JP2013523704A5 - - Google Patents
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- JP2013523704A5 JP2013523704A5 JP2013501930A JP2013501930A JP2013523704A5 JP 2013523704 A5 JP2013523704 A5 JP 2013523704A5 JP 2013501930 A JP2013501930 A JP 2013501930A JP 2013501930 A JP2013501930 A JP 2013501930A JP 2013523704 A5 JP2013523704 A5 JP 2013523704A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- solution
- additive
- alkyl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000700605 Viruses Species 0.000 claims 20
- 239000000243 solution Substances 0.000 claims 19
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 12
- 235000000346 sugar Nutrition 0.000 claims 9
- 239000000654 additive Substances 0.000 claims 8
- 230000000996 additive effect Effects 0.000 claims 8
- 239000007864 aqueous solution Substances 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 239000004471 Glycine Substances 0.000 claims 6
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 150000008163 sugars Chemical class 0.000 claims 6
- 239000003125 aqueous solvent Substances 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229930006000 Sucrose Natural products 0.000 claims 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 3
- 108700003601 dimethylglycine Proteins 0.000 claims 3
- 229940078490 n,n-dimethylglycine Drugs 0.000 claims 3
- 238000007789 sealing Methods 0.000 claims 3
- 239000005720 sucrose Substances 0.000 claims 3
- -1 sulfone compound Chemical class 0.000 claims 3
- 239000003708 ampul Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 2
- 241000701242 Adenoviridae Species 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 241000701945 Parvoviridae Species 0.000 claims 1
- 241000700625 Poxviridae Species 0.000 claims 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 108700010877 adenoviridae proteins Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940016409 methylsulfonylmethane Drugs 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000008174 sterile solution Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1005517.6A GB201005517D0 (en) | 2010-03-31 | 2010-03-31 | Stabilised liquid formulations of polypeptides |
| GBGB1005521.8A GB201005521D0 (en) | 2010-03-31 | 2010-03-31 | Stabilised liquid formulations of virus particles |
| GB1005517.6 | 2010-03-31 | ||
| GB1005521.8 | 2010-03-31 | ||
| GBGB1017648.5A GB201017648D0 (en) | 2010-10-19 | 2010-10-19 | Liquid preparation containing stabilised viruses |
| GB1017648.5 | 2010-10-19 | ||
| PCT/GB2011/000493 WO2011121301A1 (en) | 2010-03-31 | 2011-03-31 | Excipients for stabilising viral particles, polypeptides or biological material |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016001536A Division JP6053969B2 (ja) | 2010-03-31 | 2016-01-07 | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523704A JP2013523704A (ja) | 2013-06-17 |
| JP2013523704A5 true JP2013523704A5 (https=) | 2014-04-17 |
| JP5869553B2 JP5869553B2 (ja) | 2016-02-24 |
Family
ID=43902836
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501930A Active JP5869553B2 (ja) | 2010-03-31 | 2011-03-31 | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
| JP2016001536A Active JP6053969B2 (ja) | 2010-03-31 | 2016-01-07 | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016001536A Active JP6053969B2 (ja) | 2010-03-31 | 2016-01-07 | ウイルス粒子、ポリペプチド又は生体材料を安定化させる添加剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20130164296A1 (https=) |
| EP (1) | EP2552478B1 (https=) |
| JP (2) | JP5869553B2 (https=) |
| KR (2) | KR101943429B1 (https=) |
| CN (1) | CN102892427A (https=) |
| AU (2) | AU2011234264B2 (https=) |
| BR (1) | BR112012025047A2 (https=) |
| CA (1) | CA2795047C (https=) |
| DK (1) | DK2552478T3 (https=) |
| ES (1) | ES2617921T3 (https=) |
| GB (1) | GB2490644A (https=) |
| HU (1) | HUE033656T2 (https=) |
| IL (1) | IL221857A (https=) |
| WO (1) | WO2011121301A1 (https=) |
| ZA (1) | ZA201206956B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2757591T3 (es) * | 2010-03-31 | 2020-04-29 | Stabilitech Biopharma Ltd | Estabilización de partículas virales |
