ES2720952T3 - Composiciones adhesivas transdérmicas, dispositivos y métodos - Google Patents

Composiciones adhesivas transdérmicas, dispositivos y métodos Download PDF

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Publication number
ES2720952T3
ES2720952T3 ES11739245T ES11739245T ES2720952T3 ES 2720952 T3 ES2720952 T3 ES 2720952T3 ES 11739245 T ES11739245 T ES 11739245T ES 11739245 T ES11739245 T ES 11739245T ES 2720952 T3 ES2720952 T3 ES 2720952T3
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ES
Spain
Prior art keywords
acrylate
adhesive
monomers
ethyl
combinations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11739245T
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English (en)
Inventor
James P Dizio
Elizabeth E Johnson
Zheng Zhi Wu
Prince Amy Preszler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
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3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of ES2720952T3 publication Critical patent/ES2720952T3/es
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1808—C8-(meth)acrylate, e.g. isooctyl (meth)acrylate or 2-ethylhexyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09J133/08—Homopolymers or copolymers of acrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09J133/10—Homopolymers or copolymers of methacrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J4/00—Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; adhesives, based on monomers of macromolecular compounds of groups C09J183/00 - C09J183/16
    • C09J4/06—Organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups C09J159/00 - C09J187/00

Abstract

Una composición adhesiva transdérmica que comprende: un adhesivo que comprende un producto de la reacción de polimerización de al menos dos monómeros etilénicamente insaturados lavado, en donde el adhesivo comprende el producto de la copolimerización de al menos un primer monómero seleccionado del grupo que consiste en monómeros de acrilato de alquilo C4 a C12, monómeros de metacrilato de alquilo C4 a C12, y combinaciones de los mismos; y al menos un segundo monómero seleccionado del grupo que consiste en acrilamida, N,N-dietilacrilamida, metacrilamida, acetato de vinilo, alcohol vinílico, Nvinil- 2-pirrolidona, acrilato de 2-hidroxietilo, metacrilato de 2-hidroxietilo, acrilato de hidroxipropilo, acrilato de glicerilo, acrilato de 2-etoxietilo, acrilato de 2-etoxietoxietilo, acrilato de tetrahidrofurfurilo, ácido acrílico, ácido metacrílico, acrilato de pirrolidoniletilo, acrilato de 2- carboxietilo y combinaciones de los mismos; y carbamato de (S)-N-etil-N-metil-3-[1-(dimetilamino)etil]fenilo o una sal farmacéuticamente aceptable del mismo; en donde los al menos dos monómeros etilénicamente insaturados, si están presentes en el adhesivo como monómeros sin reaccionar, están presentes a un nivel inferior a 200 ppm de monómero sin reaccionar total, con respecto al peso total del adhesivo.
ES11739245T 2010-07-21 2011-07-19 Composiciones adhesivas transdérmicas, dispositivos y métodos Active ES2720952T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36635810P 2010-07-21 2010-07-21
PCT/US2011/044522 WO2012012417A1 (en) 2010-07-21 2011-07-19 Transdermal adhesive compositions, devices, and methods

Publications (1)

Publication Number Publication Date
ES2720952T3 true ES2720952T3 (es) 2019-07-25

Family

ID=44629555

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11739245T Active ES2720952T3 (es) 2010-07-21 2011-07-19 Composiciones adhesivas transdérmicas, dispositivos y métodos

Country Status (12)

Country Link
US (3) US9375510B2 (es)
EP (2) EP3517105B8 (es)
JP (3) JP2013537526A (es)
KR (1) KR101892764B1 (es)
CN (1) CN103068944B (es)
BR (1) BR112013001550A2 (es)
CA (1) CA2806183C (es)
ES (1) ES2720952T3 (es)
MX (1) MX346041B (es)
SG (2) SG187158A1 (es)
WO (1) WO2012012417A1 (es)
ZA (1) ZA201301336B (es)

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WO2012012417A1 (en) * 2010-07-21 2012-01-26 3M Innovative Properties Company Transdermal adhesive compositions, devices, and methods
EP2752188B1 (en) * 2011-08-31 2020-05-06 Toyo Ink Sc Holdings Co., Ltd. Adhesive patch
US20140083878A1 (en) * 2012-09-21 2014-03-27 Mylan Inc. Transdermal drug delivery device
WO2014111790A2 (en) 2013-01-15 2014-07-24 Zydus Technologies Limited Stable transdermal pharmaceutical drug delivery system comprising rivastigmine
US20180263920A1 (en) * 2014-12-19 2018-09-20 3M Innovative Properties Company Transdermal drug delivery device including fentanyl
JP6807848B2 (ja) * 2015-02-06 2021-01-06 ノーヴェン ファーマシューティカルズ インコーポレイテッド 経皮薬物送達のための感圧粘着剤
US10406116B2 (en) 2015-02-06 2019-09-10 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
JP2019206497A (ja) * 2018-05-30 2019-12-05 小林製薬株式会社 外用医薬組成物
US20210346662A1 (en) 2018-10-23 2021-11-11 Kindeva Drug Delivery L.P. Tamper evident transdermal patch
WO2021222215A1 (en) 2020-04-30 2021-11-04 Kindeva Drug Delivery L.P. Adhesive article and method of making same
CA3189066A1 (en) 2020-07-06 2022-01-13 Kindeva Drug Delivery L.P. Drug delivery device including patch segments

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Also Published As

Publication number Publication date
US20130122079A1 (en) 2013-05-16
MX2013000861A (es) 2013-04-03
CN103068944B (zh) 2016-03-09
CA2806183C (en) 2019-01-08
CA2806183A1 (en) 2012-01-26
EP3517105A1 (en) 2019-07-31
EP2596071B1 (en) 2019-02-13
KR20130143001A (ko) 2013-12-30
JP2018052992A (ja) 2018-04-05
US20180325838A1 (en) 2018-11-15
ZA201301336B (en) 2014-02-26
US9375510B2 (en) 2016-06-28
SG187158A1 (en) 2013-02-28
EP3517105B1 (en) 2021-04-28
EP3517105B8 (en) 2021-06-23
US10034840B2 (en) 2018-07-31
CN103068944A (zh) 2013-04-24
MX346041B (es) 2017-03-03
JP2016029093A (ja) 2016-03-03
KR101892764B1 (ko) 2018-08-28
EP2596071A1 (en) 2013-05-29
BR112013001550A2 (pt) 2016-05-24
JP6280091B2 (ja) 2018-02-14
JP2013537526A (ja) 2013-10-03
WO2012012417A1 (en) 2012-01-26
US20160271074A1 (en) 2016-09-22
US10376473B2 (en) 2019-08-13
SG10201505658RA (en) 2015-09-29

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