JP2013540423A5 - - Google Patents
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- JP2013540423A5 JP2013540423A5 JP2013519840A JP2013519840A JP2013540423A5 JP 2013540423 A5 JP2013540423 A5 JP 2013540423A5 JP 2013519840 A JP2013519840 A JP 2013519840A JP 2013519840 A JP2013519840 A JP 2013519840A JP 2013540423 A5 JP2013540423 A5 JP 2013540423A5
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- Prior art keywords
- oligonucleotide
- probe
- nanopore
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39957810P | 2010-07-14 | 2010-07-14 | |
| US61/399,578 | 2010-07-14 | ||
| PCT/US2011/044082 WO2012009578A2 (en) | 2010-07-14 | 2011-07-14 | Nanopore-facilitated single molecule detection of nucleic acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154002A Division JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540423A JP2013540423A (ja) | 2013-11-07 |
| JP2013540423A5 true JP2013540423A5 (enExample) | 2014-09-04 |
| JP6016792B2 JP6016792B2 (ja) | 2016-10-26 |
Family
ID=45470088
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013519840A Active JP6016792B2 (ja) | 2010-07-14 | 2011-07-14 | ナノポア促進型の核酸の単分子検出 |
| JP2016154002A Active JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154002A Active JP6521916B2 (ja) | 2010-07-14 | 2016-08-04 | ナノポア促進型の核酸の単分子検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9395353B2 (enExample) |
| EP (2) | EP3190193A1 (enExample) |
| JP (2) | JP6016792B2 (enExample) |
| AU (1) | AU2011279083B2 (enExample) |
| CA (1) | CA2805247C (enExample) |
| WO (1) | WO2012009578A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101495656B (zh) | 2006-06-07 | 2017-02-08 | 纽约哥伦比亚大学理事会 | 采用带修饰的核苷酸通过纳米通道进行dna序列测定 |
| US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
| WO2011108540A1 (ja) | 2010-03-03 | 2011-09-09 | 国立大学法人大阪大学 | ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置 |
| US9395353B2 (en) | 2010-07-14 | 2016-07-19 | The Curators Of The University Of Missouri | Nanopore-facilitated single molecule detection of nucleic acid |
| ES2641871T3 (es) | 2010-12-17 | 2017-11-14 | The Trustees Of Columbia University In The City Of New York | Secuenciación de ADN mediante síntesis usando nucleótidos modificados y detección con nanoporos |
| GB2500360B (en) | 2010-12-22 | 2019-10-23 | Genia Tech Inc | Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps |
| US8962242B2 (en) | 2011-01-24 | 2015-02-24 | Genia Technologies, Inc. | System for detecting electrical properties of a molecular complex |
| US9110478B2 (en) | 2011-01-27 | 2015-08-18 | Genia Technologies, Inc. | Temperature regulation of measurement arrays |
| CN104254771B (zh) * | 2012-01-20 | 2018-01-12 | 吉尼亚科技公司 | 基于纳米孔的分子检测与测序 |
| IN2014DN06796A (enExample) | 2012-02-15 | 2015-05-22 | Oxford Nanopore Tech Ltd | |
| CN104254619B (zh) | 2012-02-16 | 2018-08-24 | 吉尼亚科技公司 | 产生用于纳米孔传感器的双层的方法 |
| US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
| WO2013154999A2 (en) | 2012-04-09 | 2013-10-17 | The Trustees Of Columbia University In The City Of New York | Method of preparation of nanopore and uses thereof |
| US9494554B2 (en) | 2012-06-15 | 2016-11-15 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
| EP2880186B1 (en) | 2012-08-03 | 2019-02-06 | University Of Washington Through Its Center For Commercialization | Compositions and methods for improving nanopore sequencing |
| US9551023B2 (en) | 2012-09-14 | 2017-01-24 | Oxford Nanopore Technologies Ltd. | Sample preparation method |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
