JP2013534902A5 - - Google Patents
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- Publication number
- JP2013534902A5 JP2013534902A5 JP2013501421A JP2013501421A JP2013534902A5 JP 2013534902 A5 JP2013534902 A5 JP 2013534902A5 JP 2013501421 A JP2013501421 A JP 2013501421A JP 2013501421 A JP2013501421 A JP 2013501421A JP 2013534902 A5 JP2013534902 A5 JP 2013534902A5
- Authority
- JP
- Japan
- Prior art keywords
- indol
- dihydro
- amine
- acetyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31747610P | 2010-03-25 | 2010-03-25 | |
| US61/317,476 | 2010-03-25 | ||
| US35286310P | 2010-06-09 | 2010-06-09 | |
| US61/352,863 | 2010-06-09 | ||
| US38148010P | 2010-09-10 | 2010-09-10 | |
| US61/381,480 | 2010-09-10 | ||
| US38815110P | 2010-09-30 | 2010-09-30 | |
| US61/388,151 | 2010-09-30 | ||
| US41906810P | 2010-12-02 | 2010-12-02 | |
| US61/419,068 | 2010-12-02 | ||
| PCT/US2011/029511 WO2011119663A1 (en) | 2010-03-25 | 2011-03-23 | Chemical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013534902A JP2013534902A (ja) | 2013-09-09 |
| JP2013534902A5 true JP2013534902A5 (OSRAM) | 2014-05-08 |
| JP5876031B2 JP5876031B2 (ja) | 2016-03-02 |
Family
ID=46160738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501421A Expired - Fee Related JP5876031B2 (ja) | 2010-03-25 | 2011-03-23 | 化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20120077828A1 (OSRAM) |
| EP (1) | EP2549868B1 (OSRAM) |
| JP (1) | JP5876031B2 (OSRAM) |
| KR (1) | KR101676077B1 (OSRAM) |
| CN (1) | CN102917588B (OSRAM) |
| AR (1) | AR080792A1 (OSRAM) |
| AU (1) | AU2011232516B2 (OSRAM) |
| EA (1) | EA022325B1 (OSRAM) |
| ES (1) | ES2530955T3 (OSRAM) |
| IL (1) | IL222120A (OSRAM) |
| MX (1) | MX2012011045A (OSRAM) |
| SG (1) | SG183954A1 (OSRAM) |
| TW (1) | TW201202241A (OSRAM) |
| UY (1) | UY33288A (OSRAM) |
| WO (1) | WO2011119663A1 (OSRAM) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8598156B2 (en) * | 2010-03-25 | 2013-12-03 | Glaxosmithkline Llc | Chemical compounds |
| WO2012158123A1 (en) * | 2011-05-13 | 2012-11-22 | Agency For Science, Technology And Research | Compounds and methods for treating insulin resistance syndrome |
| CA2841886C (en) | 2011-07-19 | 2016-08-16 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk-inhibitors |
| EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| CA2886117C (en) * | 2012-10-05 | 2022-05-31 | Merck Sharp & Dohme Corp. | Indoline compounds and their use as aldosterone synthase inhibitors |
| CN104918934B (zh) | 2013-01-18 | 2017-12-22 | 霍夫曼-拉罗奇有限公司 | 3‑取代的吡唑及其作为dlk抑制剂的用途 |
| KR102274755B1 (ko) * | 2013-04-04 | 2021-07-08 | 얀센 파마슈티카 엔.브이. | Ｐｅｒｋ 저해제로서의 신규한 ｎ―（２，３―디히드로―１ｈ―피롤로［２，３―ｂ］피리딘―５―일）―４―퀴나졸린아민 및 ｎ―（２，３―디히드로―１ｈ―인돌―５―일）―４―퀴나졸린아민 유도체 |
| TWI482757B (zh) * | 2013-10-07 | 2015-05-01 | Luminescence Technology Corp | Ｖｅｇｆ－２／３受體及蛋白質酪胺酸激酶抑制劑及其醫藥用途 |
| WO2015056180A1 (en) * | 2013-10-15 | 2015-04-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Indoline derivatives as inhibitors of perk |
| CA2931431A1 (en) | 2013-12-05 | 2015-06-11 | Acerta Pharma B.V. | Therapeutic combination of a pi3k inhibitor and a btk inhibitor |
| US10272083B2 (en) | 2014-01-21 | 2019-04-30 | Acerta Pharma B.V. | Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor |
