JP2013526620A5 - - Google Patents
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- Publication number
- JP2013526620A5 JP2013526620A5 JP2013509410A JP2013509410A JP2013526620A5 JP 2013526620 A5 JP2013526620 A5 JP 2013526620A5 JP 2013509410 A JP2013509410 A JP 2013509410A JP 2013509410 A JP2013509410 A JP 2013509410A JP 2013526620 A5 JP2013526620 A5 JP 2013526620A5
- Authority
- JP
- Japan
- Prior art keywords
- glycosaminoglycan
- lipid moiety
- modified
- composition according
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 43
- 239000000203 mixture Substances 0.000 claims 19
- 150000002632 lipids Chemical group 0.000 claims 17
- 150000002016 disaccharides Chemical class 0.000 claims 6
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 4
- 239000000178 monomer Substances 0.000 claims 4
- 230000008591 skin barrier function Effects 0.000 claims 4
- 229920002674 hyaluronan Polymers 0.000 claims 3
- 229940099552 hyaluronan Drugs 0.000 claims 3
- 239000004615 ingredient Substances 0.000 claims 3
- 210000004877 mucosa Anatomy 0.000 claims 3
- 229930182558 Sterol Natural products 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 150000002313 glycerolipids Chemical class 0.000 claims 2
- 150000002402 hexoses Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000000149 penetrating effect Effects 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 150000003135 prenol lipids Chemical class 0.000 claims 2
- 150000003408 sphingolipids Chemical class 0.000 claims 2
- -1 sterol lipids Chemical class 0.000 claims 2
- 235000003702 sterols Nutrition 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- VPKDCDLSJZCGKE-UHFFFAOYSA-N carbodiimide group Chemical group N=C=N VPKDCDLSJZCGKE-UHFFFAOYSA-N 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 150000008273 hexosamines Chemical group 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000012035 limiting reagent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 229940067605 phosphatidylethanolamines Drugs 0.000 claims 1
- 230000009759 skin aging Effects 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000001502 supplementing effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2703532A CA2703532C (en) | 2010-05-10 | 2010-05-10 | Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications |
| CA2,703,532 | 2010-05-10 | ||
| PCT/CA2011/000512 WO2011140630A1 (en) | 2010-05-10 | 2011-05-04 | Topically administered, skin-penetrating glycosaminoglycan formulations suitable for use in cosmetic and pharmaceutical applications |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013526620A JP2013526620A (ja) | 2013-06-24 |
| JP2013526620A5 true JP2013526620A5 (enExample) | 2014-06-19 |
| JP6120283B2 JP6120283B2 (ja) | 2017-04-26 |
Family
ID=44912981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013509410A Expired - Fee Related JP6120283B2 (ja) | 2010-05-10 | 2011-05-04 | 化粧及び薬剤用途に適した局所投与用、皮膚浸透性グリコサミノグリカン調剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20130059769A1 (enExample) |
| EP (1) | EP2569364B1 (enExample) |
| JP (1) | JP6120283B2 (enExample) |
| KR (1) | KR101831215B1 (enExample) |
| CN (2) | CN103080204B (enExample) |
| AU (1) | AU2011252695B2 (enExample) |
| BR (1) | BR112012028592A2 (enExample) |
| CA (1) | CA2703532C (enExample) |
| RU (1) | RU2637443C2 (enExample) |
| WO (1) | WO2011140630A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014001148A (ja) * | 2012-06-15 | 2014-01-09 | Picaso Cosmetic Laboratory Ltd | 線維芽細胞増殖促進剤 |
| ITMI20130354A1 (it) | 2013-03-08 | 2014-09-09 | Again Life Italia Srl | Miscela di acidi grassi (f.a.g. fatty acids group) per uso nel trattamento di patologie infiammatorie. |
| US9763969B2 (en) | 2013-04-03 | 2017-09-19 | Cedars-Sinai Medical Center | Treatment of inflammatory conditions with hyaluronan disaccharide |
| MX2018012486A (es) * | 2016-04-12 | 2019-06-06 | Illustris Pharmaceuticals Inc | Composiciones para aplicacion topica de compuestos. |
| IL306070A (en) | 2018-05-03 | 2023-11-01 | Collplant Ltd | Dermal fillers and their uses |
| US20210000910A1 (en) | 2019-07-03 | 2021-01-07 | Jysk Skin Solutions Pte Ltd | Topical compositions |
| CN110339223A (zh) * | 2019-08-06 | 2019-10-18 | 无锡市新吴区新安街道社区卫生服务中心 | 一种缓解颈椎病症状的喷雾剂制备方法 |
| US20210106506A1 (en) * | 2019-10-11 | 2021-04-15 | Elc Management Llc | Methods for cosmetic skin remodeling |