| US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| CN105102627B (zh) | 2013-03-15 | 2018-10-19 | 纽约哥伦比亚大学理事会 | 用于检测样品中多种预定化合物的方法 |
| US10648026B2 (en) | 2013-03-15 | 2020-05-12 | The Trustees Of Columbia University In The City Of New York | Raman cluster tagged molecules for biological imaging |
| AU2014227754B2 (en) * | 2013-03-15 | 2018-03-01 | The Curators Of The University Of Missouri | Encoded nanopore sensor for multiplex nucleic acids detection |
| WO2014210219A1 (en) | 2013-06-25 | 2014-12-31 | Two Pore Guys, Inc. | Multiplexed biomarker quantitation by nanopore analysis of biomarker-polymer complexes |
| JP6334118B2 (ja) * | 2013-09-24 | 2018-05-30 | クオンタムバイオシステムズ株式会社 | 単分子識別方法、装置、及びプログラム |
| EP3578987A1 (en) | 2013-09-18 | 2019-12-11 | Quantum Biosystems Inc. | Biomolecule sequencing devices, systems and methods |
| JP2015077652A (ja) | 2013-10-16 | 2015-04-23 | クオンタムバイオシステムズ株式会社 | ナノギャップ電極およびその製造方法 |
| US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
| US9322062B2 (en) | 2013-10-23 | 2016-04-26 | Genia Technologies, Inc. | Process for biosensor well formation |
| CN105723222B (zh) | 2013-10-23 | 2019-01-22 | 吉尼亚科技公司 | 使用纳米孔的高速分子感测 |
| US10240195B2 (en) | 2014-03-24 | 2019-03-26 | The Trustees Of Columbia University In The City Of New York | Chemical methods for producing tagged nucleotides |
| US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
| WO2015170782A1 (en) | 2014-05-08 | 2015-11-12 | Osaka University | Devices, systems and methods for linearization of polymers |
| ES2984002T3 (es) * | 2014-07-31 | 2024-10-28 | Illumina Inc | Secuenciación de ácido nucleico con sensores de nanoporos híbridos |
| EP3971300B1 (en) * | 2014-10-16 | 2024-06-05 | Oxford Nanopore Technologies plc | Sorting of polymers |
| JP6824881B2 (ja) | 2014-10-17 | 2021-02-03 | オックスフォード ナノポール テクノロジーズ リミテッド | ナノ細孔ｒｎａを特徴付けるための方法 |
| CN105842453B (zh) * | 2015-01-12 | 2018-12-25 | 南京理工大学 | 一种基于末端延伸、金纳米粒子和酶三级放大电化学传感器检测dna的方法 |
| EP3303620A1 (en) | 2015-06-02 | 2018-04-11 | Nanopore Diagnostics LLC | Nucleic acid detection |
| WO2017050718A1 (en) | 2015-09-24 | 2017-03-30 | Genia Technologies, Inc. | Alpha-hemolysin variants |
| EP3436602B1 (en) | 2016-03-31 | 2024-08-14 | Genia Technologies, Inc. | Nanopore protein conjugates and uses thereof |
| CN115595360A (zh) | 2016-04-27 | 2023-01-13 | 因美纳剑桥有限公司（Gb） | 用于生物分子的测量和测序的系统和方法 |
| US10317392B2 (en) | 2016-06-23 | 2019-06-11 | Roche Sequencing Solutions, Inc. | Formation and calibration of nanopore sequencing cells |
| US11124827B2 (en) | 2016-06-23 | 2021-09-21 | Roche Sequencing Solutions, Inc. | Period-to-period analysis of AC signals from nanopore sequencing |
| JP7019665B2 (ja) * | 2016-07-12 | 2022-02-15 | レイクスユニフェルシテイト フローニンゲン | ＦｒａＣアクチノポリンに基づくバイオポリマーセンシングおよび配列決定のための生物学的ナノポア |
| WO2018093976A1 (en) | 2016-11-16 | 2018-05-24 | Nanopore Diagnostics, Llc | Analysis of nucleic acids using probe with non-linear tag |
| US11639922B2 (en) * | 2017-07-17 | 2023-05-02 | President And Fellows Of Harvard College | Nanopore-matched protein shuttle for molecular characterization and methodology for data analysis thereof |
| JP7038215B2 (ja) | 2017-12-28 | 2022-03-17 | エフ．ホフマン－ラ ロシュ アーゲー | 交流信号によって駆動されるナノポアｄｎａ配列決定システム由来の不規則信号におけるノイズの測定および除去 |
| US11034996B2 (en) | 2018-03-02 | 2021-06-15 | The Curators Of The University Of Missouri | Nucleic acid sequence and capture by formation of an abasic site-derived cross-link |