| JP2017507967A (ja) * | 2014-03-11 | 2017-03-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | Ｐｅｒｋ阻害剤として作用する化合物 |
| US9937171B2 (en) | 2014-04-11 | 2018-04-10 | Acerta Pharma B.V. | Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
| US9949971B2 (en) | 2014-06-17 | 2018-04-24 | Acerta Pharma B.V. | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor |
| PL3179991T3 (pl) | 2014-08-11 | 2022-02-14 | Acerta Pharma B.V. | Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2 |
| LT3209656T (lt) | 2014-10-24 | 2020-07-27 | Bristol-Myers Squibb Company | Indolo karboksamidai - junginiai, naudingi kaip kinazės inhibitoriai |
| US10221181B2 (en) | 2014-11-14 | 2019-03-05 | Nerviano Medical Sciences S.R.L. | 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors |
| WO2016126026A2 (ko) * | 2015-02-04 | 2016-08-11 | 서울대학교병원 | 당뇨병 치료 조성물 및 이의 용도 |
| PL3317281T3 (pl) | 2015-07-02 | 2020-11-02 | Acerta Pharma B.V. | Postacie stałe i formulacje (s)-4-(8-amino-3-(1-(but-2-ynoilo)pirolidyn-2-ylo)imidazo[1,5-a]-pirazyn-1-ylo)-n-(pirydyn-2-ylo)benzamidu |
| TW201722957A (zh) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產（第二）有限公司 | 化學化合物 |
| WO2017046739A1 (en) * | 2015-09-15 | 2017-03-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Imidazolidinone derivatives as inhibitors of perk |
| CR20200045A (es) * | 2016-04-07 | 2020-03-11 | Glaxosmithkline Ip Dev Ltd | AMIDAS HETEROCÍCLICAS ÚTILES COMO MODULADORES DE PROTEÍNAS (Divisional 2018-0472) |
| JP6943876B2 (ja) * | 2016-04-15 | 2021-10-06 | キャンサー・リサーチ・テクノロジー・リミテッドＣａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｔｅｃｈｎｏｌｏｇｙ Ｌｉｍｉｔｅｄ | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
| WO2017189837A1 (en) * | 2016-04-29 | 2017-11-02 | The Trustees Of The University Of Pennsylvania | Protein kinase rna-like endoplasmic reticulum kinase (perk) inhibitors for prevention and/or treatment of lung injury and/or inflammation |
| US10723706B2 (en) | 2016-06-13 | 2020-07-28 | Ramot At Tel-Aviv University Ltd. | Perk inhibitors and uses thereof in treating diseases associated with aggregation-prone proteins |
| RU2753520C2 (ru) | 2016-06-21 | 2021-08-17 | НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. | Производные n-(замещенный фенил)-сульфонамида в качестве ингибиторов киназы |
| KR20190028540A (ko) * | 2016-07-20 | 2019-03-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Perk 억제제로서의 이소퀴놀린 유도체 |
| US11759437B2 (en) * | 2016-09-22 | 2023-09-19 | The University Of Hong Kong | Preventive and therapeutic approach for aberrant cell differentiation and ISR-associated diseases |
| EP3573608A1 (en) | 2017-01-30 | 2019-12-04 | Université de Liège | Perk and ire-1a inhibitors against neurodevelopmental disorders |
| CN106974910B (zh) * | 2017-03-02 | 2019-11-12 | 深圳大学 | 含索拉非尼和gsk2656157的药物组合物及用途 |
| CN106963769B (zh) * | 2017-03-03 | 2019-10-25 | 深圳大学 | 含pi3k抑制剂和perk抑制剂的药物组合物及其应用 |
| WO2018164113A1 (ja) | 2017-03-06 | 2018-09-13 | 学校法人 慶應義塾 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
| SMT201900517T1 (it) * | 2017-03-20 | 2019-11-13 | Forma Therapeutics Inc | Composizioni di pirrolopirrolo come attivatori di piruvato chinasi (pkr) |
