JP2013524782A5 - - Google Patents
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- Publication number
- JP2013524782A5 JP2013524782A5 JP2013501933A JP2013501933A JP2013524782A5 JP 2013524782 A5 JP2013524782 A5 JP 2013524782A5 JP 2013501933 A JP2013501933 A JP 2013501933A JP 2013501933 A JP2013501933 A JP 2013501933A JP 2013524782 A5 JP2013524782 A5 JP 2013524782A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- glycine
- virus
- sugars
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 32
- 235000000346 sugar Nutrition 0.000 claims 23
- 241000700605 Viruses Species 0.000 claims 18
- 239000004471 Glycine Substances 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 239000002245 particle Substances 0.000 claims 12
- 150000008163 sugars Chemical class 0.000 claims 12
- 239000007864 aqueous solution Substances 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 150000002148 esters Chemical class 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 229930006000 Sucrose Natural products 0.000 claims 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 7
- 239000005720 sucrose Substances 0.000 claims 7
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 claims 6
- 241000701242 Adenoviridae Species 0.000 claims 5
- 241000712464 Orthomyxoviridae Species 0.000 claims 5
- 241000711504 Paramyxoviridae Species 0.000 claims 5
- 241000700625 Poxviridae Species 0.000 claims 5
- 108700010877 adenoviridae proteins Proteins 0.000 claims 5
- -1 carboxylate anion Chemical class 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 108700003601 dimethylglycine Proteins 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 229940078490 n,n-dimethylglycine Drugs 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000003708 ampul Substances 0.000 claims 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 2
- 150000005846 sugar alcohols Chemical class 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 229940016409 methylsulfonylmethane Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 210000002845 virion Anatomy 0.000 claims 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10250706 | 2010-03-31 | ||
| GB1005520.0 | 2010-03-31 | ||
| GB1005497.1 | 2010-03-31 | ||
| GBGB1005521.8A GB201005521D0 (en) | 2010-03-31 | 2010-03-31 | Stabilised liquid formulations of virus particles |
| EP10250706.8 | 2010-03-31 | ||
| GBGB1005520.0A GB201005520D0 (en) | 2010-03-31 | 2010-03-31 | Stabilisation of viral particles |
| GBGB1005497.1A GB201005497D0 (en) | 2010-03-31 | 2010-03-31 | Method for stabilising viruses |
| GB1005521.8 | 2010-03-31 | ||
| GBGB1014962.3A GB201014962D0 (en) | 2010-09-08 | 2010-09-08 | Mehtod for stabilising viruses |
| GB1014962.3 | 2010-09-08 | ||
| GB1017647.7 | 2010-10-19 | ||
| GBGB1017648.5A GB201017648D0 (en) | 2010-10-19 | 2010-10-19 | Liquid preparation containing stabilised viruses |
| GBGB1017647.7A GB201017647D0 (en) | 2010-10-19 | 2010-10-19 | Method for stabilising viruses |
| GB1017648.5 | 2010-10-19 | ||
| PCT/GB2011/000498 WO2011121306A1 (en) | 2010-03-31 | 2011-03-31 | Stabilisation of viral particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524782A JP2013524782A (ja) | 2013-06-20 |
| JP2013524782A5 true JP2013524782A5 (https=) | 2014-04-17 |
| JP5960120B2 JP5960120B2 (ja) | 2016-08-02 |
Family
ID=43903999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501933A Active JP5960120B2 (ja) | 2010-03-31 | 2011-03-31 | ウイルス粒子の安定化 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10206960B2 (https=) |
