JP2013535494A5 - - Google Patents

Info

Publication number

JP2013535494A5

JP2013535494A5 JP2013523598A JP2013523598A JP2013535494A5 JP 2013535494 A5 JP2013535494 A5 JP 2013535494A5 JP 2013523598 A JP2013523598 A JP 2013523598A JP 2013523598 A JP2013523598 A JP 2013523598A JP 2013535494 A5 JP2013535494 A5 JP 2013535494A5

Authority

JP

Japan

Prior art keywords

aqueous suspension

suspension according

amino acids

polypeptide

seq

Prior art date

2011-08-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000007900 aqueous suspension Substances 0.000 claims 27
• 235000001014 amino acid Nutrition 0.000 claims 15
• 150000001413 amino acids Chemical class 0.000 claims 15
• 229920001184 polypeptide Polymers 0.000 claims 13
• 102000004196 processed proteins & peptides Human genes 0.000 claims 13
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 239000007789 gas Substances 0.000 claims 8
• 239000002243 precursor Substances 0.000 claims 5
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
• 239000004472 Lysine Substances 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 125000000539 amino acid group Chemical group 0.000 claims 3
• 235000018417 cysteine Nutrition 0.000 claims 3
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
• 239000000463 material Substances 0.000 claims 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
• KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 2
• 239000000654 additive Substances 0.000 claims 2
• 230000000996 additive effect Effects 0.000 claims 2
• 239000008365 aqueous carrier Substances 0.000 claims 2
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 150000003904 phospholipids Chemical group 0.000 claims 2
• 230000008685 targeting Effects 0.000 claims 2
• NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical group O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 claims 1
• 238000002059 diagnostic imaging Methods 0.000 claims 1
• 239000000539 dimer Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
• 238000003384 imaging method Methods 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 238000003756 stirring Methods 0.000 claims 1
• QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
• 239000000725 suspension Substances 0.000 claims 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
• 238000012285 ultrasound imaging Methods 0.000 claims 1