KR101893423B1 - 표적화 기체-충전 미세소포 - Google Patents
표적화 기체-충전 미세소포 Download PDFInfo
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- KR101893423B1 KR101893423B1 KR1020177027001A KR20177027001A KR101893423B1 KR 101893423 B1 KR101893423 B1 KR 101893423B1 KR 1020177027001 A KR1020177027001 A KR 1020177027001A KR 20177027001 A KR20177027001 A KR 20177027001A KR 101893423 B1 KR101893423 B1 KR 101893423B1
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/221—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by the targeting agent or modifying agent linked to the acoustically-active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/178—Lectin superfamily, e.g. selectins
Landscapes
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- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10172318 | 2010-08-09 | ||
| EP10172318.7 | 2010-08-09 | ||
| PCT/EP2011/063720 WO2012020030A1 (en) | 2010-08-09 | 2011-08-09 | Targeted gas-filled microvesicles |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137005859A Division KR101783653B1 (ko) | 2010-08-09 | 2011-08-09 | 표적화 기체-충전 미세소포 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20170113711A KR20170113711A (ko) | 2017-10-12 |
| KR101893423B1 true KR101893423B1 (ko) | 2018-08-31 |
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| CA2871684C (en) * | 2012-04-30 | 2021-01-05 | Ge Healthcare As | Method for filling a container with a foamable composition |
| CN103565745A (zh) | 2012-08-10 | 2014-02-12 | 德克萨斯州大学系统董事会 | 用于治疗中风的神经保护性脂质体组合物和方法 |
| EP2934740B1 (en) * | 2012-12-21 | 2019-12-11 | Bracco Suisse SA | Gas-filled microvesicles |
| EP4082552A1 (en) | 2013-03-15 | 2022-11-02 | The Board of Regents of the University of Texas System | Liquids rich in noble gas and methods of their preparation and use |
| US10265424B2 (en) * | 2014-03-04 | 2019-04-23 | Trust-Biosonics, Inc. | Molecular imaging contrast agents and uses thereof |
| SI3233136T1 (sl) * | 2014-12-18 | 2019-08-30 | Bracco Suisse Sa | Formulacije s plinom napolnjenih usmerjenih mikroveziklov |
| JP2017537907A (ja) * | 2014-12-22 | 2017-12-21 | ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ | ワクチンとしての使用のためのガス入りの微小胞 |
| EP3359134B1 (en) * | 2015-10-08 | 2025-04-09 | The Children's Medical Center Corporation | Compositions and compositions for use in on-demand high-efficiency triggerable anesthesia |
| KR102771920B1 (ko) | 2016-02-09 | 2025-02-25 | 브라코 스위스 에스.에이. | 셀렉틴 표적화를 위한 재조합 키메라 단백질 |
| US20210190774A1 (en) * | 2017-12-18 | 2021-06-24 | The University Of Memphis Research Foundation | Compositions and methods for the detection and molecular profiling of membrane bound vesicles |
| US11988663B2 (en) | 2018-12-18 | 2024-05-21 | The University Of Memphis Research Foundation | Compositions and methods for the detection and molecular profiling of membrane bound vesicles |
| ES2984146T3 (es) | 2018-12-21 | 2024-10-29 | Bracco Suisse Sa | Microvesículas llenas de gas con ligando |
Citations (1)
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| WO2008131217A1 (en) | 2007-04-20 | 2008-10-30 | Oregon Healty & Science University | Ultrasound imaging with targeted microbubbles |
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| US4276885A (en) | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| US5556610A (en) | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| IN172208B (enExample) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US5445813A (en) | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| IL104084A (en) | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them |
| US5843707A (en) | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
| JP3559849B2 (ja) | 1993-07-30 | 2004-09-02 | アイエムシーオーアール ファーマシューティカル カンパニー | 超音波技術のための安定化された微小気泡組成物 |
| US6333021B1 (en) | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| IL116328A (en) | 1994-12-16 | 1999-09-22 | Bracco Research Sa | Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging |
| ATE237362T1 (de) | 1996-02-19 | 2003-05-15 | Amersham Health As | Thermostabilisiertes kontrastmittel |
| CA2404572A1 (en) | 2000-03-31 | 2001-10-11 | Michael J. Eppihimer | Inhibition of thrombosis by treatment with p-selectin antagnosits |
| AU2004210221B2 (en) | 2003-02-04 | 2008-11-20 | Bracco Suisse S.A. | Ultrasound contrast agents and process for the preparation thereof |
| US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
| US20060241022A1 (en) | 2004-10-06 | 2006-10-26 | Bowen Benjamin P | Selectin targeting bioconjugates |
| KR101658439B1 (ko) | 2005-12-09 | 2016-09-21 | 브라코 스위스 에스.에이. | 표적화 벡터-포스포리피드 컨쥬게이트 |
| WO2009074569A1 (en) * | 2007-12-11 | 2009-06-18 | Bracco International Bv | Targeting and therapeutic compounds with a polyproline-comprising spacer and gas-filled microvesicles comprising said compounds |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2008131217A1 (en) | 2007-04-20 | 2008-10-30 | Oregon Healty & Science University | Ultrasound imaging with targeted microbubbles |
Non-Patent Citations (1)
| Title |
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| MOLECULAR PHARMACEUTICS VOL. 3, NO. 5, 516-524 |
Also Published As
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| ES2673277T3 (es) | 2018-06-21 |
| CA2806639A1 (en) | 2012-02-16 |
| BR112013003393A2 (pt) | 2016-08-02 |
| DK3338807T3 (da) | 2021-02-22 |
| HUE052894T2 (hu) | 2021-05-28 |
| JP2013535494A (ja) | 2013-09-12 |
| KR20130135838A (ko) | 2013-12-11 |
| CN103079599B (zh) | 2017-05-10 |
| ZA201300660B (en) | 2013-09-25 |
| IL224628A (en) | 2016-08-31 |
| EP2603242B1 (en) | 2018-03-14 |
| SI3338807T1 (sl) | 2021-06-30 |
| US20130156706A1 (en) | 2013-06-20 |
| CA2806639C (en) | 2020-10-20 |
| EP3338807B1 (en) | 2020-12-16 |
| US20160074539A1 (en) | 2016-03-17 |
| HUE037768T2 (hu) | 2018-09-28 |
| AU2011288511A1 (en) | 2013-02-07 |
| US9333273B2 (en) | 2016-05-10 |
| EP2603242A1 (en) | 2013-06-19 |
| US9211348B2 (en) | 2015-12-15 |
| KR20170113711A (ko) | 2017-10-12 |
| KR101783653B1 (ko) | 2017-10-10 |
| SI2603242T1 (sl) | 2018-09-28 |
| ES2848721T3 (es) | 2021-08-11 |
| WO2012020030A1 (en) | 2012-02-16 |
| DK2603242T3 (en) | 2018-06-18 |
| JP5779646B2 (ja) | 2015-09-16 |
| EP3338807A1 (en) | 2018-06-27 |
| CN103079599A (zh) | 2013-05-01 |
| BR112013003393B1 (pt) | 2021-07-13 |
| AU2011288511B2 (en) | 2016-01-07 |
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