JP2013537537A5 - - Google Patents
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- Publication number
- JP2013537537A5 JP2013537537A5 JP2013523601A JP2013523601A JP2013537537A5 JP 2013537537 A5 JP2013537537 A5 JP 2013537537A5 JP 2013523601 A JP2013523601 A JP 2013523601A JP 2013523601 A JP2013523601 A JP 2013523601A JP 2013537537 A5 JP2013537537 A5 JP 2013537537A5
- Authority
- JP
- Japan
- Prior art keywords
- quinolin
- dihydro
- methoxy
- tert
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000711549 Hepacivirus C Species 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- SNKSUTBCVIHXOR-UHFFFAOYSA-N N-[4-[7-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-8-methoxyquinolin-2-yl]phenyl]methanesulfonamide Chemical compound C12=CC=C(C=3C=CC(NS(C)(=O)=O)=CC=3)N=C2C(OC)=C(C(C)(C)C)C=C1N1C=CC(=O)NC1=O SNKSUTBCVIHXOR-UHFFFAOYSA-N 0.000 claims 1
- JGINCDAVQVQSAN-UHFFFAOYSA-N N-[4-[7-tert-butyl-8-methoxy-5-(2-oxo-1H-pyridin-3-yl)quinolin-2-yl]phenyl]methanesulfonamide Chemical compound C12=CC=C(C=3C=CC(NS(C)(=O)=O)=CC=3)N=C2C(OC)=C(C(C)(C)C)C=C1C1=CC=CNC1=O JGINCDAVQVQSAN-UHFFFAOYSA-N 0.000 claims 1
- MIAIEENYIKQNJO-UHFFFAOYSA-N N-[4-[7-tert-butyl-8-methoxy-5-(6-methyl-2-oxo-1H-pyridin-3-yl)quinolin-2-yl]phenyl]methanesulfonamide Chemical compound C12=CC=C(C=3C=CC(NS(C)(=O)=O)=CC=3)N=C2C(OC)=C(C(C)(C)C)C=C1C1=CC=C(C)NC1=O MIAIEENYIKQNJO-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Description
Claims (4)
- N−{4−[7−tert−ブチル−8−メトキシ−5−(2−オキソ−1,2−ジヒドロ−ピリジン−3−イル)−キノリン−2−イル]−フェニル}−メタンスルホンアミド;
N−{4−[7−tert−ブチル−8−メトキシ−5−(6−メチル−2−オキソ−1,2−ジヒドロ−ピリジン−3−イル)−キノリン−2−イル]−フェニル}−メタンスルホンアミド;及び、
N−{4−[7−tert−ブチル−5−(2,4−ジオキソ−3,4−ジヒドロ−2H−ピリミジン−1−イル)−8−メトキシ−キノリン−2−イル]−フェニル}−メタンスルホンアミド;
からなる群より選択される化合物又はその医薬的に許容される塩。 - 治療活性物質として請求項1に記載の化合物を含んでなる医薬組成物。
- C型肝炎ウイルス(HCV)感染症の治療又は予防用医薬の製造のための、請求項1に記載の化合物の使用。
- C型肝炎ウイルス(HCV)感染症の治療又は予防における使用のための、請求項1に記載の化合物を含んでなる医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37343410P | 2010-08-13 | 2010-08-13 | |
US61/373,434 | 2010-08-13 | ||
PCT/EP2011/063733 WO2012020037A1 (en) | 2010-08-13 | 2011-08-10 | Heterocyclic antiviral compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013537537A JP2013537537A (ja) | 2013-10-03 |
JP2013537537A5 true JP2013537537A5 (ja) | 2013-11-28 |
JP5617036B2 JP5617036B2 (ja) | 2014-10-29 |
Family
ID=44503829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013523601A Expired - Fee Related JP5617036B2 (ja) | 2010-08-13 | 2011-08-10 | 複素環式抗ウイルス化合物 |
Country Status (14)
Country | Link |
---|---|
US (1) | US8734777B2 (ja) |
EP (1) | EP2603501B1 (ja) |
JP (1) | JP5617036B2 (ja) |
KR (1) | KR101382730B1 (ja) |
CN (1) | CN103068819B (ja) |
AR (1) | AR082628A1 (ja) |
BR (1) | BR112013003113A2 (ja) |
CA (1) | CA2806547A1 (ja) |
ES (1) | ES2477342T3 (ja) |
HK (1) | HK1184452A1 (ja) |
MX (1) | MX2013001273A (ja) |
RU (1) | RU2572835C2 (ja) |
TW (1) | TW201210598A (ja) |
WO (1) | WO2012020037A1 (ja) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0489480A1 (en) * | 1990-12-05 | 1992-06-10 | Nissan Chemical Industries Ltd. | Uracil derivatives and herbicides containing the same as active ingredient |
GB0201179D0 (en) * | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
WO2009039127A1 (en) | 2007-09-17 | 2009-03-26 | Abbott Laboratories | Uracil or thymine derivative for treating hepatitis c |
WO2010100178A1 (en) * | 2009-03-06 | 2010-09-10 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
JP5571167B2 (ja) * | 2009-03-25 | 2014-08-13 | アッヴィ・インコーポレイテッド | 抗ウイルス組成物およびこの使用 |
CA2986195A1 (en) * | 2009-03-25 | 2010-09-30 | Abbvie Inc. | Substituted aryl antivrial compounds and uses thereof |
TWI428332B (zh) * | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
CA2801670A1 (en) * | 2010-07-07 | 2012-01-12 | Leanna Renee Staben | Heterocyclic antiviral compounds |
-
2011
- 2011-08-10 EP EP11746520.3A patent/EP2603501B1/en not_active Not-in-force
- 2011-08-10 MX MX2013001273A patent/MX2013001273A/es not_active Application Discontinuation
- 2011-08-10 ES ES11746520.3T patent/ES2477342T3/es active Active
- 2011-08-10 US US13/813,299 patent/US8734777B2/en not_active Expired - Fee Related
- 2011-08-10 BR BR112013003113A patent/BR112013003113A2/pt not_active IP Right Cessation
- 2011-08-10 CA CA2806547A patent/CA2806547A1/en not_active Abandoned
- 2011-08-10 WO PCT/EP2011/063733 patent/WO2012020037A1/en active Application Filing
- 2011-08-10 JP JP2013523601A patent/JP5617036B2/ja not_active Expired - Fee Related
- 2011-08-10 RU RU2013108055/04A patent/RU2572835C2/ru active
- 2011-08-10 CN CN201180038498.5A patent/CN103068819B/zh not_active Expired - Fee Related
- 2011-08-10 KR KR1020137006395A patent/KR101382730B1/ko not_active IP Right Cessation
- 2011-08-11 AR ARP110102919A patent/AR082628A1/es unknown
- 2011-08-11 TW TW100128760A patent/TW201210598A/zh unknown
-
2013
- 2013-10-22 HK HK13111854.7A patent/HK1184452A1/xx not_active IP Right Cessation
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