JP2013528589A - 眼科用組成物 - Google Patents
眼科用組成物 Download PDFInfo
- Publication number
- JP2013528589A JP2013528589A JP2013509213A JP2013509213A JP2013528589A JP 2013528589 A JP2013528589 A JP 2013528589A JP 2013509213 A JP2013509213 A JP 2013509213A JP 2013509213 A JP2013509213 A JP 2013509213A JP 2013528589 A JP2013528589 A JP 2013528589A
- Authority
- JP
- Japan
- Prior art keywords
- dorzolamide
- timolol
- ophthalmic composition
- polysorbate
- solubility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 190
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims abstract description 169
- 229960004605 timolol Drugs 0.000 claims abstract description 169
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 50
- 229920006150 hyperbranched polyester Polymers 0.000 claims abstract description 39
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 17
- 239000002876 beta blocker Substances 0.000 claims abstract description 12
- 229940097320 beta blocking agent Drugs 0.000 claims abstract description 12
- 229940124186 Dehydrogenase inhibitor Drugs 0.000 claims abstract description 10
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 8
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 7
- 229920000136 polysorbate Polymers 0.000 claims abstract description 6
- 229950008882 polysorbate Drugs 0.000 claims abstract description 6
- 229960004324 betaxolol Drugs 0.000 claims abstract description 4
- LWAFSWPYPHEXKX-UHFFFAOYSA-N carteolol Chemical compound N1C(=O)CCC2=C1C=CC=C2OCC(O)CNC(C)(C)C LWAFSWPYPHEXKX-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229960001222 carteolol Drugs 0.000 claims abstract description 4
- 229960002704 metipranolol Drugs 0.000 claims abstract description 4
- 229960003712 propranolol Drugs 0.000 claims abstract description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims abstract 4
- NWIUTZDMDHAVTP-UHFFFAOYSA-N betaxolol Chemical compound C1=CC(OCC(O)CNC(C)C)=CC=C1CCOCC1CC1 NWIUTZDMDHAVTP-UHFFFAOYSA-N 0.000 claims abstract 2
- BQIPXWYNLPYNHW-UHFFFAOYSA-N metipranolol Chemical compound CC(C)NCC(O)COC1=CC(C)=C(OC(C)=O)C(C)=C1C BQIPXWYNLPYNHW-UHFFFAOYSA-N 0.000 claims abstract 2
- 229920000587 hyperbranched polymer Polymers 0.000 claims description 282
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical group CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 claims description 210
- 229960003933 dorzolamide Drugs 0.000 claims description 210
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 91
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 91
- 229920000053 polysorbate 80 Polymers 0.000 claims description 91
- 229940068968 polysorbate 80 Drugs 0.000 claims description 91
- 229960000722 brinzolamide Drugs 0.000 claims description 73
- HCRKCZRJWPKOAR-JTQLQIEISA-N brinzolamide Chemical compound CCN[C@H]1CN(CCCOC)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 HCRKCZRJWPKOAR-JTQLQIEISA-N 0.000 claims description 73
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 29
- 125000000524 functional group Chemical group 0.000 claims description 21
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- 125000005313 fatty acid group Chemical group 0.000 claims description 8
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- BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 claims description 4
- 229960000571 acetazolamide Drugs 0.000 claims description 3
- 125000003277 amino group Chemical group 0.000 claims description 3
- IXHBTMCLRNMKHZ-LBPRGKRZSA-N levobunolol Chemical compound O=C1CCCC2=C1C=CC=C2OC[C@@H](O)CNC(C)(C)C IXHBTMCLRNMKHZ-LBPRGKRZSA-N 0.000 claims description 3
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- OSRUSFPMRGDLAG-QMGYSKNISA-N dorzolamide hydrochloride Chemical compound [Cl-].CC[NH2+][C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 OSRUSFPMRGDLAG-QMGYSKNISA-N 0.000 description 44
