JP2013524782A5 - - Google Patents
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- Publication number
- JP2013524782A5 JP2013524782A5 JP2013501933A JP2013501933A JP2013524782A5 JP 2013524782 A5 JP2013524782 A5 JP 2013524782A5 JP 2013501933 A JP2013501933 A JP 2013501933A JP 2013501933 A JP2013501933 A JP 2013501933A JP 2013524782 A5 JP2013524782 A5 JP 2013524782A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- glycine
- virus
- sugars
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 32
- 235000000346 sugar Nutrition 0.000 claims 23
- 241000700605 Viruses Species 0.000 claims 18
- 239000004471 Glycine Substances 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 239000002245 particle Substances 0.000 claims 12
- 150000008163 sugars Chemical class 0.000 claims 12
- 239000007864 aqueous solution Substances 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 150000002148 esters Chemical class 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 229930006000 Sucrose Natural products 0.000 claims 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 7
- 239000005720 sucrose Substances 0.000 claims 7
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 claims 6
- 241000701242 Adenoviridae Species 0.000 claims 5
- 241000712464 Orthomyxoviridae Species 0.000 claims 5
- 241000711504 Paramyxoviridae Species 0.000 claims 5
- 241000700625 Poxviridae Species 0.000 claims 5
- 108700010877 adenoviridae proteins Proteins 0.000 claims 5
- -1 carboxylate anion Chemical class 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 108700003601 dimethylglycine Proteins 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 229940078490 n,n-dimethylglycine Drugs 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000003708 ampul Substances 0.000 claims 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 2
- 150000005846 sugar alcohols Chemical class 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 229940016409 methylsulfonylmethane Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 210000002845 virion Anatomy 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10250706 | 2010-03-31 | ||
| GBGB1005520.0A GB201005520D0 (en) | 2010-03-31 | 2010-03-31 | Stabilisation of viral particles |
| GBGB1005497.1A GB201005497D0 (en) | 2010-03-31 | 2010-03-31 | Method for stabilising viruses |
| GB1005497.1 | 2010-03-31 | ||
| GBGB1005521.8A GB201005521D0 (en) | 2010-03-31 | 2010-03-31 | Stabilised liquid formulations of virus particles |
| GB1005520.0 | 2010-03-31 | ||
| EP10250706.8 | 2010-03-31 | ||
| GB1005521.8 | 2010-03-31 | ||
| GB1014962.3 | 2010-09-08 | ||
| GBGB1014962.3A GB201014962D0 (en) | 2010-09-08 | 2010-09-08 | Mehtod for stabilising viruses |
| GB1017647.7 | 2010-10-19 | ||
| GBGB1017647.7A GB201017647D0 (en) | 2010-10-19 | 2010-10-19 | Method for stabilising viruses |
| GB1017648.5 | 2010-10-19 | ||
| GBGB1017648.5A GB201017648D0 (en) | 2010-10-19 | 2010-10-19 | Liquid preparation containing stabilised viruses |
| PCT/GB2011/000498 WO2011121306A1 (en) | 2010-03-31 | 2011-03-31 | Stabilisation of viral particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524782A JP2013524782A (ja) | 2013-06-20 |
| JP2013524782A5 true JP2013524782A5 (https=) | 2014-04-17 |
| JP5960120B2 JP5960120B2 (ja) | 2016-08-02 |
Family
ID=43903999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501933A Active JP5960120B2 (ja) | 2010-03-31 | 2011-03-31 | ウイルス粒子の安定化 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10206960B2 (https=) |
| EP (2) | EP2898890B1 (https=) |
| JP (1) | JP5960120B2 (https=) |
| CN (1) | CN102892424B (https=) |
| CA (1) | CA2795013C (https=) |
| DK (2) | DK2898890T3 (https=) |
| ES (2) | ES2757591T3 (https=) |
