JP2013537526A5 - - Google Patents
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- Publication number
- JP2013537526A5 JP2013537526A5 JP2013520808A JP2013520808A JP2013537526A5 JP 2013537526 A5 JP2013537526 A5 JP 2013537526A5 JP 2013520808 A JP2013520808 A JP 2013520808A JP 2013520808 A JP2013520808 A JP 2013520808A JP 2013537526 A5 JP2013537526 A5 JP 2013537526A5
- Authority
- JP
- Japan
- Prior art keywords
- acrylate
- reaction product
- polymerization reaction
- adhesive
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000853 adhesive Substances 0.000 claims description 69
- 230000001070 adhesive effect Effects 0.000 claims description 69
- 239000000178 monomer Substances 0.000 claims description 68
- 239000002954 polymerization reaction product Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 35
- 239000007788 liquid Substances 0.000 claims description 20
- 239000000047 product Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 12
- DXPPIEDUBFUSEZ-UHFFFAOYSA-N 6-methylheptyl prop-2-enoate Chemical group CC(C)CCCCCOC(=O)C=C DXPPIEDUBFUSEZ-UHFFFAOYSA-N 0.000 claims description 10
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 10
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 10
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims description 10
- 238000010525 oxidative degradation reaction Methods 0.000 claims description 9
- -1 alkyl methacrylate Chemical compound 0.000 claims description 8
- 239000003999 initiator Substances 0.000 claims description 8
- 150000003254 radicals Chemical class 0.000 claims description 8
- 238000013271 transdermal drug delivery Methods 0.000 claims description 6
- BTGAJCKRXPNBFI-OAHLLOKOSA-N (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-13,14-diol Chemical compound C([C@H]1N(CCC)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 BTGAJCKRXPNBFI-OAHLLOKOSA-N 0.000 claims description 5
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims description 5
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 claims description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
- GCRIIVPDNWHODP-UHFFFAOYSA-N 2-(2-oxopyrrolidin-1-yl)ethyl prop-2-enoate Chemical compound C=CC(=O)OCCN1CCCC1=O GCRIIVPDNWHODP-UHFFFAOYSA-N 0.000 claims description 5
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- FWWXYLGCHHIKNY-UHFFFAOYSA-N 2-ethoxyethyl prop-2-enoate Chemical compound CCOCCOC(=O)C=C FWWXYLGCHHIKNY-UHFFFAOYSA-N 0.000 claims description 5
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 5
- NCTBYWFEJFTVEL-UHFFFAOYSA-N 2-methylbutyl prop-2-enoate Chemical compound CCC(C)COC(=O)C=C NCTBYWFEJFTVEL-UHFFFAOYSA-N 0.000 claims description 5
- FCRJELOYDVBTGW-ILZDJORESA-N 3-[(6ar,9s,10ar)-7-propyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-yl]-1,1-diethylurea Chemical compound C1=CC([C@H]2C[C@@H](CN([C@@H]2C2)CCC)NC(=O)N(CC)CC)=C3C2=CNC3=C1 FCRJELOYDVBTGW-ILZDJORESA-N 0.000 claims description 5
- QZPSOSOOLFHYRR-UHFFFAOYSA-N 3-hydroxypropyl prop-2-enoate Chemical compound OCCCOC(=O)C=C QZPSOSOOLFHYRR-UHFFFAOYSA-N 0.000 claims description 5
- CYUZOYPRAQASLN-UHFFFAOYSA-N 3-prop-2-enoyloxypropanoic acid Chemical compound OC(=O)CCOC(=O)C=C CYUZOYPRAQASLN-UHFFFAOYSA-N 0.000 claims description 5
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims description 5
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 5
- VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 5
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 5
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 5
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 claims description 5
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims description 5
- JOAHPSVPXZTVEP-YXJHDRRASA-N Terguride Chemical compound C1=CC([C@H]2C[C@@H](CN(C)[C@@H]2C2)NC(=O)N(CC)CC)=C3C2=CNC3=C1 JOAHPSVPXZTVEP-YXJHDRRASA-N 0.000 claims description 5
