JP2013529086A5 - - Google Patents
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- Publication number
- JP2013529086A5 JP2013529086A5 JP2013511303A JP2013511303A JP2013529086A5 JP 2013529086 A5 JP2013529086 A5 JP 2013529086A5 JP 2013511303 A JP2013511303 A JP 2013511303A JP 2013511303 A JP2013511303 A JP 2013511303A JP 2013529086 A5 JP2013529086 A5 JP 2013529086A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- progeny
- genetically modified
- nucleic acid
- brassica plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000219198 Brassica Species 0.000 claims description 113
- 150000007523 nucleic acids Chemical group 0.000 claims description 81
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 73
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 23
- 235000019198 oils Nutrition 0.000 claims description 23
- 102000005870 Coenzyme A Ligases Human genes 0.000 claims description 20
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 claims description 20
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 20
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 19
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 17
- 108010001814 phosphopantetheinyl transferase Proteins 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- 235000021588 free fatty acids Nutrition 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 9
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 8
- 239000013604 expression vector Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 238000003259 recombinant expression Methods 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 150000004665 fatty acids Chemical class 0.000 claims description 6
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 claims description 6
- 230000001131 transforming effect Effects 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 4
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 claims description 4
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 claims description 4
- 108010018763 Biotin carboxylase Proteins 0.000 claims description 4
- 102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 claims description 4
- 108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 claims description 4
- 101100280636 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) fae-1 gene Proteins 0.000 claims description 4
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000005642 Oleic acid Substances 0.000 claims description 4
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 4
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 4
- 229960004488 linolenic acid Drugs 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 235000013376 functional food Nutrition 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 229940127557 pharmaceutical product Drugs 0.000 claims description 3
- 244000178993 Brassica juncea Species 0.000 claims description 2
- 235000011332 Brassica juncea Nutrition 0.000 claims description 2
- 235000014700 Brassica juncea var napiformis Nutrition 0.000 claims description 2
- 240000002791 Brassica napus Species 0.000 claims description 2
- 235000011293 Brassica napus Nutrition 0.000 claims description 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 2
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 2
- 230000002068 genetic effect Effects 0.000 claims description 2
- 108090000992 Transferases Proteins 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 239000003921 oil Substances 0.000 description 13
- 241000196324 Embryophyta Species 0.000 description 6
