JP2013540423A5 - - Google Patents
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- JP2013540423A5 JP2013540423A5 JP2013519840A JP2013519840A JP2013540423A5 JP 2013540423 A5 JP2013540423 A5 JP 2013540423A5 JP 2013519840 A JP2013519840 A JP 2013519840A JP 2013519840 A JP2013519840 A JP 2013519840A JP 2013540423 A5 JP2013540423 A5 JP 2013540423A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- probe
- nanopore
- sample
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39957810P | 2010-07-14 | 2010-07-14 | |
| US61/399,578 | 2010-07-14 | ||
| PCT/US2011/044082 WO2012009578A2 (en) | 2010-07-14 | 2011-07-14 | Nanopore-facilitated single molecule detection of nucleic acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154002A Division JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540423A JP2013540423A (ja) | 2013-11-07 |
| JP2013540423A5 true JP2013540423A5 (enExample) | 2014-09-04 |
| JP6016792B2 JP6016792B2 (ja) | 2016-10-26 |
Family
ID=45470088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013519840A Active JP6016792B2 (ja) | 2010-07-14 | 2011-07-14 | ナノポア促進型の核酸の単分子検出 |
| JP2016154002A Active JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154002A Active JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9395353B2 (enExample) |
| EP (2) | EP2593568B1 (enExample) |
| JP (2) | JP6016792B2 (enExample) |
| AU (1) | AU2011279083B2 (enExample) |
| CA (1) | CA2805247C (enExample) |
| WO (1) | WO2012009578A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8889348B2 (en) | 2006-06-07 | 2014-11-18 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by nanopore using modified nucleotides |
| US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
| US9194838B2 (en) | 2010-03-03 | 2015-11-24 | Osaka University | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
| AU2011279083B2 (en) | 2010-07-14 | 2015-03-26 | The Curators Of The University Of Missouri | Nanopore-facilitated single molecule detection of nucleic acids |
| WO2012083249A2 (en) | 2010-12-17 | 2012-06-21 | The Trustees Of Columbia University In The City Of New York | Dna sequencing by synthesis using modified nucleotides and nanopore detection |
| US9121059B2 (en) | 2010-12-22 | 2015-09-01 | Genia Technologies, Inc. | Nanopore-based single molecule characterization |
| US8962242B2 (en) | 2011-01-24 | 2015-02-24 | Genia Technologies, Inc. | System for detecting electrical properties of a molecular complex |
| US9110478B2 (en) | 2011-01-27 | 2015-08-18 | Genia Technologies, Inc. | Temperature regulation of measurement arrays |
| EP2807476A4 (en) * | 2012-01-20 | 2015-12-09 | Genia Technologies Inc | DETECTION AND SEQUENCING OF MOLECULES ON NANOPORENE BASE |
| US10739341B2 (en) | 2012-02-15 | 2020-08-11 | Oxford Nanopore Technologies Limited | Aptamer method |
| US9850534B2 (en) * | 2012-02-16 | 2017-12-26 | Genia Technologies, Inc. | Methods for creating bilayers for use with nanopore sensors |
| US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
| CA2869753A1 (en) | 2012-04-09 | 2013-10-17 | Jingyue Ju | Method of preparation of nanopore and uses thereof |
| EP2861768A4 (en) | 2012-06-15 | 2016-03-02 | Genia Technologies Inc | CHIP SETUP AND HIGH ACCURACY NUCLEIC ACID SEQUENCING |
| DK3511424T5 (da) | 2012-08-03 | 2024-05-27 | Univ Washington Through Its Center For Commercialization | Compositions and methods for improving nanopore sequencing |
