentiated cells with laminins |
| US20130330825A1 (en) * | 2012-06-07 | 2013-12-12 | City Of Hope | Attachment substrates for directed differentiation of human embryonic stem cells in culture |
| WO2014037807A2 (en) * | 2012-09-07 | 2014-03-13 | Biolamina Ab | Stem cell bank |
| HUE038620T2 (hu) | 2012-12-03 | 2018-10-29 | Biolamina Ab | Eljárások RPE sejtek elõállítására |
| EP3622960A1 (en) | 2013-02-05 | 2020-03-18 | Celularity, Inc. | Natural killer cells from placenta |
| EP3546568A3 (en) * | 2013-07-02 | 2019-10-23 | National University of Singapore | Differentiation of pluripotent stem cells and cardiac progenitor cells into striated cardiomyocyte fibers using laminins ln-511, ln-521 and ln-221 |
| US12680078B2 (en) | 2013-07-02 | 2026-07-14 | National University Of Singapore | Differentiation of pluripotent stem cells and cardiac progenitor cells into striated cardiomyocyte fibers using laminins LN-511, LN-521 and LN-221 |
| DK3064572T3 (da) * | 2013-11-01 | 2020-05-04 | Bbhc Co Ltd | Fremgangsmåde til fremstilling af inducerede pluripotente stamceller fra mesenchymale stamceller og inducerede pluripotente stamceller produceret ved fremgangsmåden |
| BR112016011096A2 (pt) | 2013-11-27 | 2017-09-19 | Kyoto Prefectural Public Univ Corp | Aplicação de laminina à cultura de célula endotelial da córnea |
| JP6770435B2 (ja) | 2014-10-31 | 2020-10-14 | 京都府公立大学法人 | ラミニンによる網膜および神経の新規治療 |
| MX387839B (es) * | 2014-10-31 | 2025-03-04 | Senju Pharma Co | Laminina para usarse en el tratamiento de una enfermedad, un trastorno o una afección de un endotelio de córnea. |
| SMT201900005T1 (it) * | 2015-02-20 | 2019-05-10 | Inst Nat Sante Rech Med | Uso di una laminina per la differenziazione di cellule pluripotenti in cellule di lignaggio epatocitario |
| WO2017034459A1 (en) * | 2015-08-23 | 2017-03-02 | Diamyd Medical Ab | New use |
| US10683486B2 (en) * | 2015-10-30 | 2020-06-16 | Biolamina Ab | Methods for producing hepatocytes |
| JP6605618B2 (ja) * | 2015-11-10 | 2019-11-20 | 日機装株式会社 | 細胞支持複合体および細胞支持複合体の製造方法 |
| CA3019514A1 (en) | 2016-03-30 | 2017-10-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| US20190211305A1 (en) * | 2016-08-25 | 2019-07-11 | Kyoto University | Method for Culturing Pluripotent Stem Cells on Specific Laminin |
| WO2018090084A1 (en) * | 2016-11-16 | 2018-05-24 | Cynata Therapeutics Limited | Pluripotent stem cell assay |
| CN106591295B (zh) * | 2016-12-31 | 2019-10-25 | 贵州北科生物科技有限公司 | 一种多功能干细胞培养方法及所用培养基 |
| AU2018262323A1 (en) | 2017-05-05 | 2019-11-21 | National University Of Singapore | Methods for culturing human keratinocytes |
| AU2019342741B2 (en) | 2018-09-19 | 2025-12-11 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| AU2020210757B2 (en) * | 2019-01-23 | 2026-04-16 | Asterias Biotherapeutics, Inc. | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
| CN111621473A (zh) * | 2019-04-03 | 2020-09-04 | 成熙(上海)生物科技有限公司 | 一种新型人源脂肪干细胞制剂的制备方法 |
| CN111617105A (zh) * | 2019-04-03 | 2020-09-04 | 成熙(上海)生物科技有限公司 | 一种脂肪干细胞多细胞活性因子冻干粉的制备方法 |
| WO2021233116A1 (zh) * | 2020-05-21 | 2021-11-25 | 北京大学 | 多能干细胞的成分明确、无异源的培养系统 |
| CN111569048B (zh) * | 2020-05-22 | 2023-04-18 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | LamG5肽在制备修复睾丸中支持细胞损伤的药物中的应用 |
| WO2025067551A1 (zh) * | 2024-05-16 | 2025-04-03 | 北京百普赛斯生物科技股份有限公司 | 活性增强的改造型Laminin 521蛋白及应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7005252B1 (en) * | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| PT1572984E (pt) * | 2002-12-16 | 2016-06-03 | Technion Res & Dev Foundation | Sistema de cultura para células estaminais embrionárias humanas sem células alimentadoras e sem xeno |