| CN110755597B (zh) * | 2019-10-24 | 2023-07-07 | 广州市希丽生物科技服务有限公司 | 用于预防和治疗类风湿性关节炎的外用药物组合物 |
| CN111249472B (zh) * | 2020-01-16 | 2024-02-23 | 上海交通大学医学院附属第九人民医院 | 一种可经皮给药的透明质酸纳米凝胶及其制备方法 |
| CN111166692A (zh) * | 2020-03-18 | 2020-05-19 | 深圳市百吉因生物科技有限公司 | 一种高保湿性组合物 |
| KR102583416B1 (ko) * | 2020-04-14 | 2023-10-04 | 코스맥스 주식회사 | 저분자 콜라겐, 엘라스틴 및 글리코사미노글리칸을 포함하는 화장료 조성물 |
| KR20230133305A (ko) | 2021-01-29 | 2023-09-19 | 가부시키가이샤 코세 | 세라마이드류 함유 조성물 |
| US12083204B2 (en) | 2022-06-02 | 2024-09-10 | L'oreal | Topical composition for homeostatic delivery of nitric oxide and uses thereof |
| CN117137830B (zh) * | 2023-11-01 | 2024-02-13 | 杭州湃肽生化科技有限公司 | 一种皮肤修复组合物及其应用 |
| CN120168654A (zh) * | 2025-05-21 | 2025-06-20 | 长春赛诺美焱科技有限公司 | 一种透皮递送耦合物、缓释透皮制剂及其制备方法和应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4009282A (en) * | 1973-12-17 | 1977-02-22 | The Regents Of The University Of Michigan | Treatment of proliferating skin diseases with prostaglandins |
| CA2067211C (en) * | 1990-07-24 | 2004-06-15 | Katsukiyo Sakurai | Phospholipid- or lipid-linked glycosaminoglycan, process for producing the same and metastasis inhibitor |
| JP2997018B2 (ja) * | 1990-07-24 | 2000-01-11 | 生化学工業株式会社 | 燐脂質又は脂質結合グリコサミノグリカン |
| US5733892A (en) * | 1990-07-24 | 1998-03-31 | Seikagaku Corporation | Metastasis inhibitor composition comprising a phospholipid-linked glycosaminoglycan and method for inhibiting metastasis employing the same |
| JP3714683B2 (ja) * | 1992-07-30 | 2005-11-09 | 生化学工業株式会社 | 抗リウマチ剤 |
| JP3615346B2 (ja) * | 1997-02-18 | 2005-02-02 | 株式会社ノエビア | 皮膚外用剤 |
| JP3032824B1 (ja) * | 1999-01-28 | 2000-04-17 | 東京医科歯科大学長 | 骨誘導促進剤 |
| US7504384B2 (en) * | 2000-01-10 | 2009-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of infection |
| US7393938B2 (en) * | 2000-01-10 | 2008-07-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of diseases |
| JP4876334B2 (ja) * | 2001-06-06 | 2012-02-15 | 日油株式会社 | ヒアルロン酸産生能増強剤およびその用途 |
| EP1423095B1 (en) * | 2001-08-14 | 2016-09-28 | Tel Aviv University Future Technology Development L.P. | Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy |
| US20030113349A1 (en) * | 2001-12-18 | 2003-06-19 | Coleman William P. | Topically applied clostridium botulinum toxin compositions and treatment methods |
| EP2434282A3 (en) * | 2002-07-01 | 2012-08-22 | Tufts University | Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers |
| EP1681306B1 (en) * | 2003-10-29 | 2013-02-20 | Teijin Limited | Hyaluronic acid compound, hydrogel thereof and material for treating joint |
| CN101217946B (zh) * | 2004-11-02 | 2012-11-07 | 特拉维夫大学未来技术研发有限公司 | 水不溶性的或低水溶性药物在脂质化糖胺聚糖颗粒中的制剂和它们的制药用途 |
| JP4832007B2 (ja) | 2005-06-13 | 2011-12-07 | 帝人株式会社 | グリコサミノグリカン誘導体の製造法 |
| CN1742623A (zh) * | 2005-07-13 | 2006-03-08 | 凌沛学 | 透明质酸磷脂复合物及其制备方法 |
| KR101554834B1 (ko) * | 2005-10-12 | 2015-09-21 | 세이가가쿠 고교 가부시키가이샤 | 점막에 적용하는 작용제 및 그것의 제조 방법 |
| US20080183282A1 (en) | 2006-03-09 | 2008-07-31 | Saul Yedgar | Use of lipid conjugates for the coating of stents and catheters |
| DE102007028360B4 (de) * | 2007-06-15 | 2016-04-14 | Marcus Asam | Wirkstoffkombination für kosmetische Zubereitungen |
| AU2008345068A1 (en) * | 2007-12-26 | 2009-07-09 | Mark A. Pinsky | Collagen formulations for improved skin care |
| US8632803B2 (en) * | 2008-02-27 | 2014-01-21 | Ramot At Tel-Aviv University Ltd. | System for delivery of protein in insoluble fibrillar or aggregate form |
-
2010
- 2010-05-10 CA CA2703532A patent/CA2703532C/en active Active
-
2011
- 2011-05-04 AU AU2011252695A patent/AU2011252695B2/en not_active Ceased
- 2011-05-04 JP JP2013509410A patent/JP6120283B2/ja not_active Expired - Fee Related
- 2011-05-04 EP EP11780002.9A patent/EP2569364B1/en not_active Not-in-force
- 2011-05-04 RU RU2012152562A patent/RU2637443C2/ru not_active IP Right Cessation
- 2011-05-04 WO PCT/CA2011/000512 patent/WO2011140630A1/en not_active Ceased
- 2011-05-04 KR KR1020127032320A patent/KR101831215B1/ko not_active Expired - Fee Related
- 2011-05-04 BR BR112012028592A patent/BR112012028592A2/pt not_active Application Discontinuation
- 2011-05-04 CN CN201180034053.XA patent/CN103080204B/zh not_active Expired - Fee Related
- 2011-05-04 US US13/696,887 patent/US20130059769A1/en not_active Abandoned
- 2011-05-04 CN CN201711123324.4A patent/CN107814853A/zh active Pending
-
2015
- 2015-06-01 US US14/727,257 patent/US10131717B2/en active Active
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