|
US3108117A
(en)
|
1959-02-12 |
1963-10-22 |
Mead Johnson & Co |
3-benzyl-1, 2-diloweralkyl-3-pyrrolidinols
|
|
US3778443A
(en)
|
1969-02-13 |
1973-12-11 |
Ciba Geigy Ag |
4-tetrahydro pyridyl,hydroxy alkyl pyrazoles
|
|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
GB1422263A
(en)
|
1973-01-30 |
1976-01-21 |
Ferrosan As |
4-phenyl-piperidine compounds
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
DE2701705A1
(de)
|
1976-01-28 |
1977-08-04 |
Sandoz Ag |
Neue organische verbindungen, ihre verwendung und herstellung
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
CA1146866A
(en)
|
1979-07-05 |
1983-05-24 |
Yamanouchi Pharmaceutical Co. Ltd. |
Process for the production of sustained release pharmaceutical composition of solid medical material
|
|
DE3438830A1
(de)
|
1984-10-23 |
1986-04-30 |
Rentschler Arzneimittel |
Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
DE69222847T3
(de)
*
|
1991-04-16 |
2005-09-15 |
Nippon Shinyaku Co., Ltd. |
Verfahren zur herstellung einer festen dispersion
|
|
US5817667A
(en)
|
1991-04-17 |
1998-10-06 |
University Of Georgia Research Foudation |
Compounds and methods for the treatment of cancer
|
|
US5340591A
(en)
|
1992-01-24 |
1994-08-23 |
Fujisawa Pharmaceutical Co., Ltd. |
Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
|
|
JP3265680B2
(ja)
|
1992-03-12 |
2002-03-11 |
大正製薬株式会社 |
経口製剤用組成物
|
|
AU4444393A
(en)
|
1992-09-01 |
1994-03-10 |
Zeneca Limited |
Pyrrolidine derivatives
|
|
GB9310713D0
(en)
|
1993-05-24 |
1993-07-07 |
Zeneca Ltd |
Aryl substituted heterocycles
|
|
AU4437896A
(en)
|
1995-01-12 |
1996-07-31 |
Glaxo Group Limited |
Piperidine derivatives having tachykinin antagonist activity
|
|
HU226635B1
(en)
|
1995-01-23 |
2009-05-28 |
Asubio Pharma Co |
Piperidine and piperazine derivatives, medicines containing them as active ingredient and their use
|
|
DE19504832A1
(de)
|
1995-02-14 |
1996-08-22 |
Basf Ag |
Feste Wirkstoff-Zubereitungen
|
|
IL123293A
(en)
|
1995-09-07 |
2003-06-24 |
Hoffmann La Roche |
Piperidine derivatives, their preparation and pharmaceutical compositions containing them
|
|
JPH11513382A
(ja)
|
1995-10-20 |
1999-11-16 |
ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング |
5員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
|
|
CA2231879C
(en)
|
1996-07-22 |
2007-01-23 |
Suntory Limited |
Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same
|
|
DE69837903T2
(de)
*
|
1997-08-11 |
2008-02-14 |
Pfizer Products Inc., Groton |
Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit
|
|
US6274735B1
(en)
|
1998-08-10 |
2001-08-14 |
Hoffmann-La Roche Inc. |
Process and intermediates for preparation of substituted piperidines
|
|
IT1303737B1
(it)
|
1998-11-11 |
2001-02-23 |
Smithkline Beecham Spa |
Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1.
|
|
US20030017528A1
(en)
|
1998-11-20 |
2003-01-23 |
Ruoping Chen |
Human orphan G protein-coupled receptors
|
|
EP1133559B1
(en)
|
1998-11-20 |
2005-08-10 |
Arena Pharmaceuticals, Inc. |
Human orphan g protein-coupled receptor rup3
|
|
DE60039379D1
(de)
*
|
1999-02-10 |
2008-08-21 |
Pfizer Prod Inc |
Pharmazeutische feste Dispersionen
|
|
US6221660B1
(en)
|
1999-02-22 |
2001-04-24 |
Synaptic Pharmaceutical Corporation |
DNA encoding SNORF25 receptor
|
|
GB9912416D0
(en)
|
1999-05-28 |
1999-07-28 |
Pfizer Ltd |
Compounds useful in therapy
|
|
GB9923177D0
(en)
|
1999-09-30 |
1999-12-01 |
Pfizer Ltd |
Novel polypeptide
|
|
IL139073A0
(en)
|
1999-10-21 |
2001-11-25 |
Pfizer |
Treatment of neuropathy
|
|
YU51701A
(sh)
|
2000-07-28 |
2003-12-31 |
Pfizer Inc. |
Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
|
|
US6770645B2
(en)
|
2001-03-16 |
2004-08-03 |
Pfizer Inc. |
Pharmaceutically active compounds
|
|
US6784185B2
(en)
|
2001-03-16 |
2004-08-31 |
