JP2013525157A5 - - Google Patents

Info

Publication number

JP2013525157A5

JP2013525157A5 JP2013508033A JP2013508033A JP2013525157A5 JP 2013525157 A5 JP2013525157 A5 JP 2013525157A5 JP 2013508033 A JP2013508033 A JP 2013508033A JP 2013508033 A JP2013508033 A JP 2013508033A JP 2013525157 A5 JP2013525157 A5 JP 2013525157A5

Authority

JP

Japan

Prior art keywords

methyl

hydroxypropyl

hydroxypropyl cellulose

carbide

extrusion

Prior art date

2011-04-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• -1 hydroxypropyl Chemical group 0.000 claims description 22
• 239000000203 mixture Substances 0.000 claims description 16
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 10
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
• 239000008186 active pharmaceutical agent Substances 0.000 claims description 10
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 10
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 10
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
• 229910010272 inorganic material Inorganic materials 0.000 claims description 9
• 239000011147 inorganic material Substances 0.000 claims description 9
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
• 238000001125 extrusion Methods 0.000 claims description 7
• 239000003054 catalyst Substances 0.000 claims description 6
• BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 4
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
• MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims description 4
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 4
• 235000012438 extruded product Nutrition 0.000 claims description 4
• 239000002243 precursor Substances 0.000 claims description 4
• 239000000377 silicon dioxide Substances 0.000 claims description 4
• 238000005245 sintering Methods 0.000 claims description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
• 229910052799 carbon Inorganic materials 0.000 claims description 3
• HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 3
• 238000000034 method Methods 0.000 claims description 3
• 229910001404 rare earth metal oxide Inorganic materials 0.000 claims description 3
• 229910000505 Al2TiO5 Inorganic materials 0.000 claims description 2
• 239000005995 Aluminium silicate Substances 0.000 claims description 2
• 229910052580 B4C Inorganic materials 0.000 claims description 2
• 229910052581 Si3N4 Inorganic materials 0.000 claims description 2
• 229910021536 Zeolite Inorganic materials 0.000 claims description 2
• PILOURHZNVHRME-UHFFFAOYSA-N [Na].[Ba] Chemical compound [Na].[Ba] PILOURHZNVHRME-UHFFFAOYSA-N 0.000 claims description 2
• 239000000654 additive Substances 0.000 claims description 2
• CAVCGVPGBKGDTG-UHFFFAOYSA-N alumanylidynemethyl(alumanylidynemethylalumanylidenemethylidene)alumane Chemical compound [Al]#C[Al]=C=[Al]C#[Al] CAVCGVPGBKGDTG-UHFFFAOYSA-N 0.000 claims description 2
• 150000004645 aluminates Chemical class 0.000 claims description 2
• 229910000323 aluminium silicate Inorganic materials 0.000 claims description 2
• 235000012211 aluminium silicate Nutrition 0.000 claims description 2
• 229910002113 barium titanate Inorganic materials 0.000 claims description 2
• JRPBQTZRNDNNOP-UHFFFAOYSA-N barium titanate Chemical compound [Ba+2].[Ba+2].[O-][Ti]([O-])([O-])[O-] JRPBQTZRNDNNOP-UHFFFAOYSA-N 0.000 claims description 2
• 239000000440 bentonite Substances 0.000 claims description 2
• 229910000278 bentonite Inorganic materials 0.000 claims description 2
• SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
• INAHAJYZKVIDIZ-UHFFFAOYSA-N boron carbide Chemical compound B12B3B4C32B41 INAHAJYZKVIDIZ-UHFFFAOYSA-N 0.000 claims description 2
• 229910052810 boron oxide Inorganic materials 0.000 claims description 2