| WO2019173799A1 (en) * | 2018-03-08 | 2019-09-12 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| JP7239965B2 (ja) * | 2018-06-26 | 2023-03-15 | 国立大学法人東京農工大学 | ２種以上の特定オリゴヌクレオチドの有無を判定する判定方法、並びに、前記判定方法を用いて検査対象が小細胞肺がん、胆管がんに罹患している又はそのリスクを有することを判定する方法 |
| US20220162692A1 (en) * | 2018-07-30 | 2022-05-26 | Oxford University Innovation Limited | Assemblies |
| US11162935B2 (en) | 2018-08-24 | 2021-11-02 | University Of Notre Dame Du Lac | Systems and methods for separating, detecting, and quantifying a target polynucleotide |
| AU2019337340B2 (en) | 2018-09-11 | 2024-10-24 | Rijksuniversiteit Groningen | Biological nanopores having tunable pore diameters and uses thereof as analytical tools |
| WO2021013041A1 (zh) * | 2019-07-22 | 2021-01-28 | 四川大学华西医院 | 一种利用纳米孔进行细菌耐药性的快速检测方法、装置和系统 |
| KR102390925B1 (ko) * | 2019-11-01 | 2022-04-27 | 한국생명공학연구원 | 나노포어를 이용한 병원성 미생물의 검출 방법 및 검출키트 |
| US20230230636A1 (en) * | 2020-05-15 | 2023-07-20 | The Curator's of the University of Missouri | Nanopore unzipping-sequencing for dna data storage |
| JP7679055B2 (ja) * | 2020-08-24 | 2025-05-19 | 国立大学法人東京農工大学 | 極低濃度のオリゴヌクレオチドの存在の有無を判定する方法、及び検査対象が特定疾患に罹患しているかどうか又は特定疾患罹患のリスクを有するかどうかを判定する方法 |
| CN112795628B (zh) * | 2021-02-05 | 2024-02-23 | 南京邮电大学 | 基于固态纳米孔传感器的miRNA检测方法、检测探针及试剂盒 |
| CN112961906B (zh) * | 2021-02-05 | 2024-01-23 | 南京邮电大学 | 金纳米棒检测探针、制备方法、检测方法及其应用 |
| CN113189070B (zh) * | 2021-04-28 | 2024-01-16 | 香港理工大学 | 一种纳米探针及其制备方法和应用、循环肿瘤细胞的miRNAs的检测系统 |
| AU2023366631A1 (en) | 2022-10-28 | 2025-05-15 | Portal Biotech Limited | Nanopore-based analysis of proteins |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| WO1999005167A1 (en) | 1997-07-25 | 1999-02-04 | University Of Massachusetts | Designed protein pores as components for biosensors |
| CA2366289A1 (en) | 1999-03-25 | 2000-09-28 | Radoje T. Drmanac | Solution-based methods and materials for sequence analysis by hybridization |
| CA2384100C (en) | 1999-09-07 | 2011-03-29 | The Regents Of The University Of California | Methods of determining the presence of double stranded nucleic acids in a sample |
| EP1255772A2 (en) | 2000-02-11 | 2002-11-13 | The Texas A & M University System | Biosensor compositions and methods of use |
| EP1478771A4 (en) | 2001-06-21 | 2005-06-15 | Harvard College | METHODS OF CHARACTERIZING NUCLEIC ACID MOLECULES |
| DE60233574D1 (de) * | 2001-07-10 | 2009-10-15 | Univ R | Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen |
| US20050019784A1 (en) | 2002-05-20 | 2005-01-27 | Xing Su | Method and apparatus for nucleic acid sequencing and identification |
| US7683036B2 (en) * | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| WO2005017025A2 (en) | 2003-08-15 | 2005-02-24 | The President And Fellows Of Harvard College | Study of polymer molecules and conformations with a nanopore |
| US20050136408A1 (en) | 2003-12-19 | 2005-06-23 | May Tom-Moy | Methods and systems for characterizing a polymer |
| JP5190263B2 (ja) | 2004-08-13 | 2013-04-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 超高スループットの光学−ナノ細孔ｄｎａ読み取りプラットフォーム |
| KR101159072B1 (ko) | 2005-01-20 | 2012-06-25 | 삼성전자주식회사 | 나노포어를 이용한 생분자의 분리방법 |
| KR100707198B1 (ko) | 2005-06-27 | 2007-04-13 | 삼성전자주식회사 | 나노포어 및 핵산에 비특이적으로 결합하는 물질을 이용한고감도 핵산 검출 방법 |
| US20070190542A1 (en) | 2005-10-03 | 2007-08-16 | Ling Xinsheng S | Hybridization assisted nanopore sequencing |
| KR100730350B1 (ko) | 2005-10-17 | 2007-06-19 | 삼성전자주식회사 | 표면처리된 나노포어를 이용한 ｄｎａ 검출방법 및검출장치 |