| EP (2) | EP2552465B1 (https=) |
| JP (1) | JP5960120B2 (https=) |
| CN (1) | CN102892424B (https=) |
| CA (1) | CA2795013C (https=) |
| DK (2) | DK2552465T3 (https=) |
| ES (2) | ES2543795T3 (https=) |
| GB (1) | GB2499479A (https=) |
| HU (2) | HUE026885T2 (https=) |
| IL (1) | IL221858A (https=) |
| WO (1) | WO2011121306A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2552410B1 (en) | 2010-03-31 | 2018-10-24 | Stabilitech Biopharma Ltd | Method for preserving alum adjuvants and alum-adjuvanted vaccines |
| BR112012025047A2 (pt) * | 2010-03-31 | 2016-06-21 | Stabilitech Ltd | formulações líquidas estabilizadas |
| HUE026885T2 (en) | 2010-03-31 | 2016-08-29 | Stabilitech Ltd | Stabilize virus fragments |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| RU2720808C2 (ru) * | 2013-09-03 | 2020-05-13 | Джорджия Тек Рисёч Корпорейшн | Термостабильные препараты вакцин и микроиглы |
| GB201406569D0 (en) * | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| BR112019014004A2 (pt) * | 2017-01-06 | 2020-02-11 | Stabilitech Biopharma Ltd | Método de fornecimento de transgene, comprimido ou cápsula, método de preparação de partículas virais e produto |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| AR113996A1 (es) * | 2017-12-22 | 2020-07-08 | Intervet Int Bv | Vacunas líquidas de virus envueltos vivos |
| EP3847246A1 (en) | 2018-09-06 | 2021-07-14 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| MX2021014912A (es) * | 2019-06-07 | 2022-01-18 | Intervet Int Bv | Celula mutante mdbk con inactivacion de irf3/irf7 y su uso para producir vacunas. |
| US20210284716A1 (en) | 2020-03-11 | 2021-09-16 | Immunitybio, Inc. | ACE2-Fc Trap |
| US11857620B2 (en) | 2020-03-11 | 2024-01-02 | Immunitybio, Inc. | Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| US20230114464A1 (en) | 2020-03-12 | 2023-04-13 | Bavarian Nordic A/S | Conditions Improving Poxvirus Stability |
| WO2021215952A1 (ru) | 2020-04-24 | 2021-10-28 | Общество С Ограниченной Ответственностью "Индженик" | Способ получения частиц бактериофагов семейства levivirus |
| AR127944A1 (es) | 2021-12-23 | 2024-03-13 | Intervet Int Bv | Vacunas líquidas estabilizadas de virus vivos |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3927208A (en) | 1973-05-14 | 1975-12-16 | Rit Rech Ind Therapeut | Live bovine adenovirus vaccines, preparation thereof and method of vaccination using them |
| US4631189A (en) | 1980-03-10 | 1986-12-23 | Da Vinci Laboratories, a division of FoodScience Corporation | N,N-dimethylglycine and use in immune response |
| JPS6013718A (ja) | 1983-07-05 | 1985-01-24 | Chemo Sero Therapeut Res Inst | Ｂ型肝炎ワクチン |
| JPS60193925A (ja) | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
| US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| JPS61189228A (ja) | 1985-02-19 | 1986-08-22 | Nippon Sekijiyuujishiya | 血液凝固第８因子製剤の製法 |
| US4950596A (en) | 1985-03-04 | 1990-08-21 | The Dow Chemical Company | Stabilization of intracellular enzymes |
| JPS6238173A (ja) | 1985-08-13 | 1987-02-19 | 三菱レイヨン株式会社 | 抗血液凝固剤 |
| US5169758A (en) | 1986-05-02 | 1992-12-08 | Boehringer Mannheim Gmbh | Stabilized, NAD(P)H-dependent, soluble nitrate reductase, a process for the preparation thereof and a reagent containing it |
| US4816568A (en) | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
| NZ221306A (en) | 1986-08-15 | 1990-02-26 | Commw Scient Ind Res Org | 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof |
| US4980277A (en) | 1987-10-16 | 1990-12-25 | Cultor Ltd. | Cryoprotectant solution and method |