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 5
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 5
- 239000003963 antioxidant agent Substances 0.000 claims description 5
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 claims description 5
- 229960004046 apomorphine Drugs 0.000 claims description 5
- 125000001743 benzylic group Chemical group 0.000 claims description 5
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 5
- 229960001736 buprenorphine Drugs 0.000 claims description 5
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 5
- 229960002896 clonidine Drugs 0.000 claims description 5
- 238000007334 copolymerization reaction Methods 0.000 claims description 5
- KBLWLMPSVYBVDK-UHFFFAOYSA-N cyclohexyl prop-2-enoate Chemical compound C=CC(=O)OC1CCCCC1 KBLWLMPSVYBVDK-UHFFFAOYSA-N 0.000 claims description 5
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 claims description 5
- 229960001140 cyproheptadine Drugs 0.000 claims description 5
- HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 claims description 5
- 229960004704 dihydroergotamine Drugs 0.000 claims description 5
- WZXNKIQZEIEZEA-UHFFFAOYSA-N ethyl 2-(2-ethoxyethoxy)prop-2-enoate Chemical compound CCOCCOC(=C)C(=O)OCC WZXNKIQZEIEZEA-UHFFFAOYSA-N 0.000 claims description 5
- 229960003976 etidocaine Drugs 0.000 claims description 5
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims description 5
- 229960002428 fentanyl Drugs 0.000 claims description 5
- ACGDKVXYNVEAGU-UHFFFAOYSA-N guanethidine Chemical compound NC(N)=NCCN1CCCCCCC1 ACGDKVXYNVEAGU-UHFFFAOYSA-N 0.000 claims description 5
- 229960003602 guanethidine Drugs 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 claims description 5
- 229960004801 imipramine Drugs 0.000 claims description 5
- NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 claims description 5
- 229960004569 indapamide Drugs 0.000 claims description 5
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims description 5
- 229960003881 letrozole Drugs 0.000 claims description 5
- 229960004194 lidocaine Drugs 0.000 claims description 5
- 229960003587 lisuride Drugs 0.000 claims description 5
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims description 5
- OVHHHVAVHBHXAK-UHFFFAOYSA-N n,n-diethylprop-2-enamide Chemical compound CCN(CC)C(=O)C=C OVHHHVAVHBHXAK-UHFFFAOYSA-N 0.000 claims description 5
- YYPWGCZOLGTTER-MZMPZRCHSA-N pergolide Chemical compound C1=CC=C2[C@H]3C[C@@H](CSC)CN(CCC)[C@@H]3CC3=CN=C1[C]32 YYPWGCZOLGTTER-MZMPZRCHSA-N 0.000 claims description 5
- 229960004851 pergolide Drugs 0.000 claims description 5
- 229960003712 propranolol Drugs 0.000 claims description 5
- 229950007140 proterguride Drugs 0.000 claims description 5
- 229960004136 rivastigmine Drugs 0.000 claims description 5
- 229960001549 ropivacaine Drugs 0.000 claims description 5
- 229960002052 salbutamol Drugs 0.000 claims description 5
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims description 5
- MUTNCGKQJGXKEM-UHFFFAOYSA-N tamibarotene Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1NC(=O)C1=CC=C(C(O)=O)C=C1 MUTNCGKQJGXKEM-UHFFFAOYSA-N 0.000 claims description 5
- 229960004558 terguride Drugs 0.000 claims description 5
- 125000001302 tertiary amino group Chemical group 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 4
- 239000002998 adhesive polymer Substances 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
- 238000006116 polymerization reaction Methods 0.000 claims description 2
- 230000000379 polymerizing effect Effects 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36635810P | 2010-07-21 | 2010-07-21 | |
| US61/366,358 | 2010-07-21 | ||
