JP2013533217A5 - - Google Patents
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- JP2013533217A5 JP2013533217A5 JP2013511302A JP2013511302A JP2013533217A5 JP 2013533217 A5 JP2013533217 A5 JP 2013533217A5 JP 2013511302 A JP2013511302 A JP 2013511302A JP 2013511302 A JP2013511302 A JP 2013511302A JP 2013533217 A5 JP2013533217 A5 JP 2013533217A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pegylated
- peptide
- neuropathy
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 108010075254 C-Peptide Proteins 0.000 claims 14
- 230000007774 longterm Effects 0.000 claims 5
- 208000033808 peripheral neuropathy Diseases 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 206010036105 Polyneuropathy Diseases 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 230000007824 polyneuropathy Effects 0.000 claims 4
- 206010061666 Autonomic neuropathy Diseases 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 210000005036 nerve Anatomy 0.000 claims 3
- 201000001119 neuropathy Diseases 0.000 claims 3
- 230000007823 neuropathy Effects 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 230000005540 biological transmission Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 201000001881 impotence Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 208000019382 nerve compression syndrome Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000008363 phosphate buffer Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010000060 Abdominal distension Diseases 0.000 claims 1
- 206010059245 Angiopathy Diseases 0.000 claims 1
- 206010002652 Anorgasmia Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 208000019736 Cranial nerve disease Diseases 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 208000004044 Hypesthesia Diseases 0.000 claims 1
- 229920001202 Inulin Polymers 0.000 claims 1
- 208000001344 Macular Edema Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 206010027525 Microalbuminuria Diseases 0.000 claims 1
- 208000009857 Microaneurysm Diseases 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- 208000010428 Muscle Weakness Diseases 0.000 claims 1
- 206010028289 Muscle atrophy Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010029174 Nerve compression Diseases 0.000 claims 1
- 206010031127 Orthostatic hypotension Diseases 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 206010037779 Radiculopathy Diseases 0.000 claims 1
- 206010065427 Reflux nephropathy Diseases 0.000 claims 1
- 206010038934 Retinopathy proliferative Diseases 0.000 claims 1
- 206010040021 Sensory abnormalities Diseases 0.000 claims 1
- 208000006568 Urinary Bladder Calculi Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 206010046555 Urinary retention Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 206010005038 bladder diverticulum Diseases 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 201000005937 cranial nerve palsy Diseases 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 230000006870 function Effects 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000030136 gastric emptying Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 208000034783 hypoesthesia Diseases 0.000 claims 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims 1
- 229940029339 inulin Drugs 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000027939 micturition Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000005518 mononeuropathy Diseases 0.000 claims 1
- 230000007659 motor function Effects 0.000 claims 1