- 235000011331 Brassica Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34553710P | 2010-05-17 | 2010-05-17 | |
| US61/345,537 | 2010-05-17 | ||
| PCT/US2011/036869 WO2011146524A1 (en) | 2010-05-17 | 2011-05-17 | Production of dha and other lc-pufas in plants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529086A JP2013529086A (ja) | 2013-07-18 |
| JP2013529086A5 true JP2013529086A5 (enExample) | 2014-07-03 |
| JP6059138B2 JP6059138B2 (ja) | 2017-01-11 |
Family
ID=44992026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013511303A Expired - Fee Related JP6059138B2 (ja) | 2010-05-17 | 2011-05-17 | 植物におけるｄｈａおよび他のｌｃ−ｐｕｆａの産生 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US20130150599A1 (enExample) |
| EP (3) | EP3354739A1 (enExample) |
| JP (1) | JP6059138B2 (enExample) |
| KR (1) | KR102184432B1 (enExample) |
| CN (2) | CN105296511A (enExample) |
| AR (1) | AR081201A1 (enExample) |
| AU (1) | AU2011256209B2 (enExample) |
| BR (1) | BR112012029255A2 (enExample) |
| CA (2) | CA2799559C (enExample) |
| CL (1) | CL2012003210A1 (enExample) |
| EA (1) | EA201291223A1 (enExample) |
| ES (1) | ES2656217T3 (enExample) |
| HU (1) | HUE036182T2 (enExample) |
| IL (1) | IL223045A0 (enExample) |
| MX (1) | MX345243B (enExample) |
| MY (1) | MY165098A (enExample) |
| NO (1) | NO2571994T3 (enExample) |
| NZ (1) | NZ604479A (enExample) |
| PH (1) | PH12012502267A1 (enExample) |
| PL (1) | PL2571994T3 (enExample) |
| PT (1) | PT2571994T (enExample) |
| SG (1) | SG185572A1 (enExample) |
| TW (1) | TW201144442A (enExample) |
| UA (1) | UA116613C2 (enExample) |
| WO (1) | WO2011146524A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11236351B2 (en) * | 2010-05-17 | 2022-02-01 | Dow Agrosciences Llc | Production of DHA and other LC PUFAs in plants |
| TW201144442A (en) * | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| WO2012091651A1 (en) * | 2010-12-30 | 2012-07-05 | Telefonaktiebolaget L M Ericsson (Publ) | Methods and apparatuses for enabling power back-off indication in phr in a telecommunications system |
| TW201307553A (zh) * | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術 |
| EP3388516A1 (en) | 2011-10-19 | 2018-10-17 | Massachusetts Institute Of Technology | Engineered microbes and methods for microbial oil production |
| AU2012362825B2 (en) * | 2011-12-30 | 2016-07-21 | Corteva Agriscience Llc | DHA retention during canola processing |
| HUE033766T2 (en) | 2012-06-15 | 2018-01-29 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
| AR091774A1 (es) * | 2012-07-16 | 2015-02-25 | Dow Agrosciences Llc | Proceso para el diseño de las secuencias de adn repetidas, largas, divergentes de codones optimizados |
| CN110876413A (zh) * | 2012-09-11 | 2020-03-13 | 美国陶氏益农公司 | 与dha共混的ω-9芸苔油 |
| BR112015023058B1 (pt) | 2013-03-15 | 2023-04-11 | Lisa Hollister | Cassete de expressão |
| WO2014152986A2 (en) * | 2013-03-15 | 2014-09-25 | Hollister Lisa | Genetically modified plants that are herbivore-resistant |
| CA2926197A1 (en) | 2013-10-04 | 2015-04-09 | Dow Agrosciences Llc | Zea mays metallothionein-like regulatory elements and uses thereof |
| BR102014025574A2 (pt) | 2013-10-15 | 2015-09-29 | Dow Agrosciences Llc | elementos regulatórios de zea mays e usos dos mesmos |
| BR102014025499A2 (pt) | 2013-10-15 | 2015-09-29 | Dow Agrosciences Llc | elementos regulatórios de zea mays e uso dos mesmos |
| BR102014029437A2 (pt) | 2013-11-26 | 2015-07-07 | Dow Agrosciences Llc | Produção de ácidos graxos ômega-3 polinsaturados de cadeia longa em culturas oleaginosas por uma pufa sintase de traustoquitrídio |