Pfizer Inc. |
Pharmaceutically active compounds
|
|
JP2004534017A
(ja)
|
2001-04-27 |
2004-11-11 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Baceのインヒビター
|
|
US20030003157A1
(en)
|
2001-06-06 |
2003-01-02 |
University Of Medicine & Dentistry Of New Jersey |
Collagen compositions and methods for making and using the same
|
|
CA2456754A1
(en)
|
2001-08-08 |
2003-02-20 |
Yuji Iizawa |
Benzazepine derivative, process for producing the same, and use
|
|
BR0307515A
(pt)
*
|
2002-02-01 |
2004-12-07 |
Pfizer Prod Inc |
Método para fabricar dispersões de drogas amorfas sólidas secas por aspersão homogêneas usando bicos de pressão
|
|
AU2003231388A1
(en)
|
2002-04-25 |
2003-11-10 |
Sumitomo Pharmaceuticals Co., Ltd. |
Novel piperidine derivative
|
|
GB0224919D0
(en)
|
2002-10-25 |
2002-12-04 |
Pfizer Ltd |
Triazole compounds useful in therapy
|
|
GB0230162D0
(en)
|
2002-12-24 |
2003-02-05 |
Metris Therapeutics Ltd |
Compounds useful in inhibiting angiogenesis
|
|
EP1599313B1
(en)
|
2003-03-05 |
2006-07-05 |
Maus S.P.A. |
Method of machining a brake disc
|
|
GB0308333D0
(en)
|
2003-04-10 |
2003-05-14 |
Glaxo Group Ltd |
Novel compounds
|
|
CA2529161A1
(en)
|
2003-06-13 |
2004-12-29 |
Schering Aktiengesellschaft |
Quinolyl amide derivatives as ccr-5 antagonists
|
|
EP2287165A3
(en)
|
2003-07-14 |
2011-06-22 |
Arena Pharmaceuticals, Inc. |
Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
|
|
AU2004261250B2
(en)
|
2003-07-29 |
2009-02-26 |
Xenon Pharmaceuticals Inc. |
Pyridyl derivatives and their use as therapeutic agents
|
|
FR2862647B1
(fr)
|
2003-11-25 |
2008-07-04 |
Aventis Pharma Sa |
Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
BRPI0418149A
(pt)
|
2003-12-24 |
2007-04-17 |
Prosidion Ltd |
derivados heterocìclicos como agonistas do receptor de gprc
|
|
TW200538433A
(en)
|
2004-02-24 |
2005-12-01 |
Irm Llc |
Immunosuppressant compounds and compositiions
|
|
DK1773772T3
(da)
|
2004-06-08 |
2010-09-13 |
Nsab Af Neurosearch Sweden Ab |
Nye disubstituerede phenylpiperidiner/piperaziner som modulatorer af dopaminneurotransmission
|
|
WO2006046779A1
(ja)
|
2004-10-29 |
2006-05-04 |
Zeria Pharmaceutical Co., Ltd. |
カルバゾール誘導体、その溶媒和物、又は薬学的に許容されるその塩
|
|
TW200633990A
(en)
|
2004-11-18 |
2006-10-01 |
Takeda Pharmaceuticals Co |
Amide compound
|
|
JP5208516B2
(ja)
|
2004-12-30 |
2013-06-12 |
エグゼリクシス, インコーポレイテッド |
キナーゼモジュレーターとしてのピリミジン誘導体および使用方法
|
|
GB0428526D0
(en)
|
2004-12-30 |
2005-02-09 |
Novartis Ag |
Organic compounds
|
|
DOP2006000008A
(es)
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
|
MY148521A
(en)
|
2005-01-10 |
2013-04-30 |
Arena Pharm Inc |
Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
|
|
US8277495B2
(en)
|
2005-01-13 |
2012-10-02 |
Candela Corporation |
Method and apparatus for treating a diseased nail
|
|
WO2006091428A2
(en)
|
2005-02-16 |
2006-08-31 |
Schering Corporation |
Heteroaryl substituted pyrazinyl-piperazine-piperidines with cxcr3 antagonist activity
|
|
AU2006247520A1
(en)
|
2005-05-18 |
2006-11-23 |
Wyeth |
3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same
|
|
WO2006133216A2
(en)
|
2005-06-06 |
2006-12-14 |
Smithkline Beecham Corporation |
4-substituted arylamine derivatives and their use in pharmaceutical compositions
|
|
CA2611216A1
(en)
|
2005-06-15 |
2006-12-21 |
Pfizer Limited |
3-phenylazetidine derivatives as dopamine agonists
|
|
US20090018123A1
(en)
|
2005-06-20 |
2009-01-15 |
Milind D Sindkhedkar |
Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
|
|
WO2007003961A2
(en)
|
2005-06-30 |
2007-01-11 |
Prosidion Limited |
Gpcr agonists
|
|
EP1907383A1
(en)
|
2005-06-30 |
2008-04-09 |
Prosidion Limited |
Gpcr agonists
|
|
EA013084B1
(ru)
|
2005-09-16 |
2010-02-26 |
Арена Фармасьютикалз, Инк. |
Модуляторы метаболизма и лечение связанных с ним нарушений