| WO1989011297A1 (en) | 1988-05-27 | 1989-11-30 | Centocor, Inc. | Freeze-dried formulation for antibody products |
| GB8826429D0 (en) | 1988-11-11 | 1988-12-14 | Univ Leeds Ind Service Ltd | Enzyme stabilisation systems |
| CA2065023A1 (en) | 1989-08-15 | 1991-02-16 | Brent Dorval | Stabilized vaccine compositions |
| CA2051092C (en) | 1990-09-12 | 2002-07-23 | Stephen A. Livesey | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| AU2309692A (en) * | 1991-07-03 | 1993-02-11 | Cryolife, Inc. | Method for stabilization of biomaterials |
| RU2099418C1 (ru) | 1991-11-21 | 1997-12-20 | Лонца Аг | Фрагмент днк, обеспечивающий использование бетаина, рекомбинантная плазмидная днк с фрагментом днк, обеспечивающим использование бетаина, штамм бактерий rhizobium/agrobacterium, предназначенный для стабильного хранения плазмиды с фрагментом днк, способ получения штамма бактерий |
| ZA936095B (en) | 1992-08-21 | 1994-03-14 | Univ Melbourne | Cytokine applications. |
| FR2698879B1 (fr) | 1992-12-09 | 1995-01-13 | Rhone Poulenc Biochimie | gellules modifiées au niveau du catabolisme de la bétaïne, préparation et utilisations, notamment pour la production de métabolites ou d'enzymes. |
| GB9320782D0 (en) | 1993-10-08 | 1993-12-01 | Univ Leeds Innovations Ltd | Stabilising of proteins on solution |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| US5580856A (en) | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| US5965438A (en) | 1995-06-07 | 1999-10-12 | Phyton, Inc. | Cryopreservation of plant cells |
| CA2226575C (en) | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| GB9521806D0 (en) | 1995-10-25 | 1996-01-03 | Cortecs Ltd | Preservation methods |
| FR2746109B1 (fr) | 1996-03-12 | 1998-04-17 | Rhone Poulenc Rorer Sa | Milieu pour la conservation de materiel biologique |
| US20070179096A1 (en) | 1996-04-24 | 2007-08-02 | Novo Nordisk A/S | Pharmaceutical Formulation |
| US6037116A (en) * | 1996-06-14 | 2000-03-14 | Biostore New Zealand, Ltd. | Compositions comprising betaine, sodium citrate and sodium chloride and methods for the preservation of biological materials |
| CA2242035C (en) | 1997-07-01 | 2004-11-23 | Transgene S.A. | Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy |
| AU5459698A (en) | 1997-11-26 | 1999-06-15 | Universal Preservation Technologies, Inc. | Preservation of sensitive biological samples by vitrification |
| DE69940354D1 (de) | 1998-11-16 | 2009-03-12 | Introgen Therapeutics Inc | Adenovirus-formulierungen zur gentherapie |
| US6689600B1 (en) | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| AUPQ347199A0 (en) | 1999-10-15 | 1999-11-11 | Csl Limited | Novel polypeptide fragments |
| EP1289494A2 (en) | 2000-06-08 | 2003-03-12 | Powderject Vaccines, Inc. | Powder compositions |
| DE10041515A1 (de) | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
| US20040110267A1 (en) | 2000-12-15 | 2004-06-10 | Stratagene | Room temperature stable competent cells |
| CA2449593A1 (en) | 2001-06-08 | 2002-12-19 | Powderject Vaccines, Inc. | Spray freeze-dried compositions |
| US7101693B2 (en) | 2001-09-07 | 2006-09-05 | Brigham Young University | Plasticized hydrophilic glasses for improved stabilization of biological agents |
| JP4936618B2 (ja) | 2001-09-21 | 2012-05-23 | 株式会社ノエビア | 微細エマルション組成物 |
| US20040161776A1 (en) | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
| DE60329070D1 (de) | 2001-12-28 | 2009-10-15 | Kyowa Hakko Kirin Co Ltd | Antikörper gegen den fibroblastenwachstumsfaktor 23 |