| WO2011121301A1 (en) | 2010-03-31 | 2011-10-06 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| GB201117233D0 (en) * | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| GB201208293D0 (en) * | 2012-05-11 | 2012-06-20 | Circassia Ltd | Hydrochlorice salt of peptide |
| US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| GB201406569D0 (en) * | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| GB201513010D0 (en) * | 2015-07-23 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel formulation |
| WO2018115305A1 (en) | 2016-12-22 | 2018-06-28 | Leibniz-Institut für Pflanzengenetik Und Kulturpflanzenforschung (IPK) | Oligomeric vaccines from plants by s-tag-s-protein fusions |
| CA3048313A1 (en) | 2017-01-06 | 2018-07-12 | Stabilitech Biopharma Ltd | Virus |
| KR101878599B1 (ko) * | 2017-03-28 | 2018-07-13 | 전북대학교산학협력단 | 메틸설포닐메테인과 만니톨의 흡수촉진 및 고미감소를 위한 공침조성물과 이의 제조방법 |
| GB2562241B (en) * | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| AR113996A1 (es) | 2017-12-22 | 2020-07-08 | Intervet Int Bv | Vacunas líquidas de virus envueltos vivos |
| AU2019336940B2 (en) | 2018-09-06 | 2025-09-11 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| JP7712284B2 (ja) | 2020-03-12 | 2025-07-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | ポックスウイルスの安定性を改善する組成物 |
| CN114649066B (zh) * | 2020-12-17 | 2025-02-11 | 南开大学 | 一种提升d-氨基酸减缓mbr膜污染效能的智能优化方法 |
| JP7748616B2 (ja) * | 2021-03-24 | 2025-10-03 | 大日本印刷株式会社 | 液体入り組合せ容器、容器セットおよび液体入り容器の製造方法 |
| CN114392237B (zh) * | 2021-12-28 | 2024-02-02 | 上海允英生物医药科技有限公司 | 一种冻干病毒制剂及其制备方法 |
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| EP2430195B1 (en) | 2009-05-11 | 2019-01-23 | Biomatrica, INC. | Compositions and methods for biological sample storage |
| CN101670104A (zh) | 2009-09-24 | 2010-03-17 | 浙江大学 | 一种含人参皂甙的油佐剂及其制备方法 |
| WO2011109415A2 (en) | 2010-03-02 | 2011-09-09 | Amgen Inc. | Reducing viscosity of pharmaceutical formulations |
| ES2757591T3 (es) * | 2010-03-31 | 2020-04-29 | Stabilitech Biopharma Ltd | Estabilización de partículas virales |
| WO2011121301A1 (en) | 2010-03-31 | 2011-10-06 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| CA2795050C (en) | 2010-03-31 | 2018-05-22 | Stabilitech Ltd. | Method for preserving alum adjuvants and alum-adjuvanted vaccines |
| GB201117233D0 (en) * | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| GB201406569D0 (en) * | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| CA3048313A1 (en) | 2017-01-06 | 2018-07-12 | Stabilitech Biopharma Ltd | Virus |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
-
2011
- 2011-03-31 WO PCT/GB2011/000493 patent/WO2011121301A1/en not_active Ceased
- 2011-03-31 KR KR1020177022631A patent/KR101943429B1/ko not_active Expired - Fee Related
- 2011-03-31 JP JP2013501930A patent/JP5869553B2/ja active Active
- 2011-03-31 AU AU2011234264A patent/AU2011234264B2/en not_active Ceased
- 2011-03-31 CN CN2011800181285A patent/CN102892427A/zh active Pending
- 2011-03-31 HU HUE11714594A patent/HUE033656T2/en unknown
- 2011-03-31 DK DK11714594.6T patent/DK2552478T3/en active
- 2011-03-31 KR KR1020127028704A patent/KR101884953B1/ko not_active Expired - Fee Related
- 2011-03-31 GB GB1216473.7A patent/GB2490644A/en not_active Withdrawn
- 2011-03-31 EP EP11714594.6A patent/EP2552478B1/en active Active
- 2011-03-31 ES ES11714594.6T patent/ES2617921T3/es active Active
- 2011-03-31 CA CA2795047A patent/CA2795047C/en active Active
- 2011-03-31 BR BR112012025047A patent/BR112012025047A2/pt not_active Application Discontinuation
- 2011-03-31 US US13/637,913 patent/US20130164296A1/en not_active Abandoned
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2012
- 2012-09-09 IL IL221857A patent/IL221857A/en active IP Right Grant
- 2012-09-17 ZA ZA2012/06956A patent/ZA201206956B/en unknown
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2016
- 2016-01-07 JP JP2016001536A patent/JP6053969B2/ja active Active
- 2016-05-03 AU AU2016202839A patent/AU2016202839B2/en not_active Ceased
- 2016-05-05 US US15/147,114 patent/US10716859B2/en active Active
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