KR101783653B1 - 표적화 기체-충전 미세소포 - Google Patents

표적화 기체-충전 미세소포 Download PDF

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Publication number
KR101783653B1
KR101783653B1 KR1020137005859A KR20137005859A KR101783653B1 KR 101783653 B1 KR101783653 B1 KR 101783653B1 KR 1020137005859 A KR1020137005859 A KR 1020137005859A KR 20137005859 A KR20137005859 A KR 20137005859A KR 101783653 B1 KR101783653 B1 KR 101783653B1
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South Korea
Prior art keywords
aqueous suspension
amino acid
gas
seq
polypeptide
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KR1020137005859A
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English (en)
Korean (ko)
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KR20130135838A (ko
Inventor
티에리 베팅거
필립 부싸
베르나드 라미
사미르 셰르카위
이렌느 길베르-브리게
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브라코 스위스 에스.에이.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/221—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by the targeting agent or modifying agent linked to the acoustically-active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/178—Lectin superfamily, e.g. selectins

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
KR1020137005859A 2010-08-09 2011-08-09 표적화 기체-충전 미세소포 Active KR101783653B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10172318 2010-08-09
EP10172318.7 2010-08-09
PCT/EP2011/063720 WO2012020030A1 (en) 2010-08-09 2011-08-09 Targeted gas-filled microvesicles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020177027001A Division KR101893423B1 (ko) 2010-08-09 2011-08-09 표적화 기체-충전 미세소포

Publications (2)

Publication Number Publication Date
KR20130135838A KR20130135838A (ko) 2013-12-11
KR101783653B1 true KR101783653B1 (ko) 2017-10-10

Family

ID=43216307

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020137005859A Active KR101783653B1 (ko) 2010-08-09 2011-08-09 표적화 기체-충전 미세소포
KR1020177027001A Active KR101893423B1 (ko) 2010-08-09 2011-08-09 표적화 기체-충전 미세소포

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020177027001A Active KR101893423B1 (ko) 2010-08-09 2011-08-09 표적화 기체-충전 미세소포

Country Status (15)

Country Link
US (2) US9211348B2 (enExample)
EP (2) EP2603242B1 (enExample)
JP (1) JP5779646B2 (enExample)
KR (2) KR101783653B1 (enExample)
CN (1) CN103079599B (enExample)
AU (1) AU2011288511B2 (enExample)
BR (1) BR112013003393B1 (enExample)
CA (1) CA2806639C (enExample)
DK (2) DK2603242T3 (enExample)
ES (2) ES2673277T3 (enExample)
HU (2) HUE037768T2 (enExample)
IL (1) IL224628A (enExample)
SI (2) SI3338807T1 (enExample)
WO (1) WO2012020030A1 (enExample)
ZA (1) ZA201300660B (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2871684C (en) * 2012-04-30 2021-01-05 Ge Healthcare As Method for filling a container with a foamable composition
CN103565745A (zh) 2012-08-10 2014-02-12 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
EP2934740B1 (en) * 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
EP4082552A1 (en) 2013-03-15 2022-11-02 The Board of Regents of the University of Texas System Liquids rich in noble gas and methods of their preparation and use
US10265424B2 (en) * 2014-03-04 2019-04-23 Trust-Biosonics, Inc. Molecular imaging contrast agents and uses thereof
SI3233136T1 (sl) * 2014-12-18 2019-08-30 Bracco Suisse Sa Formulacije s plinom napolnjenih usmerjenih mikroveziklov
JP2017537907A (ja) * 2014-12-22 2017-12-21 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ワクチンとしての使用のためのガス入りの微小胞
EP3359134B1 (en) * 2015-10-08 2025-04-09 The Children's Medical Center Corporation Compositions and compositions for use in on-demand high-efficiency triggerable anesthesia
KR102771920B1 (ko) 2016-02-09 2025-02-25 브라코 스위스 에스.에이. 셀렉틴 표적화를 위한 재조합 키메라 단백질
US20210190774A1 (en) * 2017-12-18 2021-06-24 The University Of Memphis Research Foundation Compositions and methods for the detection and molecular profiling of membrane bound vesicles
US11988663B2 (en) 2018-12-18 2024-05-21 The University Of Memphis Research Foundation Compositions and methods for the detection and molecular profiling of membrane bound vesicles
ES2984146T3 (es) 2018-12-21 2024-10-29 Bracco Suisse Sa Microvesículas llenas de gas con ligando

Family Cites Families (19)

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US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
IN172208B (enExample) 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5843707A (en) 1992-10-23 1998-12-01 Genetics Institute, Inc. Nucleic acid encoding a novel P-selectin ligand protein
JP3559849B2 (ja) 1993-07-30 2004-09-02 アイエムシーオーアール ファーマシューティカル カンパニー 超音波技術のための安定化された微小気泡組成物
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
ATE237362T1 (de) 1996-02-19 2003-05-15 Amersham Health As Thermostabilisiertes kontrastmittel
CA2404572A1 (en) 2000-03-31 2001-10-11 Michael J. Eppihimer Inhibition of thrombosis by treatment with p-selectin antagnosits
AU2004210221B2 (en) 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
US20060241022A1 (en) 2004-10-06 2006-10-26 Bowen Benjamin P Selectin targeting bioconjugates
KR101658439B1 (ko) 2005-12-09 2016-09-21 브라코 스위스 에스.에이. 표적화 벡터-포스포리피드 컨쥬게이트
CA2684752A1 (en) * 2007-04-20 2008-10-30 Oregon Health & Science University Ultrasound imaging with targeted microbubbles
WO2009074569A1 (en) * 2007-12-11 2009-06-18 Bracco International Bv Targeting and therapeutic compounds with a polyproline-comprising spacer and gas-filled microvesicles comprising said compounds

Also Published As

Publication number Publication date
ES2673277T3 (es) 2018-06-21
CA2806639A1 (en) 2012-02-16
BR112013003393A2 (pt) 2016-08-02
DK3338807T3 (da) 2021-02-22
HUE052894T2 (hu) 2021-05-28
JP2013535494A (ja) 2013-09-12
KR20130135838A (ko) 2013-12-11
CN103079599B (zh) 2017-05-10
ZA201300660B (en) 2013-09-25
IL224628A (en) 2016-08-31
KR101893423B1 (ko) 2018-08-31
EP2603242B1 (en) 2018-03-14
SI3338807T1 (sl) 2021-06-30
US20130156706A1 (en) 2013-06-20
CA2806639C (en) 2020-10-20
EP3338807B1 (en) 2020-12-16
US20160074539A1 (en) 2016-03-17
HUE037768T2 (hu) 2018-09-28
AU2011288511A1 (en) 2013-02-07
US9333273B2 (en) 2016-05-10
EP2603242A1 (en) 2013-06-19
US9211348B2 (en) 2015-12-15
KR20170113711A (ko) 2017-10-12
SI2603242T1 (sl) 2018-09-28
ES2848721T3 (es) 2021-08-11
WO2012020030A1 (en) 2012-02-16
DK2603242T3 (en) 2018-06-18
JP5779646B2 (ja) 2015-09-16
EP3338807A1 (en) 2018-06-27
CN103079599A (zh) 2013-05-01
BR112013003393B1 (pt) 2021-07-13
AU2011288511B2 (en) 2016-01-07

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