JP2013540423A5 - - Google Patents
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- JP2013540423A5 JP2013540423A5 JP2013519840A JP2013519840A JP2013540423A5 JP 2013540423 A5 JP2013540423 A5 JP 2013540423A5 JP 2013519840 A JP2013519840 A JP 2013519840A JP 2013519840 A JP2013519840 A JP 2013519840A JP 2013540423 A5 JP2013540423 A5 JP 2013540423A5
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- JP
- Japan
- Prior art keywords
- oligonucleotide
- probe
- nanopore
- sample
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- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39957810P | 2010-07-14 | 2010-07-14 | |
| US61/399,578 | 2010-07-14 | ||
| PCT/US2011/044082 WO2012009578A2 (en) | 2010-07-14 | 2011-07-14 | Nanopore-facilitated single molecule detection of nucleic acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154002A Division JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540423A JP2013540423A (ja) | 2013-11-07 |
| JP2013540423A5 true JP2013540423A5 (enExample) | 2014-09-04 |
| JP6016792B2 JP6016792B2 (ja) | 2016-10-26 |
Family
ID=45470088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013519840A Active JP6016792B2 (ja) | 2010-07-14 | 2011-07-14 | ナノポア促進型の核酸の単分子検出 |
| JP2016154002A Active JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154002A Active JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9395353B2 (enExample) |
| EP (2) | EP3190193A1 (enExample) |
| JP (2) | JP6016792B2 (enExample) |
| AU (1) | AU2011279083B2 (enExample) |
| CA (1) | CA2805247C (enExample) |
| WO (1) | WO2012009578A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101495656B (zh) | 2006-06-07 | 2017-02-08 | 纽约哥伦比亚大学理事会 | 采用带修饰的核苷酸通过纳米通道进行dna序列测定 |
| US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
| US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| US9194838B2 (en) | 2010-03-03 | 2015-11-24 | Osaka University | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
| WO2012009578A2 (en) * | 2010-07-14 | 2012-01-19 | The Curators Of The University Of Missouri | Nanopore-facilitated single molecule detection of nucleic acids |
| ES2641871T3 (es) | 2010-12-17 | 2017-11-14 | The Trustees Of Columbia University In The City Of New York | Secuenciación de ADN mediante síntesis usando nucleótidos modificados y detección con nanoporos |
| US9121059B2 (en) | 2010-12-22 | 2015-09-01 | Genia Technologies, Inc. | Nanopore-based single molecule characterization |
| US9581563B2 (en) | 2011-01-24 | 2017-02-28 | Genia Technologies, Inc. | System for communicating information from an array of sensors |
| US9110478B2 (en) | 2011-01-27 | 2015-08-18 | Genia Technologies, Inc. | Temperature regulation of measurement arrays |
| WO2013109970A1 (en) * | 2012-01-20 | 2013-07-25 | Genia Technologies, Inc. | Nanopore based molecular detection and sequencing |
| US10739341B2 (en) | 2012-02-15 | 2020-08-11 | Oxford Nanopore Technologies Limited | Aptamer method |
| ES2732256T3 (es) * | 2012-02-16 | 2019-11-21 | Genia Tech Inc | Procedimientos para crear bicapas para su uso con sensores con nanoporos |
| US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
| EP2836604B1 (en) | 2012-04-09 | 2021-09-15 | The Trustees of Columbia University in the City of New York | Method of preparation of nanopore and uses thereof |
| WO2013188841A1 (en) | 2012-06-15 | 2013-12-19 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
| CA2880274A1 (en) | 2012-08-03 | 2014-02-06 | University Of Washington Through Its Center For Commercialization | Compositions and methods for improving nanopore sequencing |