| WO2019021208A1 (en) * | 2017-07-27 | 2019-01-31 | Glaxosmithkline Intellectual Property Development Limited | USEFUL INDAZOLE DERIVATIVES AS PERK INHIBITORS |
| WO2019090088A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| CN108003163B (zh) * | 2017-11-30 | 2020-11-24 | 武汉九州钰民医药科技有限公司 | 用作激酶抑制剂的吡唑并嘧啶类化合物及其应用 |
| CN111100130B (zh) * | 2018-10-29 | 2022-07-15 | 四川大学 | 4-氨基吡咯并嘧啶衍生物及其制备方法和用途 |
| CN111213632B (zh) * | 2019-11-19 | 2022-03-01 | 长春中医药大学 | 动物药环氧树脂标本制作方法 |
| EP4161933A1 (en) | 2020-06-08 | 2023-04-12 | Halia Therapeutics, Inc. | Inhibitors of nek7 kinase |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| US20240382488A1 (en) | 2021-03-29 | 2024-11-21 | Halia Therapeutics, Inc. | Nek7 inhibitors |
| WO2022216680A1 (en) | 2021-04-05 | 2022-10-13 | Halia Therapeutics, Inc. | Nek7 inhibitors |
| WO2023034236A1 (en) * | 2021-08-31 | 2023-03-09 | Wisconsin Alumni Research Foundation | Deuterated inhibitors of rip kinases |
| GB202407386D0 (en) | 2024-05-24 | 2024-07-10 | Apollo Ap45 Ltd | 1H-pyrazolo(4,3-D)pyrimidine derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005110410A2 (en) * | 2004-05-14 | 2005-11-24 | Abbott Laboratories | Kinase inhibitors as therapeutic agents |
| SI1761528T1 (sl) * | 2004-06-11 | 2008-06-30 | Japan Tobacco Inc | 5-amino-2,4,7-triokso-3,4,7,8-tetrahidro-2H-pirido(2,3-D)pirimidinski derivati in sorodne spojine za zdravljenje raka |
| US20080255184A1 (en) * | 2005-11-04 | 2008-10-16 | Smithkline Beecham Corporation | Thienopyridine B-Raf Kinase Inhibitors |
| AU2007272330A1 (en) * | 2006-07-13 | 2008-01-17 | Zymogenetics, Inc. | Interleukin 21 and tyrosine kinase inhibitor combination therapy |
| WO2009151621A1 (en) * | 2008-06-13 | 2009-12-17 | Arena Pharmaceuticals, Inc. | Substituted (1, 2, 4-0xadiaz0l-3-yl) indolin-1-yl carboxylic acid derivatives useful as s1p1 agonists |
| JP5746032B2 (ja) * | 2008-09-19 | 2015-07-08 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | ３，４−ジヒドロ−２Ｈ−ピロロ［１，２−ａ］ピラジン−１−オン誘導体 |
-
2011
- 2011-03-22 UY UY0001033288A patent/UY33288A/es not_active Application Discontinuation
- 2011-03-23 AU AU2011232516A patent/AU2011232516B2/en not_active Ceased
- 2011-03-23 KR KR1020127027705A patent/KR101676077B1/ko not_active Expired - Fee Related
- 2011-03-23 MX MX2012011045A patent/MX2012011045A/es active IP Right Grant
- 2011-03-23 EP EP11760102.1A patent/EP2549868B1/en active Active
- 2011-03-23 WO PCT/US2011/029511 patent/WO2011119663A1/en not_active Ceased
- 2011-03-23 TW TW100109800A patent/TW201202241A/zh unknown
- 2011-03-23 ES ES11760102T patent/ES2530955T3/es active Active
- 2011-03-23 EA EA201290952A patent/EA022325B1/ru not_active IP Right Cessation
- 2011-03-23 SG SG2012066379A patent/SG183954A1/en unknown
- 2011-03-23 JP JP2013501421A patent/JP5876031B2/ja not_active Expired - Fee Related
- 2011-03-23 AR ARP110100955A patent/AR080792A1/es not_active Application Discontinuation
- 2011-03-23 CN CN201180025962.7A patent/CN102917588B/zh not_active Expired - Fee Related
- 2011-03-23 US US13/069,569 patent/US20120077828A1/en not_active Abandoned
-
2012
- 2012-09-24 IL IL222120A patent/IL222120A/en not_active IP Right Cessation
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