JP2013532492A5 - - Google Patents
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- JP2013532492A5 JP2013532492A5 JP2013523366A JP2013523366A JP2013532492A5 JP 2013532492 A5 JP2013532492 A5 JP 2013532492A5 JP 2013523366 A JP2013523366 A JP 2013523366A JP 2013523366 A JP2013523366 A JP 2013523366A JP 2013532492 A5 JP2013532492 A5 JP 2013532492A5
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- JP
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- Prior art keywords
- albumin
- pluripotent stem
- free medium
- cells
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 26
- 239000002609 medium Substances 0.000 claims 24
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 18
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 15
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 10
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 10
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 10
- 102000004877 Insulin Human genes 0.000 claims 9
- 108090001061 Insulin Proteins 0.000 claims 9
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 9
- 102000004338 Transferrin Human genes 0.000 claims 9
- 108090000901 Transferrin Proteins 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 9
- 229940125396 insulin Drugs 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 229910052711 selenium Inorganic materials 0.000 claims 9
- 239000011669 selenium Substances 0.000 claims 9
- 239000012581 transferrin Substances 0.000 claims 9
- 229940088594 vitamin Drugs 0.000 claims 9
- 229930003231 vitamin Natural products 0.000 claims 9
- 235000013343 vitamin Nutrition 0.000 claims 9
- 239000011782 vitamin Substances 0.000 claims 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 8
- 239000008103 glucose Substances 0.000 claims 8
- 230000008672 reprogramming Effects 0.000 claims 7
- 229960001031 glucose Drugs 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 239000011435 rock Substances 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 4
- 210000001082 somatic cell Anatomy 0.000 claims 4
- 230000010261 cell growth Effects 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- LZAXPYOBKSJSEX-UHFFFAOYSA-N blebbistatin Chemical compound C1CC2(O)C(=O)C3=CC(C)=CC=C3N=C2N1C1=CC=CC=C1 LZAXPYOBKSJSEX-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 230000001146 hypoxic effect Effects 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 238000007747 plating Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37112810P | 2010-08-05 | 2010-08-05 | |
| US61/371,128 | 2010-08-05 | ||
| PCT/US2011/046796 WO2012019122A2 (en) | 2010-08-05 | 2011-08-05 | Simplified basic media for human pluripotent cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016186896A Division JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532492A JP2013532492A (ja) | 2013-08-19 |
| JP2013532492A5 true JP2013532492A5 (cg-RX-API-DMAC10.html) | 2014-09-25 |
| JP6043999B2 JP6043999B2 (ja) | 2016-12-14 |
Family
ID=44543813
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523366A Active JP6043999B2 (ja) | 2010-08-05 | 2011-08-05 | ヒト多能性細胞培養のための簡易基本培地 |
| JP2016186896A Pending JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016186896A Pending JP2017018137A (ja) | 2010-08-05 | 2016-09-26 | ヒト多能性細胞培養のための簡易基本培地 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9279103B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2601288B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP6043999B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR101829488B1 (cg-RX-API-DMAC10.html) |
| CN (2) | CN108531444A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2011285531B2 (cg-RX-API-DMAC10.html) |
| BR (2) | BR112013002811A8 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2807418C (cg-RX-API-DMAC10.html) |
| DK (1) | DK2601288T3 (cg-RX-API-DMAC10.html) |
| IL (1) | IL224431A (cg-RX-API-DMAC10.html) |
| SG (1) | SG187699A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2012019122A2 (cg-RX-API-DMAC10.html) |
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| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| RU2473685C2 (ru) | 2007-07-31 | 2013-01-27 | Лайфскен, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
| CN107574142B (zh) | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| BRPI0908033A2 (pt) | 2008-02-21 | 2015-08-04 | Centocor Ortho Biotech Inc | Método placas de superfície modificada e composições para adesão, cultura e desprendimento de célula |
| CA2729121C (en) | 2008-06-30 | 2019-04-09 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| EP2346988B1 (en) | 2008-10-31 | 2017-05-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| JP2012507289A (ja) | 2008-10-31 | 2012-03-29 | ヤンセン バイオテツク，インコーポレーテツド | ヒト胚性幹細胞の膵内分泌系への分化 |
| MX2011005288A (es) | 2008-11-20 | 2011-06-01 | Centocor Ortho Biotech Inc | Celulas madre pluripotentes en microportadores. |
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| EP2291511B1 (en) * | 2008-05-02 | 2017-06-21 | Cellular Dynamics International, Inc. | Method for production of mast cells from stem cells |
| EP3450545B1 (en) | 2008-10-24 | 2023-08-23 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
| WO2011058558A2 (en) | 2009-11-12 | 2011-05-19 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
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2011
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