- 230000020763 muscle atrophy Effects 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 231100000862 numbness Toxicity 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000009747 swallowing Effects 0.000 claims 1
- 230000035900 sweating Effects 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 210000002229 urogenital system Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34529310P | 2010-05-17 | 2010-05-17 | |
| US61/345,293 | 2010-05-17 | ||
| US201161448402P | 2011-03-02 | 2011-03-02 | |
| US61/448,402 | 2011-03-02 | ||
| PCT/US2011/036858 WO2011146518A2 (en) | 2010-05-17 | 2011-05-17 | Pegylated c-peptide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013533217A JP2013533217A (ja) | 2013-08-22 |
| JP2013533217A5 true JP2013533217A5 (enExample) | 2014-07-03 |
Family
ID=44992295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511302A Pending JP2013533217A (ja) | 2010-05-17 | 2011-05-17 | Ｐｅｇ化ｃ−ペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8927488B2 (enExample) |
| EP (1) | EP2571896A4 (enExample) |
| JP (1) | JP2013533217A (enExample) |
| KR (1) | KR20130115086A (enExample) |
| CN (1) | CN103119055A (enExample) |
| CA (1) | CA2798518A1 (enExample) |
| MX (1) | MX2012013375A (enExample) |
| NZ (1) | NZ603399A (enExample) |
| WO (1) | WO2011146518A2 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0511269D0 (en) * | 2005-06-02 | 2005-07-13 | Creative Peptides Sweden Ab | Sustained release preparation of pro-insulin C-peptide |
| EP4450523A3 (en) * | 2010-04-02 | 2025-03-12 | Amunix Pharmaceuticals, Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
| US8927488B2 (en) | 2010-05-17 | 2015-01-06 | Cebix, Inc. | Pegylated C-peptide |
| EP2755675B1 (en) * | 2011-09-12 | 2018-06-06 | Amunix Operating Inc. | Glucagon-like peptide-2 compositions and methods of making and using same |
| CN104220086A (zh) * | 2011-11-17 | 2014-12-17 | 塞比克斯股份公司 | Peg化的c-肽 |
| US20130288973A1 (en) * | 2011-12-14 | 2013-10-31 | Edmund Burke | Decellularized small particle tissue |
| US9988433B2 (en) * | 2013-03-14 | 2018-06-05 | Mosaic Biosciences, Inc. | Covalent modification of biological macromolecules |
| WO2013116791A1 (en) | 2012-02-02 | 2013-08-08 | Mosaic Biosciences, Inc. | Biomaterials for delivery of blood extracts and methods of using same |
| US20150087586A1 (en) * | 2012-03-29 | 2015-03-26 | Cebix, Inc. | Pegylated c-peptide |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| EP3021834A1 (en) * | 2013-07-18 | 2016-05-25 | MannKind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| AU2014328458B2 (en) * | 2013-09-24 | 2020-03-12 | Allergan Pharmaceuticals International Limited | Method of extracting protein |
| KR20170116109A (ko) | 2015-02-09 | 2017-10-18 | 모자이크 바이오사이언스 인코포레이션 | 분해성 티올-엔 중합체 및 그의 제조 방법 |
| JP6937984B2 (ja) * | 2015-03-03 | 2021-09-22 | ナンシャ・バイオロジックス・（ホンコン）・リミテッドＮａｎｓｈａ Ｂｉｏｌｏｇｉｃｓ （Ｈｏｎｇ Ｋｏｎｇ） Ｌｉｍｉｔｅｄ | ペグ化ｉｌ−１１の組成物および方法 |
| US10627415B2 (en) | 2015-03-12 | 2020-04-21 | Board Of Trustees Of Michigan State University | Compositions and methods for diagnosing, monitoring, and treating an autoimmune disease |
| CN114805540A (zh) * | 2015-09-18 | 2022-07-29 | 国立大学法人宫崎大学 | 长效肾上腺髓质素衍生物 |
| CN108265044B (zh) * | 2016-12-31 | 2021-05-11 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇定点修饰的精氨酸脱亚胺酶及其制备方法与应用 |
| ES2989204T3 (es) | 2017-06-16 | 2024-11-25 | Zealand Pharma As | Pautas posológicas para la administración de análogos del péptido 2 similar al glucagón (GLP-2) |