• 239000000919 ceramic Substances 0.000 claims description 2
• 239000004927 clay Substances 0.000 claims description 2
• 229910052570 clay Inorganic materials 0.000 claims description 2
• PMHQVHHXPFUNSP-UHFFFAOYSA-M copper(1+);methylsulfanylmethane;bromide Chemical compound Br[Cu].CSC PMHQVHHXPFUNSP-UHFFFAOYSA-M 0.000 claims description 2
• 229910052878 cordierite Inorganic materials 0.000 claims description 2
• JKWMSGQKBLHBQQ-UHFFFAOYSA-N diboron trioxide Chemical compound O=BOB=O JKWMSGQKBLHBQQ-UHFFFAOYSA-N 0.000 claims description 2
• JSKIRARMQDRGJZ-UHFFFAOYSA-N dimagnesium dioxido-bis[(1-oxido-3-oxo-2,4,6,8,9-pentaoxa-1,3-disila-5,7-dialuminabicyclo[3.3.1]nonan-7-yl)oxy]silane Chemical compound [Mg++].[Mg++].[O-][Si]([O-])(O[Al]1O[Al]2O[Si](=O)O[Si]([O-])(O1)O2)O[Al]1O[Al]2O[Si](=O)O[Si]([O-])(O1)O2 JSKIRARMQDRGJZ-UHFFFAOYSA-N 0.000 claims description 2
• KZHJGOXRZJKJNY-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Si]=O.O=[Al]O[Al]=O.O=[Al]O[Al]=O.O=[Al]O[Al]=O KZHJGOXRZJKJNY-UHFFFAOYSA-N 0.000 claims description 2
• 238000001035 drying Methods 0.000 claims description 2
• 239000010433 feldspar Substances 0.000 claims description 2
• 239000005350 fused silica glass Substances 0.000 claims description 2
• 239000011521 glass Substances 0.000 claims description 2
• NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
• HFGPZNIAWCZYJU-UHFFFAOYSA-N lead zirconate titanate Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4].[Pb+2] HFGPZNIAWCZYJU-UHFFFAOYSA-N 0.000 claims description 2
• 229910052451 lead zirconate titanate Inorganic materials 0.000 claims description 2
• 238000002156 mixing Methods 0.000 claims description 2
• 229910052863 mullite Inorganic materials 0.000 claims description 2
• AJCDFVKYMIUXCR-UHFFFAOYSA-N oxobarium;oxo(oxoferriooxy)iron Chemical compound [Ba]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O.O=[Fe]O[Fe]=O AJCDFVKYMIUXCR-UHFFFAOYSA-N 0.000 claims description 2
• AABBHSMFGKYLKE-SNAWJCMRSA-N propan-2-yl (e)-but-2-enoate Chemical compound C\C=C\C(=O)OC(C)C AABBHSMFGKYLKE-SNAWJCMRSA-N 0.000 claims description 2
• 229910052710 silicon Inorganic materials 0.000 claims description 2
• 239000010703 silicon Substances 0.000 claims description 2
• HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 claims description 2
• 229910010271 silicon carbide Inorganic materials 0.000 claims description 2
• HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 claims description 2
• HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 claims description 2
• 229910052596 spinel Inorganic materials 0.000 claims description 2
• 239000011029 spinel Substances 0.000 claims description 2
• 229910052712 strontium Inorganic materials 0.000 claims description 2
• CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 2
• 239000000454 talc Substances 0.000 claims description 2
• 229910052623 talc Inorganic materials 0.000 claims description 2
• 239000004408 titanium dioxide Substances 0.000 claims description 2
• MTPVUVINMAGMJL-UHFFFAOYSA-N trimethyl(1,1,2,2,2-pentafluoroethyl)silane Chemical compound C[Si](C)(C)C(F)(F)C(F)(F)F MTPVUVINMAGMJL-UHFFFAOYSA-N 0.000 claims description 2
• 239000010457 zeolite Substances 0.000 claims description 2
• 229910052845 zircon Inorganic materials 0.000 claims description 2
• GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 claims description 2
• 229910000859 α-Fe Inorganic materials 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000005337 ground glass Substances 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 229920000609 methyl cellulose Polymers 0.000 description 1
• 239000001923 methylcellulose Substances 0.000 description 1