| EP1954838B1 (en) * | 2005-11-14 | 2014-02-26 | Life Technologies Corporation | Coded molecules for detecting target analytes |
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| KR101521990B1 (ko) | 2007-04-04 | 2015-05-20 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 나노포어 사용을 위한 조성물, 장치, 시스템 및 방법 |
| US9121843B2 (en) | 2007-05-08 | 2015-09-01 | Trustees Of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
| GB0713143D0 (en) | 2007-07-06 | 2007-08-15 | Ucl Business Plc | Nucleic acid detection method |
| AU2008307485A1 (en) | 2007-10-02 | 2009-04-09 | President And Fellows Of Harvard College | Capture, recapture, and trapping of molecules with a nanopore |
| US20090181390A1 (en) | 2008-01-11 | 2009-07-16 | Signosis, Inc. A California Corporation | High throughput detection of micrornas and use for disease diagnosis |
| US8852864B2 (en) * | 2008-01-17 | 2014-10-07 | Sequenom Inc. | Methods and compositions for the analysis of nucleic acids |
| EP2107040B1 (en) | 2008-03-31 | 2011-10-26 | Sony Deutschland Gmbh | A method of fabricating a membrane having a tapered pore |
| AU2009269792A1 (en) | 2008-07-07 | 2010-01-14 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| US20100099198A1 (en) | 2008-07-11 | 2010-04-22 | Board Of Regents, The University Of Texas System | Apparatus and system for pattern recognition sensing for biomolecules |
| WO2010062903A2 (en) | 2008-11-26 | 2010-06-03 | Board Of Regents, The University Of Texas System | Genomic sequencing using modified protein pores and ionic liquids |
| US20110003703A1 (en) | 2009-07-01 | 2011-01-06 | Charles Ma | Nucleic Acid Hybridization and Detection Using Enzymatic Reactions on a Microarray |
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| WO2011028494A2 (en) | 2009-08-24 | 2011-03-10 | Trustees Of Boston University | Label-free sensing of pna-dna complexes using nanopores |
| US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
| WO2011103424A2 (en) * | 2010-02-19 | 2011-08-25 | The Trustees Of The University Of Pennsylvania | High-resolution analysis devices and related methods |
| WO2011126869A2 (en) | 2010-03-30 | 2011-10-13 | Trustees Of Boston University | Tools and method for nanopores unzipping-dependent nucleic acid sequencing |
| US9395353B2 (en) * | 2010-07-14 | 2016-07-19 | The Curators Of The University Of Missouri | Nanopore-facilitated single molecule detection of nucleic acid |
| ES2641871T3 (es) | 2010-12-17 | 2017-11-14 | The Trustees Of Columbia University In The City Of New York | Secuenciación de ADN mediante síntesis usando nucleótidos modificados y detección con nanoporos |
| IN2014DN06796A (enExample) | 2012-02-15 | 2015-05-22 | Oxford Nanopore Tech Ltd |
-
2011
- 2011-07-14 US US13/810,105 patent/US9395353B2/en active Active
- 2011-07-14 CA CA2805247A patent/CA2805247C/en active Active
- 2011-07-14 JP JP2013519840A patent/JP6016792B2/ja active Active
- 2011-07-14 EP EP17157476.7A patent/EP3190193A1/en not_active Withdrawn
- 2011-07-14 EP EP11807539.9A patent/EP2593568B1/en active Active
- 2011-07-14 AU AU2011279083A patent/AU2011279083B2/en active Active
- 2011-07-14 WO PCT/US2011/044082 patent/WO2012009578A2/en not_active Ceased
-
2016
- 2016-06-15 US US15/183,152 patent/US9574228B2/en active Active
- 2016-07-13 US US15/209,443 patent/US10273527B2/en active Active
- 2016-08-04 JP JP2016154002A patent/JP6521916B2/ja active Active
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