| PCT/US2011/044522 WO2012012417A1 (en) | 2010-07-21 | 2011-07-19 | Transdermal adhesive compositions, devices, and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015218158A Division JP6280091B2 (ja) | 2010-07-21 | 2015-11-06 | 経皮接着剤組成物、デバイス、及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013537526A JP2013537526A (ja) | 2013-10-03 |
| JP2013537526A5 true JP2013537526A5 (enExample) | 2014-07-24 |
Family
ID=44629555
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013520808A Withdrawn JP2013537526A (ja) | 2010-07-21 | 2011-07-19 | 経皮接着剤組成物、デバイス、及び方法 |
| JP2015218158A Expired - Fee Related JP6280091B2 (ja) | 2010-07-21 | 2015-11-06 | 経皮接着剤組成物、デバイス、及び方法 |
| JP2018003355A Pending JP2018052992A (ja) | 2010-07-21 | 2018-01-12 | 経皮接着剤組成物、デバイス、及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015218158A Expired - Fee Related JP6280091B2 (ja) | 2010-07-21 | 2015-11-06 | 経皮接着剤組成物、デバイス、及び方法 |
| JP2018003355A Pending JP2018052992A (ja) | 2010-07-21 | 2018-01-12 | 経皮接着剤組成物、デバイス、及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9375510B2 (enExample) |
| EP (2) | EP3517105B8 (enExample) |
| JP (3) | JP2013537526A (enExample) |
| KR (1) | KR101892764B1 (enExample) |
| CN (1) | CN103068944B (enExample) |
| BR (1) | BR112013001550A2 (enExample) |
| CA (1) | CA2806183C (enExample) |
| ES (1) | ES2720952T3 (enExample) |
| MX (1) | MX346041B (enExample) |
| SG (2) | SG187158A1 (enExample) |
| WO (1) | WO2012012417A1 (enExample) |
| ZA (1) | ZA201301336B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12186426B2 (en) | 2009-10-30 | 2025-01-07 | Ix Biopharma Ltd. | Solid dosage form |
| EP2493457B1 (en) | 2009-10-30 | 2017-08-09 | IX Biopharma Ltd | Fast dissolving solid dosage form |
| EP3517105B8 (en) * | 2010-07-21 | 2021-06-23 | Kindeva Drug Delivery L.P. | Transdermal adhesive compositions, devices, and methods |
| CN103796645B (zh) * | 2011-08-31 | 2017-06-20 | 东洋油墨Sc控股株式会社 | 贴剂 |
| US20140083878A1 (en) * | 2012-09-21 | 2014-03-27 | Mylan Inc. | Transdermal drug delivery device |
| WO2014111790A2 (en) | 2013-01-15 | 2014-07-24 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising rivastigmine |
| JP6940407B2 (ja) * | 2014-12-19 | 2021-09-29 | キンデーバ ドラッグ デリバリー リミティド パートナーシップ | フェンタニルを含む経皮薬物送達デバイス |
| EP3253840B1 (en) * | 2015-02-06 | 2019-07-31 | Noven Pharmaceuticals, INC. | Pressure-sensitive adhesives for transdermal drug delivery |
| US10406116B2 (en) | 2015-02-06 | 2019-09-10 | Noven Pharmaceuticals, Inc. | Pressure-sensitive adhesives for transdermal drug delivery |
| JP2019206497A (ja) * | 2018-05-30 | 2019-12-05 | 小林製薬株式会社 | 外用医薬組成物 |
| EP3870262A1 (en) | 2018-10-23 | 2021-09-01 | Kindeva Drug Delivery L.P. | Tamper evident transdermal patch |
| DE102019120403A1 (de) * | 2019-07-29 | 2021-02-04 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Herstellung von Haftklebemassen zur Verwendung in einem transdermalen therapeutischen System |
| CN117202878A (zh) | 2020-04-30 | 2023-12-08 | 金德瓦药物控释有限公司 | 粘合剂制品及其制备方法 |
| CN117337172A (zh) | 2020-07-06 | 2024-01-02 | 金德瓦药物控释有限公司 | 包括贴片区段的药物递送装置 |
| WO2024129424A1 (en) | 2022-12-16 | 2024-06-20 | Kindeva Drug Delivery L.P. | Drug delivery device |
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- 2011-07-19 EP EP19155852.7A patent/EP3517105B8/en active Active
- 2011-07-19 BR BR112013001550A patent/BR112013001550A2/pt not_active IP Right Cessation
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- 2011-07-19 CN CN201180038702.3A patent/CN103068944B/zh active Active
- 2011-07-19 KR KR1020137004235A patent/KR101892764B1/ko active Active
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- 2011-07-19 US US13/811,343 patent/US9375510B2/en not_active Expired - Fee Related
- 2011-07-19 WO PCT/US2011/044522 patent/WO2012012417A1/en not_active Ceased
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