| WO2014041337A1 (en) | 2012-09-14 | 2014-03-20 | Oxford Nanopore Technologies Limited | Sample preparation method |
| US9995728B2 (en) | 2012-11-06 | 2018-06-12 | Oxford Nanopore Technologies Ltd. | Quadruplex method |
| US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
| GB201318465D0 (en) * | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| US10648026B2 (en) | 2013-03-15 | 2020-05-12 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
| CN105102627B (zh) | 2013-03-15 | 2018-10-19 | 纽约哥伦比亚大学理事会 | 用于检测样品中多种预定化合物的方法 |
| AU2014227754B2 (en) | 2013-03-15 | 2018-03-01 | The Curators Of The University Of Missouri | Encoded nanopore sensor for multiplex nucleic acids detection |
| US10048245B2 (en) | 2013-06-25 | 2018-08-14 | Two Pore Guys, Inc. | Multiplexed biomarker quantitation by nanopore analysis of biomarker-polymer complexes |
| KR20160079780A (ko) | 2013-09-18 | 2016-07-06 | 퀀텀 바이오시스템즈 가부시키가이샤 | 생체분자를 서열화하는 디바이스들, 시스템들 및 방법들 |
| JP6334118B2 (ja) * | 2013-09-24 | 2018-05-30 | クオンタムバイオシステムズ株式会社 | 単分子識別方法、装置、及びプログラム |
| JP2015077652A (ja) | 2013-10-16 | 2015-04-23 | クオンタムバイオシステムズ株式会社 | ナノギャップ電極およびその製造方法 |
| US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
| EP3060918B1 (en) | 2013-10-23 | 2019-09-18 | Genia Technologies, Inc. | High speed molecular sensing with nanopores |
| US9567630B2 (en) | 2013-10-23 | 2017-02-14 | Genia Technologies, Inc. | Methods for forming lipid bilayers on biochips |
| CA2943952A1 (en) | 2014-03-24 | 2015-10-01 | The Trustees Of Columbia University In The City Of New York | Chemical methods for producing tagged nucleotides |
| US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
| WO2015170782A1 (en) | 2014-05-08 | 2015-11-12 | Osaka University | Devices, systems and methods for linearization of polymers |
| WO2016019030A1 (en) * | 2014-07-31 | 2016-02-04 | Illumina, Inc. | Hybrid nanopore sensors |
| CN120666008A (zh) * | 2014-10-16 | 2025-09-19 | 牛津楠路珀尔科技股份有限公司 | 聚合物的分析 |
| CN107109489B (zh) | 2014-10-17 | 2021-11-30 | 牛津纳米孔技术公司 | 纳米孔rna表征方法 |
| CN105842453B (zh) * | 2015-01-12 | 2018-12-25 | 南京理工大学 | 一种基于末端延伸、金纳米粒子和酶三级放大电化学传感器检测dna的方法 |
| AU2016271384A1 (en) | 2015-06-02 | 2018-01-18 | Nanopore Diagnostics, Llc | Nucleic acid detection |
| CN108137656A (zh) * | 2015-09-24 | 2018-06-08 | 豪夫迈·罗氏有限公司 | α-溶血素变体 |
| WO2017167811A1 (en) * | 2016-03-31 | 2017-10-05 | Genia Technologies, Inc. | Nanopore protein conjugates and uses thereof |
| ES2877193T3 (es) | 2016-04-27 | 2021-11-16 | Quantum Biosystems Inc | Sistemas y métodos para la medición y secuenciación de biomoléculas |
| US11124827B2 (en) | 2016-06-23 | 2021-09-21 | Roche Sequencing Solutions, Inc. | Period-to-period analysis of AC signals from nanopore sequencing |
| US10317392B2 (en) | 2016-06-23 | 2019-06-11 | Roche Sequencing Solutions, Inc. | Formation and calibration of nanopore sequencing cells |
| ES2843099T3 (es) * | 2016-07-12 | 2021-07-15 | Univ Groningen | Nanoporos biológicos para la detección y la secuenciación de biopolímeros basados en la actinoporina FraC |
| WO2018093976A1 (en) * | 2016-11-16 | 2018-05-24 | Nanopore Diagnostics, Llc | Analysis of nucleic acids using probe with non-linear tag |
| EP4265733A1 (en) * | 2017-07-17 | 2023-10-25 | President and Fellows of Harvard College | Analysis of nanopore-matched protein shuttle for molecular characterization |
| CN111512155B (zh) | 2017-12-28 | 2022-07-05 | 豪夫迈·罗氏有限公司 | 测量和去除来自交流信号驱动的纳米孔dna测序系统的随机信号中的噪声 |
