JP2013540734A5 - - Google Patents

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JP2013540734A5
JP2013540734A5 JP2013528366A JP2013528366A JP2013540734A5 JP 2013540734 A5 JP2013540734 A5 JP 2013540734A5 JP 2013528366 A JP2013528366 A JP 2013528366A JP 2013528366 A JP2013528366 A JP 2013528366A JP 2013540734 A5 JP2013540734 A5 JP 2013540734A5
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mll
romidepsin
pharmaceutical composition
composition
dose
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JP2013528366A
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JP5948332B2 (ja
JP2013540734A (ja
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Priority claimed from PCT/US2011/051173 external-priority patent/WO2012037008A2/en
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Figure 2013540734

Claims (14)

  1. ロミデプシンを含む、MLL再構成急性リンパ性白血病(ALL)の治療に使用するための医薬組成物。
  2. 前記ロミデプシンが、約0.5mg/m2から約28mg/m2の範囲の用量、若しくは約5mg/m2から約15mg/m2の範囲、若しくは約8mg/m2の用量、若しくは約10mg/m2の用量、若しくは約12mg/m2の用量、若しくは約14mg/m2の用量での静脈内投与に適したものであり、4時間かけて注入される、請求項１記載の医薬組成物。
  3. 28日周期の第1、8、及び15日に投与され、該周期が28日毎に繰り返される、請求項２記載の医薬組成物。
  4. 前記ロミデプシンが、約1mg/m2から約300mg/m2の範囲の用量、若しくは約15mg/m2から約100mg/m2の範囲の用量、若しくは25mg/m2から約75mg/m2の範囲の用量での経口投与に適したものである、請求項１記載の医薬組成物。
  5. 前記MLL再構成ALLが、MLL再構成乳児ALLである、請求項１記載の医薬組成物。
  6. 細胞をロミデプシンと接触させることにより細胞を処理するための組成物であって、該ロミデプシンの濃度が、該細胞の成長を阻害するか又は該細胞を死滅させるのに十分なものであり、該細胞が、MLL再構成ALL細胞である、前記組成物。
  7. 前記細胞が、MLL再構成乳児ALL細胞株である、請求項６記載の組成物。
  8. 前記細胞株が、SEM又はRS4:11細胞株である、請求項７記載の組成物。
  9. 前記ロミデプシンの濃度が、約0.01nMから500nMの範囲であるか、又は約0.1nMから100nMの範囲であるか、又は約1nMから5nMの範囲である、請求項６記載の組成物。
  10. 前記細胞が、MLL再構成乳児ALL細胞である、請求項６記載の組成物。
  11. MLL再構成乳児ALLの治療に使用するための医薬組成物であって、こうした治療を必要とする患者に、28日周期の第1、8、及び15日に、4時間かけて静脈内注入することによって、14mg/m2の用量で投与されることに適したものであり、該周期が、28日毎に繰り返される、前記医薬組成物。
  12. ロミデプシン及び医薬として許容し得る担体、賦形剤又は希釈剤を含む、MLL再構成ALLを治療するための医薬組成物。
  13. ロミデプシン又はその医薬組成物を装入した1以上の容器を含む、MLL再構成ALLを治療するためのキット。
  14. 前記MLL再構成ALLが、MLL再構成乳児ALLである、請求項１３記載のキット。
JP2013528366A 2010-09-13 2011-09-12 Ｍｌｌ再構成白血病の治療法 Active JP5948332B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38245910P 2010-09-13 2010-09-13
US61/382,459 2010-09-13
PCT/US2011/051173 WO2012037008A2 (en) 2010-09-13 2011-09-12 Therapy for mll-rearranged leukemia

Publications (3)

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JP2013540734A JP2013540734A (ja) 2013-11-07
JP2013540734A5 true JP2013540734A5 (ja) 2015-01-08
JP5948332B2 JP5948332B2 (ja) 2016-07-06

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JP2013528366A Active JP5948332B2 (ja) 2010-09-13 2011-09-12 Ｍｌｌ再構成白血病の治療法

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US (1) US8859502B2 (ja)
EP (1) EP2616054A2 (ja)
JP (1) JP5948332B2 (ja)
WO (1) WO2012037008A2 (ja)

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