JP2013539774A5 - - Google Patents
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- Publication number
- JP2013539774A5 JP2013539774A5 JP2013533184A JP2013533184A JP2013539774A5 JP 2013539774 A5 JP2013539774 A5 JP 2013539774A5 JP 2013533184 A JP2013533184 A JP 2013533184A JP 2013533184 A JP2013533184 A JP 2013533184A JP 2013539774 A5 JP2013539774 A5 JP 2013539774A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- alkyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- -1 imidazolpyridyl Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- RPXZUCOCEKQSRG-INIZCTEOSA-N (1s)-1-(4-methyl-1,3-thiazol-2-yl)-1-[5-[[1-[(2-methyl-1,3-thiazol-4-yl)methyl]pyrazol-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanol Chemical compound CC1=CSC([C@](C)(O)C=2SC(NC3=NN(CC=4N=C(C)SC=4)C=C3)=NN=2)=N1 RPXZUCOCEKQSRG-INIZCTEOSA-N 0.000 claims 1
- CNNABHCCUHSVOG-KRWDZBQOSA-N (1s)-1-[5-[[1-[(3-fluoropyridin-2-yl)methyl]pyrazol-3-yl]amino]-1,3,4-thiadiazol-2-yl]-1-(4-methyl-1,3-thiazol-2-yl)ethanol Chemical compound CC1=CSC([C@](C)(O)C=2SC(NC3=NN(CC=4C(=CC=CN=4)F)C=C3)=NN=2)=N1 CNNABHCCUHSVOG-KRWDZBQOSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10382266 | 2010-10-13 | ||
| EP10382266.4 | 2010-10-13 | ||
| PCT/EP2011/067705 WO2012049161A1 (en) | 2010-10-13 | 2011-10-11 | 3 -amino- pyrazole derivatives useful against tuberculosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013539774A JP2013539774A (ja) | 2013-10-28 |
| JP2013539774A5 true JP2013539774A5 (enExample) | 2014-11-27 |
| JP5855668B2 JP5855668B2 (ja) | 2016-02-09 |
Family
ID=44924357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533184A Active JP5855668B2 (ja) | 2010-10-13 | 2011-10-11 | 結核に対して有用な３−アミノ−ピラゾール誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8779153B2 (enExample) |
| EP (1) | EP2627653B1 (enExample) |
| JP (1) | JP5855668B2 (enExample) |
| ES (1) | ES2532703T3 (enExample) |
| WO (1) | WO2012049161A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8779153B2 (en) * | 2010-10-13 | 2014-07-15 | Glaxo Group Limited | 3-amino-pyrazole derivatives useful against tuberculosis |
| PT106651A (pt) * | 2012-11-20 | 2014-05-20 | Tecnimede Sociedade Tecnico Medicinal S A | Quinolil hidrazonas para o tratamento de tuberculose e doenças relacionadas |
| US9546138B2 (en) | 2012-12-13 | 2017-01-17 | Novartis Ag | Pyridone derivatives and uses thereof in the treatment of tuberculosis |
| WO2016138335A1 (en) | 2015-02-27 | 2016-09-01 | Lycera Corporation | Indazolyl thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease |
| WO2018039539A1 (en) | 2016-08-26 | 2018-03-01 | Lycera Corporation | Indazolyl-l,2,4-thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease |
| US12404265B2 (en) | 2020-08-04 | 2025-09-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
| WO2022060812A1 (en) * | 2020-09-16 | 2022-03-24 | Nura Bio, Inc. | Substituted pyridine derivatives as sarm1 inhibitors |
| CA3226869A1 (en) | 2021-07-28 | 2023-02-02 | Rao Kolluri | Substituted pyridine derivatives as sarm1 inhibitors |
| US11807640B1 (en) | 2023-03-28 | 2023-11-07 | King Faisal University | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as anti-tubercular agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010058423A2 (en) * | 2008-11-20 | 2010-05-27 | Panacea Biotec Ltd. | Novel antimicrobials |
| US8779153B2 (en) * | 2010-10-13 | 2014-07-15 | Glaxo Group Limited | 3-amino-pyrazole derivatives useful against tuberculosis |
-
2011
- 2011-10-11 US US13/878,889 patent/US8779153B2/en active Active
- 2011-10-11 EP EP11771075.6A patent/EP2627653B1/en active Active
- 2011-10-11 ES ES11771075.6T patent/ES2532703T3/es active Active
- 2011-10-11 WO PCT/EP2011/067705 patent/WO2012049161A1/en not_active Ceased
- 2011-10-11 JP JP2013533184A patent/JP5855668B2/ja active Active
-
2014
- 2014-06-04 US US14/295,589 patent/US9000181B2/en active Active
-
2015
- 2015-03-05 US US14/639,241 patent/US9334265B2/en active Active
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