| US11034996B2 (en) | 2018-03-02 | 2021-06-15 | The Curators Of The University Of Missouri | Nucleic acid sequence and capture by formation of an abasic site-derived cross-link |
| WO2019173799A1 (en) * | 2018-03-08 | 2019-09-12 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| JP7239965B2 (ja) * | 2018-06-26 | 2023-03-15 | 国立大学法人東京農工大学 | ２種以上の特定オリゴヌクレオチドの有無を判定する判定方法、並びに、前記判定方法を用いて検査対象が小細胞肺がん、胆管がんに罹患している又はそのリスクを有することを判定する方法 |
| US20220162692A1 (en) * | 2018-07-30 | 2022-05-26 | Oxford University Innovation Limited | Assemblies |
| US11162935B2 (en) | 2018-08-24 | 2021-11-02 | University Of Notre Dame Du Lac | Systems and methods for separating, detecting, and quantifying a target polynucleotide |
| JP2022500074A (ja) | 2018-09-11 | 2022-01-04 | レイクスユニフェルシテイト フローニンゲン | 調節可能な孔直径を有する生物学的ナノポアと分析ツールとしてのその使用 |
| WO2021013041A1 (zh) * | 2019-07-22 | 2021-01-28 | 四川大学华西医院 | 一种利用纳米孔进行细菌耐药性的快速检测方法、装置和系统 |
| WO2021086134A1 (ko) * | 2019-11-01 | 2021-05-06 | 한국생명공학연구원 | 나노포어를 이용한 병원성 미생물의 검출 방법 및 검출키트 |
| WO2021231920A1 (en) * | 2020-05-15 | 2021-11-18 | The Curators Of The University Of Missouri | Nanopore unzipping-sequencing for dna data storage |
| JP7679055B2 (ja) * | 2020-08-24 | 2025-05-19 | 国立大学法人東京農工大学 | 極低濃度のオリゴヌクレオチドの存在の有無を判定する方法、及び検査対象が特定疾患に罹患しているかどうか又は特定疾患罹患のリスクを有するかどうかを判定する方法 |
| CN112795628B (zh) * | 2021-02-05 | 2024-02-23 | 南京邮电大学 | 基于固态纳米孔传感器的miRNA检测方法、检测探针及试剂盒 |
| CN112961906B (zh) * | 2021-02-05 | 2024-01-23 | 南京邮电大学 | 金纳米棒检测探针、制备方法、检测方法及其应用 |
| CN113189070B (zh) * | 2021-04-28 | 2024-01-16 | 香港理工大学 | 一种纳米探针及其制备方法和应用、循环肿瘤细胞的miRNAs的检测系统 |
| AU2023366631A1 (en) | 2022-10-28 | 2025-05-15 | Portal Biotech Limited | Nanopore-based analysis of proteins |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| WO1999005167A1 (en) | 1997-07-25 | 1999-02-04 | University Of Massachusetts | Designed protein pores as components for biosensors |
| JP2003527075A (ja) | 1999-03-25 | 2003-09-16 | ハイセック，インコーポレーテッド | ハイブリダイゼーションによる配列分析のための、溶液ベースの方法 |
| DE60025739T2 (de) | 1999-09-07 | 2006-08-31 | The Regents Of The University Of California, Oakland | Verfahren um die anwesenheit von doppelsträngiger dns in einer probe nachzuweisen |
| US6916665B2 (en) | 2000-02-11 | 2005-07-12 | The Texas A&M University System | Biosensor compositions and methods of use |
| EP1478771A4 (en) | 2001-06-21 | 2005-06-15 | Harvard College | METHODS OF CHARACTERIZING NUCLEIC ACID MOLECULES |
| WO2003067210A2 (en) | 2001-07-10 | 2003-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting the activation state of the multiple proteins in single cells |
| US20050019784A1 (en) | 2002-05-20 | 2005-01-27 | Xing Su | Method and apparatus for nucleic acid sequencing and identification |
| WO2005013901A2 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| US7846738B2 (en) | 2003-08-15 | 2010-12-07 | President And Fellows Of Harvard College | Study of polymer molecules and conformations with a nanopore |
| US20050136408A1 (en) | 2003-12-19 | 2005-06-23 | May Tom-Moy | Methods and systems for characterizing a polymer |
| AU2005272823B2 (en) | 2004-08-13 | 2012-04-12 | President And Fellows Of Harvard College | An ultra high-throughput opti-nanopore DNA readout platform |
| KR101159072B1 (ko) | 2005-01-20 | 2012-06-25 | 삼성전자주식회사 | 나노포어를 이용한 생분자의 분리방법 |
| KR100707198B1 (ko) | 2005-06-27 | 2007-04-13 | 삼성전자주식회사 | 나노포어 및 핵산에 비특이적으로 결합하는 물질을 이용한고감도 핵산 검출 방법 |
| WO2007041621A2 (en) | 2005-10-03 | 2007-04-12 | Xingsheng Sean Ling | Hybridization assisted nanopore sequencing |