| EA037817B1 (ru) | 2013-12-18 | 2021-05-25 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты |
| TW201527312A (zh) | 2013-12-31 | 2015-07-16 | Dow Agrosciences Llc | 新穎玉米泛素啓動子（一） |
| TW201527313A (zh) | 2013-12-31 | 2015-07-16 | Dow Agrosciences Llc | 新穎玉米泛素啓動子（二） |
| TW201527314A (zh) | 2013-12-31 | 2015-07-16 | Dow Agrosciences Llc | 新穎玉米泛素啓動子（三） |
| TW201527316A (zh) | 2013-12-31 | 2015-07-16 | Dow Agrosciences Llc | 新穎玉米泛素啓動子（五） |
| BR102015000943A2 (pt) | 2014-01-17 | 2016-06-07 | Dow Agrosciences Llc | expressão aumentada de proteína em planta |
| US10087430B2 (en) | 2014-01-28 | 2018-10-02 | Dsm Ip Assets B.V. | Factors for the production and accumulation of polyunsaturated fatty acids (PUFAS) derived from PUFA synthases |
| TW201538518A (zh) | 2014-02-28 | 2015-10-16 | Dow Agrosciences Llc | 藉由嵌合基因調控元件所賦予之根部特異性表現 |
| CA2953008C (en) | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
| US11484560B2 (en) | 2014-11-14 | 2022-11-01 | Basf Plant Science Company Gmbh | Stabilising fatty acid compositions |
| BR112017021703B1 (pt) | 2015-04-15 | 2023-11-28 | Corteva Agriscience Llc | Promotor de planta para expressão de transgene |
| EP3283633A2 (en) | 2015-04-15 | 2018-02-21 | Dow AgroSciences LLC | Plant promoter for transgene expression |
| TW201718862A (zh) | 2015-09-22 | 2017-06-01 | Dow Agrosciences Llc | 用於轉殖基因表現之植物啟動子及３’ｕｔｒ |
| TW201718861A (zh) | 2015-09-22 | 2017-06-01 | 道禮責任有限公司 | 用於轉殖基因表現之植物啟動子及３’ｕｔｒ |
| UY36957A (es) | 2015-10-22 | 2017-05-31 | Dow Agrosciences Llc | Promotor de vegetales para la expresión transgénica |
| US20170121726A1 (en) | 2015-11-04 | 2017-05-04 | Dow Agrosciences Llc | Plant promoter for transgene expression |
| JP6966040B2 (ja) | 2016-05-12 | 2021-11-10 | ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. | 微細藻類中でのオメガ−３多価不飽和脂肪酸産生を増加させる方法 |
| IL296501B2 (en) * | 2016-06-16 | 2025-07-01 | Nuseed Nutritional Australia Pty Ltd | Canola NS–B50027–4 |
| CN110291199B (zh) | 2016-10-03 | 2023-12-22 | 美国陶氏益农公司 | 用于转基因表达的植物启动子 |
| CN109996436B (zh) | 2016-10-03 | 2023-09-29 | 科迪华农业科技有限责任公司 | 用于转基因表达的植物启动子 |
| WO2019005183A1 (en) | 2017-06-28 | 2019-01-03 | Dow Agrosciences Llc | PLANT PROMOTER FOR TRANSGENIC EXPRESSION |
| EP3676383B1 (en) | 2017-08-31 | 2024-06-19 | Corteva Agriscience LLC | Compositions and methods for expressing transgenes using regulatory elements from chlorophyll binding ab genes |
| BR112021002299A2 (pt) * | 2018-08-10 | 2021-05-04 | Kyowa Hakko Bio Co., Ltd | micro-organismo produzindo ácido graxo poli-insaturado e método para produzir ácido graxo poli-insaturado |
| EP3835410A4 (en) * | 2018-08-10 | 2022-05-18 | Kyowa Hakko Bio Co., Ltd. | MICROORGANISM PRODUCING EICOSAPENTAENOIC ACID AND METHOD FOR PRODUCTION OF EICOSAPENTAENOIC ACID |
| CN109852724A (zh) * | 2019-04-03 | 2019-06-07 | 深圳出入境检验检疫局食品检验检疫技术中心 | 转基因油菜品系oxy235检测方法、试剂和试剂盒 |
| CA3237962A1 (en) | 2021-11-09 | 2023-05-19 | Benson Hill, Inc. | Promoter elements for improved polynucleotide expression in plants |
| US20250051792A1 (en) | 2021-12-15 | 2025-02-13 | Benson Hill, Inc. | Spatio-temporal promoters for polynucleotide expression in plants |
| PE20251265A1 (es) * | 2022-06-27 | 2025-05-07 | Monsanto Technology Llc | Evento transgenico de soja gm_csm63770 y metodos para su deteccion y sus usos |
| WO2024127362A1 (en) | 2022-12-15 | 2024-06-20 | Benson Hill, Inc. | Spatio-temporal promoters for polynucleotide expression in plants |
| WO2025238190A1 (en) | 2024-05-15 | 2025-11-20 | Dsm Ip Assets B.V. | Spray-dried powders having high pufa content |