| US9551023B2 (en) | 2012-09-14 | 2017-01-24 | Oxford Nanopore Technologies Ltd. | Sample preparation method |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| US10648026B2 (en) | 2013-03-15 | 2020-05-12 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
| US10732183B2 (en) | 2013-03-15 | 2020-08-04 | The Trustees Of Columbia University In The City Of New York | Method for detecting multiple predetermined compounds in a sample |
| JP2016517275A (ja) * | 2013-03-15 | 2016-06-16 | ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ | 多重核酸検出のためのコード化ナノポアセンサー |
| EP3014264A4 (en) | 2013-06-25 | 2016-11-16 | Two Pore Guys Inc | QUANTIFICATION OF MULTIPLEXED BIOMARKERS BY NANOPORENT ANALYSIS OF BIOMARKER POLYMER COMPLEXES |
| EP3047282B1 (en) | 2013-09-18 | 2019-05-15 | Quantum Biosystems Inc. | Biomolecule sequencing devices, systems and methods |
| JP6334118B2 (ja) * | 2013-09-24 | 2018-05-30 | クオンタムバイオシステムズ株式会社 | 単分子識別方法、装置、及びプログラム |
| JP2015077652A (ja) | 2013-10-16 | 2015-04-23 | クオンタムバイオシステムズ株式会社 | ナノギャップ電極およびその製造方法 |
| US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
| US9567630B2 (en) | 2013-10-23 | 2017-02-14 | Genia Technologies, Inc. | Methods for forming lipid bilayers on biochips |
| JP6461943B2 (ja) | 2013-10-23 | 2019-01-30 | ジェニア・テクノロジーズ・インコーポレイテッド | ナノポアを備えた高速分子検知 |
| CN106715453B (zh) | 2014-03-24 | 2021-04-30 | 哥伦比亚大学董事会 | 用于生产带标签的核苷酸的化学方法 |
| US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
| WO2015170782A1 (en) | 2014-05-08 | 2015-11-12 | Osaka University | Devices, systems and methods for linearization of polymers |
| CN106796214B (zh) * | 2014-07-31 | 2020-01-14 | 伊鲁米那股份有限公司 | 混合纳米孔传感器 |
| EP4397972A3 (en) * | 2014-10-16 | 2024-10-09 | Oxford Nanopore Technologies PLC | Alignment mapping estimation |
| KR102457147B1 (ko) | 2014-10-17 | 2022-10-19 | 옥스포드 나노포어 테크놀로지즈 피엘씨 | 나노 세공 rna 특징 규명을 위한 방법 |
| CN105842453B (zh) * | 2015-01-12 | 2018-12-25 | 南京理工大学 | 一种基于末端延伸、金纳米粒子和酶三级放大电化学传感器检测dna的方法 |
| CA2986921A1 (en) | 2015-06-02 | 2016-12-08 | Nanopore Diagnostics, Llc | Nucleic acid detection |
| JP6889701B2 (ja) * | 2015-09-24 | 2021-06-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | アルファ溶血素バリアント |
| WO2017167811A1 (en) * | 2016-03-31 | 2017-10-05 | Genia Technologies, Inc. | Nanopore protein conjugates and uses thereof |
| ES2877193T3 (es) | 2016-04-27 | 2021-11-16 | Quantum Biosystems Inc | Sistemas y métodos para la medición y secuenciación de biomoléculas |
| US10317392B2 (en) | 2016-06-23 | 2019-06-11 | Roche Sequencing Solutions, Inc. | Formation and calibration of nanopore sequencing cells |
| US11124827B2 (en) | 2016-06-23 | 2021-09-21 | Roche Sequencing Solutions, Inc. | Period-to-period analysis of AC signals from nanopore sequencing |
| EP3828280A1 (en) * | 2016-07-12 | 2021-06-02 | Rijksuniversiteit Groningen | Biological nanopores for biopolymer sensing and sequencing based on frac actinoporin |
| WO2018093976A1 (en) * | 2016-11-16 | 2018-05-24 | Nanopore Diagnostics, Llc | Analysis of nucleic acids using probe with non-linear tag |
| CN116087307B (zh) * | 2017-07-17 | 2025-10-17 | 哈佛大学校董委员会 | 用于分子表征的纳米孔匹配的蛋白质穿梭物及其数据分析方法 |
| CN111512155B (zh) | 2017-12-28 | 2022-07-05 | 豪夫迈·罗氏有限公司 | 测量和去除来自交流信号驱动的纳米孔dna测序系统的随机信号中的噪声 |
| US11034996B2 (en) | 2018-03-02 | 2021-06-15 | The Curators Of The University Of Missouri | Nucleic acid sequence and capture by formation of an abasic site-derived cross-link |
| WO2019173799A1 (en) * | 2018-03-08 | 2019-09-12 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| JP7239965B2 (ja) * | 2018-06-26 | 2023-03-15 | 国立大学法人東京農工大学 | ２種以上の特定オリゴヌクレオチドの有無を判定する判定方法、並びに、前記判定方法を用いて検査対象が小細胞肺がん、胆管がんに罹患している又はそのリスクを有することを判定する方法 |
