JP2013525782A5 - - Google Patents

Info

Publication number

JP2013525782A5

JP2013525782A5 JP2013505597A JP2013505597A JP2013525782A5 JP 2013525782 A5 JP2013525782 A5 JP 2013525782A5 JP 2013505597 A JP2013505597 A JP 2013505597A JP 2013505597 A JP2013505597 A JP 2013505597A JP 2013525782 A5 JP2013525782 A5 JP 2013525782A5

Authority

JP

Japan

Prior art keywords

erbb ligand

agent

activity

amount

fragment

Prior art date

2011-03-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000003446 ligand Substances 0.000 claims 21
• 239000003795 chemical substances by application Substances 0.000 claims 10
• 230000000694 effects Effects 0.000 claims 10
• 239000012634 fragment Substances 0.000 claims 9
• 238000000034 method Methods 0.000 claims 8
• 239000013543 active substance Substances 0.000 claims 7
• 230000003463 hyperproliferative effect Effects 0.000 claims 7
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 238000004519 manufacturing process Methods 0.000 claims 6
• 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 claims 5
• 102100033762 Proheparin-binding EGF-like growth factor Human genes 0.000 claims 5
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 3
• 101800004564 Transforming growth factor alpha Proteins 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 102100038778 Amphiregulin Human genes 0.000 claims 2
• 108010033760 Amphiregulin Proteins 0.000 claims 2
• 101800001382 Betacellulin Proteins 0.000 claims 2
• 102000012545 EGF-like domains Human genes 0.000 claims 2
• 108050002150 EGF-like domains Proteins 0.000 claims 2
• 101800000155 Epiregulin Proteins 0.000 claims 2
• 102100029837 Probetacellulin Human genes 0.000 claims 2
• 102100025498 Proepiregulin Human genes 0.000 claims 2
• 108020004459 Small interfering RNA Proteins 0.000 claims 2
• 102000009618 Transforming Growth Factors Human genes 0.000 claims 2
• 108010009583 Transforming Growth Factors Proteins 0.000 claims 2
• 239000012472 biological sample Substances 0.000 claims 2
• 244000005700 microbiome Species 0.000 claims 2
• 239000005022 packaging material Substances 0.000 claims 2
• 102100030323 Epigen Human genes 0.000 claims 1
• 108010016906 Epigen Proteins 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 102000014413 Neuregulin Human genes 0.000 claims 1
• 108050003475 Neuregulin Proteins 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 235000019410 glycyrrhizin Nutrition 0.000 claims 1
• 239000003102 growth factor Substances 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1