JP5855668B2 - 結核に対して有用な３−アミノ−ピラゾール誘導体 - Google Patents
結核に対して有用な３−アミノ−ピラゾール誘導体 Download PDFInfo
- Publication number
- JP5855668B2 JP5855668B2 JP2013533184A JP2013533184A JP5855668B2 JP 5855668 B2 JP5855668 B2 JP 5855668B2 JP 2013533184 A JP2013533184 A JP 2013533184A JP 2013533184 A JP2013533184 A JP 2013533184A JP 5855668 B2 JP5855668 B2 JP 5855668B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound
- mmol
- formula
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *C(c1nccc(O)c1)[n](c(*)c1*)nc1NC1=N*C(C(*)(*)*2NC(*)C*2)=S1 Chemical compound *C(c1nccc(O)c1)[n](c(*)c1*)nc1NC1=N*C(C(*)(*)*2NC(*)C*2)=S1 0.000 description 3
- NDSRDGCTVOYQKO-UHFFFAOYSA-N CC(c1nnc(Nc2n[n](Cc(nccc3)c3F)cc2)[s]1)[n]1nc(C)cc1 Chemical compound CC(c1nnc(Nc2n[n](Cc(nccc3)c3F)cc2)[s]1)[n]1nc(C)cc1 NDSRDGCTVOYQKO-UHFFFAOYSA-N 0.000 description 1
- GRNPWSIXBWBIQF-UHFFFAOYSA-N CCOC(C(C)[n]1nc(C)cc1C)=O Chemical compound CCOC(C(C)[n]1nc(C)cc1C)=O GRNPWSIXBWBIQF-UHFFFAOYSA-N 0.000 description 1
- NDSRDGCTVOYQKO-LBPRGKRZSA-N C[C@@H](c1nnc(Nc2n[n](Cc3ncccc3F)cc2)[s]1)[n]1nc(C)cc1 Chemical compound C[C@@H](c1nnc(Nc2n[n](Cc3ncccc3F)cc2)[s]1)[n]1nc(C)cc1 NDSRDGCTVOYQKO-LBPRGKRZSA-N 0.000 description 1
- NDSRDGCTVOYQKO-GFCCVEGCSA-N C[C@H](c1nnc(Nc2n[n](Cc3ncccc3F)cc2)[s]1)[n]1nc(C)cc1 Chemical compound C[C@H](c1nnc(Nc2n[n](Cc3ncccc3F)cc2)[s]1)[n]1nc(C)cc1 NDSRDGCTVOYQKO-GFCCVEGCSA-N 0.000 description 1
- TXJMOUZMFKYCOY-UHFFFAOYSA-N O=C(c1c2cccc1)N(c1n[nH]cc1)C2=O Chemical compound O=C(c1c2cccc1)N(c1n[nH]cc1)C2=O TXJMOUZMFKYCOY-UHFFFAOYSA-N 0.000 description 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N O=C(c1c2cccc1)OC2=O Chemical compound O=C(c1c2cccc1)OC2=O LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10382266 | 2010-10-13 | ||
| EP10382266.4 | 2010-10-13 | ||
| PCT/EP2011/067705 WO2012049161A1 (en) | 2010-10-13 | 2011-10-11 | 3 -amino- pyrazole derivatives useful against tuberculosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013539774A JP2013539774A (ja) | 2013-10-28 |
| JP2013539774A5 JP2013539774A5 (enExample) | 2014-11-27 |
| JP5855668B2 true JP5855668B2 (ja) | 2016-02-09 |
Family
ID=44924357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013533184A Active JP5855668B2 (ja) | 2010-10-13 | 2011-10-11 | 結核に対して有用な３−アミノ−ピラゾール誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8779153B2 (enExample) |
| EP (1) | EP2627653B1 (enExample) |
| JP (1) | JP5855668B2 (enExample) |
| ES (1) | ES2532703T3 (enExample) |
| WO (1) | WO2012049161A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8779153B2 (en) * | 2010-10-13 | 2014-07-15 | Glaxo Group Limited | 3-amino-pyrazole derivatives useful against tuberculosis |
| PT106651A (pt) * | 2012-11-20 | 2014-05-20 | Tecnimede Sociedade Tecnico Medicinal S A | Quinolil hidrazonas para o tratamento de tuberculose e doenças relacionadas |
| US9546138B2 (en) | 2012-12-13 | 2017-01-17 | Novartis Ag | Pyridone derivatives and uses thereof in the treatment of tuberculosis |
| WO2016138335A1 (en) | 2015-02-27 | 2016-09-01 | Lycera Corporation | Indazolyl thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease |
| WO2018039539A1 (en) | 2016-08-26 | 2018-03-01 | Lycera Corporation | Indazolyl-l,2,4-thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease |
| US12404265B2 (en) | 2020-08-04 | 2025-09-02 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
| WO2022060812A1 (en) * | 2020-09-16 | 2022-03-24 | Nura Bio, Inc. | Substituted pyridine derivatives as sarm1 inhibitors |
| CA3226869A1 (en) | 2021-07-28 | 2023-02-02 | Rao Kolluri | Substituted pyridine derivatives as sarm1 inhibitors |
| US11807640B1 (en) | 2023-03-28 | 2023-11-07 | King Faisal University | 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates as anti-tubercular agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010058423A2 (en) * | 2008-11-20 | 2010-05-27 | Panacea Biotec Ltd. | Novel antimicrobials |
| US8779153B2 (en) * | 2010-10-13 | 2014-07-15 | Glaxo Group Limited | 3-amino-pyrazole derivatives useful against tuberculosis |
-
2011
- 2011-10-11 US US13/878,889 patent/US8779153B2/en active Active
- 2011-10-11 EP EP11771075.6A patent/EP2627653B1/en active Active
- 2011-10-11 ES ES11771075.6T patent/ES2532703T3/es active Active
- 2011-10-11 WO PCT/EP2011/067705 patent/WO2012049161A1/en not_active Ceased
- 2011-10-11 JP JP2013533184A patent/JP5855668B2/ja active Active
-
2014
- 2014-06-04 US US14/295,589 patent/US9000181B2/en active Active
-
2015
- 2015-03-05 US US14/639,241 patent/US9334265B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8779153B2 (en) | 2014-07-15 |
| EP2627653A1 (en) | 2013-08-21 |
| US20130203802A1 (en) | 2013-08-08 |
| US20150307485A1 (en) | 2015-10-29 |
| US9000181B2 (en) | 2015-04-07 |
| US20140288133A1 (en) | 2014-09-25 |
| EP2627653B1 (en) | 2014-12-24 |
| WO2012049161A1 (en) | 2012-04-19 |
| ES2532703T3 (es) | 2015-03-31 |
| US9334265B2 (en) | 2016-05-10 |
| JP2013539774A (ja) | 2013-10-28 |
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| Brentford | Castro Pichel et al.(43) Pub. Date: Aug. 8, 2013 |
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