JP2013526554A5 - - Google Patents
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- JP2013526554A5 JP2013526554A5 JP2013510566A JP2013510566A JP2013526554A5 JP 2013526554 A5 JP2013526554 A5 JP 2013526554A5 JP 2013510566 A JP2013510566 A JP 2013510566A JP 2013510566 A JP2013510566 A JP 2013510566A JP 2013526554 A5 JP2013526554 A5 JP 2013526554A5
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- 150000001875 compounds Chemical class 0.000 claims description 39
- 239000003814 drug Substances 0.000 claims description 24
- 208000027866 inflammatory disease Diseases 0.000 claims description 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 17
- 201000010099 disease Diseases 0.000 claims description 10
- 208000012902 Nervous system disease Diseases 0.000 claims description 6
- 208000025966 Neurological disease Diseases 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 4
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 4
- 208000006673 asthma Diseases 0.000 claims description 4
- 208000033679 diabetic kidney disease Diseases 0.000 claims description 4
- 210000002345 respiratory system Anatomy 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 150000007513 acids Chemical class 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000002193 Pain Diseases 0.000 description 11
- 208000035475 disorder Diseases 0.000 description 7
- 208000004296 neuralgia Diseases 0.000 description 7
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- 208000007848 Alcoholism Diseases 0.000 description 2
- 206010003591 Ataxia Diseases 0.000 description 2
- 208000015879 Cerebellar disease Diseases 0.000 description 2
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- 208000003954 Spinal Muscular Atrophies of Childhood Diseases 0.000 description 2
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- 206010008748 Chorea Diseases 0.000 description 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 102000015554 Dopamine receptor Human genes 0.000 description 1
- 108050004812 Dopamine receptor Proteins 0.000 description 1
- 201000010374 Down Syndrome Diseases 0.000 description 1
- 208000024412 Friedreich ataxia Diseases 0.000 description 1
- 206010019196 Head injury Diseases 0.000 description 1
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- 208000035154 Hyperesthesia Diseases 0.000 description 1
- 208000006264 Korsakoff syndrome Diseases 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
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- 208000009829 Lewy Body Disease Diseases 0.000 description 1
- 206010024626 Lipoprotein deficiency Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
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- 206010033425 Pain in extremity Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 206010036105 Polyneuropathy Diseases 0.000 description 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000032225 Proximal spinal muscular atrophy type 1 Diseases 0.000 description 1
- 208000033526 Proximal spinal muscular atrophy type 3 Diseases 0.000 description 1
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 1
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- 201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 206010053552 allodynia Diseases 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 210000002226 anterior horn cell Anatomy 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000002594 corticospinal effect Effects 0.000 description 1
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- 230000003210 demyelinating effect Effects 0.000 description 1
- 208000012285 hip pain Diseases 0.000 description 1
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- 238000011542 limb amputation Methods 0.000 description 1
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- 206010027599 migraine Diseases 0.000 description 1
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- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000007824 polyneuropathy Effects 0.000 description 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10162919.4 | 2010-05-17 | ||
| EP10162919 | 2010-05-17 | ||
| PCT/EP2011/057539 WO2011144501A1 (en) | 2010-05-17 | 2011-05-10 | Ccr2 antagonists and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013526554A JP2013526554A (ja) | 2013-06-24 |
| JP2013526554A5 true JP2013526554A5 (enExample) | 2014-11-06 |
| JP5647339B2 JP5647339B2 (ja) | 2014-12-24 |
Family
ID=42732650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510566A Active JP5647339B2 (ja) | 2010-05-17 | 2011-05-10 | Ｃｃｒ２アンタゴニスト及びこれらの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8841313B2 (enExample) |
| EP (1) | EP2571870B1 (enExample) |
| JP (1) | JP5647339B2 (enExample) |
| WO (1) | WO2011144501A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5603770B2 (ja) | 2007-05-31 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体拮抗薬およびその使用 |
| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
| US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
| PT3317270T (pt) | 2015-07-02 | 2020-08-24 | Centrexion Therapeutics Corp | (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidina-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-pirano-2-il)metilamino)pirimidina-4-il)citrato de metanona |
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| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
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| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| EP2513086B1 (en) | 2009-12-17 | 2015-04-29 | Boehringer Ingelheim International GmbH | Novel antagonists for ccr2 and uses thereof |
| JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
| US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
| WO2012171863A1 (en) | 2011-06-16 | 2012-12-20 | Boehringer Ingelheim International Gmbh | New selective ccr2 antagonists |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
-
2011
- 2011-05-10 WO PCT/EP2011/057539 patent/WO2011144501A1/en not_active Ceased
- 2011-05-10 US US13/698,065 patent/US8841313B2/en active Active
- 2011-05-10 JP JP2013510566A patent/JP5647339B2/ja active Active
- 2011-05-10 EP EP11718996.9A patent/EP2571870B1/en active Active
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