| EP3210624A1 (en) | 2002-02-27 | 2017-08-30 | Immunex Corporation | Stabilized tnfr-fc composition comprising arginine |
| JP2003261591A (ja) | 2002-03-08 | 2003-09-19 | Koji Hayade | 凍結乾燥安定剤 |
| EP1539244A1 (en) | 2002-06-27 | 2005-06-15 | Novo Nordisk A/S | Use of dimethyl sulfone as isotonicity agent |
| US20060228334A1 (en) * | 2002-07-10 | 2006-10-12 | Manuel Rosa-Calatrava | Modified adenoviral fiber with ablated to cellular receptors |
| WO2004035818A1 (en) | 2002-10-21 | 2004-04-29 | Biotage Ab | Use of osmolytes to heat stabilise luciferase and/or apyrase |
| US7462700B2 (en) | 2002-12-10 | 2008-12-09 | Schering-Plough Animal Health Corporation | Canine RANKL and methods for preparing and using the same |
| EP1633391B1 (en) | 2003-06-03 | 2011-10-19 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
| EP1638993A4 (en) | 2003-06-10 | 2007-05-09 | Univ Melbourne | IMMUNOMODULATING COMPOSITIONS, APPLICATIONS THEREOF AND METHOD FOR THE PRODUCTION THEREOF |
| US20060247167A1 (en) | 2003-09-01 | 2006-11-02 | Novo Nordisk A/S | Stable formulations of peptides |
| US7642077B2 (en) | 2003-12-08 | 2010-01-05 | Genencor International, Inc. | Biocomposite comprising co-precipitate of enzyme, silicate and polyamine |
| EP1711619A4 (en) | 2003-12-30 | 2007-04-11 | Virumar Pituach Tarkivin Ltd | INTEGRATED VIRUS COMPLEXES, METHOD FOR THE MANUFACTURE THEREOF, VACCINES CONTAINING THEM AND METHOD FOR THE USE THEREOF |
| CA2558676C (en) | 2004-03-03 | 2019-04-16 | Essentia Biosystems, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
| US20060058238A1 (en) | 2004-09-15 | 2006-03-16 | Lee Laurent-Applegate | Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same |
| EP2452670A1 (en) | 2004-10-01 | 2012-05-16 | Ramscor, Inc. | Conveniently implantable sustained release drug compositions |
| CA2586846C (en) * | 2004-11-10 | 2013-12-31 | Qlt Usa Inc. | A stabilized polymeric delivery system |
| BRPI0606867A2 (pt) | 2005-01-28 | 2009-07-21 | Wyeth Corp | formulação lìquida; forma de dosagem unitária farmacêutica; kit; recipiente; método para aumentar a estabilidade de um polipeptìdeo de ligação a antìgeno numa formulação; método para preparar uma forma de dosagem unitária farmacêutica; formulação estável; formulação; e produto terapêutico |
| GB0502661D0 (en) | 2005-02-09 | 2005-03-16 | Stabilitech Ltd | A desiccated product |
| TWI398272B (zh) * | 2005-03-08 | 2013-06-11 | Intervet Int Bv | 化學定義的安定劑 |
| CN101155914B (zh) | 2005-04-08 | 2013-03-06 | 阿戈斯治疗公司 | 树状细胞组合物和方法 |
| PT1954308E (pt) | 2005-09-16 | 2011-11-03 | Merial Ltd | Estabilizadores para vacinas liofilizadas |
| EP1933867A1 (en) | 2005-10-04 | 2008-06-25 | Alk-Abello A/S | Solid vaccine formulation |
| CN101360821A (zh) | 2005-11-21 | 2009-02-04 | 圣诺菲·帕斯图尔有限公司 | 重组病毒的稳定制剂 |
| ES2352855T3 (es) | 2005-11-30 | 2011-02-23 | International Institute Of Cancer Immunology, Inc. | Nuevos compuestos peptídicos del tumor de wilms. |
| WO2008051245A2 (en) | 2005-12-02 | 2008-05-02 | Novartis Ag | Nanoparticles for use in immunogenic compositions |
| AU2007215012A1 (en) | 2006-02-15 | 2007-08-23 | Imclone Llc | Antibody formulation |
| US8021659B2 (en) | 2006-04-28 | 2011-09-20 | Naidu Lp | Coenzyme Q10, lactoferrin and angiogenin compositions and uses thereof |
| ES2286951B1 (es) | 2006-05-26 | 2008-10-01 | Instituto Cientifico Y Tecnologico De Navarra, S.A | Nanoparticulas bioadhesivas para la administracion de moleculas biologicamente activas. |