| GB (1) | GB2499479A (https=) |
| HU (2) | HUE047521T2 (https=) |
| IL (1) | IL221858A (https=) |
| WO (1) | WO2011121306A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2795050C (en) | 2010-03-31 | 2018-05-22 | Stabilitech Ltd. | Method for preserving alum adjuvants and alum-adjuvanted vaccines |
| WO2011121301A1 (en) * | 2010-03-31 | 2011-10-06 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| ES2757591T3 (es) | 2010-03-31 | 2020-04-29 | Stabilitech Biopharma Ltd | Estabilización de partículas virales |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| EP3041504B1 (en) * | 2013-09-03 | 2021-08-25 | Georgia Tech Research Corporation | Thermally stable vaccine formulations and microneedles |
| GB201406569D0 (en) * | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| CA3048313A1 (en) * | 2017-01-06 | 2018-07-12 | Stabilitech Biopharma Ltd | Virus |
| GB2562241B (en) * | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| AR113996A1 (es) | 2017-12-22 | 2020-07-08 | Intervet Int Bv | Vacunas líquidas de virus envueltos vivos |
| AU2019336940B2 (en) | 2018-09-06 | 2025-09-11 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| WO2020245355A1 (en) * | 2019-06-07 | 2020-12-10 | Intervet International B.V. | Mdbk irf3/irf7 knock out mutant cell and its use for vaccine production |
| US20210284716A1 (en) | 2020-03-11 | 2021-09-16 | Immunitybio, Inc. | ACE2-Fc Trap |
| US11857620B2 (en) | 2020-03-11 | 2024-01-02 | Immunitybio, Inc. | Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| JP7712284B2 (ja) | 2020-03-12 | 2025-07-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | ポックスウイルスの安定性を改善する組成物 |
| EP4141110A4 (en) | 2020-04-24 | 2025-04-09 | Sf Biotech Laboratuvar Danismanlik Anonim Sirketi | Method for producing particles of bacteriophages of the genus levivirus |
| AR127944A1 (es) | 2021-12-23 | 2024-03-13 | Intervet Int Bv | Vacunas líquidas estabilizadas de virus vivos |
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| WO2011109415A2 (en) | 2010-03-02 | 2011-09-09 | Amgen Inc. | Reducing viscosity of pharmaceutical formulations |
| CA2795050C (en) * | 2010-03-31 | 2018-05-22 | Stabilitech Ltd. | Method for preserving alum adjuvants and alum-adjuvanted vaccines |
| WO2011121301A1 (en) | 2010-03-31 | 2011-10-06 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| ES2757591T3 (es) | 2010-03-31 | 2020-04-29 | Stabilitech Biopharma Ltd | Estabilización de partículas virales |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
-
2011
- 2011-03-31 ES ES15158279T patent/ES2757591T3/es active Active
- 2011-03-31 CN CN201180018127.0A patent/CN102892424B/zh not_active Expired - Fee Related
- 2011-03-31 HU HUE15158279A patent/HUE047521T2/hu unknown
- 2011-03-31 EP EP15158279.8A patent/EP2898890B1/en active Active
- 2011-03-31 DK DK15158279T patent/DK2898890T3/da active
- 2011-03-31 CA CA2795013A patent/CA2795013C/en active Active
- 2011-03-31 DK DK11714373.5T patent/DK2552465T3/en active
- 2011-03-31 HU HUE11714373A patent/HUE026885T2/en unknown
- 2011-03-31 EP EP11714373.5A patent/EP2552465B1/en active Active
- 2011-03-31 JP JP2013501933A patent/JP5960120B2/ja active Active
- 2011-03-31 US US13/637,817 patent/US10206960B2/en active Active
- 2011-03-31 GB GB1216469.5A patent/GB2499479A/en not_active Withdrawn
- 2011-03-31 ES ES11714373.5T patent/ES2543795T3/es active Active
- 2011-03-31 WO PCT/GB2011/000498 patent/WO2011121306A1/en not_active Ceased
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2012
- 2012-09-09 IL IL221858A patent/IL221858A/en active IP Right Grant
-
2019
- 2019-01-02 US US16/237,889 patent/US20190307819A1/en not_active Abandoned
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