| JP7058857B2 (ja) * | 2017-08-30 | 2022-04-25 | クラシエホームプロダクツ株式会社 | 毛髪タンパク質の水との相互作用測定方法 |
| EP3449935A1 (en) * | 2017-08-31 | 2019-03-06 | Erytech Pharma | Arginine deiminase encapsulated inside erythrocytes and their use in treating cancer and arginase-1 deficiency |
| US12226546B2 (en) * | 2017-09-28 | 2025-02-18 | The Regents Of The University Of California | Polyion complex polypeptide hydrogels and uses thereof |
| WO2019066609A1 (ko) | 2017-09-29 | 2019-04-04 | 한미약품 주식회사 | 링커로서 비펩타이드성 중합체 결합 지방산 유도체 화합물을 포함하는 단백질 결합체 및 이의 제조방법 |
| HRP20240475T8 (hr) * | 2017-12-01 | 2024-08-02 | Csl Behring Llc | A1at za smanjenje rizika od nastanka akutne bolesti graft versus host nakon transplantacije hematopoetskih stanica |
| CA3084013A1 (en) | 2017-12-01 | 2019-06-06 | StemRIM Inc. | Ectodermal mesenchymal stem cells and method for producing same |
| AU2019268410B2 (en) * | 2018-05-16 | 2025-01-02 | Csl Limited | Soluble complement receptor type 1 variants and uses thereof |
| EP3628682A1 (en) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| EP3628683A1 (en) * | 2018-09-28 | 2020-04-01 | Zealand Pharma A/S | Formulations of glucagon-like-peptide-2 (glp-2) analogues |
| CN113423466B (zh) * | 2018-10-25 | 2025-04-25 | 国立大学法人大阪大学 | 软骨病症的治疗剂 |
| MX2021005757A (es) | 2018-11-15 | 2021-08-11 | Quantum Si Inc | Metodos y composiciones para la secuenciacion de proteinas. |
| US20220177704A1 (en) * | 2019-03-27 | 2022-06-09 | The Regents Of Theuniversity Of California | Mixtures of synthetic copolypeptide hydrogels |
| KR102836637B1 (ko) * | 2019-03-29 | 2025-07-21 | 니치유 가부시키가이샤 | 분기형 분해성 폴리에틸렌 글리콜 유도체 |
| US12390534B2 (en) | 2019-03-29 | 2025-08-19 | Nof Corporation | Branched degradable polyethylene glycol binder |
| CN111939244B (zh) * | 2019-05-14 | 2024-08-06 | 阿莫生命科学有限公司 | 用于预防或治疗糖尿病并发症的药物组合物 |
| KR102456958B1 (ko) | 2019-05-14 | 2022-10-21 | 강원대학교 산학협력단 | 당뇨병성 합병증의 예방 또는 치료용 약제학적 조성물 |
| JP7750489B2 (ja) * | 2020-04-20 | 2025-10-07 | 塩野義製薬株式会社 | Ｈｍｇｂ１部分ペプチドを含有する製剤 |
| US12090206B2 (en) | 2020-04-23 | 2024-09-17 | The Regents Of The University Of California | Compositions comprising tri- and penta-block synthetic copolypeptide hydrogels |
| US12065466B2 (en) * | 2020-05-20 | 2024-08-20 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
| CN114137094A (zh) * | 2020-09-03 | 2022-03-04 | 北京渼颜空间生物医药有限公司 | 一种聚左旋乳酸中有关物质的检测方法 |
| US20220401525A1 (en) * | 2021-06-16 | 2022-12-22 | Biocell Technology, Llc | Use of collagen compositions for increasing telomere length |
| CN116554267A (zh) * | 2022-01-30 | 2023-08-08 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇修饰的激肽或其变体和药物应用 |
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-
2011
- 2011-05-17 US US13/109,522 patent/US8927488B2/en not_active Expired - Fee Related
- 2011-05-17 JP JP2013511302A patent/JP2013533217A/ja active Pending
- 2011-05-17 CA CA2798518A patent/CA2798518A1/en not_active Abandoned
- 2011-05-17 WO PCT/US2011/036858 patent/WO2011146518A2/en not_active Ceased
- 2011-05-17 NZ NZ603399A patent/NZ603399A/en not_active IP Right Cessation
- 2011-05-17 CN CN2011800350917A patent/CN103119055A/zh active Pending
- 2011-05-17 KR KR1020127031723A patent/KR20130115086A/ko not_active Withdrawn
- 2011-05-17 MX MX2012013375A patent/MX2012013375A/es not_active Application Discontinuation
- 2011-05-17 EP EP11784109.8A patent/EP2571896A4/en not_active Withdrawn
-
2012
- 2012-05-04 US US13/463,887 patent/US8691755B2/en not_active Expired - Fee Related
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