| US20220162692A1 (en) * | 2018-07-30 | 2022-05-26 | Oxford University Innovation Limited | Assemblies |
| US11162935B2 (en) | 2018-08-24 | 2021-11-02 | University Of Notre Dame Du Lac | Systems and methods for separating, detecting, and quantifying a target polynucleotide |
| CA3111488A1 (en) | 2018-09-11 | 2020-03-19 | Rijksuniversiteit Groningen | Biological nanopores having tunable pore diameters and uses thereof as analytical tools |
| CN112280875B (zh) * | 2019-07-22 | 2023-07-18 | 四川大学华西医院 | 一种利用纳米孔进行细菌耐药性的快速检测方法、装置和系统 |
| KR102390925B1 (ko) * | 2019-11-01 | 2022-04-27 | 한국생명공학연구원 | 나노포어를 이용한 병원성 미생물의 검출 방법 및 검출키트 |
| WO2021231920A1 (en) * | 2020-05-15 | 2021-11-18 | The Curators Of The University Of Missouri | Nanopore unzipping-sequencing for dna data storage |
| JP7679055B2 (ja) * | 2020-08-24 | 2025-05-19 | 国立大学法人東京農工大学 | 極低濃度のオリゴヌクレオチドの存在の有無を判定する方法、及び検査対象が特定疾患に罹患しているかどうか又は特定疾患罹患のリスクを有するかどうかを判定する方法 |
| CN112795628B (zh) * | 2021-02-05 | 2024-02-23 | 南京邮电大学 | 基于固态纳米孔传感器的miRNA检测方法、检测探针及试剂盒 |
| CN112961906B (zh) * | 2021-02-05 | 2024-01-23 | 南京邮电大学 | 金纳米棒检测探针、制备方法、检测方法及其应用 |
| CN113189070B (zh) * | 2021-04-28 | 2024-01-16 | 香港理工大学 | 一种纳米探针及其制备方法和应用、循环肿瘤细胞的miRNAs的检测系统 |
| IL320502A (en) | 2022-10-28 | 2025-06-01 | Univ Groningen | Nanopore-based protein efflux |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| AU8586298A (en) | 1997-07-25 | 1999-02-16 | University Of Massachusetts | Designed protein pores as components for biosensors |
| CA2366289A1 (en) | 1999-03-25 | 2000-09-28 | Radoje T. Drmanac | Solution-based methods and materials for sequence analysis by hybridization |
| CA2384100C (en) | 1999-09-07 | 2011-03-29 | The Regents Of The University Of California | Methods of determining the presence of double stranded nucleic acids in a sample |
| US6916665B2 (en) | 2000-02-11 | 2005-07-12 | The Texas A&M University System | Biosensor compositions and methods of use |
| WO2003000920A2 (en) | 2001-06-21 | 2003-01-03 | President And Fellows Of Harvard College | Methods for characterization of nucleic acid molecules |
| AU2002365421A1 (en) | 2001-07-10 | 2003-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting the activation state of the multiple proteins in single cells |
| US20050019784A1 (en) | 2002-05-20 | 2005-01-27 | Xing Su | Method and apparatus for nucleic acid sequencing and identification |
| WO2005013901A2 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| US7846738B2 (en) | 2003-08-15 | 2010-12-07 | President And Fellows Of Harvard College | Study of polymer molecules and conformations with a nanopore |
| US20050136408A1 (en) | 2003-12-19 | 2005-06-23 | May Tom-Moy | Methods and systems for characterizing a polymer |
| CN102925549A (zh) | 2004-08-13 | 2013-02-13 | 哈佛学院院长等 | 超高处理量光学-纳米孔dna读出平台 |
| KR101159072B1 (ko) | 2005-01-20 | 2012-06-25 | 삼성전자주식회사 | 나노포어를 이용한 생분자의 분리방법 |
| KR100707198B1 (ko) | 2005-06-27 | 2007-04-13 | 삼성전자주식회사 | 나노포어 및 핵산에 비특이적으로 결합하는 물질을 이용한고감도 핵산 검출 방법 |
| US20070190542A1 (en) | 2005-10-03 | 2007-08-16 | Ling Xinsheng S | Hybridization assisted nanopore sequencing |
| KR100730350B1 (ko) | 2005-10-17 | 2007-06-19 | 삼성전자주식회사 | 표면처리된 나노포어를 이용한 ｄｎａ 검출방법 및검출장치 |
| WO2007120265A2 (en) | 2005-11-14 | 2007-10-25 | Applera Corporation | Coded molecules for detecting target analytes |
| WO2007117832A2 (en) | 2006-03-12 | 2007-10-18 | Applera Corporation | Methods of detecting target nucleic acids |