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 36
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- PTBDIHRZYDMNKB-UHFFFAOYSA-N 2,2-Bis(hydroxymethyl)propionic acid Chemical compound OCC(C)(CO)C(O)=O PTBDIHRZYDMNKB-UHFFFAOYSA-N 0.000 description 14
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 14
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- 239000012049 topical pharmaceutical composition Substances 0.000 description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
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- PQMWYJDJHJQZDE-UHFFFAOYSA-M Methantheline bromide Chemical compound [Br-].C1=CC=C2C(C(=O)OCC[N+](C)(CC)CC)C3=CC=CC=C3OC2=C1 PQMWYJDJHJQZDE-UHFFFAOYSA-M 0.000 description 5
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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- CHDPSNLJFOQTRK-UHFFFAOYSA-N betaxolol hydrochloride Chemical compound [Cl-].C1=CC(OCC(O)C[NH2+]C(C)C)=CC=C1CCOCC1CC1 CHDPSNLJFOQTRK-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/774,419 US8211450B2 (en) | 2010-05-05 | 2010-05-05 | Ophthalmic composition |
| US12/774,419 | 2010-05-05 | ||
| PCT/US2011/035147 WO2011140194A1 (en) | 2010-05-05 | 2011-05-04 | Ophthalmic composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013528589A true JP2013528589A (ja) | 2013-07-11 |
| JP2013528589A5 JP2013528589A5 (cg-RX-API-DMAC10.html) | 2015-02-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013509213A Pending JP2013528589A (ja) | 2010-05-05 | 2011-05-04 | 眼科用組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8211450B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2566487A4 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2013528589A (cg-RX-API-DMAC10.html) |
| KR (1) | KR20130121685A (cg-RX-API-DMAC10.html) |
| CN (1) | CN103096901A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2797123A1 (cg-RX-API-DMAC10.html) |
| MX (1) | MX2012012846A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2011140194A1 (cg-RX-API-DMAC10.html) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6050454B1 (ja) * | 2015-09-28 | 2016-12-21 | 参天製薬株式会社 | 水性医薬組成物 |
| JP2017503805A (ja) * | 2014-01-24 | 2017-02-02 | センティス ファーマ プライベート リミテッド | ブリンゾラミドを含む医薬組成物 |
| JPWO2016006702A1 (ja) * | 2014-07-11 | 2017-04-27 | 富士フイルム株式会社 | 眼科用水性組成物 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017503805A (ja) * | 2014-01-24 | 2017-02-02 | センティス ファーマ プライベート リミテッド | ブリンゾラミドを含む医薬組成物 |
| JPWO2016006702A1 (ja) * | 2014-07-11 | 2017-04-27 | 富士フイルム株式会社 | 眼科用水性組成物 |
| JP6050454B1 (ja) * | 2015-09-28 | 2016-12-21 | 参天製薬株式会社 | 水性医薬組成物 |
| WO2017057434A1 (ja) * | 2015-09-28 | 2017-04-06 | 参天製薬株式会社 | 水性医薬組成物 |
| WO2017159586A1 (ja) * | 2016-03-14 | 2017-09-21 | 参天製薬株式会社 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
| JP2017165707A (ja) * | 2016-03-14 | 2017-09-21 | 参天製薬株式会社 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
| JP2017186372A (ja) * | 2016-03-14 | 2017-10-12 | 参天製薬株式会社 | ドルゾラミドとチモロールと界面活性剤を含有する医薬組成物 |
| JPWO2023140357A1 (cg-RX-API-DMAC10.html) * | 2022-01-21 | 2023-07-27 | ||
| WO2023140357A1 (ja) * | 2022-01-21 | 2023-07-27 | センジュ ユーエスエー、インコーポレイテッド | 水性液剤 |
| JP7479744B2 (ja) | 2022-01-21 | 2024-05-09 | センジュ ユーエスエー、インコーポレイテッド | 水性液剤 |
| US12296015B2 (en) | 2022-01-21 | 2025-05-13 | Senju Usa, Inc. | Aqueous liquid preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103096901A (zh) | 2013-05-08 |
| EP2566487A4 (en) | 2014-06-18 |
| US20130053374A1 (en) | 2013-02-28 |
| WO2011140194A1 (en) | 2011-11-10 |
| MX2012012846A (es) | 2013-05-22 |
| US20110275617A1 (en) | 2011-11-10 |
| US8211450B2 (en) | 2012-07-03 |
| EP2566487A1 (en) | 2013-03-13 |
| CA2797123A1 (en) | 2011-11-10 |
| KR20130121685A (ko) | 2013-11-06 |
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