| BRPI0514778B1 (pt) * | 2004-09-08 | 2018-07-10 | Wisconsin Alumni Research Foundation | Meio para cultivar células tronco embrionárias |
| JP2006087396A (ja) | 2004-09-27 | 2006-04-06 | National Institute For Environmental Studies | 細胞培養基質及びその製造方法 |
| WO2007058401A1 (en) * | 2005-11-18 | 2007-05-24 | Imgen Co., Ltd. | Composition comprising okadaic acid for undifferentiated proliferation of embryonic stem cells |
| EP2420565B1 (en) * | 2006-02-23 | 2017-08-30 | ViaCyte, Inc. | Compositions and methods useful for culturing differentiable cells |
| US10829733B2 (en) | 2007-01-04 | 2020-11-10 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent human stem cells |
| US8951799B2 (en) * | 2007-01-04 | 2015-02-10 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent stem cells |
| CN101605885B (zh) * | 2007-01-04 | 2013-03-27 | 卡尔·特吕格瓦松 | 能够使多能干细胞增殖的组合物及方法 |
| EP2559756B1 (en) | 2007-07-01 | 2019-12-18 | Janssen Biotech, Inc. | Single pluripotent stem cell culture |
| JP5951254B2 (ja) * | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| CN102131919B (zh) * | 2008-03-31 | 2017-05-03 | 东方酵母工业株式会社 | 一种增殖多能性干细胞的方法 |
| WO2010005995A1 (en) | 2008-07-07 | 2010-01-14 | Mass Institute Of Technology | Micropatterned co-culture systems as infectious disease analysis platforms |
| WO2010137746A1 (en) | 2009-05-29 | 2010-12-02 | Kyoto University | Method for producing induced pluripotent stem cells and method for culturing the same |
| JP5700301B2 (ja) * | 2009-06-03 | 2015-04-15 | 国立大学法人大阪大学 | 多能性幹細胞からの神経堤細胞群の分化誘導方法 |
| CA2707296A1 (en) | 2009-06-12 | 2010-12-12 | Richard T. Scott, Jr. | Method for relative quantitation of chromosomal dna copy number in a single or few cells |
| KR101921350B1 (ko) | 2010-12-17 | 2018-11-22 | 바이오라미나 에이비 | 인간 다능성 줄기세포를 유지하기 위한 시스템 |
-
2011
- 2011-12-16 KR KR1020137018840A patent/KR101921350B1/ko active Active
- 2011-12-16 MX MX2013006959A patent/MX345861B/es active IP Right Grant
- 2011-12-16 SG SG2013046727A patent/SG191216A1/en unknown
- 2011-12-16 CN CN201180067656.XA patent/CN103384680B/zh active Active
- 2011-12-16 AU AU2011342904A patent/AU2011342904B2/en active Active
- 2011-12-16 JP JP2013543905A patent/JP6002675B2/ja active Active
- 2011-12-16 MX MX2013006958A patent/MX343462B/es active IP Right Grant
- 2011-12-16 US US13/328,156 patent/US10138292B2/en active Active
- 2011-12-16 CN CN201180067474.2A patent/CN103384679B/zh active Active
- 2011-12-16 CA CA2826252A patent/CA2826252C/en active Active
- 2011-12-16 SG SG10201510405PA patent/SG10201510405PA/en unknown
- 2011-12-16 US US13/328,145 patent/US8415156B2/en active Active
- 2011-12-16 BR BR112013017632A patent/BR112013017632A2/pt not_active Application Discontinuation
- 2011-12-16 EP EP11820800.8A patent/EP2651973B1/en active Active
- 2011-12-16 SG SG2013046701A patent/SG191215A1/en unknown
- 2011-12-16 WO PCT/IB2011/003265 patent/WO2012080844A1/en not_active Ceased
- 2011-12-16 CA CA2828794A patent/CA2828794C/en active Active
- 2011-12-16 KR KR1020197003578A patent/KR101966033B1/ko active Active
- 2011-12-16 BR BR112013017629A patent/BR112013017629A2/pt not_active Application Discontinuation
- 2011-12-16 WO PCT/IB2011/003258 patent/WO2012080842A1/en not_active Ceased
- 2011-12-16 KR KR1020137018841A patent/KR20140012047A/ko not_active Abandoned
- 2011-12-16 JP JP2013543904A patent/JP5990531B2/ja active Active
- 2011-12-16 EP EP11820801.6A patent/EP2651974B1/en active Active
-
2013
- 2013-06-16 IL IL226971A patent/IL226971B/en active IP Right Grant
-
2019
- 2019-10-26 IL IL270186A patent/IL270186B/en active IP Right Grant
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