|
|
RU2008112198A
(ru)
|
2005-09-29 |
2009-10-10 |
Санофи-Авентис (Fr) |
Производные фенил-1,2,4-оксадиазолона, способы их получения и их применение в качестве фармацевтических средств
|
|
WO2007066189A2
(en)
*
|
2005-12-09 |
2007-06-14 |
Pfizer Products Inc. |
Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea
|
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
|
WO2008008887A2
(en)
|
2006-07-13 |
2008-01-17 |
Smithkline Beecham Corporation |
Gpr119 agonists for treating metabolic disorders
|
|
US8343548B2
(en)
*
|
2006-08-08 |
2013-01-01 |
Shin-Etsu Chemical Co., Ltd. |
Solid dosage form comprising solid dispersion
|
|
AU2007291252A1
(en)
|
2006-08-30 |
2008-03-06 |
Inovacia Ab |
Pyridine compounds for treating GPR119 related disorders
|
|
WO2008047201A2
(en)
*
|
2006-10-17 |
2008-04-24 |
Pfizer Products Inc. |
Solid dispersion comprising a poorly water soluble drug
|
|
EP2325182A1
(en)
|
2006-12-06 |
2011-05-25 |
Glaxosmithkline LLC |
Bicyclic compounds and use as antidiabetics
|
|
US7638541B2
(en)
*
|
2006-12-28 |
2009-12-29 |
Metabolex Inc. |
5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
|
|
CN101616586B
(zh)
*
|
2006-12-28 |
2014-08-13 |
赛马拜制药公司 |
治疗糖尿病和代谢性病症的杂环受体激动剂
|
|
US20100120807A1
(en)
|
2007-03-08 |
2010-05-13 |
Irm Llc |
Compounds and compositions as modulators of gpr119 activity
|
|
EP2014656A3
(en)
|
2007-06-11 |
2011-08-24 |
High Point Pharmaceuticals, LLC |
New heteocyclic h3 antagonists
|
|
UY31232A1
(es)
|
2007-07-19 |
2009-03-02 |
|
Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
|
|
FR2918986B1
(fr)
|
2007-07-19 |
2009-09-04 |
Sanofi Aventis Sa |
Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique
|
|
CA2693169C
(en)
|
2007-07-19 |
2016-01-12 |
Metabolex, Inc. |
N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
|
|
PT2019104E
(pt)
|
2007-07-19 |
2013-12-03 |
Sanofi Sa |
Agentes citotóxicos compreendendo novos derivados de tomaimicina e sua utilização terapêutica
|
|
RU2010105682A
(ru)
|
2007-07-19 |
2011-08-27 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Новые гетероциклические соединения и их применение в качестве хемокиновых антагонистов
|
|
RU2474580C2
(ru)
|
2007-07-19 |
2013-02-10 |
Шеринг Корпорейшн |
Гетероциклические амидные соединения как ингибиторы протеинкиназ
|
|
CA2707565A1
(en)
|
2007-12-04 |
2009-06-11 |
Merck Frosst Canada Ltd. |
Renin inhibitors
|
|
CL2009000782A1
(es)
*
|
2008-03-31 |
2010-04-30 |
Metabolex Inc |
Metodo que comprende un compuesto derivado de oximetilen-arilo sustituido, inhibidores de dpp-iv; y su uso en el tratamiento de la diabetes y disminucion de trigliceridos, entre otras enfermedades.
|
|
MX2010013876A
(es)
|
2008-06-20 |
2011-03-04 |
Metabolex Inc |
Agonistas de arilo grpr119 y sus usos .
|
|
US8536176B2
(en)
|
2008-08-01 |
2013-09-17 |
Nippon Chemiphar Co., Ltd. |
GPR119 agonist
|
|
MX2011002558A
(es)
*
|
2008-09-10 |
2011-04-26 |
Boehringer Ingelheim Int |
Terapia de combinacion para el tratamiento de diabetes y estados relacionados.
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
US20110160222A1
(en)
|
2008-11-26 |
2011-06-30 |
Metabolex, Inc. |
Modulators of glucose homeostasis for the treatment of diabetes and metabolic disorders
|
|
JP5667180B2
(ja)
|
2009-07-01 |
2015-02-12 |
イオン メディックス インコーポレイテッド |
哺乳類の有核細胞に由来するマイクロベシクル及びその用途
|
|
CA2775840C
(en)
|
2009-10-01 |
2018-02-06 |
Metabolex, Inc. |
Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
|
|
US20110313160A1
(en)
|
2010-06-04 |
2011-12-22 |
Metabolex, Inc. |
Preparation of 5-ethyl-2--pyrimidine
|
|
ES2676209T3
(es)
|
2010-06-23 |
2018-07-17 |
Metabolex Inc. |
Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina
|
|
US20120184572A1
(en)
|
2011-01-13 |
2012-07-19 |
Metabolex, Inc. |
Aryl gpr119 agonists and uses thereof
|