| US20090053197A1 (en) | 2006-06-14 | 2009-02-26 | Ramaekers Joseph C | Transfer Factor Compositions and Methods |
| NZ576563A (en) * | 2006-11-03 | 2012-09-28 | Alphavax Inc | Alphavirus and alphavirus replicon particle formulations and methods |
| GB0705245D0 (en) * | 2007-03-19 | 2007-04-25 | Stabilitech Ltd | Stable biological products |
| CA2681567C (en) | 2007-03-22 | 2016-07-19 | The Regents Of The University Of Colorado, A Body Corporate | Method of preparing an immunologically-active adjuvant-bound dried vaccine composition |
| JP2010530846A (ja) | 2007-06-01 | 2010-09-16 | アコロジックス インコーポレイティッド | 高温で安定なペプチド製剤 |
| WO2009006097A1 (en) | 2007-06-29 | 2009-01-08 | Johnson & Johnson Regenerative Therapeutics, Llc | Liquid protein formulations comprising gdf-5 for use at elevated temperatures |
| EP2192908A4 (en) | 2007-07-25 | 2010-09-01 | Bioe Inc | DIFFERENTIATION OF PRECURSOR CELLS OF MULTIPLE ABSTRACTS AGAINST CHONDROCYTES |
| US20090123436A1 (en) | 2007-11-08 | 2009-05-14 | Surmodics, Inc. | Cryopreservative compositions and methods |
| BRPI0911048A2 (pt) | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| US20110212127A1 (en) | 2008-09-24 | 2011-09-01 | Stabilitech Ltd. | Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine |
| BRPI0918988A2 (pt) | 2008-09-24 | 2015-12-01 | Stabilitech Ltd | métodos para preservar um polipeptídeo e um imunógeno de vacina, e para preparar uma vacina, pó seco, produto preservado, frasco selado, ampola ou seringa, uso de um excipiente, e, vacina. |
| US8795686B2 (en) | 2008-11-07 | 2014-08-05 | Serum Institute Of India | Stable, dried rotavirus vaccine, compositions and process for preparation thereof |
| EP2430195B1 (en) * | 2009-05-11 | 2019-01-23 | Biomatrica, INC. | Compositions and methods for biological sample storage |
| CN101670104A (zh) | 2009-09-24 | 2010-03-17 | 浙江大学 | 一种含人参皂甙的油佐剂及其制备方法 |
| WO2011109415A2 (en) | 2010-03-02 | 2011-09-09 | Amgen Inc. | Reducing viscosity of pharmaceutical formulations |
| BR112012025047A2 (pt) | 2010-03-31 | 2016-06-21 | Stabilitech Ltd | formulações líquidas estabilizadas |
| HUE026885T2 (en) | 2010-03-31 | 2016-08-29 | Stabilitech Ltd | Stabilize virus fragments |
| EP2552410B1 (en) * | 2010-03-31 | 2018-10-24 | Stabilitech Biopharma Ltd | Method for preserving alum adjuvants and alum-adjuvanted vaccines |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
-
2011
- 2011-03-31 HU HUE11714373A patent/HUE026885T2/en unknown
- 2011-03-31 DK DK11714373.5T patent/DK2552465T3/en active
- 2011-03-31 JP JP2013501933A patent/JP5960120B2/ja active Active
- 2011-03-31 GB GB1216469.5A patent/GB2499479A/en not_active Withdrawn
- 2011-03-31 HU HUE15158279A patent/HUE047521T2/hu unknown
- 2011-03-31 WO PCT/GB2011/000498 patent/WO2011121306A1/en not_active Ceased
- 2011-03-31 US US13/637,817 patent/US10206960B2/en active Active
- 2011-03-31 EP EP11714373.5A patent/EP2552465B1/en active Active
- 2011-03-31 ES ES11714373.5T patent/ES2543795T3/es active Active
- 2011-03-31 DK DK15158279T patent/DK2898890T3/da active
- 2011-03-31 CN CN201180018127.0A patent/CN102892424B/zh not_active Expired - Fee Related
- 2011-03-31 CA CA2795013A patent/CA2795013C/en active Active
- 2011-03-31 ES ES15158279T patent/ES2757591T3/es active Active
- 2011-03-31 EP EP15158279.8A patent/EP2898890B1/en active Active
-
2012
- 2012-09-09 IL IL221858A patent/IL221858A/en active IP Right Grant
-
2019
- 2019-01-02 US US16/237,889 patent/US20190307819A1/en not_active Abandoned
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