JP2013536233A - グルコキナーゼ調節タンパク質と相互作用する糖尿病治療用の化合物 - Google Patents

グルコキナーゼ調節タンパク質と相互作用する糖尿病治療用の化合物 Download PDF

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JP2013536233A
JP2013536233A JP2013526063A JP2013526063A JP2013536233A JP 2013536233 A JP2013536233 A JP 2013536233A JP 2013526063 A JP2013526063 A JP 2013526063A JP 2013526063 A JP2013526063 A JP 2013526063A JP 2013536233 A JP2013536233 A JP 2013536233A
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piperazinyl
phenyl
methyl
trifluoro
propanol
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JP2013536233A5 (OSRAM
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アシユトン，ケイト
バートバーガー，マイケル・デイビツド
ボー，ユンシン
ブライアン，マリアン・シー
クローガン，マイケル
フオツシユ，クリストフアー・ハロルド
ヘイル，クラレンス・ヘンダーソン
クンツ，ロクサーヌ・ケイ
リウ，ロンビン
信子 西村
ノーマン，マーク・エイチ
ペンニントン，ルイス・デイル
プーン，ステイーブ・フオン
ステツク，マーキアン・マイロスロウ
セント・ジーン，デイビツド・ジヨセフ・ジユニア
タマヨ，ヌリア・エイ
テグリー，クリストフアー・マイケル
ヤン，ケビン・チヤオ
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アムジエン・インコーポレーテツド
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Publication of JP2013536233A publication Critical patent/JP2013536233A/ja
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Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
WO2013123444A1 (en) * 2012-02-17 2013-08-22 Amgen Inc. Sulfonyl compounds that interact with glucokinase regulatory protein
WO2013173382A1 (en) * 2012-05-15 2013-11-21 Amgen Inc. Benzothiophene sulfonamides and other compounds that interact with glucokinase regulatory protein
WO2014035872A1 (en) * 2012-08-27 2014-03-06 Amgen Inc. Tricyclic alkynes that interact with glucokinase regulatory protein
JP6102637B2 (ja) * 2013-08-22 2017-03-29 Jsr株式会社 芳香族ジハライド化合物、重合体、重合体組成物及び成形体
CN108912020B (zh) * 2018-06-05 2021-05-28 上海博志研新药物技术有限公司 奥当卡替及其中间体的制备方法
US20240124400A1 (en) * 2019-10-11 2024-04-18 Duke University Lpxh targeting compounds, compositions thereof, and methods of making and using the same
CN114349711B (zh) * 2022-02-28 2023-08-15 四川依维欣医药科技有限公司 一种（R）-1-Boc-3-羟甲基哌嗪的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505088A (ja) * 2003-09-12 2007-03-08 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 糖尿病の治療のためのスルホンアミド誘導体
WO2008116107A2 (en) * 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
JP2009519933A (ja) * 2005-12-14 2009-05-21 アムゲン インコーポレイティッド ジアザ複素環式スルホンアミド誘導体およびそれらの使用法
WO2009096198A1 (ja) * 2008-02-01 2009-08-06 Pharma Ip Limited Liability Intermediary Corporations 新規ビアリール誘導体
JP2009530390A (ja) * 2006-03-23 2009-08-27 アムゲン インコーポレイティッド １−フェニルスルホニル−ジアザ複素環アミド化合物およびヒドロキシステロイドデヒドロゲナーゼ調節因子としてのその使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9821199D0 (en) 1998-09-30 1998-11-25 Glaxo Group Ltd Chemical compounds
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
CN104178491B (zh) 2002-09-06 2018-07-03 安姆根有限公司 治疗性人抗-il-1r1单克隆抗体
FR2874011B1 (fr) 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
GB0505084D0 (en) 2005-03-11 2005-04-20 Glaxo Group Ltd Compounds
EP1916985A4 (en) 2005-08-19 2010-06-09 Elan Pharm Inc BRIDGED N-CYCLIC SULPHONAMIDE INHIBITORS OF THE GAMMED CRYSTETRY
UA101166C2 (ru) 2007-09-21 2013-03-11 Аррей Биофарма Инк. Производные пиридин-2-иламино-1,2,4-тиадиазола как активаторы глюкокиназы для лечения сахарного диабета
MX2010013333A (es) 2008-06-04 2011-04-05 Amgen Inc Mutantes fgf21 y usos de los mismos.
FR2935380B1 (fr) 2008-08-29 2010-09-10 Galderma Res & Dev Nouveaux composes hexafluoro-2-biphenyl-isopropanol, modulateurs des recepteurs de type lxrs, leur procede de preparation et leur application comme medicaments en medecine humaine ou veterinaire ainsi qu'en cosmetique.
CA2736130C (en) 2008-09-11 2014-01-14 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use
EA032727B1 (ru) 2008-10-10 2019-07-31 Амген Инк. Мутантный резистентный к протеолизу полипептид fgf21 и его применение

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505088A (ja) * 2003-09-12 2007-03-08 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 糖尿病の治療のためのスルホンアミド誘導体
JP2009519933A (ja) * 2005-12-14 2009-05-21 アムゲン インコーポレイティッド ジアザ複素環式スルホンアミド誘導体およびそれらの使用法
JP2009530390A (ja) * 2006-03-23 2009-08-27 アムゲン インコーポレイティッド １−フェニルスルホニル−ジアザ複素環アミド化合物およびヒドロキシステロイドデヒドロゲナーゼ調節因子としてのその使用
WO2008116107A2 (en) * 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
WO2009096198A1 (ja) * 2008-02-01 2009-08-06 Pharma Ip Limited Liability Intermediary Corporations 新規ビアリール誘導体

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