| US8314220B2 (en) | 2007-01-26 | 2012-11-20 | Agilent Technologies, Inc. | Methods compositions, and kits for detection of microRNA |
| WO2008097190A1 (en) | 2007-02-05 | 2008-08-14 | Agency For Science, Technology And Research | Methods of electrically detecting a nucleic acid by means of an electrode pair |
| US8500982B2 (en) | 2007-04-04 | 2013-08-06 | The Regents Of The University Of California | Compositions, devices, systems, and methods for using a nanopore |
| WO2009020682A2 (en) | 2007-05-08 | 2009-02-12 | The Trustees Of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
| GB0713143D0 (en) | 2007-07-06 | 2007-08-15 | Ucl Business Plc | Nucleic acid detection method |
| JP5309145B2 (ja) | 2007-10-02 | 2013-10-09 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | ナノポアによる分子の捕捉、再捕捉およびトラッピング |
| US20090181390A1 (en) | 2008-01-11 | 2009-07-16 | Signosis, Inc. A California Corporation | High throughput detection of micrornas and use for disease diagnosis |
| WO2009092035A2 (en) * | 2008-01-17 | 2009-07-23 | Sequenom, Inc. | Methods and compositions for the analysis of biological molecules |
| ATE530497T1 (de) | 2008-03-31 | 2011-11-15 | Sony Deutschland Gmbh | Verfahren zur herstellung einer membran mit konischer pore |
| JP2011527191A (ja) | 2008-07-07 | 2011-10-27 | オックスフォード ナノポア テクノロジーズ リミテッド | 塩基検出細孔 |
| US20100099198A1 (en) | 2008-07-11 | 2010-04-22 | Board Of Regents, The University Of Texas System | Apparatus and system for pattern recognition sensing for biomolecules |
| WO2010062903A2 (en) | 2008-11-26 | 2010-06-03 | Board Of Regents, The University Of Texas System | Genomic sequencing using modified protein pores and ionic liquids |
| US20110003703A1 (en) | 2009-07-01 | 2011-01-06 | Charles Ma | Nucleic Acid Hybridization and Detection Using Enzymatic Reactions on a Microarray |
| US9416409B2 (en) | 2009-07-31 | 2016-08-16 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| WO2011028494A2 (en) | 2009-08-24 | 2011-03-10 | Trustees Of Boston University | Label-free sensing of pna-dna complexes using nanopores |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| EP2537026B1 (en) * | 2010-02-19 | 2018-06-27 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| US20130203610A1 (en) | 2010-03-30 | 2013-08-08 | Trustees Of Boston University | Tools and Method for Nanopores Unzipping-Dependent Nucleic Acid Sequencing |
| WO2012009578A2 (en) | 2010-07-14 | 2012-01-19 | The Curators Of The University Of Missouri | Nanopore-facilitated single molecule detection of nucleic acids |
| ES2641871T3 (es) | 2010-12-17 | 2017-11-14 | The Trustees Of Columbia University In The City Of New York | Secuenciación de ADN mediante síntesis usando nucleótidos modificados y detección con nanoporos |
| US10739341B2 (en) | 2012-02-15 | 2020-08-11 | Oxford Nanopore Technologies Limited | Aptamer method |
-
2011
- 2011-07-14 WO PCT/US2011/044082 patent/WO2012009578A2/en not_active Ceased
- 2011-07-14 JP JP2013519840A patent/JP6016792B2/ja active Active
- 2011-07-14 CA CA2805247A patent/CA2805247C/en active Active
- 2011-07-14 EP EP17157476.7A patent/EP3190193A1/en not_active Withdrawn
- 2011-07-14 US US13/810,105 patent/US9395353B2/en active Active
- 2011-07-14 EP EP11807539.9A patent/EP2593568B1/en active Active
- 2011-07-14 AU AU2011279083A patent/AU2011279083B2/en active Active
-
2016
- 2016-06-15 US US15/183,152 patent/US9574228B2/en active Active
- 2016-07-13 US US15/209,443 patent/US10273527B2/en active Active
- 2016-08-04 JP JP2016154002A patent/JP6521916B2/ja active Active
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