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| AU669478B2 (en) | 1991-04-09 | 1996-06-13 | Unilever Plc | Plant promoter involved in controlling lipid biosynthesis in seeds |
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| WO2006135866A2 (en) | 2005-06-10 | 2006-12-21 | Martek Biosciences Corporation | Pufa polyketide synthase systems and uses thereof |
| WO2007016521A2 (en) * | 2005-08-01 | 2007-02-08 | Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Foods Canada | Low fiber yellow canola seeds comprising high oleic, low linolenic oil |
| US7868228B2 (en) | 2006-01-31 | 2011-01-11 | Monsanto Technology Llc | Phosphopantetheinyl transferases from bacteria |
| MX340759B (es) * | 2006-03-15 | 2015-03-11 | Dsm Ip Assets B V * | Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados. |
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| CN101951755A (zh) | 2007-12-21 | 2011-01-19 | 加拿大国家研究委员会 | 来自藻类的二酰基甘油酰基转移酶2基因及其编码的蛋白质 |
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| ES2717102T3 (es) * | 2009-03-19 | 2019-06-19 | Dsm Ip Assets Bv | Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos |
| TW201144442A (en) * | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
-
2011
- 2011-05-16 TW TW100117098A patent/TW201144442A/zh unknown
- 2011-05-17 HU HUE11784114A patent/HUE036182T2/hu unknown
- 2011-05-17 BR BR112012029255A patent/BR112012029255A2/pt not_active IP Right Cessation
- 2011-05-17 WO PCT/US2011/036869 patent/WO2011146524A1/en not_active Ceased
- 2011-05-17 EP EP17206033.7A patent/EP3354739A1/en not_active Withdrawn
- 2011-05-17 PL PL11784114T patent/PL2571994T3/pl unknown
- 2011-05-17 AR ARP110101691A patent/AR081201A1/es not_active Application Discontinuation
- 2011-05-17 MX MX2012013401A patent/MX345243B/es active IP Right Grant
- 2011-05-17 NO NO11784114A patent/NO2571994T3/no unknown
- 2011-05-17 PH PH1/2012/502267A patent/PH12012502267A1/en unknown
- 2011-05-17 CN CN201510664546.1A patent/CN105296511A/zh active Pending
- 2011-05-17 CN CN201180035255.6A patent/CN103080319B/zh not_active Expired - Fee Related
- 2011-05-17 CA CA2799559A patent/CA2799559C/en active Active
- 2011-05-17 EP EP11784114.8A patent/EP2571994B1/en not_active Not-in-force
- 2011-05-17 PT PT117841148T patent/PT2571994T/pt unknown
- 2011-05-17 SG SG2012083796A patent/SG185572A1/en unknown
- 2011-05-17 MY MYPI2012004965A patent/MY165098A/en unknown
- 2011-05-17 ES ES11784114.8T patent/ES2656217T3/es active Active
- 2011-05-17 EA EA201291223A patent/EA201291223A1/ru unknown
- 2011-05-17 UA UAA201213968A patent/UA116613C2/uk unknown
- 2011-05-17 KR KR1020127033006A patent/KR102184432B1/ko active Active
- 2011-05-17 JP JP2013511303A patent/JP6059138B2/ja not_active Expired - Fee Related
- 2011-05-17 NZ NZ604479A patent/NZ604479A/en not_active IP Right Cessation
- 2011-05-17 EP EP19162968.2A patent/EP3517617A1/en not_active Withdrawn
- 2011-05-17 US US13/698,412 patent/US20130150599A1/en not_active Abandoned
- 2011-05-17 AU AU2011256209A patent/AU2011256209B2/en not_active Ceased
- 2011-05-17 CA CA3161375A patent/CA3161375A1/en active Pending
-
2012
- 2012-11-15 IL IL223045A patent/IL223045A0/en unknown
- 2012-11-16 CL CL2012003210A patent/CL2012003210A1/es unknown
-
2017
- 2017-11-29 US US15/825,107 patent/US10669554B2/en not_active Expired - Fee Related
-
2018
- 2018-09-24 US US16/139,534 patent/US20190010510A1/en not_active Abandoned
-
2020
- 2020-06-02 US US16/890,740 patent/US11168332B2/en not_active Expired - Fee Related
-
2022
- 2022-02-11 US US17/669,945 patent/US12006504B2/en active Active
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