| KR100730350B1 (ko) | 2005-10-17 | 2007-06-19 | 삼성전자주식회사 | 표면처리된 나노포어를 이용한 ｄｎａ 검출방법 및검출장치 |
| WO2007120265A2 (en) * | 2005-11-14 | 2007-10-25 | Applera Corporation | Coded molecules for detecting target analytes |
| WO2007117832A2 (en) | 2006-03-12 | 2007-10-18 | Applera Corporation | Methods of detecting target nucleic acids |
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| EP2158476B8 (en) | 2007-05-08 | 2019-10-09 | Trustees of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
| GB0713143D0 (en) | 2007-07-06 | 2007-08-15 | Ucl Business Plc | Nucleic acid detection method |
| US8273532B2 (en) | 2007-10-02 | 2012-09-25 | President And Fellows Of Harvard College | Capture, recapture, and trapping of molecules with a nanopore |
| US20090181390A1 (en) | 2008-01-11 | 2009-07-16 | Signosis, Inc. A California Corporation | High throughput detection of micrornas and use for disease diagnosis |
| US8852864B2 (en) | 2008-01-17 | 2014-10-07 | Sequenom Inc. | Methods and compositions for the analysis of nucleic acids |
| ATE530497T1 (de) | 2008-03-31 | 2011-11-15 | Sony Deutschland Gmbh | Verfahren zur herstellung einer membran mit konischer pore |
| WO2010004273A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| US20100099198A1 (en) | 2008-07-11 | 2010-04-22 | Board Of Regents, The University Of Texas System | Apparatus and system for pattern recognition sensing for biomolecules |
| US20100148126A1 (en) | 2008-11-26 | 2010-06-17 | Board Of Regents, The University Of Texas System | Genomic sequencing using modified protein pores and ionic liquids |
| US20110003703A1 (en) | 2009-07-01 | 2011-01-06 | Charles Ma | Nucleic Acid Hybridization and Detection Using Enzymatic Reactions on a Microarray |
| US9416409B2 (en) | 2009-07-31 | 2016-08-16 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| US20120276530A1 (en) | 2009-08-24 | 2012-11-01 | Trustees Of Boston University | Label-free sensing of pna-dna complexes using nanopores |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| WO2011103424A2 (en) * | 2010-02-19 | 2011-08-25 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| CA2795042A1 (en) | 2010-03-30 | 2011-10-13 | Trustees Of Boston University | Tools and method for nanopores unzipping-dependent nucleic acid sequencing |
| AU2011279083B2 (en) * | 2010-07-14 | 2015-03-26 | The Curators Of The University Of Missouri | Nanopore-facilitated single molecule detection of nucleic acids |
| WO2012083249A2 (en) | 2010-12-17 | 2012-06-21 | The Trustees Of Columbia University In The City Of New York | Dna sequencing by synthesis using modified nucleotides and nanopore detection |
| US10739341B2 (en) | 2012-02-15 | 2020-08-11 | Oxford Nanopore Technologies Limited | Aptamer method |
-
2011
- 2011-07-14 AU AU2011279083A patent/AU2011279083B2/en active Active
- 2011-07-14 US US13/810,105 patent/US9395353B2/en active Active
- 2011-07-14 CA CA2805247A patent/CA2805247C/en active Active
- 2011-07-14 WO PCT/US2011/044082 patent/WO2012009578A2/en not_active Ceased
- 2011-07-14 JP JP2013519840A patent/JP6016792B2/ja active Active
- 2011-07-14 EP EP11807539.9A patent/EP2593568B1/en active Active
- 2011-07-14 EP EP17157476.7A patent/EP3190193A1/en not_active Withdrawn
-
2016
- 2016-06-15 US US15/183,152 patent/US9574228B2/en active Active
- 2016-07-13 US US15/209,443 patent/US10273527B2/en active Active
- 2016-08-04 JP JP2016154002A patent/JP6521916B2/ja active Active
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